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Effectiveness of hepatoprotective medication during cancer chemotherapy

TMR Cancer 2018年第2期1卷 13-22页

作者： Cordeiro Carlos jie-ge huo Feng Yu Tianjin University of Chinese Medicine Tianjin China Nanjing University of Chinese Medicine Jiangsu China China Pharmaceutical University Jiangsu China

Objective Chemotherapy may cause drug-induced liver damage and studying the effectiveness of hepatoprotective substances in the clinical context is still warranted. We assessed the effectiveness of three commonly used natural substances for liver protection in East Asia. Methods： Retrospectively, we collected all medical records during a period of three years of cancer patients that underwent chemotherapy treatment and received glutathione, magnesium isoglicyrrhyzinate or polyene phosphatidylcholine at a Chinese integrative medicine hospital. Liver enzymes before and after one treatment cycle were detected. Paired t-test, chi-square, Snedcor＇s F distribution and ANOVA were used to analyze data. Results： 98 individuals were eligible for inclusion. After treatment, in the glutathione group, there were lower values in alanine aminotransferase （P 〈 0.05） and aspartate aminotransferase （P 〈 0.05）. There was also a lower level of liver injury in patients （P 〈 0.05）. In the magnesium isoglycyrrhizinate group there were lower values in total protein （P 〈 0.05）, alkaline phosphatase （P 〈 0.05） and gamma glutamyl transpeptidase values （P 〈 0.05）. There was also a lower level of liver injury in patients after treatment （P 〈 0.05）. In the polyene phosphatidylcholine group, there were no lower values of interest, including those of liver injury in patients （P 〉 0.05）. Conclusion： Glutathione and magnesium isoglicyrrhyzinate may be similarly effective in preserving liver function and preventing drug-induced liver injury in cancer patients undergoing chemotherapy. Polyene phosphatidylcholine may have no significant activity in protecting liver function and preventing drug-induced liver injury in advanced cancer patients undergoing chemotherapy. Since elevated glutathione levels may increase the antioxidant capacity and the resistance to oxidative stress by cancer cells, it is plausible to conclude that maintenance of high intracellular levels of glutat

关键词： Cancer Chemotherapy Hepatoprotective Drug-induced liver injury Magnesium Isoglycyrrhizinate Glutathione Phosphatidylcholine.

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恶性肠梗阻的治疗现状与进展

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世界华人消化杂志 2017年第21期25卷 1921-1927页

作者：马骏霍介格南京中医药大学江苏省南京市210023 南京中医药大学附属中西医结合医院江苏省南京市210028

恶性肠梗阻(malignant bowel obstruction,MBO)是晚期肿瘤常见并发症之一,严重影响患者的生活质量.恶性肿瘤本身的复杂性导致肠梗阻治疗的复杂性、难治性.近年来,随着腹腔镜、内镜技术及介入技术的发展以及对姑息手术适应证的把握,肠梗... 详细信息

恶性肠梗阻(malignant bowel obstruction,MBO)是晚期肿瘤常见并发症之一,严重影响患者的生活质量.恶性肿瘤本身的复杂性导致肠梗阻治疗的复杂性、难治性.近年来,随着腹腔镜、内镜技术及介入技术的发展以及对姑息手术适应证的把握,肠梗阻患者的生存质量及治疗率得以提高,但尚存在一定争议,且在药物治疗方面暂无显著进展.另外,中医药在该领域亦有较多研究,显示出一定的效果,但尚缺乏前瞻性的随机对照研究.临床处理要充分考虑治疗可能带来的益处及风险,慎重选择个性化的治疗方案.本文对国内外近年来MBO的中西医诊疗进展进行系统综述,以期对临床诊疗具有一定的指导意义.

关键词：恶性肠梗阻姑息性治疗自扩张金属支架全肠外营养中医药疗法

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肝内胆管癌的分子靶向治疗进展

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世界华人消化杂志 2018年第29期26卷 1707-1716页

作者：奚松阳房栋霍介格镇江市中西医结合医院肿瘤内科江苏省镇江市212000 江苏省中西医结合医院肿瘤内科江苏省南京市210028

肝内胆管癌是一类相对少见的恶性肿瘤.极其不良的预后源于对其分子发病机制认识不足和有效治疗方法的匮乏,精准医疗计划的提出和癌症基因组学的研究,有助于对肿瘤分子发病机制深入了解以及发现潜在治疗靶点.随着基础和临床研究的深入,... 详细信息

肝内胆管癌是一类相对少见的恶性肿瘤.极其不良的预后源于对其分子发病机制认识不足和有效治疗方法的匮乏,精准医疗计划的提出和癌症基因组学的研究,有助于对肿瘤分子发病机制深入了解以及发现潜在治疗靶点.随着基础和临床研究的深入,精准靶向治疗将能够更好地改善患者预后,提高总生存率.

关键词：肝内胆管癌分子靶向治疗分子机制研究临床研究精准医学

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Potential active compounds and mechanisms of Shen-Qi-Yi-Chang granule for the treatment of colorectal cancer:an analysis of network pharmacology and molecular docking

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Drug Combination Therapy 2021年第3期3卷 1-9页

作者： Jia-Lin Gu Jia-Lin Yu Zi-Wei Song Guo-Li Wei Yi Ji Ling-Chang Li Can-Hong Hu jie-ge huo Department of Oncology Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingJiangsu 210028China The Third Clinical Medical College Nanjing University of Chinese MedicineNanjingJiangsu 210046China Department of Oncology Jiangsu Province Academy of Traditional Chinese MedicineNanjingJiangsu 210028China.

Background:In recent years,herbal formulations have assumed an influential part in preventing and treating *** Yichang granules(SQYCG)have proven effective in the adjuvant treatment of colorectal cancer(CRC),but their mechanism has not been *** study aimed to explore the potential active compounds and mechanisms of SQYCG in the treatment of CRC using network pharmacology and molecular ***:The active compounds and targets of SQYCG and the CRC genes were found using the Traditional Chinese Medicine Systems Pharmacology,DrugBank,and DisgeNET *** intersected targets of disease genes and drug targets were depicted using a Venn *** protein-protein interaction(PPI)network of these targets was obtained by String platform and visualized using *** Ontology(GO)and Kyoto Encyclopedia of genes and genomes(KEGG)enrichment analysis were carried using the DAVID database to obtain the core molecular mechanism of SQYCG in CRC *** docking techniques were used to validate the ***:A total of 63 compounds and 245 targets were obtained from the herbal prescription after the screening,of which 122 targets crossed with CRC *** showed that the core regulatory targets include MAPK1,TNF,TP53,JUN,RELA,MAPK14,and MAPK *** GO analysis indicated regulation of drug response,apoptotic process,response to hypoxia,angiogenesis,and response to *** pathway enrichment analysis mainly involves TNF,T cell receptor,Toll-like receptor,PI3K-Akt,and MAPK signal ***:Through network pharmacology,we havedemonstrated that SQYCG has multiple targets,components,and pathways in treating CRC,with anti inflammation and inhibition of cell proliferation being critical components of its mechanism.

关键词： pharmacology Shenqi Yichang granule treatment of post-operative and advanced CRC.The efficacy(SQYCG) Colorectal cancer Molecular Docking

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免疫检查点抑制剂的毒副作用及其管理

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世界华人消化杂志 2020年第16期28卷 755-764页

作者：李文宇李灵常霍介格南京中医药大学第三临床医学院江苏省南京市210028 南京中医药大学附属中西结合医院江苏省南京市210028

免疫检查点抑制剂是针对相应免疫检查点的一些单抗类药物,发挥阻断肿瘤细胞对免疫细胞的抑制作用.基于免疫治疗特有的作用机制,其相关性毒副反应不同于其他癌症疗法,机体的所有器官均可累及,以皮肤、胃肠道、肝脏、内分泌和肺部毒性为多... 详细信息

免疫检查点抑制剂是针对相应免疫检查点的一些单抗类药物,发挥阻断肿瘤细胞对免疫细胞的抑制作用.基于免疫治疗特有的作用机制,其相关性毒副反应不同于其他癌症疗法,机体的所有器官均可累及,以皮肤、胃肠道、肝脏、内分泌和肺部毒性为多见,通常是轻微、可逆的,但严重的毒副反应可危及生命.因此,加强对其相关性不良事件的管理,减少中重度毒副反应的发生,对于提高免疫治疗的疗效至关重要.本文汇总各临床指南和最新研究,分别从临床表现和管理措施两个方面对抗细胞毒性T淋巴细胞相关抗原4单抗和抗程序性死亡受体1及其配体1单抗在治疗中的常见毒副作用进行综述,为临床更有效地处理免疫相关毒性事件提供参考.

关键词：免疫检查点抑制剂细胞毒性T淋巴细胞相关抗原4 程序性死亡受体1 免疫相关不良事件毒性管理

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免疫检查点抑制剂治疗原发性肝癌的临床研究进展

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世界华人消化杂志 2020年第14期28卷 605-616页

作者：张金枝马雨竹顾佳麟霍介格南京中医药大学第三临床医学院江苏省中西医结合医院江苏省南京市210002

原发性肝癌(primary liver cancer,PLC)是我国常见的消化系统恶性肿瘤之一,其主要病理类型为肝细胞癌(hepatocellular carcinoma,HCC).目前HCC的主要治疗手段有手术切除、射频消融、化疗、经动脉栓塞化疗、肝移植等.因晚期肝癌(liver ca... 详细信息

原发性肝癌(primary liver cancer,PLC)是我国常见的消化系统恶性肿瘤之一,其主要病理类型为肝细胞癌(hepatocellular carcinoma,HCC).目前HCC的主要治疗手段有手术切除、射频消融、化疗、经动脉栓塞化疗、肝移植等.因晚期肝癌(liver cancer,LC)患者能选择的治疗方式有限,整体五年生存率仍较低,他们迫切需要新的治疗方法延长生存期及改善生活质量.近年来以程序性死亡受体-1和细胞毒T淋巴细胞相关抗原4为代表的多个免疫检察点抑制剂在治疗LC上有突破性的进展,为LC患者带来新的治疗希望.本文就免疫检查点抑制剂在PLC治疗中的临床研究进展进行阐述.

关键词：原发性肝癌免疫检查点抑制剂 PD-1/PD-L1 CTLA-4 联合用药

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MSS型mCRC的免疫治疗策略及中医药研究探索

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世界华人消化杂志 2023年第24期31卷 1007-1013页

作者：江雨静郭乃婷夏雪萍季漪霍介格南京中医药大学第三临床医学院江苏省南京市210028 南京中医药大学附属中西医结合医院江苏省南京市210028

结直肠癌(colorectal cancer,CRC)发病率和死亡率逐年上升,除传统的放疗、化疗、靶向治疗模式外,免疫治疗也为更多转移性结直肠癌患者带来希望,但这仅限于对高微卫星不稳定型的患者,对约占95%的微卫星稳定(microsatellite stable,MSS)... 详细信息

结直肠癌(colorectal cancer,CRC)发病率和死亡率逐年上升,除传统的放疗、化疗、靶向治疗模式外,免疫治疗也为更多转移性结直肠癌患者带来希望,但这仅限于对高微卫星不稳定型的患者,对约占95%的微卫星稳定(microsatellite stable,MSS)型的转移性结直肠癌(metastatic colorectal cancer,mCRC)患者尚不能从中获益,如何增强MSS型mCRC患者对免疫治疗的应答是当前研究的热点.近年来研究发现免疫治疗的联合策略有望改善此类患者的临床疗效,中医药联合免疫治疗的研究报道日趋增多.因此,本文旨在对MSS型结直肠癌的免疫治疗和中医药研究进行综述.

关键词：结直肠癌微卫星稳定免疫治疗中医药

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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao Cheng Chuankai Fu geping Yin Liguang Wang Yongmin Wu Hua huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

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Formation mechanism of streamer discharges in liquids:a review

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High Voltage 2016年第2期1卷 74-80页

作者： Anbang Sun Chao huo jie Zhuang State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049People’s Republic of China Leibniz Institute for Plasma Science and Technology(INP Greifswald) Felix-Hausdorff-Str.217489 GreifswaldGermany Northwestern Polytechnical University Xi’an 710072People’s Republic of China

Streamer discharges in liquids have received lots of attention with respect to their considerable applications invarious disciplines. Much effort has been spent to understand the basis of streamer ignition and propagation in dielectricliquids, but a comprehensive mechanism is far from conclusive. In this review, based on an introduction to the streamerphysics and experimentally observed characteristics in various liquids, the authors emphasise on the current status ofstreamer discharge ignition mechanisms and present their understanding for each theory.

关键词： dielectric discharge characteristics

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