Effectiveness of hepatoprotective medication during cancer chemotherapy
Effectiveness of hepatoprotective medication during cancer chemotherapy作者机构：Tianjin University of Chinese Medicine Tianjin China Nanjing University of Chinese Medicine Jiangsu China China Pharmaceutical University Jiangsu China
出 版 物：《TMR Cancer》 (TMR肿瘤)
年 卷 期：2018年第1卷第2期
页 面：13-22页
学科分类：10[医学]
主 题：Cancer Chemotherapy Hepatoprotective Drug-induced liver injury Magnesium Isoglycyrrhizinate Glutathione Phosphatidylcholine.
摘 要：Objective Chemotherapy may cause drug-induced liver damage and studying the effectiveness of hepatoprotective substances in the clinical context is still warranted. We assessed the effectiveness of three commonly used natural substances for liver protection in East Asia. Methods： Retrospectively, we collected all medical records during a period of three years of cancer patients that underwent chemotherapy treatment and received glutathione, magnesium isoglicyrrhyzinate or polyene phosphatidylcholine at a Chinese integrative medicine hospital. Liver enzymes before and after one treatment cycle were detected. Paired t-test, chi-square, Snedcor＇s F distribution and ANOVA were used to analyze data. Results： 98 individuals were eligible for inclusion. After treatment, in the glutathione group, there were lower values in alanine aminotransferase （P 〈 0.05） and aspartate aminotransferase （P 〈 0.05）. There was also a lower level of liver injury in patients （P 〈 0.05）. In the magnesium isoglycyrrhizinate group there were lower values in total protein （P 〈 0.05）, alkaline phosphatase （P 〈 0.05） and gamma glutamyl transpeptidase values （P 〈 0.05）. There was also a lower level of liver injury in patients after treatment （P 〈 0.05）. In the polyene phosphatidylcholine group, there were no lower values of interest, including those of liver injury in patients （P 〉 0.05）. Conclusion： Glutathione and magnesium isoglicyrrhyzinate may be similarly effective in preserving liver function and preventing drug-induced liver injury in cancer patients undergoing chemotherapy. Polyene phosphatidylcholine may have no significant activity in protecting liver function and preventing drug-induced liver injury in advanced cancer patients undergoing chemotherapy. Since elevated glutathione levels may increase the antioxidant capacity and the resistance to oxidative stress by cancer cells, it is plausible to conclude that maintenance of high intracellular levels of glutat
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