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Co-overexpression of genes for nitrogen transport, assimilation, and utilization boosts rice grain yield and nitrogen use efficiency

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The Crop Journal 2023年第3期11卷 785-799页

作者： jie Luo Junnan Hang Bilong Wu Xilin Wei Quanzh. zh.o zh.ngming Fang Institute of Rice Industry Technology Research Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education)College of Agricultural SciencesGuizhou UniversityGuiyang 550025GuizhouChina Center of Applied Biotechnology Wuhan University of BioengineeringWuhan 430415HubeiChina

Nitrogen(N)fertilization is necessary for obtaining high rice *** excessive N fertilizer reduces rice plant N efficiency and causes negative effects such as environmental *** this study,we assembled key genes involved in different nodes of N pathways to boost nitrate and ammonium uptake and assimilation,and to strengthen amino acid utilization to increase grain yield and nitrogen use efficiency(NUE)in *** combinations OsNPF8.9a×OsNR2,OsAMT1;2×OsGS1;2×OsAS1,and OsGS2×OsAS2×OsANT3 optimized nitrate assimilation,ammonium conversion,and N reutilization,*** co-overexpressing rice lines obtained by co-transformation,the tiller number,biomass,and grain yield per plant of the OsAMT1;2×OsGS1;2×OsAS1-overexpressing line exceeded those of wild-type zh.1,the OsNPF8.9a×OsNR2×OsGS1;2×OsAS1-overexpressing line,and the OsGS2×OsAS2×OsANT3-overexpressing *** glutamine synthase activity,free amino acids,and nitrogen utilization efficiency(NUt E)of the OsAMT1;2×OsGS1;2×OsAS1-overexpressing line exceeded those of zh.1 and other lines that combined key genes.N influx efficiency was increased in the OsAMT1;2×OsGS1;2×OsAS1-overexpressing line and OsNPF8.9a×OsNR2×OsGS1;2×OsAS1-overexpressing line under a low ammonium and a low nitrate treatment,*** propose that combining overexpression of OsAMT1;2,OsGS1;2,and OsAS1 is a promising breeding strategy for systematically increasing rice grain yield and NUE by focusing on key nodes in the N pathway.

关键词： Nitrogen Rice tillering Grain yield Nitrogen use efficiency Co-transformation

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Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

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Frontiers of Medicine 2020年第2期14卷 185-192页

作者： Xin Zou Ke Chen Jiawei Zou Peiyi Han jie Hao Zeguang Han Key Laboratory of Systems Biomedicine(Ministry of Education) Shanghai Centre for Systems BiomedicineShanghai Jiao Tong UniversityShanghai 200240China Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025China

It has been known that,the novel coronavirus,2019-nCoV,which is considered similar to SARS-CoV,invades human cells via the receptor angiotensin converting enzyme II(ACE2).Moreover,lung cells that have ACE2 expression may be the main target cells during 2019-nCoV ***,some patients also exhibit non-respiratory symptoms,such as kidney failure,implying that 2019-nCoV could also invade other *** construct a risk map of different human organs,we analyzed the single-cell RNA sequencing(scRNA-seq)datasets derived from major human physiological systems,including the respiratory,cardiovascular,digestive,and urinary *** scRNA-seq data analyses,we identified the organs at risk,such as lung,heart,esophagus,kidney,bladder,and ileum,and located specific cell types(i.e.,type II alveolar cells(AT2),myocardial cells,proximal tubule cells of the kidney,ileum and esophagus epithelial cells,and bladder urothelial cells),which are vulnerable to 2019-nCoV *** on the findings,we constructed a risk map indicating the vulnerability of different organs to 2019-nCoV *** study may provide potential clues for further investigation of the pathogenesis and route of 2019-nCoV infection.

关键词： 2019-nCoV ACE2 single-cell RNA-seq

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Direct construction of 3',4'-dihydrospiro[pyrrol-3,2'-oxindoles]through a cascade Michael/cyclization reaction of 3-aminoindolin-2-ones with enones/enals

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Chinese Chemical Letters 2015年第8期26卷 1050-1053页

作者： Dao-Cai Wang Hang Song Chun-Yun Xu Hui Dong jie Liu Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center for Biotherapy Department of Pharmaceutical and Biological Engineering College of Chemical Engineering Sichuan University

A simple and efficient cascade Michael/cyclization reaction of 3-aminoindolin-2-ones with enones/enals was identified for the synthesis of potentially biologically active 3＇,4＇-dihydrospiro[pyrrol-3,2＇-oxindoles], using DBU as an efficient catalyst and ethylene glycol as an environmentally benign solvent. More diverse 3＇,4＇-dihydrospiro[pyrrol-3,2＇-oxindoles] analog libraries were prepared in good yields（up to 97%）. The structure of 3＇,4＇-dihydrospiro[pyrrol-3,2＇-oxindoles] was confirmed by mass spectrometry analysis, NMR analysis and single crystal X-ray diffraction. The main advantages of this method include the availability of starting materials, simple experimental operation, short reaction time,as well as high yields observed.

关键词： cyclization glycol cascade starting analog biologically diverse potentially pyrrolidine spiro

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英语应用文写作现状及其对策——以南通航运职业技术学院为例

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岳阳职业技术学院学报 2015年第4期30卷 80-83页

作者：郑洁萍广东交通职业技术学院基础部广东广州510650

本文采用问卷调查的方式了解高职高专学生英语应用文写作现状,分析造成这些状况的原因,提出了处理这些状况的对策:把增加学生英语应用文写作的元认知知识作为主要教学目标,激发写作兴趣,积累写作素材,夯实英语语言基础和多写多改。

关键词：英语应用文写作现状对策

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神经外科手术部位感染危险因素及SAA与HBP诊断价值

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中华医院感染学杂志 2024年第7期34卷 1021-1025页

作者：徐伟丹潘昌玲徐丽英艾洁辛百龙杨莉丽水市中心医院手术室浙江丽水323000 丽水市中心医院院感科浙江丽水323000 丽水市中心医院神经外科浙江丽水323000

目的调查神经外科手术部位感染情况并分析血清淀粉样蛋白A(SAA)、肝素结合蛋白(HBP)对感染的预测价值。方法对2019年1月-2022年12月丽水市中心医院2930例神经外科手术患者进行回顾性调查,统计手术部位感染情况,分析不同感染类型的一般... 详细信息

目的调查神经外科手术部位感染情况并分析血清淀粉样蛋白A(SAA)、肝素结合蛋白(HBP)对感染的预测价值。方法对2019年1月-2022年12月丽水市中心医院2930例神经外科手术患者进行回顾性调查,统计手术部位感染情况,分析不同感染类型的一般临床资料以及感染患者的病原菌分布情况,采用Logistic回归分析手术部位感染的独立影响因素,通过绘制受试者工作特征(ROC)曲线分析术后血清SAA、HBP对手术部位感染的预测价值。结果2930例患者中,术后发生手术部位感染47例,发生率为1.60%,其中表浅切口感染9例,占比19.15%,器官腔隙感染38例,占比80.85%;47例切口感染患者中,33例检测到细菌,其中金黄色葡萄球菌是最常见的病原菌,占比36.54%;Logistic多因素回归分析显示,手术所在洁净手术室等级、使用植入物及血清SAA、HBP水平均为手术部位感染的相关影响因素(P<0.05);ROC曲线显示,血清SAA、HBP联合预测手术部位感染的敏感度、特异度、曲线下面积分别为83.91%、67.92%、0.860。结论神经外科手术部位感染发生率较高,金黄色葡萄球菌为主要病原菌,手术所在洁净手术室等级、使用植入物以及血清SAA、HBP水平是感染的独立相关因素,尤其是SAA和HBP,作为联合预测标志物,对手术部位感染的预测具有重要的临床价值。

关键词：神经外科手术手术部位感染病原菌危险因素淀粉样蛋白A 肝素结合蛋白

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城市公共不动产对创新产出的空间溢出效应研究

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经济问题 2021年第1期 97-105页

作者：闫昱洁张所地李斌赵华平山西财经大学管理工程研究中心山西太原030006

在新一轮科技革命背景下,优化城市公共不动产是打造未来发展新优势的战略抉择。基于2008—2018年35个大中城市的空间面板数据,探讨城市公共不动产对创新产出的作用机理,构建公共不动产影响创新产出的指标体系,采用空间计量模型分析城市... 详细信息

在新一轮科技革命背景下,优化城市公共不动产是打造未来发展新优势的战略抉择。基于2008—2018年35个大中城市的空间面板数据,探讨城市公共不动产对创新产出的作用机理,构建公共不动产影响创新产出的指标体系,采用空间计量模型分析城市公共不动产对创新产出的空间溢出效应。研究表明:城市创新产出存在空间集聚分布特征;城市公共不动产促进本地创新产出,对周边城市创新产出具有显著为负的空间溢出效应;不同区域城市公共不动产对创新产出的影响呈异质性,影响程度为东北>中部>西部>东部,东部表现为本地和周边城市的极化效应显著。基于此,从优化城市公共不动产、协同发展、因城施策等方面提出对策建议,以期推进创新型城市建设。

关键词：城市公共不动产创新产出空间溢出效应

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Assembly of selenoniobate-vanadoniobate double-anion heteropolyoxoniobate:synthesis,structure,and magnetic property

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Tungsten 2023年第1期5卷 75-80页

作者： zh.-jie Liang Nan Li Hai-Bing Cheng Wei-Xin Du Guan Wang Dong-Di zh.ng School of Textiles and Clothing Nantong UniversityNantong 226019China Henan Key Laboratory of Polyoxometalate Chemistry College of Chemistry and Chemical EngineeringHenan UniversityKaifeng 475004China

Recently,continuous interests and persisting efforts on heteropolyniobate have been dedicated to its preparation and *** this work,a novel Se-centred heteropolyniobate,[H2SeNb12(VO)4O40][Cu(en)2]2{[VNb12(VO)4O40][Cu(en)2]4}0.5·39H2O(en=ethanediamine),was *** compound was synthesized in aqueous solution by reacting the K7HNb6O19·13H2O with a mixture of vanadate(Ⅴ) and selenite(Ⅳ) source,which consists of two polyanions,i.e.,V-centred one and Se-centred *** architecture was characterized by infrared spectra,thermogravimetric analysis,X-ray powder diffraction spectroscopy,ultraviolet-visible and X-ray photoelectron ***,the magnetic property shows the antiferromagnetic interaction of the compound.

关键词： Heteropolyniobate Crystal structure Double-anion Self-assembly Magnetic property

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Global and regional burdens of oral cancer from 1990 to 2017:Results from the global burden of disease study

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Cancer Communications 2020年第2期40卷 81-92页

作者： zh.n-Hu Ren Chuan-Yu Hu Hai-Rong He Yuan-jie Li Jun Lyu Department of Clinical Research The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong510632P.R.China Department of Oral and Maxillofacial&Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011P.R.China Department of Oral and Maxillofacial Surgery Hainan West Central HospitalDanzhouHainan571700P.R.China Stomatology Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei430030P.R.China School of Public Health Xi’an Jiaotong University Health Science CenterXi’anShaanxi710061P.R.China Department of Human Anatomy Histology and EmbryologySchool of Basic Medical SciencesXi’an Jiaotong University Health Science CenterXi’anShaanxi710061P.R.China

Background:Data on the incidence,mortality,and other burden of oral cancer as well as their secular trends are necessary to provide policy-makers with the information needed to allocate resources *** purpose of this study was to use the Global Burden of Disease(GBD)2017 results to estimate the incidence,mortality,and disability-adjusted life years(DALYs)for oral cancer from 1990 to ***:We collected detailed data on oral cancer from 1990 to 2017 from the GBD *** global incidence,mortality,and DALYs attributable to oral cancer as well as the corresponding age-standardized rates(ASRs)were *** estimated annual percentage changes in the ASRs of incidence(ASRI)and mortality(ASRM)and age-standardized DALYs of oral cancer were also calculated according to regions and countries to quantify the secular trends in these ***:We tracked the incidence,mortality,and DALYs of oral cancer in 195 countries/territories over 28 ***,the incidence,mortality,and DALYs of oral cancer increased by about 1.0-fold from 1990 to *** ASRI of oral cancer showed a similar trend,increasing from 4.41 to 4.84 per 100,000 person-years during the study *** ASRM remained approximately stable at about 2.4 per 100,000 from 1990 to 2017,as did the age-standardized DALYs,at about 64.0 per 100,000 *** was highest in Pakistan(27.03/100,000,95%CI=22.13-32.75/100,000),followed by Taiwan China,and lowest in Iraq(0.96/100,000,95%CI=0.86-1.06/100,000).ASRM was highest in Pakistan(16.85/100,000,95%CI=13.92-20.17/100,000)and lowest in Kuwait(0.51/100,000,95%CI=0.45-0.58/100,000).Conclusions:The ASRI of oral cancer has increased slightly worldwide,while the ASRM and age-standardized DALY have remained ***,these characteristics vary between countries,suggesting that current prevention strategies should be reoriented,and much more targeted and specific strategies should be established in some countries to forestall the incre

关键词： Age-standardized rates Disability-adjusted life years Global Burden of Disease study Incidence Mortality Oral cancer

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细胞分裂周期相关蛋白5和叉头框蛋白A1在宫颈癌中的表达及临床意义

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中国妇幼保健 2024年第4期39卷 713-716页

作者：温梅英卢洁芳温伦辉叶夏斌丽水市人民医院妇产科浙江丽水323000

目的检测宫颈癌组织中细胞分裂周期相关蛋白5(CDCA5)和叉头框蛋白A1(FOXA1)的表达,分析两者在宫颈癌患者中的临床意义。方法选取2016年2月—2018年11月在丽水市人民医院确诊为宫颈癌的患者80例,利用实时荧光定量(qRT-PCR)技术检测宫颈... 详细信息

目的检测宫颈癌组织中细胞分裂周期相关蛋白5(CDCA5)和叉头框蛋白A1(FOXA1)的表达,分析两者在宫颈癌患者中的临床意义。方法选取2016年2月—2018年11月在丽水市人民医院确诊为宫颈癌的患者80例,利用实时荧光定量(qRT-PCR)技术检测宫颈癌组织和癌旁组织中CDCA5和FOXA1的相对表达量。分析宫颈癌组织中CDCA5和FOXA1表达与患者临床病理参数之间的关系。绘制Kaplan-Meier生存曲线,分析CDCA5和FOXA1与宫颈癌患者预后的关系。分析宫颈癌组织中CDCA5与FOXA1表达的相关性。结果癌旁组织中CDCA5和FOXA1相对表达量分别为(1.00±0.00)和(1.00±0.00),宫颈癌组织中CDCA5和FOXA1相对表达量分别为(1.53±0.29)和(1.58±0.34),差异均有统计学意义(t=16.346、15.258,均P<0.05)。CDCA5和FOXA1相对表达量与宫颈癌患者的肿瘤直径、FIGO分期、肌层浸润深度之间关系密切(均P<0.05)。CDCA5和FOXA1高表达组患者的生存率低于低表达组患者(均P<0.05)。宫颈癌组织中CDCA5和FOXA1相对表达量呈正相关(r=0.548,P<0.05)。结论CDCA5、FOXA1在宫颈癌组织中表达上调,两者关系密切,可能共同参与宫颈癌的发病机制和病情进展,并且与患者预后有关。

关键词：宫颈癌细胞分裂周期相关蛋白5 叉头框蛋白A1

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Phenotypic characterization and genetic mapping of the dwarf mutant m34 in maize

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Journal of Integrative Agriculture 2019年第5期18卷 948-957页

作者： LI jie-ping Soomro Ayaz Ali XIAO Gui CHEN Fan-jun YUAN Li-xing GU Ri-liang Lab of Plant-Soil Interaction Ministry of Agriculture/Department of Plant Nutrition College of Resources and Environmental Sciences China Agricultural University Center for Seed Science and Technology College of Agronomy and Biotechnology China Agricultural University

Plant height is one of the most important agronomic traits associated with yield in *** this study,a gibberellins(GA)-insensitive dwarf mutant,m34,was screened from inbred line Ye478 by treatment with the chemical mutagen ethylmethanesulfonate(EMS).Compared to Ye478,m34 showed a dwarf phenotype with shorter internodes,and smaller leaf length and width,but with similar leaf ***,m34 exhibited smaller guard cells in internodes than Ye478,suggesting that smaller cells might contribute to its dwarf *** analysis indicated that the m34 dwarf phenotype was controlled by a recessive nuclear *** F2 population derived from a cross between m34 and B73 was used for mutational gene cloning and this gene was mapped to a chromosome region between umc2189 and umc1553 in chromosome 1 bin1.10,which harbored a previously identified dwarf gene Zm *** analysis showed a nucleotide substitution(G1606 to A1606)in the sixth exon of ZmVP8,which resulted in an amino acid change(E531 to K531)from Ye478 to *** amino acid change resulted in anα-helix changing to aβ-sheet in the secondary protein structure and the‘SPEC’domain changed to a‘BOT1NT’domain in the tertiary protein *** together,these results suggested that m34 is a novel allelic mutant originally derived from Ye478 that is useful for further ZmVP8 functional analysis in maize.

关键词： dwarf plant height GA application ZmVP8 maize

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