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Precise nano-programmed ferroptosis with enhanced tumor chemotherapy

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Science China Materials 2020年第10期63卷 2086-2088页

作者： xing-jie Liang College of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Laboratory of Controllable Nanopharmaceuticals CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology of ChinaChinese Academy of Sciences(CAS)Beijing 100190China CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing 100190China

Cancer treatment is one of the greatest challenges in biomedical research,and the development of novel tumor-inhibition mechanisms has long been a topic of interest for researchers in this *** is one such candidate that holds promise for clinical *** is a recently discovered non-apoptotic model of regulated cell death that shows high iron-dependence.

关键词： Cancer clinical chemotherapy

Nonlinear dynamical systems and bistability in linearly forced isotropic turbulence

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Acta Mechanica Sinica 2013年第6期29卷 823-826页

作者： Zheng Ran xing-jie Yuan Shanghai Institute of Applied Mathematics and Mechanics Shanghai University

In this paper, we present an extensive study of the linearly forced isotropic turbulence. By using analytical method, we identify two parametric choices, of which they seem to be new as far as our knowledge goes. We prove that the underlying nonlinear dynamical system for linearly forced isotropic turbulence is the general case of a cubic Lienard equation with linear damping. We also discuss a FokkerPlanck approach to this new dynamical system, which is bistable and exhibits two asymmetric and asymptotically stable stationary probability densities.

关键词： Isotropic turbulence Nonlinear dynamical system Karman-Howarth equation

Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology

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Chinese Journal of Cancer 2012年第2期31卷 100-109页

作者： Xue, Xue Liang, xing-jie Natl Ctr Nanosci & Technol China CAS Key Lab Biomed Effects Nanomat & Nanosafety Beijing 100190 Peoples R China

Multidrug resistance(MDR),which significantly decreases the efficacy of anticancer drugs and causes tumor recurrence,has been a major challenge in clinical cancer treatment with chemotherapeutic drugs for *** mechanisms of overcoming drug resistance have been *** known P-glycoprotein(P-gp) and other drug efflux transporters are considered to be critical in pumping anticancer drugs out of cells and causing chemotherapy *** theranostic(therapeutic and diagnostic) strategies with nanoparticles are rapidly evolving and are anticipated to offer opportunities to overcome these *** this review,we discuss the mechanisms of drug efflux-mediated resistance and the application of multiple nanoparticle-based platforms to overcome chemoresistance and improve therapeutic outcome.

关键词：抗癌药物多药耐药纳米技术外排癌症 P-糖蛋白临床治疗化疗药物

Dual Control Methods for a Mixed Control Problem with Optimal Stopping Arising in Optimal Consumption and Investment

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Numerical Mathematics(Theory,Methods and Applications) 2022年第3期15卷 641-661页

作者： Jingtang Ma jie xing Shan Yang School of Mathematics Southwestern University of Finance and EconomicsChengdu 611130China Guiyang Institute for Big Data and Finance Guizhou University of Finance and EconomicsGuiyang 550025China

This paper studies a problem of optimal investment and consumption with early retirement option under constant elasticity variation(CEV)model with finite *** risky assets are involved in the model with one following geometric Brownian motion and the other a CEV *** problem is a kind of two dimensional mixed control and optimal stopping problems with finite *** existence and continuity of the optimal retirement threshold surfaces are proved and the working and retirement regions are characterized ***-squares Monte-Carlo methods are developed to solve this mixed control and optimal stopping *** algorithms are well implemented and the optimal retirement threshold surfaces,optimal investment strategies and the optimal consumptions are drawn via examples.

关键词： Optimal investment and consumption stochastic control with optimal stopping nonlinear free boundary problems least-squares Monte-Carlo methods

Numerical investigation of the effect of wedge-type cavitating-bubble generator on attached unsteady cavitating flows using proper orthogonal decomposition method

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Journal of Hydrodynamics 2023年第2期35卷 314-329页

作者： Bo-jie Hong Chang-li Hu Zhi-ying Wang Hao-jie xing School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing210094China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing100190China

The objective of this work is to reveal the effect of a passive control method called wedge-type cavitating-bubble generator(WCG)on the cloud cavitation dynamics of National Advisory Committee for Aeronautics(NACA)66 *** simulations are performed using the Partially-averaged Navier-Stokes(PANS)method coupled with the Zwart cavitation *** proper orthogonal decomposition(POD)method is applied to extract the dominant flow *** results show that the WCG can induce the attached cavity to occur just behind the WCG instead of the hydrofoil leading *** the periodical time-evolution process of the unsteady cavity,it is found that the attached cavity with a larger scale around the hydrofoil with WCG has a rougher surface,accompanied with more shedding behaviors of small *** is further illustrated by the POD modes,that is,the mode 1 and modes 2–4 present the large and small cavity vortex structures ***,the dominant frequencies of 50 Hz,47.5 Hz are given by the POD method respectively for the hydrofoils without and with WCG,which is in good agreement with that of FFT *** addition,the correlation distribution of POD modal coefficients shows that the WCG can strengthen the vortex energy as well as the turbulence intensity.

关键词： Cavitating-bubble generator proper orthogonal decomposition(POD) attached cavity vortex structures

Correlation between intrinsic dipole moment and pyroelectric coefficient of Fe-Mg tourmaline

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International Journal of Minerals,Metallurgy and Materials 2014年第2期21卷 105-112页

作者： Chang-chun Zhao Li-bing Liao jie xing School of Science China University of Geosciences School of Materials Science and Technology China University of Geosciences

Single-crystal X-ray diffraction structural data of four Fe-Mg tourmalines with different Fe contents from Xinjiang, Sichuan, and Yunnan Provinces, China, were collected at room temperature and-100oC. The intrinsic dipole moments of polyhedra and the total intrinsic dipole moment of the unit cell were calculated. By comparing the intrinsic electric dipole moments of the X, Y, Z, T, and B site polyhedra, it is found that the T site polyhedron makes the greatest contribution to the total intrinsic dipole moment. The pyroelectric coefficients of four Fe-Mg tourmalines were experimentally determined, and the influence of intrinsic dipole moments on their pyroelectric properties was inves-tigated. The experimental results show that, compared with the case at room temperature, the intrinsic dipole moments change with the total Fe content at-100oC in a completely different way. With the decrease of temperature, the total intrinsic dipole moments of tourmaline de-crease. Over the same temperature interval, the pyroelectric coefficients increase with the increase in intrinsic dipole moment.

关键词： tourmaline pyroelectricity dipole moment polyhedra

High sensitive and ultrafast UV photodetector based on ZrO_2 single crystals

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Science China(Physics,Mechanics & Astronomy) 2011年第8期54卷 1416-1419页

作者： xing jie GUO ErJia LU HuiBin School of Materials Sciences and Technology China University of Geosciences Beijing 100083 China National Laboratory of Mineral Materials China University of Geosciences Beijing 100083 China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China

The fast-response ultraviolet (UV) photoelectric effect in ZrO2 single crystals with interdigitated electrodes has been investigated experimentally at room temperature. The photovoltage of ZrO2 single crystals exhibits a linear dependence on applied bias and light power density. The photocurrent responsivity to the UV light with a wavelength of 253.65 nm is 9.8 mA/W. For the photovoltaic pulse, a rise time of 501 ps and a full width at half maximum of 1.5 ns have been obtained, when the ZrO2 single crystal is illuminated by a 266 nm pulsed laser. These results indicate that the ZrO2 single crystal is a promising candidate for UV photodetectors.

关键词： photoelectric effect ultraviolet photodetector ZrO2 single crystals

Nanomaterial-assisted sensitization of oncotherapy

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Nano Research 2018年第6期11卷 2932-2950页

作者： Yufei Wang Juan Liu Xiaowei Ma xing-jie Liang CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China Tissue Engineering Lab Beijing Institute of Transfusion Medicine Beijing 100850 China

Globally, cancer is growing at an alarming pace, which calls for development of more efficient cancer treatments. Conventional chemotherapy and radiotherapy have become crucial first-line clinical treatments for cancer. However, along with their wide usage, limited therapeutic effects, severe adverse reactions, unaffordable costs, and complicated operations lead to failures of these treat- ments. Moreover, the emergence of multidrug resistance inhibits the longtirne usage of chemotherapeutics. One of the major causes of treatment failure is the insufficient sensitivity of cancer cells to therapeutic drugs or treatments. With the rigorous development of nanotechnolog~ tailored nanoparticles can efficiently sensitize malignant cells by inducing intracellular structural and functional changes, which could affect vital intracellular processes such as metabolism, signal conduction, proliferation, cell death as well as intracellular drug delivery. Here, we review recent advances in nanomaterial-assisted sensitization of oncotherapy, and challenges and strategies in the development of nanomedical approaches.

关键词： nanomaterial oncotherapy sensitization of oncotherapy mulfidrug resistance

Boosting Whale Optimizer with Quasi-Oppositional Learning and Gaussian Barebone for Feature Selection and COVID-19 Image Segmentation

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Journal of Bionic Engineering 2023年第2期20卷 797-818页

作者： jie xing Hanli Zhao Huiling Chen Ruoxi Deng Lei Xiao Key Laboratory of Intelligent Informatics for Safety&Emergency of Zhejiang Province Wenzhou UniversityWenzhou325035China

Whale optimization algorithm(WOA)tends to fall into the local optimum and fails to converge quickly in solving complex *** address the shortcomings,an improved WOA(QGBWOA)is proposed in this ***,quasi-opposition-based learning is introduced to enhance the ability of WOA to search for optimal ***,a Gaussian barebone mechanism is embedded to promote diversity and expand the scope of the solution space in *** verify the advantages of QGBWOA,comparison experiments between QGBWOA and its comparison peers were carried out on CEC 2014 with dimensions 10,30,50,and 100 and on CEC 2020 test with dimension ***,the performance results were tested using Wilcoxon signed-rank(WS),Friedman test,and post hoc statistical tests for statistical *** accuracy and speed are remarkably improved,as shown by experimental ***,feature selection and multi-threshold image segmentation applications are demonstrated to validate the ability of QGBWOA to solve complex real-world *** proves its superiority over compared algorithms in feature selection and multi-threshold image segmentation by performing several evaluation metrics.

关键词： Whale optimization algorithm Quasi-opposition-based learning Gaussian barebone Image segmentation Feature selection Bionic algorithm