Nanomaterial-assisted sensitization of oncotherapy

作     者：Yufei Wang Juan Liu Xiaowei Ma Xing-Jie Liang 

作者机构：CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China Tissue Engineering Lab Beijing Institute of Transfusion Medicine Beijing 100850 China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2018年第11卷第6期

页      面：2932-2950页

核心收录：

学科分类：081702[工学-化学工艺] 080503[工学-材料加工工程] 08[工学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：国家自然科学基金 北京市自然科学基金 supported by the Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CAS supported in part by the Natural Science Foundation key projects support of the Strategic Priority Research Program of the Chinese Academy of Sciences 

主　　题：nanomaterial oncotherapy sensitization of oncotherapy mulfidrug resistance 

摘      要：Globally, cancer is growing at an alarming pace, which calls for development of more efficient cancer treatments. Conventional chemotherapy and radiotherapy have become crucial first-line clinical treatments for cancer. However, along with their wide usage, limited therapeutic effects, severe adverse reactions, unaffordable costs, and complicated operations lead to failures of these treat- ments. Moreover, the emergence of multidrug resistance inhibits the longtirne usage of chemotherapeutics. One of the major causes of treatment failure is the insufficient sensitivity of cancer cells to therapeutic drugs or treatments. With the rigorous development of nanotechnolog~ tailored nanoparticles can efficiently sensitize malignant cells by inducing intracellular structural and functional changes, which could affect vital intracellular processes such as metabolism, signal conduction, proliferation, cell death as well as intracellular drug delivery. Here, we review recent advances in nanomaterial-assisted sensitization of oncotherapy, and challenges and strategies in the development of nanomedical approaches.