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Frequency and Reliability Analysis of Load-Bearing Composite Beams

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Automotive Innovation 2024年第1期7卷 194-207页

作者： Junlei Wei Lingyu Sun Xinli Gao Wenfeng Pan jiaxin wang Jinxi wang School of Transportation Science and Engineering Beihang University37 Xueyuan RoadHaidian DistrictBeijing 100191China Beijing Key Laboratory for High-Efficient Power Transmission and System Control of New Energy Resource Vehicle Beihang University37 Xueyuan RoadHaidian DistrictBeijing 100191China Beijing Hangshu Vehicle Data Research Institute Co. Ltd.Beijing 100062China

The increasing utilization of fiber-reinforced thermoplastics(FRTPs)as a substitute for metal in load-bearing structures poses challenges related to NVH issues arising from frequency variations and reliability concerns stemming from fiber dispersion within the resin *** this study,the steel automobile seat beam serves as a benchmark for *** beams are designed and fabricated using two distinct processes:compression molding and injection ***,their modal frequency and reliability are meticulously *** investigations are conducted to explore the influence of various factors,including the combination of laminates and ribs,as well as the stacking sequence of laminates,on the modal *** findings reveal that the modal frequency and vibration mode are subject to alterations based on the fiber type,beam material,and laminate stacking ***,in comparison to the steel benchmark,the first-order frequency of the FRTP beam in this study experiences a 6.59%increase while simultaneously achieving a weight reduction of 32.42%.To assess reliability,a comprehensive analysis is performed,considering a six-fold standard *** analysis yields the permissible range of fluctuation for material elastic constants,bending performance,and frequency ***,the FRTP beams meet the required reliability *** results provide valuable insights for comprehending the stiffness-dependent response and effectively controlling structural performance when implementing FRTP for weight reduction purposes.

关键词： Automobile Fiber-reinforced thermoplastics Lightweight design Frequency change Reliability analysis

ROS-responsive hydrogels with spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs for the repair of MRSA-infected wounds

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Regenerative Biomaterials 2024年第1期3卷 119-131页

作者： Bowen Qiao jiaxin wang Lipeng Qiao Aziz Maleki Yongping Liang Baolin Guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Zanjan Pharmaceutical Nanotechnology Research Center(ZPNRC) Zanjan 45139-56184Iran Department of Orthopaedics The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061People’s Republic of China

For the treatment of MRSA-infected wounds,the spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs is a promising *** this study,ROS-responsive HA-PBA/PVA(HPA)hydrogel was prepared by phenylborate ester bond cross-linking between hyaluronic acid-grafted 3-amino phenylboronic acid(HA-PBA)and polyvinyl alcohol(PVA)to achieve spatiotemporally controlled release of two kinds of drug to treat MRSA-infected *** hydrophilic antibiotic moxifloxacin(M)was directly loaded in the *** hydrophobic curcumin(Cur)with anti-inflammatory function was first mixed with Pluronic F127(PF)to form Cur-encapsulated PF micelles(Cur-PF),and then loaded into the HPA *** to the different hydrophilic and hydrophobic nature of moxifloxacin and Cur and their different existing forms in the HPA hydrogel,the final HPA/M&Cur-PF hydrogel can achieve different spatiotemporally sequential delivery of the two *** addition,the swelling,degradation,self-healing,antibacterial,anti-inflammatory,antioxidant property,and biocompatibility of hydrogels were ***,in the MRSA-infected mouse skin wound,the hydrogel-treated group showed faster wound closure,less inflammation and more collagen *** experiments further confirmed that the hydrogel promoted better repair by reducing inflammation(TNF-a)and promoting vascular(VEGF)*** conclusion,this HPA/M&CurPF hydrogel that can spatiotemporally sequential deliver antibacterial and anti-inflammatory drugs showed great potential for the repair of MRSA-infected skin wounds.

关键词： MRSA-infected wounds spatiotemporally sequential delivery antibacterial anti-inflammatory

Highly selectiveα-C(sp^(3))-H arylation of alkenyl amides via nickel chain-walking catalysis

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Chinese Chemical Letters 2024年第7期35卷 271-275页

作者： Haoran Shi jiaxin wang Yuqin Zhu Hongyang Li Guodong Ju Lanlan Zhang Chao wang Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China

Herein,we report the migratory hydroarylation of unactivated alkenes with aryl iodides using native and weakly coordinating amide directors under mild *** coordination of the monodentate directing group and the ligand enable the highly regioselective migratory hydroarylation via a chain walking process to form the thermodynamically stable five-membered nickelacyle *** protocol provides a variety of valuableα-aryl-substituted alkylamine products,and exhibited good functional group *** modification of bioactive compounds such as fenofibrate and indomethacin further highlights the synthetic value of this protocol.

关键词： Alkenes Hydroarylation Chain-walking Regioselective Nickel catalysis

Bacteria-responsive programmed self-activating antibacterial hydrogel to remodel regeneration microenvironment for infected wound healing

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National Science Review 2024年第4期11卷 254-270页

作者： Yutong Yang jiaxin wang Shengfei Huang Meng Li Jueying Chen Dandan Pei Zhen Tang Baolin Guo State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology and Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine ResearchCollege of Stomatology Xi'an Jiaotong University Department of Orthopedics Tangdu Hospital Fourth Military Medical University Department of Orthopedics The First Affiliated Hospital of Xi'an Jiaotong University

There is still an urgent need to develop hydrogels with intelligent antibacterial ability to achieve on-demand treatment of infected wounds and accelerate wound healing by improving the regeneration microenvironment. We proposed a strategy of hydrogel wound dressing with bacteria-responsive self-activating antibacterial property and multiple nanozyme activities to remodel the regeneration microenvironment in order to significantly promote infected wound healing. Specifically, p H-responsive H2O2self-supplying composite nanozyme（MSCO） and p H/enzyme-sensitive bacteria-responsive triblock micelles encapsulated with lactate oxidase（PPEL） were prepared and encapsulated in hydrogels composed of L-arginine-modified chitosan（CA） and phenylboronic acid-modified oxidized dextran（ODP） to form a cascade bacteria-responsive self-activating antibacterial composite hydrogel platform. The hydrogels respond to multifactorial changes of the bacterial metabolic microenvironment to achieve on-demand antibacterial and biofilm eradication through transformation of bacterial metabolites, and chemodynamic therapy enhanced by nanozyme activity in conjunction with self-driven nitric oxide（NO） release. The composite hydrogel showed 'self-diagnostic' treatment for changes in the wound *** self-activating antibacterial therapy in the infection stage to self-adaptive oxidative stress relief and angiogenesis in the post-infection stage, it promotes wound closure, accelerates wound collagen deposition and angiogenesis, and completely improves the microenvironment of infected wound regeneration, which provides a new method for the design of intelligent wound dressings.

关键词： bacterial response hydrogel dressing multiple nanozyme activity biofilm elimination infected motion wound healing

Retrospective and prospective review of the generalized nonlinear strength theory for geomaterials

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1767-1787页

作者： Shunchuan Wu jiaxin wang Shihuai Zhang Shigui Huang Lei Xia Qianping Zhao Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093China Key Laboratory of Geohazard Forecast and Geoecological Restoration in Plateau Mountainous Area MNRKunming 650093China Yunnan Key Laboratory of Geohazard Forecast and Geoecological Restoration in Plateau Mountainous Area Kunming 650093China School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China

Strength theory is the basic theory for calculating and designing the strength of engineering materials in civil,hydraulic,mechanical,aerospace,military,and other engineering ***,the comprehensive study of the generalized nonlinear strength theory(GNST)of geomaterials has significance for the construction of engineering rock *** paper reviews the GNST of geomaterials to demonstrate the research status of nonlinear strength characteristics of geomaterials under complex stress ***,it systematically summarizes the research progress of GNST(classical and empirical criteria).Then,the latest research the authors conducted over the past five years on the GNST is introduced,and a generalized three-dimensional(3D)nonlinear Hoek‒Brown(HB)criterion(NGHB criterion)is proposed for practical *** criterion can be degenerated into the existing three modified HB criteria and has a better prediction *** strength prediction errors for six rocks and two in-situ rock masses are 2.0724%-3.5091%and 1.0144%-3.2321%,***,the development and outlook of the GNST are expounded,and a new topic about the building strength index of rock mass and determining the strength of in-situ engineering rock mass is *** summarization of the GNST provides theoretical traceability and optimization for constructing in-situ engineering rock mass strength.

关键词： rock mechanics rock mass strength strength theory failure criterion Hoek-Brown criterion intermediate principal stress deviatoric plane smoothness and convexity

Corrigendum to"SEMA4D acts as a novel oligogenic pathogenic gene of idiopathic hypogonadotropic hypogonadism through the PlexinB1/MET/RND1/RHOA/RAF1/MAPK signaling axis"[Genes&Diseases 10(2023)65-68]

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Genes & Diseases 2024年第4期11卷 428-429页

作者： Daoqi wang Yonghua Niu Jiahong Tan jiaxin wang Le Ling Yinwei Chen Jianan Gong Hao Xu Qing Ling Jianhe Liu Jihong Liu Department of Urology The Second Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650033China Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Pediatric Surgery Tongji HospitalTongji Medical CollegeWuhanHubei 430030China Department of Obstetrics and Gynecology The First People's Hospital of Yunnan ProvinceKunmingYunnan 650034China Department of Urology First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150007China

The authors regret to correct the error in the order of the institute of the first author,which should go as the following.

关键词： Cor Diseases pogon

孤独症人群的公共设施需求——初步实证与规划思考

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城市规划 2024年第2期48卷 84-93页

作者：朱玮王嘉欣同济大学建筑与城市规划学院城市规划系上海同济城市规划设计研究院有限公司数字规划技术研究中心

包容性城市理念下,城乡规划须兼顾孤独症人群的公共设施需求。基于文献研究、问卷调查、孤独症家庭及专家机构访谈,总结孤独症人群使用公共设施的行为和需求特征,重点分析其“痛点”需求,讨论规划应对原则和措施。研究发现:公园绿地的... 详细信息

包容性城市理念下,城乡规划须兼顾孤独症人群的公共设施需求。基于文献研究、问卷调查、孤独症家庭及专家机构访谈,总结孤独症人群使用公共设施的行为和需求特征,重点分析其“痛点”需求,讨论规划应对原则和措施。研究发现:公园绿地的使用强度最高、障碍最小;体育设施虽常用,但配套功能缺乏、存在潜在危险,社区运动场地是其主要替代;其他设施的使用都存在较大困境,硬件、公众认识和服务支持的包容性缺失是主要障碍;重点需求设施功能包括干预训练、家庭咨询、日间照料、庇护就业、全日养护。当前规划主要任务是制定面向孤独症人群的公共设施配置标准,同时在专用型、共用型设施(服务)上分别制定配置指标或包容性设计导则。

关键词：孤独症公共设施需求规划标准

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米歇尔·亨利论“我思”的给予与感受生命

学术研究 2024年第5期 32-38页

作者：王嘉新西安交通大学人文社会科学学院陕西西安710049

米歇尔·亨利是法国新现象学的代表人物之一。通过自身感受的概念,亨利批评了胡塞尔基于明见性奠基“我思”的策略,并将“我思”置于生命感受性之中。亨利强调,我思是内在性绝对的自身运动,强调内在对外在的优先性。他把主体性与世界的... 详细信息

米歇尔·亨利是法国新现象学的代表人物之一。通过自身感受的概念,亨利批评了胡塞尔基于明见性奠基“我思”的策略,并将“我思”置于生命感受性之中。亨利强调,我思是内在性绝对的自身运动,强调内在对外在的优先性。他把主体性与世界的交互关联转换为由内在性运动规定的同一过程的双面显现。为了阐明这一模式,亨利将内在性的感受运动解释为大写感受与小写感受两个方向,并将这两方面对应于基督教神学中的神子关系。在此基础上,亨利把构成世界的意向性“我思”理解为一种在世界中的超越论幻觉。由此,亨利赋予了现象学主体一种新的意涵,即在自身中的生命感受性,并从现象学的角度辩护了生命的不可还原的优先性。

关键词：我思内在性自我超越论幻觉

同频共振:英国产业发展与职业教育建设衔接路径与匹配机制

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比较教育研究 2024年第5期46卷 105-112页

作者：王佳昕山西师范大学教育科学学院山西太原030031

职业教育承载着为区域经济发展服务的重大使命,必须紧跟产业结构调整的步伐,按照区域经济产业发展需求确定人才培养规格才能切实提升职业教育吸引力。英国职业教育体系坚持以“雇主主导,多方利益共同体有机参与”为导向,产业发展与职业... 详细信息

职业教育承载着为区域经济发展服务的重大使命,必须紧跟产业结构调整的步伐,按照区域经济产业发展需求确定人才培养规格才能切实提升职业教育吸引力。英国职业教育体系坚持以“雇主主导,多方利益共同体有机参与”为导向,产业发展与职业教育建设的衔接路径以行业协作为实施抓手、以政府引领为实施导向和以培训机构为实施主体,有效提升职业教育吸引力。英国产业发展与职业教育建设的匹配机制包括动态互动的治理机制、灵活精准的投资机制、以雇主满意度为标准的质量认证与评估机制和双管齐下的资格认定制度,保障职业教育建设与产业发展协调发展,实现同频共振。

关键词：职业教育雇主职业资格行业协会