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Multi-omics Approach Reveals Influenza-A Virus Target Genes Associated Genomic,Clinical and Immunological Characteristics in Cancers

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Biomedical and Environmental Sciences 2024年第7期37卷 698-715页

作者： jiaojiao wang Yong Liao Pinglian Yang Weile Ye Yong Liu Chunxia Xiao Weixiong Liao Chunbo Chen Zhiping Liu Zunnan Huang Center of Scientific Research Department of CardiologyMaoming People’s HospitalMaoming 525000GuangdongChina Department of Pharmacy Maoming People’s HospitalMaoming 525000GuangdongChina State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632GuangdongChina Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632GuangdongChina Key Laboratory of Big Data Mining and Precision Drug Design of Guangdong Medical University Key Laboratory of Computer-Aided Drug Design of Dongguan CityKey Laboratory for Research and Development of Natural Drugs of Guangdong ProvinceSchool of PharmacyGuangdong Medical UniversityDongguan 523808GuangdongChina Department of Critical Care Medicine Maoming People’s HospitalMaoming 525000GuangdongChina

Objective To examine the precise function of influenza A virus target genes(IATGs)in *** Using multi-omics data from the TCGA and TCPA datasets,33 tumor types were evaluated for *** expression in cancer cells was analyzed using transcriptome *** number variation(CNV)was assessed using GISTICS ***’s analysis was used to correlate mRNA expression with methylation *** was used for the enrichment ***’s correlation analysis was used to examine the association between IATG mRNA expression and *** ImmuCellAI algorithm was used to calculate the infiltration scores of 24 immune cell *** In 13 solid tumors,IATG mRNA levels were atypically *** for UCS,UVM,KICH,PCPG,THCA,CHOL,LAMI,and MESO,most cancers contained somatic IATG *** main types of CNVs in IATGs are heterozygous amplifications and *** most tumors,IATG mRNA expression is adversely associated with ***-PCR demonstrated that EGFR,ANXA5,CACNA1C,CD209,UVRAG were upregulated and CLEC4M was downregulated in KIRC cell lines,consistent with the TCGA and GTEx *** Genomic changes and clinical characteristics of IATGs were identified,which may offer fresh perspectives linking the influenza A virus to cancer.

关键词： Genomic changes Immune microenvironment Prognosis Drug resistance Experimental validation

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AI for science: Predicting infectious diseases

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Journal of Safety Science and Resilience 2024年第2期5卷 130-146页

作者： Alexis Pengfei Zhao Shuangqi Li Zhidong Cao Paul Jen-Hwa Hu jiaojiao wang Yue Xiang Da Xie Xi Lu Institute of Automation Chinese Academy of SciencesUniversity of Chinese Academy of SciencesBejing 100090China Systems Engineering Cornll UniversityIthacaNY 14853USA David Eccles School of Business the University of UtahUtahUSA Collge of Electrical Engineering Sichuan UniversityChina Department of Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Electrical Engineering Southeast UniversityNanjing 210096China

The global health landscape has been persistently challenged by the emergence and re-emergence of infectious *** epidemiological models,rooted in the early 2oth century,have provided foundational in-sights into disease ***,the intricate web of modern global interactions and the exponential growth of available data demand more advanced predictive *** is where AI for Science(AI4S)comes into play,offering a transformative approach by integrating artificial intelligence(Al)into infectious disease *** paper elucidates the pivotal role of AI4s in enhancing and,in some instances,superseding tradi-tional epidemiological *** harnessing AI's capabilities,AI4S facilitates real-time monitoring,sophisticated data integration,and predictive modeling with enhanced *** comparative analysis highlights the stark contrast between conventional models and the innovative strategies enabled by *** essence,Al4S represents a paradigm shift in infectious disease *** addresses the limitations of traditional models and paves the way for a more proactive and informed response to future *** we navigate the complexities of global health challenges,Al4S stands as a beacon,signifying the next phase of evolution in disease prediction,characterized by increased accuracy,adaptability,and efficiency.

关键词： AI for science(AI4S) Data integration Global healthchallenges Infectious disease prediction Predictive modeling Real-timemonitoring

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FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 1605-1623页

作者： Zhifeng Huang Tongtong Pan Liang Xu Lu Shi Xiong Ma Liya Zhou Luyao wang jiaojiao wang Guoqing Zhu Dazhi Chen Lingtao Song Xiaomin Pan Xiaodong wang Xiaokun Li Yongde Luo Yongping Chen Hepatology Diagnosis and Treatment Center Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseasesthe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)&School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China School of Laboratory Medicine and Life Sciences Wenzhou Medical University&Key Laboratory of Laboratory MedicineMinistry of EducationWenzhou Medical UniversityWenzhou 325035China Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and HepatologyMinistry of HealthState Key Laboratory for Oncogenes and Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Hangzhou Medical College Hangzhou 311300China

Immune-mediated liver injury (ILI) is a condition where an aberrant immune response due to various triggers causes the destruction of hepatocytes. Fibroblast growth factor 4 (FGF4) was recently identified as a hepatoprotective cytokine;however, its role in ILI remains unclear. In patients with autoimmune hepatitis (type of ILI) and mouse models of concanavalin A (ConA)- or S-100-induced ILI, we observed a biphasic pattern in hepatic FGF4 expression, characterized by an initial increase followed by a return to basal levels. Hepatic FGF4 deficiency activated the mitochondria-associated intrinsic apoptotic pathway, aggravating hepatocellular apoptosis. This led to intrahepatic immune hyper-reactivity, inflammation accentuation, and subsequent liver injury in both ILI models. Conversely, administration of recombinant FGF4 reduced hepatocellular apoptosis and rectified immune imbalance, thereby mitigating liver damage. The beneficial effects of FGF4 were mediated by hepatocellular FGF receptor 4, which activated the Ca^(2+)/calmodulin-dependent protein kinasekinase 2 (CaMKKβ) and its downstream phosphatase and tensin homologue-induced putative kinase 1 (PINK1)-dependent B-cell lymphoma 2-like protein 1-isoform L (Bcl-XL) signalling axis in the mitochondria. Hence, FGF4 serves as an early response factor and plays a protective role against ILI, suggesting a therapeutic potential of FGF4 and its analogue for treating clinical immune disorder-related liver injuries.

关键词： Fibroblast growthfactor 4 Fibroblast growth factor receptor 4 Immune liver injury Ca^(2+)/Calmodulin dependent protein

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Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba

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Acta Pharmaceutica Sinica B 2024年第1期14卷 1-19页

作者： Weile Ye jiaojiao wang Peter JLittle Jiami Zou Zhihua Zheng Jing Lu Yanjun Yin Hao Liu Dongmei Zhang Peiqing Liu Suowen Xu Wencai Ye Zhiping Liu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Pharmacy Australia Centre of Excellence School of PharmacyUniversity of QueenslandWoolloongabba QLD 4102Australia Sunshine Coast Health Institute and School of Health and Behavioural Sciences University of the Sunshine CoastBirtinya QLD 4575Australia National-Local Joint Engineering Lab of Druggability and New Drugs Evaluation Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510006China School of Pharmacy Bengbu Medical CollegeBengbu 233030China Institute of Endocrine and Metabolic Diseases the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

Bioactive compounds derived from herbal medicinal plants modulate various therapeutic targets and signaling pathways associated with cardiovascular diseases(CVDs),the world’s primary cause of *** biloba,a well-known traditional Chinese medicine with notable cardiovascular actions,has been used as a cardio-and cerebrovascular therapeutic drug and nutraceutical in Asian countries for *** studies have shown that ginkgolide B,a bioactive component in Ginkgo biloba,can ameliorate atherosclerosis in cultured vascular cells and disease *** clinical relevance,several clinical trials are ongoing or being completed to examine the efficacy and safety of ginkgolide B-related drug preparations in the prevention of cerebrovascular diseases,such as ischemia ***,we present a comprehensive review of the pharmacological activities,pharmacokinetic characteristics,and mechanisms of action of ginkgolide B in atherosclerosis prevention and *** highlight new molecular targets of ginkgolide B,including nicotinamide adenine dinucleotide phosphate oxidases(NADPH oxidase),lectin-like oxidized LDL receptor-1(LOX-1),sirtuin 1(SIRT1),platelet-activating factor(PAF),proprotein convertase subtilisin/kexin type 9(PCSK9)and ***,we provide an overview and discussion of the therapeutic potential of ginkgolide B and highlight the future perspective of developing ginkgolide B as an effective therapeutic agent for treating atherosclerosis.

关键词： Cardiovascular disease Atherosclerosis Ginkgo biloba Ginkgolide B Endothelial dysfunction LOX-1 PCSK9 PAF-R antagonist

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Fine mapping of the powdery mildew resistance gene PmXQ-0508 in bread wheat

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The Crop Journal 2024年第4期12卷 1176-1184页

作者： Zejun Qian Guohao Han Ningning Yu Cheng Liu Ran Han Paula E.Jameson jiaojiao wang Ya Zhao Bei Xiao Ruishan Liu Jiadong Zhang Yuli Jin Hongjie Li Pengtao Ma Yantai Key Laboratory of Characteristic Agricultural Biological Resources Conservation and Germplasm Innovative Utilization College of Life SciencesYantai UniversityYantai 264005ShandongChina Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050021HebeiChina Crop Research Institute Shandong Academy of Agriculture SciencesJinan 250100ShandongChina School of Biological Sciences University of CanterburyChristchurch 8140CanterburyNew Zealand The National Engineering Laboratory of Crop Molecular Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

In a wheat breeding line XQ-0508 showing consistent resistance to powdery mildew disease,a recessive gene,designated PmXQ-0508,was identified and mapped to a distal region on chromosome arm *** three resistance-associated genes in this region,one encoding a protein kinase was selected as the primary candidate for *** closely linked DNA markers developed in the study could be used for marker-assisted selection for powdery-mildew resistance in breeding programs.

关键词： Wheat powdery mildew PmXQ-0508 BSR-Seq Fine mapping Marker-assisted selection

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让新手教师都能胜任教学:基于高能实践的美国特殊教育教师职前培养探究

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中国特殊教育 2024年第5期 87-96页

作者：王娇娇唐佳益王雁北京师范大学教育学部北京100875 重庆师范大学教育科学学院重庆401331

高能实践是美国实践取向特殊教育教师职前培养的一个侧枝,旨在摆脱职前培养项目长期存在的重理论轻实践困境,避免职前教师在缺乏变量控制的无序实践中学习。它在承认教学复杂性的前提下,强调提炼并总结教学中频繁发生的、基础的、“生... 详细信息

高能实践是美国实践取向特殊教育教师职前培养的一个侧枝,旨在摆脱职前培养项目长期存在的重理论轻实践困境,避免职前教师在缺乏变量控制的无序实践中学习。它在承认教学复杂性的前提下,强调提炼并总结教学中频繁发生的、基础的、“生成性”的实践活动,并通过精心设计的职前培养课程与教学帮助职前教师熟练掌握并运用核心实践集,实现每位新手教师都能胜任教学的愿景。本文对美国基于高能实践的特殊教育教师职前培养的提出背景、制定与实施、影响与挑战进行梳理与介绍。在此基础上,结合我国高质量特殊教育及其师资队伍建设的现实背景,提出相应建议。

关键词：高能实践职前培养特殊教育教师美国

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浙江省高等职业院校专业设置与产业结构契合性实证研究

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职业技术教育 2024年第2期45卷 34-39页

作者：王娇娇韩鑫彤浙江省发展规划研究院杭州310012 中国人民大学

专业设置是否契合区域产业发展是制约职业教育与产业发展深度融合的重要前端因素。基于对浙江50所高等职业院校(包含2所职业本科)专业设置的实证分析发现,当前浙江高等职业院校专业结构与产业结构基本匹配,但随着新时期产业发展定位的... 详细信息

专业设置是否契合区域产业发展是制约职业教育与产业发展深度融合的重要前端因素。基于对浙江50所高等职业院校(包含2所职业本科)专业设置的实证分析发现,当前浙江高等职业院校专业结构与产业结构基本匹配,但随着新时期产业发展定位的调整变化,二者的契合性仍存在结构化问题突出、梯度化差异显著、特色化程度不够等问题,据此提出加强统筹规划、锚定错位发展、注重特色发展、健全动态专业调整机制、从需求侧推动专业设置优化等对策建议。

关键词：高职院校专业设置产业结构契合性

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抗苗勒管激素与促黄体生成素/卵泡刺激素比值联合检测在多囊卵巢综合征中的诊断价值分析

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实用妇科内分泌电子杂志 2024年第9期11卷 81-83页

作者：王姣娇南通市妇幼保健院检验科江苏南通226000

目的探讨抗苗勒管激素(AMH)与促黄体生成素(LH)/卵泡刺激素(FSH)比值联合检测在多囊卵巢综合征(PCOS)中的诊断价值。方法选取45例PCOS患者作为观察组;另选取同期体检的健康育龄期女性80例作为健康组。检测并比较两组的AMH、LH、FSH以及L... 详细信息

目的探讨抗苗勒管激素(AMH)与促黄体生成素(LH)/卵泡刺激素(FSH)比值联合检测在多囊卵巢综合征(PCOS)中的诊断价值。方法选取45例PCOS患者作为观察组;另选取同期体检的健康育龄期女性80例作为健康组。检测并比较两组的AMH、LH、FSH以及LH/FSH指标,分析检查指标的相互关系及对PCOS的诊断价值。结果健康组AMH、LH、FSH以及LH/FSH低于观察组(P<0.05)。经Pearson相关分析,AMH与LH、FSH、LH/FSH之间相互成正相关(P<0.05),LH与FSH、LH/FSH之间相互成正相关(P<0.05)。AMH联合LH/FSH对PCOS的诊断敏感度和特异度明显高于单一指标(P<0.05)。结论AMH与LH/FSH联合应用可以进一步提高PCOS诊断的敏感度和特异度,具有较高的辅助价值。

关键词：抗苗勒管激素促黄体生成素卵泡刺激素多囊卵巢综合征

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组蛋白修饰调控心脏衰老的研究进展

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中华心血管病杂志 2024年第9期52卷 1126-1130页

作者：王娇娇黄逸凡张静杨简三峡大学第一临床医学院宜昌市中心人民医院心内科缺血性心血管病湖北省重点实验室湖北省缺血性心血管疾病临床医学研究中心宜昌443003

心脏衰老与相关心血管疾病是中老年群体生命健康的主要威胁, 揭示其发病机制对全面认识心脏衰老, 推动相关防治策略发展具有重要意义。组蛋白修饰作为表观遗传学的重要组成部分, 已被证实在心脏衰老过程中发挥关键作用, 该文就组蛋白修... 详细信息

心脏衰老与相关心血管疾病是中老年群体生命健康的主要威胁, 揭示其发病机制对全面认识心脏衰老, 推动相关防治策略发展具有重要意义。组蛋白修饰作为表观遗传学的重要组成部分, 已被证实在心脏衰老过程中发挥关键作用, 该文就组蛋白修饰调控心脏衰老的效应及分子生物学机制作一综述。

关键词：衰老心脏衰老组蛋白组蛋白甲基化组蛋白乙酰化组蛋白磷酸化

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基于改进BP神经网络的软土路基沉降预测研究

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黑龙江科学 2024年第16期15卷 72-76页

作者：王恒王佼佼中冶南方城市建设工程技术有限公司武汉430070

结合软土路基沉降观测值,分别从精度、安全性和预测期限等角度对双曲线模型、S型成长曲线模型和BP神经网络进行适用性分析。为了提高沉降预测精度、克服传统BP神经网络缺陷,采用LM优化算法改进BP神经网络,验证了LM算法的优越性,在此基... 详细信息

结合软土路基沉降观测值,分别从精度、安全性和预测期限等角度对双曲线模型、S型成长曲线模型和BP神经网络进行适用性分析。为了提高沉降预测精度、克服传统BP神经网络缺陷,采用LM优化算法改进BP神经网络,验证了LM算法的优越性,在此基础上建立了一种考虑趋势部分和随机部分的组合预测模型。该模型既符合路基沉降的发展规律,又能够充分利用BP神经网络的非线性外推能力,弥补趋势函数的精度下降。工程实例研究表明,该模型优于各单一预测模型,具有很好的预测效果,均方差为0.03,残差平方和为1.8,相关系数接近1。

关键词：沉降预测 BP神经网络组合预测 LM算法适用性

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