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Potential therapeutic effect of epigenetic therapy on Ireatment-induced neuroendocrine prostate cancer

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Asian Journal of Andrology 2017年第6期19卷 686-693页

作者： Xiang Xu Yu-Hua huang Yan-Jing Li Alexa Cohen Zhen Li Jill Squires Wei Zhang Xu-Feng Chen Min Zhang jiao-ti huang School of Life Sciences Anhui University Hefei China Department of Pathology and Laboratory Medicine University of California at Los Angeles Los Angeles California USA Department of Urology The First Affiliated Hospital of SooChow University Suzhou China Department of Medical Oncology Rutgers Cancer Institute of New Jersey New Brunswick New Jersey USA Department of Pathology Beijing Hospital Beijing China

Although adenocarcinomas of the prostate are relatively indolent, some patients with advanced adenocarcinomas show recurrence of treatment-induced neuroendocrine prostate cancer, which is highly aggressive and lethal. Detailed biological features of treatment-induced neuroendocrine prostate cancer have not been characterized owing to limited biopsies/resections and the lack of a cellular model. In this study, we used a unique cellular model （LNCaP/NE1.8） to investigate the potential role of cancer stem cells in treatment-induced neuroendocrine prostate cancer with acquired resistance to hormonal therapy and chemotherapy. We also studied the role of cancer stem cells in enhancing invasion in treatment-induced neuroendocrine prostate cancer cells that recurred after long-term androgen-ablation treatment. Using an in vitro system mimicking clinical androgen-ablation, our results showed that the neuroendocrine-like subclone NE1.8 cells were enriched with cancer stem cells. Compared to parental prostate adenocarcinoma LNCaP cells, NE1.8 cells are more resistant to androgen deprivation therapy and chemotherapeutic agents and show increased cancer cell invasiveness. Results from this study also suggest a potential epigenetic therapeutic strategy using suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, as a chemotherapeutic agent for therapy-resistant treatment-induced neuroendocrine prostate cancer cells to minimize the risk of prostate cancer recurrence and metastasis.

关键词： cancer stem cell epigenetic therapy hormonal therapy neuroendocrine prostate cancer suberoylanilide hydroxamic acid

Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion

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Asian Journal of Andrology 2014年第2期16卷 319-324,I0012页

作者： Yi Sun Min Wei Shan-Cheng Ren Rui Chen Wei-Dong Xu Fu-Bo Wang Ji Lu Jian Shen Yong-Wei Yu Jian-Guo Hou Chuan-Liang Xu jiao-ti huang Ying-Hao Sun Department of Urology Shanghai Changhai Hospital Second Military Medical University Shanghai Department of Urology Huadong Hospital Fudan University Shanghai China Department of Pathology and Laboratory Medicine David Geffen School of Medicine at the University of California at Los Angeles 10833 Le Conte Avenue 13-229 CHS Los Angeles California USA.

SETDB1 has been established as an oncogene in a number of human carcinomas. The present study was to evaluate the expression of SETDB1 in prostate cancer （PCa） tissues and cells and to preliminarily investigate the role of SETDB1 in prostate tumorigenesis in vitro. Quantitative reverse transcription polymerase chain reaction （qRT-PCR） and immunohistochemistry （IHC） were used to detect the expression of SETDB1 in PCa tissues, adjacent normal tissues, benign prostatic hyperplasia （BPH） tissues, PCa cell lines and normal prostate epithelial cells. The results suggested that SETDB1 was upregulated in human PCa tissues compared with normal tissues at the mRNA and protein levels. The role of SETDB1 in proliferation was analyzed with cell counting kit-8, colony-forming efficiency and flow cytometry assays. The results indicated that downregulation of SETDB1 by siRNA inhibited PCa cell growth, and induced GO/G1 cell cycle arrest. The PCa cell migration and invasion decreased by silcencing SETDBt which were assessed by using in vitro scratch and transwell invasion assay respectively. Our data suggested that SETDB1 is overexpressed in human PCa. Silencing SETDB1 inhibited PCa cell proliferation, migration and invasion.

关键词： epigenomics histone methyltransferases prostate cancer (PCa) SETDB1

Machine learning driven rational design of dual atom catalysts on graphene for carbon dioxide electroreduction

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Nano Research 2025年第1期18卷 186-194页

作者： Dongxu jiao Xinyi Li Mingzi Sun Lin Liu Jinchang Fan Jingxiang Zhao Bolong huang Xiaoqiang Cui State Key Laboratory of Automotive Simulation and Control School of Materials Science and Engineeringand Key Laboratory of Automobile Materials of MOEJilin UniversityChangchun 130012China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina College of Chemistry and Chemical Engineering and Key Laboratory of Photonic and Electronic Bandgap MaterialsMinistry of EducationHarbin Normal UniversityHarbin 150025China

The development of high-performance atomiccatalysts for the carbon dioxide reduction reaction(CO_(2)RR)is atime-consuming process due to the complexity of the reactionmechanism and the uncertainty of the active ***,wehave proposed combining density functional theory(DFT)andmachine learning(ML)to investigate the potential of topologicalgraphene-based dual-atom catalysts(DACs)as CO_(2)*** analyzing the ML results,we identify thenumber of d-orbital electrons in the active site as a key factorinfluencing the CO_(2)RR catalytic ***,wepropose a simple descriptor to measure the CO_(2)RR activity ofthese *** findings provide plausible explanations for thesynergistic interactions between bimetallic atoms in CO_(2)RR andallow us to screen the homogeneous Ni-Ni pair as the mostpromising dual-atom *** work offers a fast MLapproach based on limited DFT calculations to predict the mostelectroactive and stable DACs on carbon support for CO_(2)RR,facilitating rapid screening of high-performance dual-atomcatalysts.

关键词： CO_(2)reaction reduction dual-atom catalysts density functional theory machine learning

Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-Shou Kuo Kuan-Hsun Lin Ying-Yi Chen Yuan-Ming Tsai ti-Hui Wu Hsu-Kai huang Tsai-Wang huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

Image segmentation based on differential immune clone clustering algorithm

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International Journal of Intelligent Computing and Cybernetics 2013年第1期6卷 83-102页

作者： Wenping Ma Feifei ti Congling Li Licheng jiao Key Lab of Intelligent Perception and Image Understanding of Ministry of Education of China Xidian UniversityXi’anChina

Purpose–The purpose of this paper is to present a Differential Immune Clone Clustering Algorithm(DICCA)to solve image ***/methodology/approach–DICCA combines immune clone selection and differential evolution,and two populations are used in the evolutionary *** reproduction and selection,differential mutation,crossover and selection are adopted to evolve two populations,which can increase population diversity and avoid local *** extracting the texture features of an image and encoding them with real numbers,DICCA is used to partition these features,and the final segmentation result is ***–This approach is applied to segment all sorts of images into homogeneous regions,including artificial synthetic texture images,natural images and remote sensing images,and the experimental results show the effectiveness of the proposed ***/value–The method presented in this paper represents a new approach to solving clustering *** novel method applies the idea two populations are used in the evolutionary *** proposed clustering algorithm is shown to be effective in solving image segmentation.

关键词： Differential evolution Clone selection Clustering Image segmentation Image processing Cluster analysis

Some Properties of Abnormal Extremals on Lie Groups

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Acta Mathematica Sinica,English Series 2014年第12期30卷 2119-2136页

作者： ti Ren huang Xiao Ping YANG Department of Mathematics Zhejiang Sci-Tech University Department of Applied Mathematics Nanjing University of Science & Technology

Let G be a connected Lie group and D be a bracket generating left invariant *** this paper,first,we prove that all sub-Riemannian minimizers are smooth in Lie groups if the distribution D satisfies [D,[D,D]]D and [K,[K,K]]K for any proper sub-distribution K of ***,we prove that all sub-Riemannian minimizers are smooth in Lie group if the rank-3 distribution D satisfies Condition（B）.Third,we discuss characterizations of normal extremals,abnormal extremals,rigid curves,and minimizers on product sub-riemannian Lie *** prove that not all strictly abnormal minimizers are rigid curves and construct a strictly abnormal minimizer which is not a rigid curve.

关键词： Extremal geodesic rigid curve Lie group

Acidichromism in the LB film of bolaform Schiff base

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Chinese Chemical Letters 2007年第1期18卷 30-32页

作者： Mei Fang Yin ti Feng jiao Ming Hua Liu Beijing National Laboratory for Molecular Sciences （BNLMS） CAS Key Laboratory of Colloid and Interface Science CAS Beijing 100080 China

A bolaform （BNC10） and single-headed （HNOA） amphiphilic Schiff bases containing naphthyl group were designed and their Langmuir-Blodgett films were investigated. It was found that both the LB films show acidichromism, i.e. a reversible color change upon alternatively exposing the films to HC1 and NH3 gases, respectively. It was further found that the bolaform Schiff bases film could trap NH3 gas during the acidichromic process.

关键词： Acidiehromism Schiff base Langmuir-Blodgett (LB) film Bolaamphiphile

Tailoring edge and interface states in topological metastructures exhibiting the acoustic valley Hall effect

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Science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 82-92页

作者： jiao Wang Yang huang WeiQiu Chen Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China State Key Lab of CAD&CG Zhejiang UniversityHangzhou 310058China Soft Matter Research Center Zhejiang UniversityHangzhou 310027China

In this study, we investigate the acoustic topological insulator or topological metastructure, where an acoustic wave can exist only in an edge or interface state instead of propagating in bulk. Breaking the structural symmetry enables the opening of the Dirac cone in the band structure and the generation of a new band gap, wherein a topological edge or interface state ***, we systematically analyze two types of topological states that stem from the acoustic valley Hall effect mechanism;one type is confined to the boundary, whereas the other type can be observed at the interface between two topologically different structures. Results denote that the selection of different boundaries along with appropriately designed interfaces provides the acoustic waves in the band gap range with abilities of one-way propagation, dual-channel propagation, immunity from backscattering at sharp corners, and/or transition between propagation at interfaces and boundaries. Furthermore, we show that the acoustic wave propagation paths can be tailored in diverse and arbitrary ways by combing the two aforementioned types of topological states.

关键词： acoustic crystals valley Hall effect edge states interface states Dirac cone

Hormander Type Multipliers on Anisotropic Hardy Spaces

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Acta Mathematica Sinica,English Series 2019年第11期35卷 1841-1853页

作者： jiao CHEN Liang huang School of Mathematical Sciences Chongqing Normal UniversityChongqing 401131P.R.China School of Mathematical Sciences Beijing Normal UniversityBeijing 100875P.R.China

The main purpose of this paper is to establish, using the Littlewood–Paley–Stein theory(in particular, the Littlewood–Paley–Stein square functions), a Calderón–Torchinsky type theorem for the following Fourier multipliers on anisotropic Hardy spaces Hp(Rn;A) associated with expensive dilation A:■Our main Theorem is the following: Assume that m(ξ) is a function on Rn satisfying ■with s > ζ--1(1/p-1/2). Then Tm is bounded from Hp(Rn;A) to Hp(Rn;A) for all 0 tions mj(ξ) = m(A*jξ)φ(ξ) and φ(ξ) is a suitable cut-off function on Rn, and Ws(A*) is an anisotropic Sobolev space associated with expansive dilation A* on Rn.

关键词： Hormander multiplier Littlewood-Paley’s inequality anisotropic Hardy space anisotropic Sobolev spaces