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Early adenocarcinoma mixed with a neuroendocrine carcinoma component arising in the gastroesophageal junction: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 563-570页

作者： yu-Qing Cheng Geng-Fang Wang xiao-Li Zhou Min Lin Xin-Wen Zhang Qin Huang Department of Pathology The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Gastroenterology Center The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMA 02215United States

BACKGROUND Early adenocarcinoma mixed with a neuroendocrine carcinoma(NEC)component arising in the gastroesophageal junctional(GEJ)region is rare and even rarer in young ***,we report such a case in a 29-year-old Chinese *** SUMMARY This patient presented to our hospital with a 3-mo history of dysphagia and *** endoscopy revealed an elevated nodule in the distal esophagus 1.6 cm above the GEJ line,without Barrett’s esophagus or involvement of the gastric *** nodule was completely resected by endoscopic submu-cosal dissection(ESD).Pathological examination confirmed diagnosis of intra-mucosal adenocarcinoma mixed with an NEC component,measuring 1.5 ***,both adenocarcinoma and NEC components were positive for P53 with a Ki67 index of 90%;NEC was positive for synaptophysin and ***-generation sequencing of 196 genes demonstrated a novel germline mutation of the ERCC3 gene in the DNA repair pathway and a germline mutation of the RNF43 gene,a common gastric cancer driver gene,in addition to pathogenic somatic mutations in P53 and CHEK2 *** patient was alive without evidence of the disease 36 mo after *** Early adenocarcinoma with an NEC component arising in the distal esophageal side of the GEJ region showed evidence of gastric origin.

关键词： Adenocarcinoma Neuroendocrine carcinoma Gastroesophageal junction Next generation sequencing Case report

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永磁同步电机驱动电动汽车速度自适应控制

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电机与控制学报 2011年第11期15卷 83-89页

作者：焦晓红李帅燕山大学电气工程学院河北秦皇岛066004

针对电动汽车行进过程中复杂的车辆运行环境易造成驱动电机参数变化和系统外界干扰引入的现象,研究永磁同步电机驱动电动汽车行进速度的自适应跟踪控制问题。将电动汽车驱动部分与传动系整合,建立整个系统的非线性数学模型。针对该系统... 详细信息

针对电动汽车行进过程中复杂的车辆运行环境易造成驱动电机参数变化和系统外界干扰引入的现象,研究永磁同步电机驱动电动汽车行进速度的自适应跟踪控制问题。将电动汽车驱动部分与传动系整合,建立整个系统的非线性数学模型。针对该系统本身的非线性、强耦合性等特点,同时考虑实际系统中一些物理量出现的变化,运用非线性反步法结合解耦控制技术,综合设计系统的非线性自适应控制器。理论分析表明,即使在系统参数不确定性和负载扰动存在的情况下,仍能保证整个闭环系统的稳定性。仿真结果验证了该方法可以有效地克服系统的非线性特性及运行过程中参数变化和负载扰动引起的跟踪误差,达到期望的运行性能。

关键词：电动汽车永磁同步电机自适应控制速度控制跟踪控制反步法

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Giant hemangioma of the caudate lobe of the liver with surgical treatment:A case report

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World Journal of Clinical Cases 2021年第21期9卷 5980-5987页

作者： Xin-Xin Wang Bao-Long Dong Biao Wu Shi-Yong Chen yu He xiao-Jun Yang Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Gansu University of Chinese Medicine The 1st Clinical Medicine CollegeLanzhou 730000Gansu ProvinceChina Peoples Clinical Medicine College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Gansu Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Gansu Research Center of Prevention and Control Project for Digestive Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Caudate lobe hemangioma of the liver is relatively *** to the unique anatomical location of the caudate lobe,the caudate lobectomy accounts for only 0.5%to 4%of hepatic resection,which is difficult to operate and takes a long time,and even has many postoperative *** SUMMARY A 34-year-old female presented with a 1 year history of intermittent pain in the right side of the waist without obvious *** laboratory blood tests were within normal *** green 15 min retention was rated 2.9%,and Child-Pugh was rated *** tomography and magnetic resonance imaging diagnosed giant hemangioma of the caudate lobe with hemangioma of left lobe of *** discussion,surgical treatment was performed,which lasted 410 min,with intraoperative bleeding of about 600 mL and postoperative pathological findings of cavernous *** were no obvious postoperative complications,and the patient was discharged 10 d after *** Caudate lobectomy is difficult due to its special anatomical *** the condition of fully exposing the anatomy of the first porta hepatis,the second porta hepatis,the third porta hepatis,the fourth porta hepatis and middle hepatic vein and combining with the Pringle maneuver,caudate lobectomy can be performed in a precise and safe process.

关键词： Caudate lobe hemangioma Caudate lobectomy Case report

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Mixing of Enriched Lithospheric Mantle-Derived and Crustal Magmas： Evidence from the Habo Cenozoic Porphyry in Western yunnan

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Acta Geologica Sinica(English Edition) 2018年第5期92卷 1753-1768页

作者： XIA Bin LU Ye yuAN Yajuan CHEN Weiyan ZHANG xiao XU Chi yu Shengrui WAN Zhifeng School of Marine Sciences Sun Yat-sen University Guangzhou 510006 China Key Laboratory of Offshore Oil Exploration and Development of Guangdong Higher Education Institutes Guangzhou 51006 China Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering Guangzhou 510006China

New zircon U–Pb ages, whole-rock geochemistry and zircon Hf isotopes from the Habo porphyry Western yunnan, China, were determined to provide constraints on the timing of uplift of the Eastern Tibetan Plateau. The intrusive rocks consist of shoshonitic porphyry（syenite porphyry and monzonite porphyry）. Zircon laser ablation inductively coupled plasma mass spectrometry（LA-ICPMS） U–Pb dating indicates coeval emplacement ages of ～35 Ma. The porphyries have alkaline affinities, enrichment in large ion lithophile elements（LILEs） and light rare earth elements（LREEs）（e.g., Rb, Th, U, Pb）, with depletion of high field strength elements（HFSEs）（e.g., Nb, Ti, Ta） and weak Eu anomalies. They display uniform Lu–Hf isotopic compositions with negative zircon εHf（t） values ranging from-3.9 to-0.6. The chemical characteristics of the syenite porphyries indicated that they most likely originated from the lower crust, with mantle-derived material involved in their generation. Geochemically, the monzonite porphyries are similar to the syenite porphyries; however, the lower MgO contents suggest that they were produced by different degrees of partial melting of the same lower crust source. Combined with the geochemical and isotopic data in this paper, imply that the alkali-rich porphyries of the Habo polymetallic deposit were derived from the partial melting of lower crust, enriched by mantle magma, formed in a conversion stage from stress extrusion（a strike-slip shear process） to local stress relaxation（a strike-slip pull-apart process） at the Ailaoshao tectonic zone.

关键词： geochronology geochemistry Lu–Hf isotopes Habo porphyry western yunnan

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Analysis of the vortices in the inner flow of reversible pump turbine with the new omega vortex identification method

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Journal of Hydrodynamics 2018年第3期30卷 463-469页

作者： yu-ning Zhang Kai-hua Liu Jin-wei Li Hai-zhen Xian xiao-ze Du Key Laboratory of Fluid and Power Machinery Ministry of EducationXihua UniversityChengdu 610039China Key Laboratory of Condition Monitoring and Control for Power Plant Equipment(Ministry of Education) North China Electric Power UniversityBeijing 102206China Beijing South-to-North Water Diversion Tuancheng Lake Management Office Beijing 100195China China Institute of Water Resources and Hydropower Research Beijing 100048China

Reversible pump turbines are widely employed in the pumped hydro energy storage power plants. The frequent shifts among various operational modes for the reversible pump turbines pose various instability problems, e.g., the strong pressure fluctuation, the shaft swing, and the impeller damage. The instability is related to the vortices generated in the channels of the reversible pump turbines in the generating mode. In the present paper, a new omega vortex identification method is applied to the vortex analysis of the reversible pump turbines. The main advantage of the adopted algorithm is that it is physically independent of the selected values for the vortex identification in different working modes. Both weak and strong vortices can be identified by setting the same omega value in the whole passage of the reversible pump turbine. Five typical modes（turbine mode, runaway mode, turbine brake mode, zero-flow-rate mode and reverse pump mode） at several typical guide vane openings are selected for the analysis and comparisons. The differences between various modes and different guide vane openings are compared both qualitatively in terms of the vortex distributions and quantitatively in terms of the areas of the vortices in the reversible pump turbines. Our findings indicate that the new omega method could be successfully applied to the vortex identification in the reversible pump turbines.

关键词： Reversible pump turbine vorticity vortex identification omega method

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Combined remediation of DDT congeners and cadmium in soil by Sphingobacterium sp.D-6 and Sedum alfredii Hance

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Journal of Environmental Sciences 2012年第6期24卷 1036-1046页

作者： Hua Fang Wei Zhou Zhengya Cao Feifan Tang Dandan Wang Kailin Liu Xiangwei Wu xiao'e Yang Yongge Sun yunlong yu Department of Plant Protection College of Agriculture & Biotechnology Zhefiang University Hangzhou 310058 China. E-mail: agri@*** Key Laboratory of Molecular Biology of Crop Pathogens and Insects Ministry of Agriculture Hangzhou 310058 China MOE Key Lab of Environment Remediation & Ecosystem Health College of Environmental and Resource Sciences Zhejiang University Hangzhou 310058 China Department of Earth Science Zhejiang University Hangzhou 310027 China State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China

Combined pollution of 1,1,1-trichloro-2,2-bis （4-chlorophenyl） ethane （DDT） and cadmium （Cd） in agricultural soils is of great concern because they present serious risk to food security and human *** order to develop a cost-effective and safe method for the removal of DDTs and Cd in soil,combined remediation of DDTs and Cd in soil by Sphingobacterium sp.D-6 and the hyperaccumulator,Sedum alfredii Hance was *** treatment for 210 days,the degradation half-lives of DDTs in soils treated by strain D-6 decreased by 8.1% to 68.0% compared with those in the *** inoculation of strain D-6 into soil decreased the uptake of DDTs by pak choi and *** shoots/roots ratios of *** for the Cd accumulation ranged from 12.32 to *** Cd concentration in soil decreased to 65.8%-71.8% for *** treatment and 14.1%-58.2% for *** and strain D-6 combined treatment,respectively,compared with that in the *** population size of the DDTs-degrading strain,Simpson index （1/D） and soil respiratory rate decreased in the early stage of treatment and then gradually increased,ultimately recovering to or exceeding the initial *** results indicated that synchronous incorporation of strain D-6 and *** into soil was found to significantly （p 0.05） enhance the degradation of DDTs in soil and the hyperaccumulation of Cd in *** was concluded that strain D-6 and *** could be used successfully to control DDTs and Cd in contaminated soil.

关键词： bioremediation cadmium Sphingobacterium sp. Sedum alfredii Hance 1,1,1-trichloro-2,2-bis (4-chlorophenyl) ethane

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Multiple “Omics” data-based biomarker screening for hepatocellular carcinoma diagnosis

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World Journal of Gastroenterology 2019年第30期25卷 4199-4212页

作者： xiao-Na Liu Dan-Ni Cui yu-Fang Li yun-He Liu Gang Liu Lei Liu Institutes of Biomedical Sciences Fudan University

The huge prognostic difference between early and late stage hepatocellular carcinoma(HCC)is a challenging diagnostic ***-fetoprotein is the mostly widely used biomarker for HCC used in the clinic,however it’s sensitivity and specificity of is not *** development and application of multiple biotechnologies,including next generation sequencing,multiple“omics”data,that include genomics,epigenomics,transcriptomics,proteomics,metabolomics,metagenomics has been used for HCC diagnostic biomarker *** biomarkers/panels/models have been identified and validated at different clinical levels.A large proportion of these have a good diagnostic performance for HCC,especially for early *** this article,we reviewed the various HCC biomarkers derived from“omics”data and discussed the advantages and disadvantages for diagnosis HCC.

关键词： Hepatocellular carcinoma Diagnosis Circulating tumor cells Exosomes Circulating tumor DNA RNA Metabolomics Protein

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Machine Learning Models in Type 2 Diabetes Risk Prediction:Results from a Cross-sectional Retrospective Study in Chinese Adults

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Current Medical Science 2019年第4期39卷 582-588页

作者： xiao-lu XIONG Rong-xin ZHANG Yan BI Wei-hong ZHOU yun yu Da-long ZHU Department of Endocrinology Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjing 210008China School of Biomedical Engineering and Informatics Nanjing Medical UniversityNanjing 211166China

Type 2 diabetes mellitus (T2DM) has become a prevalent health problem in China,especially in urban *** prevention strategies are needed to reduce the associated mortality and *** applied the combination of rules and different machine learning techniques to assess the risk of development of T2DM in an urban Chinese adult population.A retrospective analysis was performed on 8000 people with non-diabetes and 3845 people with T2DM in *** Perceptron (MLP),AdaBoost (AD),Trees Random Forest (TRF),Support Vector Machine (SVM),and Gradient Tree Boosting (GTB) machine learning techniques with 10 cross validation methods were used with the proposed model for the prediction of the risk of development of *** performance of these models was evaluated with accuracy,precision,sensitivity,specificity,and area under receiver operating characteristic (ROC) curve (AUC).After comparison,the prediction accuracy of the different five machine models was 0.87,0.86,0.86,0.86 and 0.86 *** combination model using the same voting weight of each component was built on T2DM,which was performed better than individual *** findings indicate that,combining machine learning models could provide an accurate assessment model for T2DM risk prediction.

关键词： type 2 diabetes risk prediction machine learning

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KAI1 inhibits lymphangiogenesis and lymphatic metastasis of pancreatic cancer in vivo

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 87-92页

作者： Xu Liu xiao-Zhong Guo Hong-yu Li Jiang Chen Li-Nan Ren Chun-Yan Wu Department of Gastroenterology General Hospital of Shenyang Military Area

BACKGROUND: Several studies have shown that KAI1 inhibits tumor metastasis, but its mechanism is not clear. The present study aimed to determine the role of KAI1 in lymphatic metastasis, specifically in pancreatic cancer. METHODS: The KAI1 gene was transfected into the pancreatic cancer cell line MIA PaCa-2 and PANC-1 by using liposomes and selected by G418, and the protein was measured by Western blotting. After successful infection, the cell growth curve was studied by MTT, vascular endothelial growth factor C(VEGF-C) secretion by pancreatic cancer cell were measured by ELISA. The KAI1 and pCMV transfected MIA PaCa-2 cells were renamed as MIA PaCa-2-K and MIA PaCa-2-p. These two kinds of cells were injected into the subcuticular layer of nude mice; both tumor growth and metastasis through the lymphatic nodes were assessed. Lymphangiogenesis in tumors was measured by immunohistochemistry. RESULTS: The VEGF-C secretion was significantly reduced in MIA PaCa-2 cells compared with PANC-1 cells after being transfected with the KAI1 gene. The growth rate of subcutaneous tumors was similar after the injection of MIA PaCa-2-K, MIA PaCa-2, and MIA PaCa-2-p. MIA PaCa-2-K tumors showed slower lymphangiogenesis and lymph node metastasis compared with MIA PaCa-2 and MIA PaCa-2-p tumors. CONCLUSION: The overexpression of KAI1 inhibits the lymphangiogenesis and lymph node metastasis of MIA PaCa-2 pancreatic tumors.

关键词： KAI1 pancreatic cancer lymphatic metastasis lymphangiogenesis

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栓菌漆酶在毕赤酵母中高效表达及重组酶的性质

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生物工程学报 2007年第6期23卷 1055-1059页

作者：周宏敏洪宇植肖亚中 CUI Teng-jiao WANG xiao-Tang 蒲春蕾安徽大学生命科学学院＆现代实验技术中心合肥230039 佛罗里达国际大学化学与生物化学系迈阿密FL33199美国中国科学技术大学生命科学学院合肥230026

栓菌420（Trametes sp．420）漆酶基因lacD以两种方式在巴斯德毕赤酵母（Pichiapastoris）进行异源表达，产生两种重组漆酶：rLacDx（具有天然N-末端）和rLacDe（N-末端带有8个额外的氨基酸残基）。摇瓶发酵18d，rLacDx和rLacDe的产量... 详细信息

栓菌420（Trametes sp．420）漆酶基因lacD以两种方式在巴斯德毕赤酵母（Pichiapastoris）进行异源表达，产生两种重组漆酶：rLacDx（具有天然N-末端）和rLacDe（N-末端带有8个额外的氨基酸残基）。摇瓶发酵18d，rLacDx和rLacDe的产量分别为1．21×10^5u／L、7、38×10^4u／L[以2，2＇-连氮-3-乙苯-二噻唑-6磺酸（ABTS）为底物]。在高密度发酵条件下，rLacDx的产量增加到2．39×10^5u／L，同时其生产周期降至7．5d。两种重组酶对愈创木酚底物的氧化特性相似，且在50℃和pH3～10的范围内均稳定。然而，rLacDx对底物ABTS的比活力（1761u／mg）高于rLacDe（1122u／mg），其表观Km值（427μmol／L）低于rLacDe（604μmol／L）。

关键词：异源表达高密度发酵漆酶毕赤酵母栓菌420

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