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Translational oncology toward benefiting cancer patients:the Sun Yat-sen University Cancer Center experience

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Science China(Life Sciences) 2016年第10期59卷 1057-1062页

作者： Mathilde Guerin Chaonan Qian Qian Zhong Qian Cui Yunmiao Guo Jinxin Bei jianyong shao Xiaofeng Zhu Wenlin Huang Jiangxue Wu Ranyi Liu Qiang Liu Jing Wang Weihua Jia Xiaohui Zheng Yixin Zeng Sun Yat-sen University Cancer Center Guangzhou 510060China

Cancer is a leading cause of death in China with an estima- tion of nearly 2 million deaths every year （Chen and Fu, 2011b）. Matter of a public health importance in China and worldwide, the scientific community is still facing many obstacles to eradicate cancer： complexity of a mul- ti-factorial disease with organ-based specificities, high fail- ure rate of many anti-cancer drugs in clinical trials, lack of understanding of the cancer genesis factors.

关键词：癌症患者中山大学肿瘤转化器官特异性多因子疾病公共卫生抗癌药物

CD30 expression in extranodal natural killer/T-cell lymphoma,nasal type among 622 cases of mature T-cell and natural killer-cell lymphoma at a single institution in South China

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Chinese Journal of Cancer 2017年第6期36卷 258-266页

作者： Yanfen Feng Huilan Rao Yiyan Lei Yuhua Huang Fang Wang Yu Zhang shaoyan Xi Qiuliang Wu jianyong shao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center Department of Pathology Sun Yat-sen University Cancer Center Department of Thoracic Surgery The First Affiliated Hospital of Sun Yat-sen University Department of Molecular Diagnostics Sun Yat-sen University Cancer Center

Background:Mature T-cell and natural killer(NK)-cell lymphomas compose a heterogeneous group of non-Hodgkin lymphomas,and extranodal NK/T-cell lymphoma,nasal type(ENKTL) is an aggressive subtype with sporadic CD30 ***,the significance of CD30 expression in ENKTL is *** aimed to classify a large cohort of patients with mature T-cell and NK-cell lymphomas according to the 2016 World Health Organization(WHO) classification guidelines and to study the association between CD30 expression and prognosis of patients with ***:We selected consecutive patients with mature T-cell and NK-cell lymphomas who attended our institution between September 1,2009 and August 31,*** classified the lymphomas according to the 2016 revision of the WHO classification of lymphoid neoplasms,analyzed the associations between CD30 expression and clinicopathologic features of ENKTL patients,and evaluated the prognostic implications of CD30 ***:We identified 622 consecutive patients with mature T-cell and NK-cell lymphomas,including 317(51.0%)patients with *** addition,CD30 expression was detected in 43(47.3%) of a subset of 91 patients with *** clinicopathologic features were associated with CD30 expression,and CD30 positivity showed no prognostic significance in patients with ***:ENKTL is the most common type of mature T-cell and NK-cell lymphoma diagnosed at our ***30 is frequently expressed in ENKTL and represents a therapeutic target;however,it may not be a prognostic marker.

关键词： NK细胞淋巴瘤 T细胞中国南方地区成熟机构世界卫生组织鼻

中国南方单中心622例成熟T细胞和自然杀伤细胞淋巴瘤患者中CD30在结外鼻型自然杀伤/T细胞淋巴瘤组织中的表达

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癌症 2018年第5期37卷 219-228页

作者： Yanfen Feng Huilan Rao Yiyan Lei Yuhua Huang Fang Wang Yu Zhang shaoyan Xi Qiuliang Wu jianyong shao 华南肿瘤学国家重点实验室肿瘤医学协同创新中心中山大学肿瘤防治中心病理科中山大学肿瘤防治中心胸外科中山大学第一附属医院分子诊断科中山大学肿瘤防治中心

背景与目的成熟T细胞和自然杀伤细胞(natural killer,NK)淋巴瘤为非霍奇金淋巴瘤中的一类异质性肿瘤,其中结外鼻型NK/T细胞淋巴瘤(extranodal NK/T?cell lymphoma,nasal type,ENKTL)为一个侵袭性的亚型,伴有散发性CD30表达。但是CD30表... 详细信息

背景与目的成熟T细胞和自然杀伤细胞(natural killer,NK)淋巴瘤为非霍奇金淋巴瘤中的一类异质性肿瘤,其中结外鼻型NK/T细胞淋巴瘤(extranodal NK/T?cell lymphoma,nasal type,ENKTL)为一个侵袭性的亚型,伴有散发性CD30表达。但是CD30表达在ENKTL中的意义仍存有争议。本研究的目的是根据2016年世界卫生组织(World Health Organization,WHO)的分类指南,对大样本成熟T细胞和NK细胞淋巴瘤患者进行分类,并研究CD30表达与ENKTL患者预后之间的关系。方法我们选择了2009年9月1日到2013年8月31日之间,来我中心治疗的所有成熟T细胞和NK细胞淋巴瘤的患者。根据WHO 2016年淋巴瘤分类指南进行了分类,分析了CD30表达与ENKTL患者临床病理因素的相关性,并评价了CD30表达对ENKTL患者预后的影响。结果我们共鉴定了622例成熟T细胞和NK细胞淋巴瘤的患者,其中317例(51.0%)为ENKTL患者。我们在其中的91例ENKTL患者标本中检测了CD30的表达,其中43例(47.3%)表达阳性。在这91例ENKTL患者中,CD30表达与临床病理因素无相关性,CD30表达阳性对患者预后无影响。结论在本中心确诊的成熟T细胞和NK细胞淋巴瘤中,ENKTL是最常见的一个亚型。CD30在ENKTL中高频表达,可作为一个治疗靶点;然而它可能不是ENKTL的预后标志物。

关键词：淋巴瘤 T细胞自然杀伤细胞 CD30 Epstein-Barr病毒

血清miR-103可作为乳腺癌潜在的诊断标记物

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南方医科大学学报 2012年第5期32卷 631-634,638页

作者：王小拍吴兴平颜黎栩邵建永中山大学肿瘤防治中心分子诊断科广东广州510060 中山大学肿瘤防治中心检验科广东广州510060 广东省人民医院//广东省医学科学院病理医学部广东广州510080

目的探究血清miR-103在乳腺浸润性癌患者中表达的诊断价值及其与乳腺癌临床病理特征的关系。方法搜集50例首治的乳腺癌患者的血清及相应的石蜡包埋组织和50例正常女性的血清作为对照,从血清中提取总RNA,运用荧光定量PCR的技术检测miR-10... 详细信息

目的探究血清miR-103在乳腺浸润性癌患者中表达的诊断价值及其与乳腺癌临床病理特征的关系。方法搜集50例首治的乳腺癌患者的血清及相应的石蜡包埋组织和50例正常女性的血清作为对照,从血清中提取总RNA,运用荧光定量PCR的技术检测miR-103在乳腺癌和正常人血清中的表达情况。运用SPSS16.0软件行t检验、ANOVA、χ2检验、秩和检验及MedCalc软件进行受试者工作特征曲线(ROC)分析。结果与对照组相比,miR-103在乳腺癌患者血清中表达量显著上调(P<0.01),血清中miR-103上调的相对表达量与乳腺癌临床分期(P<0.05)、淋巴结转移(P<0.05)相关。miR-103所得ROC曲线下面积为84.3%,区别乳腺癌和正常人的敏感性和特异性分别为84%、70%。结论血清miR-103可作为乳腺癌一项潜在的诊断标记物,并对乳腺癌的临床病理特征具有提示作用。

关键词： miRNA 乳腺肿瘤诊断

Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology

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Cancer Biology & Medicine 2019年第1期16卷 189-204页

作者： Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu jianyong shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu Guangdong Lung Cancer Institute Medical Research Center Cancer Center of Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences Affiliated Guangdong Provincial People's Hospital South China University of Technology Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences National Research Center for Translational Medicine Shanghai Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Lung Tumor Clinical Medical Center Shanghai Chest Hospital Shanghai Jiao Tong University Division of Respiratory Medicine Jinling Hospital Nanjing University School of Medicine Department of Oncology Jilin Cancer Hospital Department of Pathology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology West China Hospital Sichuan University Department of Pathology Zhongshan Hospital Fudan University Department of Hematology First Affiliated Hospital Institute of Hematology School of Medicine Jinan University Laboratory of Oncology Affiliated Hospital of the Academy of Military Medical Sciences Department of Oncology First Clinical College of South China University of Technology/Guangdong Lung Cancer Institute People's Liberation Army Cancer Center of Bayi Hospital Affiliated to Nanjing University of Chinese Medicine Department of Pathology Sun Yat-sen University Cancer Center Department of Pathology Affiliated Hospital of the Academy of Military Medical Sciences Department of Pathology Beijing Hospital Department of Breast Cancer Pathology and Research Laboratory of Cancer Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Tianjin’s Clinical Research Center for Cancer Department of Pathology Jinling Hospital Nanjing University School of Medicine State Key Laboratory of Molecular Oncology Department of Medical Oncology National Cancer Center/Canc

Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules ***, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation.

关键词： Next-generation sequencing technology cancer consensus

304/Q235B爆炸焊接不锈钢复合板的热处理工艺研究

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热加工工艺 2017年第23期46卷 250-253页

作者：邵建勇杨爱元孙爱楠王军宏酒钢集团宏兴股份公司天源公司甘肃嘉峪关735100

以爆炸焊接的304/Q235B不锈钢复合板为研究对象,进行了不同的热处理工艺试验,分析了不同热处理工艺条件下不锈钢复合板的组织和性能,以探索适合爆炸焊接不锈钢复合板的热处理工艺。结果证明,304/Q235B不锈钢复合板不宜进行去应力退火,... 详细信息

以爆炸焊接的304/Q235B不锈钢复合板为研究对象,进行了不同的热处理工艺试验,分析了不同热处理工艺条件下不锈钢复合板的组织和性能,以探索适合爆炸焊接不锈钢复合板的热处理工艺。结果证明,304/Q235B不锈钢复合板不宜进行去应力退火,应进行固溶热处理。去应力退火后304/Q235B不锈钢复合板的塑性、韧性偏低,抗晶间腐蚀性能下降。304/Q235B不锈钢复合板固溶热处理温度不宜超过950℃。

关键词： 304/Q235B不锈钢复合板去应力退火固溶热处理晶间腐蚀

Analysis of Survivin Expression in the Subtypes of Lymphoma

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The Chinese-German Journal of Clinical Oncology 2005年第4期4卷 238-243页

作者：顾霞林汉良邵建勇张萌梁惠珍广州中山大学基础医学院病理教研室 510089

Objective： To detect the expression of survivin in subtypes of lymphoma and its value in classifying subtypes of lymphoma. Methods： Paraffin-embedded samples collected from 219 cases of lymphoma and 13 cases of lymph node reactive proliferation from affiliated hospitals of Sun Yat-sen University during 2001-2003 were examined for the expression of survivin by using immunohistochemical staining. Reverse transcription-polymerase chain reaction （RT-PCR） was used to detect the mRNA expression of survivin in K562, HL60, Raji, and Jurkat cell lines. Semi-quantitative assay was used to evaluate the quantity of survivin protein and mRNA expression in subtypes of lymphoma. Results： Protein expression of survivin was high and strong in diffuse large B-cell lymphoma （DLBL）（88.6%, 70/79）, Burkitt lymphoma （BL）（100%, 2/2）, and lymphoblastic lymphoma （LBL）（92.3%, 12/13）, while their expression was always lower and weaker in follicular lymphoma （FL）（18.2%）, extranodal marginal zone B-cell lymphoma of mucosaassociated lymphoid tissue （MALT lymphoma）（40.9%） and marginal zone lymphoma （MZL）（33.3%）. There was a significant difference between the higher expression group （DLBL, BL and LBL） and lower one （FL, MZL, and MALT） in the expression of survivin （Chi-square test, X^2=24.77, P〈0.01）. Almost all of Reed-Sternberg cells （R-S cells） in Hodgkin lymphoma （HL） strongly expressed survivin. The protein expression of survivin was positively correlated with mRNA （r=0.6270, P〈0.01）. Conclusion： The expression level of survivin mRNA and protein shows significant difference in subtypes of lymphoma. The expression of survivin mRNA might act as a biomarker to classify the subtypes of lymphoma.

关键词： survivin lymphoma classification reverse transcription-polymerase chain reaction

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基于WAP的校友通讯录模块的设计和实现

计算机工程与应用 2004年第1期40卷 126-128页

作者：吴晓琼许剑勇肖燕华邵世煌东华大学信息学院上海200051

该文提出了基于WAP的校友通讯录模块的设计,让用户通过手机就能查询校友通讯方式。该模块具有查询速度快、维护方便,并且支持PUSH的功能,在用户预定的校友通讯方式发生改变时,能够及时地通知用户。最后通过WML、IIS和ASP实现模块功能。

关键词：无线应用协议推技术无线标记语言

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伞骨钢丝用盘条研发

金属制品 2016年第1期42卷 40-42页

作者：鲁维东董建军邵建勇酒泉钢铁(集团)有限责任公司炼轧厂甘肃嘉峪关735100 酒泉钢铁(集团)有限责任公司钢铁研究院甘肃嘉峪关735100

伞骨钢丝用盘条必须保证钢材冷顶锻性能和冷加工性能。介绍35GL钢的化学成分及生产工艺流程。35GL钢转炉冶炼出钢温度控制在1 600~1 650℃。轧制过程中,确定均热温度为1 120~1 140℃,开轧时钢坯中部温度为960~980℃,精轧阶段采用较低温... 详细信息

伞骨钢丝用盘条必须保证钢材冷顶锻性能和冷加工性能。介绍35GL钢的化学成分及生产工艺流程。35GL钢转炉冶炼出钢温度控制在1 600~1 650℃。轧制过程中,确定均热温度为1 120~1 140℃,开轧时钢坯中部温度为960~980℃,精轧阶段采用较低温度轧制,入精轧机温度为（920±20）℃,吐丝温度为（840±20）℃。轧后采用缓慢冷却工艺,保温罩全部闭合,冷却速度为1~1.5℃/s。结果表明,盘条金相组织均匀,晶粒度9.5~10级,无可见脱碳层,力学性能符合用户要求。

关键词： 35GL钢伞骨钢丝力学性能金相组织晶粒度