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Bimolecular reduction of carbon dioxide: double synthons for alkynes trifunctionalization

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Science China Chemistry 2024年第3期67卷 841-847页

作者： Wenfang Xiong Xiaobin Tan Hongjian liu Baiyao Zhu Jinwu Zhao jianxiao li Chaorong Qi Huanfeng Jiang School of Pharmacy Guangdong Medical UniversityDongguan 523808China Key Lab of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China

Carbon dioxide reduction, as a sustainable and versatile strategy for the access of chemical fuels, has attracted increasing attention and enormous efforts have been devoted to it in recent years. However, employing carbon dioxide as double synthons via bimolecular reduction remains challenging. Here, by leveraging the bimolecular reduction of carbon dioxide to carbonyl and methyl respectively, we describe a Pd-catalyzed trifunctionalization of alkynes with aryl iodide for the first time and showcase its advantages on the formation of various β-diketones and their application in the constructing of heterocyclic compounds with important biological activity, including pyrimidine, oxazole, pyrazole.

关键词： carbon dioxide bimolecular reduction trifunctionalization double synthons

Palladium-catalyzed vinylation of indoles with vinyl ethers via deoxygenative coupling

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Science China Chemistry 2024年

作者： Bowen Wang jianxiao li Wanqing Wu liangbin Huang Huanfeng Jiang Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of Technology

Indole is a promising heteroarene in many natural products and pharmaceuticals; therefore, various synthetic methods for indole functionalizations have arisen in recent years. Herein, we report a Pd-catalyzed deoxygenative coupling for the N-vinylation of indoles by employing vinyl ethers. The vinylated indoles could be readily prepared in good to excellent yields with N1-regioselectivity regardless of the electronic characteristics and substitution patterns of indole substrates. Some indole-based pharmaceutical molecules, such as gramine, evodiamine, rutaecarpine, and melatonine, are also successfully vinylated. Moreover, carbazoles and indazoles are shown to participate. Additionally, vinylated indole can readily transform into structurally interesting indole derivatives.

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马克思劳资关系理论的演化逻辑及现实意义——基于《1844年经济学哲学手稿》至《雇佣劳动与资本》的文本群分析

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中国劳动关系学院学报 2024年第4期38卷 67-76页

作者：李建肖中共北京市委党校/北京行政学院马克思主义学院北京100044

马克思的思想发展史亦是一部劳资关系理论的演进史。从《1844年经济学哲学手稿》至《雇佣劳动与资本》,马克思劳资关系理论的叙事逻辑历经以异化劳动和私有财产为核心的经济学哲学反思到以分工和交往形式为核心的历史分析,再到以生产方... 详细信息

马克思的思想发展史亦是一部劳资关系理论的演进史。从《1844年经济学哲学手稿》至《雇佣劳动与资本》,马克思劳资关系理论的叙事逻辑历经以异化劳动和私有财产为核心的经济学哲学反思到以分工和交往形式为核心的历史分析,再到以生产方式和生产关系为核心的政治经济学批判的演化。至此,马克思贯通了唯物史观、政治经济学与科学社会主义,搭建了劳资关系研究的简明框架,把异化劳动批判内蕴于资本主义生产方式和生产关系批判之中,从而建构了认识与改造世界的革命范式。以马克思劳资关系理论为启鉴,是解构21世纪资本主义劳资关系样态、推进我国劳资关系治理现代化的应然选择。

关键词：劳资关系异化劳动生产方式和生产关系 21世纪资本主义劳资关系治理现代化

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三维规划辅助系统设计与实现

绿色科技 2024年第12期26卷 191-196页

作者：厉建晓王凤民程璐黄成日照市自然资源和规划局山东日照276826 日照市规划设计研究院集团有限公司山东日照276826 未来景区智能服务山东省工程研究中心山东日照276826 武汉吉嘉时空信息技术有限公司湖北武汉430079

为满足三维立体空间的规划管理和空间治理需求,利用WebGIS、GeoServer、Cesium、PostgreSQL等技术,设计了国土空间规划数据库,开发了三维规划辅助系统。该系统形成了涵盖基础功能、信息查询、辅助分析、辅助设计、辅助审查的框架体系,... 详细信息

为满足三维立体空间的规划管理和空间治理需求,利用WebGIS、GeoServer、Cesium、PostgreSQL等技术,设计了国土空间规划数据库,开发了三维规划辅助系统。该系统形成了涵盖基础功能、信息查询、辅助分析、辅助设计、辅助审查的框架体系,其中基础功能包括飞行漫游、量测、图层管理、分屏、卷帘等,信息查询包括兴趣点查询、属性查询、楼层分层分户查询等,辅助分析包括通视分析、可视域分析、日照分析、挖填方分析和裁切分析等,辅助设计包括天际线分析、生成控规盒子、控高分析、贴线率分析和宽高比分析等,辅助审查包括设计方案加载、符合性判断、对比和提交意见等。该系统实现了国土空间规划编制流程中的三维辅助分析,实现了国土空间规划审查流程中的三维审查及意见留痕,提升了国土空间规划编制和审查水平。

关键词：空间规划地理信息系统三维辅助设计

Palladium-Catalyzed Sequential Cyclization/Functionalization of Oxime Ethers with Unactivated Vinyl Ethers for Tunable Assembly of Structurally Diverse Isoxazoles

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Chinese Journal of Chemistry 2021年第12期39卷 3285-3291页

作者： jianxiao li Zidong lin Dan He Wanqing Wu Huanfeng Jianga Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhouGuangdong 510640China Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates South China University of TechnologyGuangzhouGuangdong 510640China

A novel and viable palladium-catalyzed sequential cyclization/functionalization of alkynone O-methyloximes with unactivated vinyl ethers under aerobic conditions was *** structure of the products could be successfully controlled by varying the nature of the substituents of the vinyl *** new approach provides a convenient and straightforward synthetic protocol for the preparation of structurally diverse 4-(1-alkoxyvinyl)-isoxazoles and 4-vinylisoxazoles in moderate to good yields with highly ***,this protocol can be performed on a gram scale,showing the promising application in synthetic and pharmaceutical chemistry.

关键词： Palladium Alkenes Alkynes Annulation Cross-coupling

An overview of detecting gene-trait associations by integrating GWAS summary statistics and eQTLs

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Science China(life Sciences) 2024年第6期67卷 1133-1154页

作者： Yang Zhang Mengyao Wang Zhenguo li Xuan Yang Keqin li Ao Xie Fang Dong Shihan Wang Jianbing Yan jianxiao liu National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Smart Farming for Agricultural Animals Huazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Agricultural Bioinformatics Huazhong Agricultural UniversityWuhan 430070China College of Informatics Huazhong Agricultural UniversityWuhan 430070China College of life Sciences Nankai UniversityTianjin 300071China

Detecting genes that affect specific traits(such as human diseases and crop yields)is important for treating complex diseases and improving crop quality.A genome-wide association study(GWAS)provides new insights and directions for understanding complex traits by identifying important single nucleotide *** GWAS summary statistics data related to various complex traits have been gathered *** have shown that GWAS risk loci and expression quantitative trait loci(e QTLs)often have a lot of overlaps,which makes gene expression gradually become an important intermediary to reveal the regulatory role of *** this review,we review three types of gene-trait association detection methods of integrating GWAS summary statistics and e QTLs data,namely colocalization methods,transcriptome-wide association study-oriented approaches,and Mendelian randomization-related *** the theoretical level,we discussed the differences,relationships,advantages,and disadvantages of various algorithms in the three kinds of gene-trait association detection *** further discuss the performance of various methods,we summarize the significant gene sets that influence highdensity lipoprotein,low-density lipoprotein,total cholesterol,and triglyceride reported in 16 *** discuss the performance of various algorithms using the datasets of the four lipid *** advantages and limitations of various algorithms are analyzed based on experimental results,and we suggest directions for follow-up studies on detecting gene-trait associations.

关键词： gene-trait association GWAS eQTL colocalization transcriptome-wide association study(TWAS) Mendelian randomization(MR)

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晋语并州片平声不分阴阳的演变机制

山西大学学报(哲学社会科学版) 2023年第5期46卷 57-65页

作者：李建校曲阜师范大学文学院

晋语并州片平声不分阴阳方言与古全浊声母平声白读不送气方言在地理上高度吻合，与周边平分阴阳方言在调型调值对应整齐。可见方言语音特征的空间差异与演变的时间序列有相当整齐的对应和深刻关系。随着中古全浊声母的清化，并州片平声... 详细信息

晋语并州片平声不分阴阳方言与古全浊声母平声白读不送气方言在地理上高度吻合，与周边平分阴阳方言在调型调值对应整齐。可见方言语音特征的空间差异与演变的时间序列有相当整齐的对应和深刻关系。随着中古全浊声母的清化，并州片平声字原清浊声母间的对立，变成了全浊声母今白读不送气清音与送气清音的对立，在一定程度上保留了平声未分阴阳时原有的对立关系，加之浊平调的浊音性，清平调的清音性，以及浊平与清平各自的显赫特征，使并州片在中古浊音清化后，延续了浊平调或清平调的调值，造成今方言一个平声的结果。在清浊声母对立时代，清声母和浊声母分别影响平声调而产生不同的羡余调值，这样的羡余调值又会在当时的字组中产生变调。由于变调与单字调相对独立，这种变调一旦产生，就可能随着某些词汇一直沿用到现在，导致并州片单字调不分阴阳，但在连调等形式存在零散的、不系统的分阴阳现象。

关键词：并州片平声不分阴阳羡余调值清平调浊平调

Carbon-neutral pathway to mitigating transport-power grid cross-sector effects

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The Innovation 2024年第3期5卷 27-29页

作者： Jing Ma Huiwen Kong jianxiao Wang Haiwang Zhong Bo li Jie Song Daniel M.Kammen State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources School of Electrical and Electronic EngineeringNorth China Electric Power UniversityBeijing 102206China National Engineering Laboratory for Big Data Analysis and Applications Peking UniversityBeijing 100871China Peking University Ordos Research Institute of Energy Ordos 017000China State Key Laboratory of Power Systems and Generation Equipment Department of Electrical EngineeringTsinghua UniversityBeijing 100084China School of Electrical Engineering Guangxi UniversityNanning 530004China Department of Industrial Engineering and Management College of EngineeringPeking UniversityBeijing 100871China Energy and Resources Group and Goldman School of Public PolicyUniversity of CaliforniaBerkeleyBerkeleyCA 94720USA

Dear Editor,The growing demand for transportation energy has brought increasing challenges to reducing greenhouse gas ***,many countries or regions have proposed solutions to achieve carbon-neutral transportation such as the rapid expansion of the global electric vehicle(EV)***,these benefits are not *** the goal of decarbonization in electricity is achieved,the“pseudo net zero emissions”effect of the transportation sector will inevitably be accompanied by a quiet shifting of carbon responsibility.1 This shift is undoubtedly fatal for both net zero emissions at the national level and carbon responsibility at the industry level;however,the corresponding effects have not yet been clarified.

关键词： neutral doubt shifting

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平台资本主义的三维透视及理论评析

工会理论研究 2023年第4期 15-25页

作者：李建肖中共北京市委党校马克思主义学院北京100044

平台资本主义以生产资料数据化、生产与流通过程加速化、劳动组织弹性化、剩余价值褫夺泛在化及运行形象政治化等策略实现资本积累。在系统化的宰制机制下,资本主义社会日渐成为资本全过程剥削劳动的“赛博工厂”,资本主义劳资关系也表... 详细信息

平台资本主义以生产资料数据化、生产与流通过程加速化、劳动组织弹性化、剩余价值褫夺泛在化及运行形象政治化等策略实现资本积累。在系统化的宰制机制下,资本主义社会日渐成为资本全过程剥削劳动的“赛博工厂”,资本主义劳资关系也表现为全景异化,具有剥削遮蔽性强化、劳动过程数字泰勒主义显化、阶级收入差距与国际数字鸿沟扩大化、工人阶级内部分化和工人运动离散化等特征。这意味着资本主义国家的平台资本主义既无助于工人阶级的境遇改善,也无法规避生产过剩等导致的经济危机。在中国特色社会主义制度背景下,应始终坚持以人民为中心的价值取向,规制防范资本在平台经济中的无序扩张与野蛮生长,有效发挥中国工会组织依法维护平台劳动者劳动权益的独特优势,推动我国平台经济规范有序健康发展。

关键词：平台资本主义资本积累劳资关系内在悖论