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Effect of autologous bone marrow stem cells-scaffold transplantation on the ongoing pregnancy rate in intrauterine adhesion women:a randomized,controlled trial

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Science China(Life Sciences) 2024年第1期67卷 113-121页

作者： Hui Zhu Taishun Li Peizhen Xu Lijun Ding Xianghong Zhu Bin Wang Xiaoqiu Tang Juan Li Pengfeng Zhu Huiyan Wang Chenyan dai Haixiang Sun jianwu dai Yali Hu Department of Obstetrics and Gynecology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Department of Biostatistics Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Department of Gynecology Changzhou Maternal and Child Health Care HospitalChangzhou Medical CenterNanjing Medical UniversityChangzhou 213004China Clinical Center for Stem Cell Research Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Department of Hematology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100190China

Intrauterine adhesion is a major cause of female reproductive *** we and others uncontrolled pilot studies showed that treatment with autologous bone marrow stem cells made a few patients with severe intrauterine adhesion obtain live birth,no large sample randomized controlled studies on this therapeutic strategy in such patients have been reported so *** verify if the therapy of autologous bone marrow stem cells-scaffold is superior to traditional treatment in moderate to severe intrauterine adhesion patients in increasing their ongoing pregnancy rate,we conducted this randomized controlled clinical *** 195 participants with moderate to severe intrauterine adhesion were screened and 152 of them were randomly assigned in a 1:1 ratio to either group with autologous bone marrow stem cells-scaffold plus Foley balloon catheter or group with only Foley balloon catheter(control group)from February 2016 to January *** per-protocol analysis included 140 participants:72 in bone marrow stem cells-scaffold group and 68 in control *** ongoing pregnancy occurred in 45/72(62.5%)participants in the bone marrow stem cells-scaffold group which was significantly higher than that in the control group(28/68,41.2%)(RR=1.52,95%CI 1.08–2.12,P=0.012).The situation was similar in live birth rate(bone marrow stem cells-scaffold group 56.9%(41/72)*** group 38.2%(26/68),RR=1.49,95%CI 1.04–2.14,P=0.027).Compared with control group,participants in bone marrow stem cells-scaffold group showed more menstrual blood volume in the 3rd and 6th cycles and maximal endometrial thickness in the 6th cycle after hysteroscopic *** incidence of mild placenta accrete was increased in bone marrow stem cells-scaffold group and no severe adverse effects were *** conclusion,transplantation of bone marrow stem cells-scaffold into uterine cavities of the participants with moderate to severe intrauterine adhesion increased their ongoing pregnancy and

关键词： intrauterine adhesion Asherman’s syndrome uterine infertility autologous bone marrow stem cells transplantation endometrial regeneration ongoing pregnancy rate

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不同干燥方式对红托竹荪干燥特性和品质的影响

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农业工程学报 2024年第6期40卷 90-100页

作者：代建武周厚彬黄杰张庆李莹露秦文四川农业大学机电学院雅安625014 四川农业大学食品学院雅安625014

为提高红托竹荪干燥品质并获得最佳干燥工艺,采用真空红外干燥(vacuum infrared drying,VID)、气流冲击干燥(air impingement drying,AID)、控湿干燥(moisture control drying,MCD)等不同干燥方式对红托竹荪进行对比研究,以热风干燥(hot... 详细信息

为提高红托竹荪干燥品质并获得最佳干燥工艺,采用真空红外干燥(vacuum infrared drying,VID)、气流冲击干燥(air impingement drying,AID)、控湿干燥(moisture control drying,MCD)等不同干燥方式对红托竹荪进行对比研究,以热风干燥(hot air drying,HAD)作为对照组,研究不同干燥方式及温度对红托竹荪干燥品质的影响。试验结果表明不同干燥方式对竹荪宏观品质产生了显著影响,其中MCD可获得最小的色差∆E和收缩率,AID则能够保证较高的复水比;干燥速率方面,MCD在前期能够获得较高的干燥速率,但后期干燥速率会放缓,而AID在整个干燥过程都具有较高的干燥速率,干燥时间较短;在成分保留上,MCD可以保留较高含量的多糖、三萜和黄酮,而采用VID可以有效保护多酚。单位能耗随干燥温度的升高明显降低,不同方式下VID的干燥能耗值整体偏大,MCD的单位能耗最低(18.82 kW·h/kg)。通过主成分分析法,上述干燥方式对红托竹荪综合评分后得到的结果排序为:MCD>AID>VID>HAD,MCD干燥方式中采用60℃相对湿度为40%,保湿时间15min的干燥工艺综合品质较佳,在此加工方式下的红托竹荪综合评分为2.94,该研究可为红托竹荪高品质干燥提供一定参考。

关键词：红托竹荪真空红外干燥气流冲击干燥控湿干燥主成分分析

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智慧图书馆背景下规范控制工作发展探究

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江苏科技信息 2024年第4期41卷 22-25页

作者：戴建武国家图书馆北京100081

随着“十四五”规划纲要的发布,中国已经进入高质量发展阶段。智慧型城市建设作为今后国家重点发展方向,为图书馆事业发展带来了新的发展思路。规范控制工作作为图书编目核心环节,影响着图书馆信息组织建设的质量,如何在图书馆智慧化转... 详细信息

随着“十四五”规划纲要的发布,中国已经进入高质量发展阶段。智慧型城市建设作为今后国家重点发展方向,为图书馆事业发展带来了新的发展思路。规范控制工作作为图书编目核心环节,影响着图书馆信息组织建设的质量,如何在图书馆智慧化转型背景下做好规范控制工作显得尤为重要。文章从智慧图书馆的概念和特点出发,剖析新形势下规范控制工作的现状和问题,针对性地提出智慧图书馆发展背景下规范控制工作的发展方向,旨在为规范控制工作的未来发展方向提供探究性建议。

关键词：智慧图书馆规范控制关联数据

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胶原基质生物膜治疗盆腔放疗后的难治性放射性肠炎1例(含视频)

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中华消化内镜杂志 2024年第3期41卷 241-243页

作者：庄颖佳王频戴建武陈敏邹晓平南京医科大学鼓楼临床医学院、南京鼓楼医院消化内科南京210008 南京大学医学院附属鼓楼医院消化内科南京210008 中国科学院遗传与发育生物学研究所、分子发育生物学国家重点实验室北京100101 南京大学医学院附属泰康仙林鼓楼医院消化内科南京210046

放射性肠炎因其进行性、难治性,会严重影响患者的生活质量。报道1例内镜下应用胶原基质生物膜成功治疗的难治性放射性肠炎病例,结果显示患者肠道溃疡和糜烂明显修复,症状明显改善。

关键词：组织再生放射性肠炎胶原基质生物膜

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阿替普酶静脉溶栓后替罗非班桥接双重抗血小板聚集治疗内囊预警综合征病例报道

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中国卒中杂志 2024年第3期19卷 326-330页

作者：郑剑华崔燕玲曹莹戴建武广州市第十二人民医院神经内科广州510000

内囊预警综合征(capsule warning s yndrome,CWS)是一组罕见的临床症状,具有反复发作刻板样神经功能缺损症状,易进展成完全性卒中的特点。本研究报道1例表现为发作性言语不清伴左侧肢体无力的CWS,该患者经阿替普酶静脉溶栓治疗后24 h内... 详细信息

内囊预警综合征(capsule warning s yndrome,CWS)是一组罕见的临床症状,具有反复发作刻板样神经功能缺损症状,易进展成完全性卒中的特点。本研究报道1例表现为发作性言语不清伴左侧肢体无力的CWS,该患者经阿替普酶静脉溶栓治疗后24 h内,仍反复发作刻板样言语不清、左侧肢体无力。经评估风险后,静脉溶栓后24 h内予以替罗非班抗血小板聚集治疗,3 d后桥接双重抗血小板聚集治疗,患者未再发作神经功能缺损症状。静脉溶栓治疗后启动抗血小板聚集时机以及抗血小板聚集的方案,仍需大规模数据进一步探讨。

关键词：内囊预警综合征阿替普酶静脉溶栓替罗非班阿司匹林氯吡格雷

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Microgravity may help future organ/tissue manufacture

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Science China(Life Sciences) 2016年第8期59卷 850-853页

作者： Jin Han jianwu dai State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101China

Stem cells are a group of multipotent or pluripotent cells which could differentiate into specialized cells or could self-renew to duplicate themselves. During the body devel- oping period, stem cells differentiated into specialized cells to build the whole body. In the adult organisms, stem cells live in seclusion and are ready to repair the injuries of tis- sues. Within one tissue, stem cells could differentiate in to all types of somatic cells of the tissue, for example,

关键词： manufacture specialized pluripotent differentiate duplicate renew repair themselves ready injuries

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Complete canine spinal cord transection model: a large animal model for the translational research of spinal cord regeneration

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Science China(Life Sciences) 2018年第1期61卷 115-117页

作者： Sufang Han Xing Li Zhifeng Xiao jianwu dai State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences

Traumatic spinal cord injury (SCI) usually results in devastating neurologic deficits and disability. In the United States,approximately 12,500 new cases are reported each year, while an estimated 100,000–140,000 new cases occur every year in China (National Spinal Cord Injury Statistical Center, 2016).Spinal cord injuries are highly disabling and primarily affect young adults, and therefore create great psychological and financial burden on the affected individuals and their families.

关键词： In Complete canine spinal cord transection model SCI

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Functional biomaterial-based regenerative microenvironment for spinal cord injury repair

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National Science Review 2017年第4期4卷 530-532页

作者： Bing Chen Zhifeng Xiao Yannan Zhao jianwu dai State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences

Spinal cord injury(SCI)often leads to the serious loss of motor and sensory functions below the level of the *** etiology of SCI is mainly traumatic,caused by events such as car accidents and *** remains a worldwide c... 详细信息

关键词： Functional biomaterial-based regenerative microenvironment for spinal cord injury repair SCI CBD

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Effects of splice sites on the intron retention in histamine H_3 receptors from rats and mice

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Journal of Genetics and Genomics 2009年第8期36卷 475-482页

作者： Wenyong Ding Lin Lin Feng Ren Hanfa Zou Ziyuan Duan jianwu dai Department of Biochemistry and Molecular Biology Dalian Medical University Dalian 116044 China Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100080 China National Chromatographic Research and Analysis Center Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

In the alternative splicing, intron retention, of histamine H3 receptors in rats and mice, the short transcript isoforms that are excised alternatively spliced introns are easily detected in a very low level in rats and are undetectable in mice using the regular PCR protocol. The retained introns have common 5＇ splice site and different 3＇ splice sites. The detailed mechanism for the special alternative splicing remains largely unclear. In this study, we developed a minigene splicing system to recapitulate natural alternative splicing of the receptors and investigated the effects of 5＇ and 3＇ splice sites on intron retention in HeLa cells. Mutating weak 5＇ and 3＇ splice sites of the alternatively spliced introns toward the canonical consensus sequences promoted the splicing of the corresponding introns in rat and mouse minigenes. The effect of splice site strength was context-dependent and much more sigiaificant for the 3＇ splice site of the longer alternative intron than for the 3＇ splice site of the shorter alternative intron and the common 5＇ splice sites; it was also more significant in the rat minigene than in the mouse minigene. Mutating the 3＇ splice site of the longer alternative intron resulted in almost complete splicing of the intron and made the corresponding isoform to become the nearly exclusive transcript in the rat minigene.

关键词： histamine H3 receptor (H3R) altemative splicing intron retention splice site minigene

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Transplantation of adult spinal cord grafts into spinal cord transected rats improves their locomotor function

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Science China(Life Sciences) 2019年第6期62卷 725-733页

作者： He Shen Xi Chen Xing Li Ke Jia Zhifeng Xiao jianwu dai Key Laboratory for Nano-Bio Interface Research Division of Nanobiomedicine Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou 215123 China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Shigatse Branch Xinqiao Hospital Army Medical University (Third Military Medical University) Shigatse 857000 China Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan Province Xiangya Hospital Central South University Changsha 410008 China

Grafted embryonic central neural tissue pieces can recover function of hemisected spinal cord in neonatal rats and promote axonal growth in adults. However, spinal cord segments from adults have not been used as donor segments for allogeneic transplantation. Here, we utilized adult spinal cord tissue grafts(aSCGs) as donor constructs for repairing complete spinal cord injury(SCI). Moreover, to provide a favourable microenvironment for SCI treatment, a growth factor cocktail containing three growth factors(brain-derived neurotrophic factor, neurotrophin-3 and vascular endothelial growth factor), was applied to the aSCG transplants. We found that the locomotor function was significantly improved 12 weeks after transplantation of aSCGs into the spinal cord lesion site in adult rats. Transplantation of aSCGs combined with these growth factors enhanced neuron and oligodendrocyte survival and functional restoration. These encouraging results indicate that treatment of complete SCI by transplanting aSCGs, especially in the presence of growth factors, has a positive effect on motor functional recovery, and therefore could be considered as a possible therapeutic strategy for SCI.

关键词： spinal cord injury (SCI) transplantation adult spinal cord grafts (aSCGs) function recovery adult host transection

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