检索结果-南通市图书馆

复方玄驹胶囊治疗Ⅲ型慢性前列腺炎(肾虚血瘀证)的多中心临床疗效评价

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国男科学杂志 2017年第2期31卷 40-46页

作者：王彬李海松高瞻沈建武赵冰王传航马卫国贾连城李曰庆林海敏北京中医药大学东直门医院北京100700 中国中医科学院西苑医院中日友好医院中医男科中国中医科学院广安门医院首都医科大学附属北京中医医院浙江施强制药有限公司

目的评价复方玄驹胶囊治疗Ⅲ型慢性前列腺炎(肾虚血瘀证)患者的临床疗效。方法采用单臂、多中心、前瞻性纵向临床试验方法,将5家医院的144例符合Ⅲ型慢性前列腺炎(肾虚血瘀证)诊断标准的患者按照自身前后对照方法,给予患者6周复方玄驹胶... 详细信息

目的评价复方玄驹胶囊治疗Ⅲ型慢性前列腺炎(肾虚血瘀证)患者的临床疗效。方法采用单臂、多中心、前瞻性纵向临床试验方法,将5家医院的144例符合Ⅲ型慢性前列腺炎(肾虚血瘀证)诊断标准的患者按照自身前后对照方法,给予患者6周复方玄驹胶囊,每次3粒,每天3次的治疗。通过观察治疗前、后总有效率,NIHCPSI评分,中医证候评分,EPS中白细胞与卵磷脂小体数量,IIEF-5评分,以及TT、FT、IL-8、IL-10等有效指标阐述复方玄驹胶囊对该类型慢性前列腺炎的治疗机制及临床疗效。结果通过6周观察,临床总有效率达90.97%。NIH-CPSI总分及各分项评分治疗后显著下降(P0.05);IL-8与治疗前相比处于下降趋势,但差异也不显著(P>0.05)。结论复方玄驹胶囊对Ⅲ型慢性前列腺炎(肾虚血瘀证)的临床症状有不同程度的改善,尤其是对于疼痛症状改善明显,且对伴有勃起功能障碍的患者有明显的治疗作用,且通过对患者内分泌及炎症因子的干预影响,以达到增强患者免疫、祛邪扶正的作用,为临床治疗提供一定的研究价值。

关键词：前列腺炎肾虚血瘀复方玄驹胶囊多中心研究

Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine

在线全文

学校读者我要写书评

暂无评论

Frontiers of Agricultural Science and Engineering 2015年第1期2卷 90-99页

作者： Jianxiang XU Dengke PAN Jie zhao jianwu WANG Xiaohong HE Yuehui MA Ning LI State Key Laboratory for Agrobiotechnology China Agricultural University Institute of Animal Sciences Chinese Academy of Agricultural Sciences

Myostatin is a transforming growth factor-beta family member that normally acts to limit skeletal muscle growth. Myostatin gene (MSTN) knockout (KO) mice show possible effects for the prevention or treatment of metabolic disorders such as obesity and type 2 diabetes. We applied chromatography and mass spectrometry based metabonomics to assess system-wide metabolic response of heterozygous MSTN KO (MSTN+/-) swine. Most of the metabolic data for MSTN+/- swine were similar to the data for wild type (WT) control swine. There were, however, metabolic changes related to fatty acid metabolism, glucose utilization, lipid metabolism, as well as BCAA catabolism caused by monoallelic MSTN depletion. The statistical analyses suggested that: (1) most metabolic changes were not significant in MSTN+/- swine compared to WT swine; (2) only a few metabolic properties were significantly different between KO and WT swine, especially for lipid metabolism. Significantly, these minor changes were most evident in female KO swine and suggested differences in gender sensitivity to myostatin.

关键词： myostatin transforming growth factor-beta family skeletal muscle metabolic disorders chromatography mass spectrometry metabonomics

在线全文

学校读者我要写书评

暂无评论

个体化牵引治疗椎动脉型颈椎病的临床研究

中国中医骨伤科杂志 2016年第12期24卷 32-37页

作者：郑宇党建军程宏毅于杰李强齐磊王雷辛荣超王建武李文高赵强陕西省中医医院骨伤一科西安710003 中国中医科学院望京医院

目的:以个体化牵引为核心治疗理念,通过自行研发的可调式颈椎固定牵引器对椎动脉型颈椎病患者行个体化牵引及制动,结合中药湿热敷治疗,观察临床治疗效果,进行疗效评价。方法:2015年1月至2015年12月共收集椎动脉型颈椎病住院患者180例,... 详细信息

目的:以个体化牵引为核心治疗理念,通过自行研发的可调式颈椎固定牵引器对椎动脉型颈椎病患者行个体化牵引及制动,结合中药湿热敷治疗,观察临床治疗效果,进行疗效评价。方法:2015年1月至2015年12月共收集椎动脉型颈椎病住院患者180例,按住院日期单双数分为两组,可调式颈椎固定牵引器结合中药湿热敷(观察组)90例,充气式颈椎牵引器结合中药湿热敷(对照组)90例。通过彩色多普勒测量治疗前后左、右椎动脉和基底动脉的收缩期峰值血流速度、平均血流速度、搏动指数、阻力指数等血流参数,并进行比较分析。分别对患者治疗前后的颈椎活动度、颈部压痛、颈部疼痛等指标的评分、睡眠工作影响积分和总积分的改善指数和总的有效率进行观察,2周后观察疗效。结果:两组患者治疗后观察组痊愈76.1%、显效14.5%、好转6.3%、无效3.1%、总有效率96.9%;对照组痊愈55.7%、显效12.7%、好转10.9%、无效20.7%、总有效率80.3%。两组间治愈率和有效率比较差异均有统计学意义(P<0.05),观察组疗效明显优于对照组。结论:牵引是治疗椎动脉型颈椎病的有效方法,采用可调式颈椎牵引器进行个体化牵引,临床疗效优于采用充气式颈椎牵引器的伸直位或过伸位牵引。

关键词：椎动脉颈椎病牵引个体化

Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2022年第4期65卷 757-769页

作者： Xiaoyu Xue Muya Shu Zhifeng Xiao Yannan zhao Xing Li Haipeng Zhang Yongheng Fan Xianming Wu Bing Chen Bai Xu Yaming Yang Weiyuan Liu Sumei Liu jianwu Dai State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100190China

Nestin is expressed extensively in neural stem/progenitor cells during neural development, but its expression is mainly restricted to the ependymal cells in the adult spinal cord. After spinal cord injury(SCI), Nestin expression is reactivated and Nestinpositive(Nestin;) cells aggregate at the injury site. However, the derivation of Nestin;cells is not clearly defined. Here, we found that Nestin expression was substantially increased in the lesion edge and lesion core after SCI. Using a tamoxifen inducible CreER(T2)-loxP system, we verified that ependymal cells contribute few Nestin;cells either to the lesion core or the lesion edge after SCI. In the lesion edge, GFAP+astrocytes were the main cell type that expressed Nestin;they then formed an astrocyte *** the lesion core, Nestin;cells expressed αSMA or Desmin, indicating that they might be derived from pericytes. Our results reveal that Nestin;cells in the lesion core and edge came from various cell types and rarely from ependymal cells after complete transected SCI, which may provide new insights into SCI repair.

关键词： Nestin ependymal cells spinal cord injury astrocytes pericytes

One-year clinical study of NeuroR egen scaffold implantation following scar resection in complete chronic spinal cord injury patients

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2016年第7期59卷 647-655页

作者： Zhifeng Xiao Fengwu Tang Jiaguang Tang Huilin Yang Yannan zhao Bing Chen Sufang Han Nuo Wang Xing Li Shixiang Cheng Guang Han Changyu zhao Xiaoxiong Yang Yumei Chen Qin Shi Shuxun Hou Sai Zhang jianwu Dai State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Department of Orthopaedics First Affiliated Hospital of People’s Liberation Army (PLA) General Hospital Neurology and Neurosurgery Hospital Affiliated Hospital of Logistics University of Chinese People’s Armed Police Forces (CAPF) Department of Orthopaedics The First Affiliated Hospital of Soochow University Department of Nerve Electrophysiology First Affiliated Hospital of People’s Liberation Army (PLA) General Hospital

The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, Neuro Regen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration. However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5–4.5 cm were surgically resected in five complete chronic spinal cord injury(SCI) patients. The NeuroR egen scaffold along with autologous bone marrow mononuclear cells(BMMCs), which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or Neuro Regen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials(SSEP) from the lower limbs was also detected. The results indicate that scar resection and Neuro Regen scaffold transplantation could be a promising clinical approach to treating SCI.

关键词： NeuroRegen scaffold chronic spinal cord injury scar resection collagen scaffold transplantation bone marrow mon-onuclear cells tissue regeneration

Dual ultrasound-guided totally implantable venous access ports via the right internal jugular vein in pediatric patients with cancer:a preliminary experience in a single institution

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatric Surgery 2023年第3期6卷 175-179页

作者： Xiao Bin Deng Liang Peng Jun Zhang Xiangru Kong Zhenzhen zhao Shan Wang Changchun Li Yifei Du jianwu Zhou Lifei Liu Chao Yang Department of Surgical Oncology National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of PediatricsChongqing Medical University Affiliated Children's HospitalChongqingChina Department of Pediatric Anesthesia National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongging Key Laboratory of PediatricsChongqing Medical University Affiliated Children's HospitalChongqingChina

Objective To assess the efficacy and safety of dual ultrasound-guided(DUG)totally implantable venous access port(TIVAP)implantation(namely,using ultrasoundguided percutaneous puncture with transesophageal echocardiography-guided catheterization)via the right internal jugular vein(IJV)in pediatric patients with *** Fifty-five children with cancer requiring chemotherapy underwent DUG-TIVAP implantation via the right *** data were recorded,including the procedure success rate,first attempt success rate,and perioperative and postoperative *** All 55 cases were successfully operated *** first puncture success rate was 100%.The operation time was 22–41min,with a mean time of 30.8±*** mean TIVAP implantation time was 253±145 days(range 42–520 days).There were no perioperative *** postoperative complication rate was 5.4%(3/55),including skin infections around the port in one case,catheter-related infection in one case,and fibrin sheath formation in one *** ports were all preserved after anti-infection or thrombolytic *** unplanned port withdrawal was recorded in this *** DUG-TIVAP implantation is a technique with a high success rate and a low complication rate;therefore,it provides an alternative for children with *** randomized controlled studies are needed to confirm the efficacy and safety of DUG-TIVAP via the right IJV in children.

关键词： implantation totally port

FREQUENCY-DIFFERENTIATED BRAIN NETWORK DYNAMICS IN REAL WORDS AND PSEUDOWORDS PERCEPTION

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国语音学报 2020年第1期 114-122页

作者： Guo Taiyang zhao Bin ZHANG Gaoyan Dang jianwu UNOKI Masashi Japan Advanced Institute of Science and Technology Ishikawa PrefectureJapan College of Intelligence and Computing Tianjin UniversityTianjinChina Japan Advanced Institute of Science and Technology(JAIST) Tianjin University TianjinChina School of Information Science at JAIST

Brain mechanisms of lexical-semantic processing have been well researched using electroencephalography(EEG)technique with high temporal ***,the detailed brain dynamics regarding spatial connectivity and the spectral characteristics remain to be *** this reason,this study performed frequency-specific effective connectivity analysis for the EEG recordings during the processing of real and *** addition,we introduced f MRI-based network templates into a representational similarity analysis to compare the functional differences between real and pseudowords in different frequency *** results revealed that real words could rapidly activate the brain network for speech perception and complete its comprehension with efficiency,especially when the first syllable of the real word has clear categorical *** contrast,the pseudowords were delayed in the initiation of speech perception and required a longer time span to retrieve its *** frequency-specific analysis showed that the theta,alpha,and beta rhythms contribute more to semantic processing than the gamma *** results showed that semantic processing is frequency-specific and time-dependent on the word categories.

关键词： Speech perception EEG Brain network Dynamic brain network Frequency specified brain network

Single-cell RNA sequencing reveals Nestin+active neural stem cells outside the central canal after spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2022年第2期65卷 295-308页

作者： Muya Shu Xiaoyu Xue Hu Nie Xianming Wu Minghan Sun Lianyong Qiao Xing Li Bai Xu Zhifeng Xiao Yannan zhao Yongheng Fan Bing Chen Jixiang Zhang Ya Shi Yaming Yang Falong Lu jianwu Dai State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100080China University of the Chinese Academy of Sciences Beijing 100101China Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangsha 410008China

Neural stem cells(NSCs)in the spinal cord hold great potential for repair after spinal cord injury(SCI).The ependyma in the central canal(CC)region has been considered as the NSCs source in the spinal ***,the ependyma function as NSCs after SCI is still under *** used Nestin as a marker to isolate potential NSCs and their immediate progeny,and characterized the cells before and after SCI by single-cell RNA-sequencing(scRNA-seq).We identified two subgroups of NSCs:the subgroup located within the CC cannot prime to active NSCs after SCI,while the subgroup located outside the CC were activated and exhibited the active NSCs properties after *** demonstrated the comprehensive dynamic transcriptome of NSCs from quiescent to active NSCs after *** study reveals that Nestin+cells outside CC were NSCs that activated upon SCI and may thus serve as endogenous NSCs for regenerative treatment of SCI in the future.

关键词： neural stem cell Nestin scRNA-seq Smart-seq2 ependymal cell

Human placenta-derived mesenchymal stem cells loaded on linear ordered collagen scaffold improves functional recovery after completely transected spinal cord injury in canine

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2018年第1期61卷 2-13页

作者： Sufang Han Zhifeng Xiao Xing Li Huan zhao Bin Wang Zhixue Qiu Zhi Li Xin Mei Bai Xu Caixia Fan Bing Chen Jin Han Yanzheng Gu Huilin Yang Qin Shi jianwu Dai State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Department of Orthopaedics The First Affiliated Hospital of Soochow University Orthopaedic Institute Soochow University Key Laboratory for Nano-Bio Interface Research Division of Nanobiomedicine Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences

Traumatic spinal cord injury(SCI) is a major challenge in the clinic. In this study, we sought to examine the synergistic effects of linear ordered collagen scaffold(LOCS) and human placenta-derived mesenchymal stem cells(hPMSCs) when transplanted into completely transected beagle dogs. After 36 weeks observation, we found that LOCS+hPMSCs implants promoted better hindlimb locomotor recovery than was observed in the non-treatment(control) group and LOCS group. Histological analysis showed that the regenerated tissue after treatment was well integrated with the host tissue, and dramatically reduced the volume of cystic and chondroitin sulfate proteoglycans(CSPGs) expression. Furthermore, the LOCS+hPMSCs group also showed more neuron-specific βIII-tubulin(Tuj-1)-and NeuN-positive neurons in the lesion area, as well as axonal regeneration, remyelination and synapse formation in the lesion site. Additionally, dogs in the LOCS+hPMSCs group experienced enhanced sprouting of both ascending(CGRP-positive) sensory fibers and descending(5-HT-and TH-positive) motor fibers at the lesion area. All these data together suggested that the combined treatment had beneficial effects on neuronal regeneration and functional improvement in a canine complete transection model. Therefore, LOCS+hPMSCs implantation holds a great promise for bridging the nerve defect and may be clinically useful in the near future.

关键词： spinal cord injury hPMSCs LOCS canine regeneration