One-year clinical study of NeuroR egen scaffold implantation following scar resection in complete chronic spinal cord injury patients

作     者：Zhifeng Xiao Fengwu Tang Jiaguang Tang Huilin Yang Yannan Zhao Bing Chen Sufang Han Nuo Wang Xing Li Shixiang Cheng Guang Han Changyu Zhao Xiaoxiong Yang Yumei Chen Qin Shi Shuxun Hou Sai Zhang Jianwu Dai 

作者机构：State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Department of Orthopaedics First Affiliated Hospital of People’s Liberation Army (PLA) General Hospital Neurology and Neurosurgery Hospital Affiliated Hospital of Logistics University of Chinese People’s Armed Police Forces (CAPF) Department of Orthopaedics The First Affiliated Hospital of Soochow University Department of Nerve Electrophysiology First Affiliated Hospital of People’s Liberation Army (PLA) General Hospital 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2016年第59卷第7期

页      面：647-655页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by grants from the "Stem Cell and Regenerative Medicine Strategic Priority Research Program of the Chinese Academy of Sciences" (Grant No. XDA01030000) the Key Research Program of the Chinese Academy of Sciences (Grant No. ZDRW-ZS-2016-2) 

主　　题：NeuroRegen scaffold chronic spinal cord injury scar resection collagen scaffold transplantation bone marrow mon-onuclear cells tissue regeneration 

摘      要：The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, Neuro Regen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration. However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5–4.5 cm were surgically resected in five complete chronic spinal cord injury(SCI) patients. The NeuroR egen scaffold along with autologous bone marrow mononuclear cells(BMMCs), which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or Neuro Regen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials(SSEP) from the lower limbs was also detected. The results indicate that scar resection and Neuro Regen scaffold transplantation could be a promising clinical approach to treating SCI.