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Flexible wearable sensors:An emerging platform for monitoring of bacterial infection in skin wounds

Engineered Regeneration 2024年第2期5卷 186-198页

作者： Hao Meng Weicheng Zhong Kui Ma jianlong su Liqian Ma Yaying Hao Yufeng Jiang Xi Liu Xiaobing Fu Cuiping Zhang Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical CollegeBeijing 100048PR China PLA Key Laboratory of Tissue Repair and Regenerative Medicine Beijing 100048PR China Beijing Key Research Laboratory of Skin Injury Repair and RegenerationBeijing 100048PR China Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048PR China College of Graduate Tianjin Medical UniversityTianjin300070PR China Department of Tissue Regeneration and Wound Repair PLA General HospitalBeijingPR China

Persistent inflammatory responses often occur when bacteria and other microorganisms frequently invade and colonize open wounds and eventually result in the formation of chronic ***,achieving real-time detection of invasive bacteria accurately and promptly is essential for efficient wound management and accelerat-ing the healing ***,flexible wearable sensors have garnered significant attention,especially those designed for monitoring real-time biophysical or biochemical signals in wound sites in a minimally invasive *** provide more precise and continuous monitoring data,making them as emerging tools for clinical *** this review,we first discuss the species and community distribution of different types of bacteria in chronic ***,we introduce currently developed techniques for detecting bacteria at wound ***-lowing that,we discuss the recent progress and unresolved issues of various flexible wearable sensors in detecting bacteria at wound *** believe that this review can provide meaningful guidance for the development of flexible wearable sensors for bacteria detection.

关键词： Flexible wearable sensors Chronic wounds Bacterial infections Real-time detection

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Microfluidic chip of concentration gradient and fluid shear stress on a single cell level

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Chinese Chemical Letters 2022年第6期33卷 3133-3138页

作者： Xuexia Lin jianlong su Shufeng Zhou Department of Chemical Engineering&Pharmaceutical Engineering College of Chemical EngineeringHuaqiao UniversityXiamen 361021China

Concentration gradient and fluid shear stress(FSS)for cell microenvironment were investigated through microfluidic *** Darcy–Weisbach equation combined with computational fluid dynamics modeling was exploited to design the microfluidic chip,and the FSS distribution on the cell model with varying micro-channels(triangular,conical,and elliptical).The diffusion with the incompressible laminar flow model by solving the time-dependent diffusion–convection equation was applied to simulate the gradient profiles of concentration in the *** the study of single cell in-depth,the FSS was investigated by the usage of polystyrene particles and the concentration diffusion distribution was studied by the usage of different colors of dyes.A successful agreement between model simulations and experimental data was ***,based on the established method,the communication between individual cells was envisaged and *** developed method provides valuable insights and allows to continuously improve the design of microfluidic devices for the study of single cell,the occurrence and development of tumors,and therapeutic applications.

关键词： Concentration gradient Fluid shear stress Single particle Computational fluid dynamics Microfluidic chip

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miR-29c-5p通过上调LRP6调控铁死亡减轻脑梗死缺血再灌注损伤

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河北医学 2024年第5期30卷 738-744页

作者：甄文剑郝进敏苏建龙孙宇婷河北省邢台市中心医院/邢台医学高等专科学校附属医院神经外科河北邢台054000

目的:探究miR-29c-5p在脑缺血-再灌注损伤中调控铁死亡的机制。方法:在这项研究中,雄性SD大鼠接受大脑中动脉闭塞(MCAO)手术,随后恢复血液流动。采用神经功能评分和TTC染色来评估脑组织损伤和梗死体积。采用qPCR方法检测miR-29c-5p的相... 详细信息

目的:探究miR-29c-5p在脑缺血-再灌注损伤中调控铁死亡的机制。方法:在这项研究中,雄性SD大鼠接受大脑中动脉闭塞(MCAO)手术,随后恢复血液流动。采用神经功能评分和TTC染色来评估脑组织损伤和梗死体积。采用qPCR方法检测miR-29c-5p的相对表达水平。通过Western Blot检测谷胱甘肽过氧化物酶4(GPx4)、低密度脂蛋白受体相关蛋白6(LRP6)的表达水平。采用相应的检测试剂盒检测GSH、Fe和丙二醛(MDA)的含量,并通过双荧光素酶报告基因实验验证miR-29c-5p的靶基因。结果:随着大鼠缺血再灌注时间的增加,miR-29c-5p的相对表达水平升高,铁死亡加重。此外,agomiR-29c-5p干预也加重了脑组织损伤和铁死亡,而antagomiR-29c-5p干预则使这些影响得到逆转。此外,agomiR-29c-5p和Fer-1联合干预可减轻脑组织损伤和铁死亡。双荧光素酶报告基因实验结果表明,LRP6是miR-29c-5p的靶基因。结论:在本研究中,miR-29c-5p通过负调控LRP6促进铁死亡进而加重大鼠脑缺血-再灌注损伤。

关键词：脑缺血再灌注损伤 miR-29c-5p 铁死亡 LRP6

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无人机实时摄影测量技术的应用研究与展望

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有色金属（矿山部分） 2024年第3期76卷 1-6页

作者：黄立鑫苏建龙李小军郭瑞霞兰州信息科技学院兰州730030 兰州交通大学测绘与地理信息学院兰州730070

无人机实时摄影测量是一种快速发展且具有广泛应用前景的高新技术。为更好地理解现阶段无人机实时摄影测量技术的应用现状与未来的发展趋势,通过文献综述的方法,系统地梳理了无人机摄影测量技术的基本原理;从飞行平台与控制、航线规划... 详细信息

无人机实时摄影测量是一种快速发展且具有广泛应用前景的高新技术。为更好地理解现阶段无人机实时摄影测量技术的应用现状与未来的发展趋势,通过文献综述的方法,系统地梳理了无人机摄影测量技术的基本原理;从飞行平台与控制、航线规划与导航、影像处理与提取和三维建模与应用四个方面评述了无人机摄影测量的关键技术;从城市规划与建设、灾害监测与评估、文物保护与研究和土地利用与管理四个领域论述了无人机摄影测量技术的应用现状。研究表明,通过数据处理与分析算法的优化和智能化与自动化的发展提升这两方面的创新应用,能够极大地推动无人机实时摄影测量技术的发展,更好地实现高质量、高效益和高安全的发展目标。

关键词：无人机摄影测量关键技术应用领域创新发展

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神经内镜辅助下经颞下入路治疗重症脑干出血的临床研究

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立体定向和功能性神经外科杂志 2024年第1期37卷 39-43页

作者：杨利辉贾亚男宋纪宁马克杰苏建龙宋志俊邢台市第三医院神经外四科邢台054000

目的分析神经内镜辅助下经颞下入路治疗重症脑干出血的临床疗效。方法回顾性分析我院2021年1月至2023年1月收治的重症脑干出血患者78例,根据家属意愿分为手术组和保守治疗组。手术组36例,保守组42例。手术组应用神经内镜经颞下入路清除... 详细信息

目的分析神经内镜辅助下经颞下入路治疗重症脑干出血的临床疗效。方法回顾性分析我院2021年1月至2023年1月收治的重症脑干出血患者78例,根据家属意愿分为手术组和保守治疗组。手术组36例,保守组42例。手术组应用神经内镜经颞下入路清除血肿,保守组按脑出血的治疗指南对症治疗。对比两组并发症、临床预后及血清中神经元特异性烯醇化酶(NSE)和S100钙结合蛋白(S100B)含量变化。结果两组并发症相比手术组重症肺炎、下肢静脉血栓、电解质紊乱、应激性溃疡发生的人数均少于保守组,两组对比P<0.05,差异有统计学意义。通过两组格拉斯哥预后评分(glasgow prognostic score,GOS)对比发现手术组中能正常生活、轻度残疾人数多于保守治疗组,重度残疾人数少于保守治疗,两组对比P<0.05,差异有统计学意义。经治疗1周、2周后对比发现手术组血清中NSE、S100B含量较保守组明显降低,两组对比P<0.05,差异有统计学意义。结论神经内镜辅助下经颞下入路治疗重症脑干出血能降低患者的并发症及死亡率,提高患者的预后。

关键词：神经内镜颞下入路临床预后并发症

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P-MSC-derived extracellular vesicles facilitate diabetic wound healing via miR-145-5p/CDKN1A-mediated functional improvements of high glucose-induced senescent fibroblasts

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Burns & Trauma 2023年第1期11卷 325-348页

作者： jianlong su Qian Wei Kui Ma Yaxi Wang Wenzhi Hu Hao Meng Qiankun Li Yuehou Zhang Wenhua Zhang Haihong Li Xiaobing Fu Cuiping Zhang Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and the 4th Medical Center of Chinese PLA General Hospital 51 Fucheng RoadHaidian DistrictBeijing 100048China School of Medicine NanKai University94Weijin RoadNankai DistrictTianjin 300071China Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences2019RU05151 Fucheng RoadHaidian DistrictBeijing 100048China Burn and Plastic surgery Zhongda Hospital Affiliated Southeast UniversityDingjiaqiao 87Gulou DistrictNanjing 210009China Department of Wound Repair Institute of Wound Repair and Regeneration MedicineSouthern University of Science and Technology HospitalSouthern University of Science and Technology School of Medicine6019 Xililiuxian RoadNanshan DistrictShenzhen 518055China PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury Repair and Regeneration51 Fucheng RoadHaidian DistrictBeijing 100048China

Background:Persistent hyperglycaemia in diabetes causes functional abnormalities of human dermal fibroblasts(HDFs),partially leading to delayed skin wound *** vesicles(EVs)containing multiple pro-healing microRNAs(miRNAs)have been shown to exert therapeutic effects on diabetic wound *** present study aimed to observe the effects of EVs derived from placental mesenchymal stem cells(P-MSC-EVs)on diabetic wound healing and high glucose(HG)-induced senescent fibroblasts and to explore the underlying ***:P-MSC-EVs were isolated by differential ultracentrifugation and locally injected into the full-thickness skin wounds of diabetic mice,to observe the beneficial effects on wound healing in vivo by measuring wound closure rates and histological ***,a series of assays were conducted to evaluate the effects of low(2.28 x 1010 particles/ml)and high(4.56 x 1010 particles/ml)concentrations of P-MSC-EVs on the senescence,proliferation,migration,and apoptosis of HG-induced senescent HDFs in ***,miRNA microarrays and real-time quantitative PCR(RT-qPCR)were carried out to detect the differentially expressed miRNAs in HDFs after EVs *** RNA inhibitors,miRNA mimics,and small interfering RNA(siRNA)were used to evaluate the role of a candidate miRNA and its target genes in P-MSC-EV-induced improvements in the function of HG-induced senescent ***:Local injection of P-MSC-EVs into diabetic wounds accelerated wound closure and reduced scar widths,with better-organized collagen deposition and decreased p16INK4a *** vitro,P-MSC-EVs enhanced the antisenescence,proliferation,migration,and antiapoptotic abilities of HG-induced senescent fibroblasts in a dose-dependent ***-145-5p was found to be highly enriched in ***-145-5p inhibitors effectively attenuated the P-MSC-EV-induced functional improvements of senescent ***-145-5p mimics simulated the effects of P-MSC-EVs on funct

关键词： Diabetic wounds Mesenchymal stem cells Extracellular vesicles miR-145-5p CDKN1A Senescence Fibroblast Glucose

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MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1224-1236页

作者： Qiankun Li Wenzhi Hu Qilin Huang Jie Yang Bingmin Li Kui Ma Qian Wei Yaxi Wang jianlong su Mengli sun Shengnan Cui Rungong Yang Haihong Li Xiaobing Fu Cuiping Zhang Department of Tissue Repair and Regeneration The First Medical CenterChinese PLA General HospitalBeijing 100853China Research Center for Tissue Repair and Regeneration Medical Innovation Research Department and the Fourth Medical CenterChinese PLA General HospitalBeijing 100048China Dermatology Department The Fourth Medical CenterChinese PLA General HospitalBeijing 100048China Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048China PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury Repair and RegenerationBeijing 100048China School of Medicine NanKai UniversityTianjing 300071China Department of Wound Repair and Dermatologic surgery Taihe HospitalHubei University of MedicineShiyan 442000China

Unhealable diabetic wounds need to be addressed with the help of newer,more efficacious *** combined with biomaterials for sustained delivery of therapeutic agents are expected to bring new hope for chronic wound ***,the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch(SFP)were demonstrated to promote diabetic wound *** fibroin binding peptide(SFBP)was screened through phage display,and SFBP-Gluc-MS2(SGM)and pac-miR146a-pac fusion protein were *** designed exosomes(SGM-Exos,miR146a-Exos,and SGM-miR146a-Exos)were isolated from the engineered placental mesenchymal stem cells(PMSCs)transduced with SGM or/and pac-miR146a-pac *** signals indicated SGM-Exo@SFP markedly increased the binding rate and the stability of ***,the loading efficiency of miR146a in SGM-miR146a-Exos was ten-fold higher than that in *** to untreated,SGM-miR146a-Exo-only treated,and SFP-only treated groups,SGM-miR146a-Exo@SFP drived wound healing associated with less inflammation,collagen deposition,and *** transcriptomics analysis suggested anti-inflammatory and regenerative effects with SGM-miR146a-Exo@SFP ***,we show efficient exosome@biomaterial-based miRNA delivery systems for regenerative medicine and tissue engineering.

关键词： miR146a wound healing

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Development of the Highly Homogeneous Magnetic Field for Simulative Gyrotron by HTS

Southwestern Institute of Physics Annual Report

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Southwestern Institute of Physics Annual Report 2004年第1期 152-154页

作者： HOU Binglin ZHU Xuewu LIN jianlong su Bin

The low temperature superconducting magnet system, with the highly homogeneous magnetic field, has been applied extensively, and has had important effects on many domains. With the development of the cryogenic and superconducting techniques, it is possible that high temperature superconducting magnet with highly homogeneous magnetic field is manufactured by high temperature superconductor（HTS）. Therefore, a simulative gyrotron applied into war, with highly homogeneous magnetic field, is designed and manufactured by high temperature superconducting material.

关键词： HTS Highly homogeneous magnetic field Gyrotron

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托卡马克等离子体的高精度快响应平衡控制系统的研究

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自动化学报 1999年第4期25卷 524-527页

作者：苏建龙潘垣刘保华中国科学院等离子体物理研究所

为了实现高功率波加热下等离子体的水平位移平衡控制，针对ＨＴ－６Ｍ托卡马克装置薄壁真空室的特点，成功地研制了由载流等离子体、薄壁真空室和反馈场磁体所组成的平衡控制系统．用１ＭＷ大功率ＧＴＯ直流斩波器作为反馈控制磁场电源... 详细信息

为了实现高功率波加热下等离子体的水平位移平衡控制，针对ＨＴ－６Ｍ托卡马克装置薄壁真空室的特点，成功地研制了由载流等离子体、薄壁真空室和反馈场磁体所组成的平衡控制系统．用１ＭＷ大功率ＧＴＯ直流斩波器作为反馈控制磁场电源，并采用Ｂａｎｇ－Ｂａｎｇ控制模式的技术，使该系统响应快、控制精度高．在各种实验条件下，等离子体的实际水平位置控制在±３ｍｍ以内，相应的控制精度小于１．５％．

关键词：核聚变等离子体托卡马克装置平衡控制系统

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电磁法仪器高精度GPS同步系统设计

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中南大学学报（自然科学版） 2016年第12期47卷 4035-4040页

作者：于生宝何建龙苏发李刚孙长玉吉林大学仪器科学与电气工程学院吉林长春130061

为了提高电磁法勘探仪器同步系统的同步精度和抗干扰性,提出一种新的基于全球定位系统(GPS)和恒温晶振(OCXO)的同步系统方案。通过对GPS秒脉冲特性和OCXO频率特性的分析,采用卡尔曼滤波对秒脉冲中的随机噪声进行滤波处理,提高其精度。... 详细信息

为了提高电磁法勘探仪器同步系统的同步精度和抗干扰性,提出一种新的基于全球定位系统(GPS)和恒温晶振(OCXO)的同步系统方案。通过对GPS秒脉冲特性和OCXO频率特性的分析,采用卡尔曼滤波对秒脉冲中的随机噪声进行滤波处理,提高其精度。并以处理后的秒脉冲信号作为基准在线校正OCXO基本时钟,保证其输出频率的精度。采用具有电磁兼容设计的MC9S12XS128微控制器实现秒脉冲的卡尔曼滤波和OCXO在线PID校正,提高系统的抗干扰能力。研究结果表明:GPS锁定时同步脉冲精度稳定在25 ns以内。该方案提高同步系统的同步精度和抗干扰性,同时可以提高仪器野外工作的效率。

关键词：电磁法仪器 GPS同步卡尔曼滤波 OCXO校正

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