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Effects of soil metal(loid)s pollution on microbial activities and environmental risks in an abandoned chemical smelting site

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Journal of Environmental Sciences 2024年第9期143卷 60-70页

作者： Hao Li Jun Yao jianli liu Ning Min Geoffrey Sunahara Dongyang Men Robert Duran School of Water Resources and Environment Research Center of Environmental Science and EngineeringChina University of Geosciences(Beijing)Beijing 100083China Department of Natural Resource Sciences McGill University21111Lakeshore DriveSte-Anne-de-BellevueQuebecH9X 3V9Canada Equipe Environnement et Microbiologie MELODY groupUniversitéde Pau et des Pays de l’AdourE2S-UPPAIPREM UMR CNRS 5254BP 115564013 Pau CedexFrance

Abandoned chemical smelting sites containing toxic substances can seriously threaten and pose a risk to the surrounding ecological environment.Soil samples were collected from different depths(0 to 13 m)and analyzed for metal(loid)s content and fractionation,as well as microbial activities.The potential ecological risk indices for the different soil depths(ordered from high to low)were:1 m(D-1)>surface(S-0)>5 m(D-5)>13 m(D-13)>9 m(D-9),ranging between 1840.65-13,089.62,and representing extremely high environmental risks,of which Cd(and probably not arsenic)contributed to the highest environmental risk.A modified combined pollution risk index(MCR)combining total content and mobile proportion of metal(loid)s,and relative toxicities,was used to evaluate the degree of contamination and potential environmental risks.For the near-surface samples(S-0 and D-1 layers),the MCR considered that As,Cd,Pb,Sb,and Zn achieved high and alarming degrees of contamination,whereas Fe,Mn,and Ti were negligible or low to moderate pollution degrees.Combined microcalorimetry and enzymatic activity measurements of contaminated soil samples were used to assess the microbial metabolic activity characteristics.Correlation analysis elucidated the relationship between metal(loid)s exchangeable fraction or content and microbial activity characteristics(p<0.05).The microbial metabolic activity in the D-1 layer was low presumably due to heavy metal stress.Enzyme activity indicators and microcalorimetric growth rate(k)measurements were considered sensitive indicators to reflect the soil microbial activities in abandoned chemical smelting sites.

关键词： Abandoned chemical smelting sites Microbial activities Modified combined pollution risk Microcalorimetry Enzymatic activities

Gga3 gene-deleted C57BL/6J mice have elevated fasting blood glucose levels

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Genes & Diseases 2023年第6期10卷 2206-2209页

作者： Xiaohong Zhang Song Yue Dongjun Jiang Guoan Zhang jianli liu Xuezhi Li Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong 272013China Shandong Key Laboratory of Behavioral Medicine School of Mental HealthJining Medical UniversityJiningShandong 272013China Department of Pathology Weifang Medical UniversityWeifangShandong 261053China Institute of Forensic Medicine and Laboratory Medicine Jining Medical UniversityForensic Science Center of Jining Medical UniversityJiningShandong 272067China Department of Pathology Affiliated Hospital of Jining Medical UniversityJiningShandong 272000China

Diabetes mellitus(DM)is one of the most common diseases in the elderly,and among DM patients,more than 90%have type 2 DM(T2DM).The etiology of T2DM is complex and associated with risk factors such as age,genetic disposition,and diet.The genetic factors underlying T2DM are currently the focus of intense research,and it has been established that the susceptibility genes associated with T2DM vary among different populations.A recent longitudinal exome-wide association study in the Japanese population has identified GGA3 as a susceptible locus for T2DM.1 GGA3 is one of the Golgi-localized-ear-containing ARF binding proteins(GGAs)that function widely in the transport of Golgi-derived vesicles and in endocytic trafficking pathways.However,although it is widely acknowledged that the control of glucose homeostasis via endocytosis and glucose metabolism plays a vital role in T2DM,the associations between intracellular trafficking and diabetes pathogenesis have not been sufficiently established.In this study,we used a Gga3 gene knockout mouse strain to investigate the potential involvement of GGA3 in controlling blood glucose.The study was approved by the ethics committee of Jining Medical University(No.2019-JS-005).Our results indicate that the GGA3 gene might play a protective role against diabetes.

关键词： metabolism elevated protective

Blow up for Initial-Boundary Value Problem of Wave Equation with a Nonlinear Memory in 1-D

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Chinese Annals of Mathematics,Series B 2017年第3期38卷 827-838页

作者： Ning-An LAI jianli liu Jinglei ZHAO Department of Mathematics Lishui UniversityLishui 323000ZhejiangChina Department of Mathematics Shanghai UniversityShanghai 200444China College of Education Lishui UniversityLishui 323000ZhejiangChina

The present paper is devoted to studying the initial-boundary value problem of a 1-D wave equation with a nonlinear memory: u_(tt) - u_(xx) = 1/ Γ(1 - γ) ∫_0~t (t - s)^(-γ)|u(s)|~pds. The blow up result will be established when p > 1 and 0 < γ < 1, no matter how small the initial data are, by introducing two test functions and a new functional.

关键词：一维波动方程初边值问题非线性波动方程爆破检验函数非线性记忆 PDS

木刻运动的推行机——抗战时期敌后根据地的木刻工场

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美术 2024年第5期 75-83页

作者：张向辉刘建理湖北美术学院云南艺术学院美术学院

成立于抗战时期敌后根据地的木刻工场,虽然因为战争的原因,工作场所并不稳定,设备也极其简陋,但所建之处,吸纳和培养了不少抗战时期美术宣传工作所需的工人与木刻创作者,有效地配合和服务了敌后抗日宣传的现实需要,在敌后方的美术运动... 详细信息

成立于抗战时期敌后根据地的木刻工场,虽然因为战争的原因,工作场所并不稳定,设备也极其简陋,但所建之处,吸纳和培养了不少抗战时期美术宣传工作所需的工人与木刻创作者,有效地配合和服务了敌后抗日宣传的现实需要,在敌后方的美术运动中发挥了重要作用。本文探讨了木刻工场成立的时代背景、建立的过程、服务宗旨及其历史贡献等几个方面,并在此基础上,循着木刻工场的历史轨迹,分析了木刻工场在中国新兴木刻运动中所发挥的积极作用,以及在新年画的创新和开启现代版画工作室早期“工作坊”模式等方面所发挥的特殊意义。

关键词：木刻工场抗战美术彦涵宣传画新年画

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论老年人数字享益权实现的国家义务

中州学刊 2024年第4期 84-92页

作者：袁佳音刘建利东南大学法学院江苏南京210000

数字享益权作为老年人在数字时代享有的一项新兴权利,具有尊重与保障人权、回应民生需求与积极老龄化、弥补现有法律保障不足的价值。老年人数字享益权的实现需要依靠国家义务,国家义务是实现老年人数字享益权的根本保障。在内容体系上... 详细信息

数字享益权作为老年人在数字时代享有的一项新兴权利,具有尊重与保障人权、回应民生需求与积极老龄化、弥补现有法律保障不足的价值。老年人数字享益权的实现需要依靠国家义务,国家义务是实现老年人数字享益权的根本保障。在内容体系上,老年人数字享益权实现的国家义务包含尊重、保护与给付三个层次。尊重义务要求国家不得妨碍老年人数字自由权行使;保护义务要求当老年人数字享益权受到第三人侵害时,国家应当及时制止并排除妨害;给付义务要求国家应当在物质、服务与制度方面为老年人数字享益权的实现创造条件。国家违反保障老年人数字享益权实现的义务具有可诉性:违反尊重义务具有高度可诉性,违反保护义务具有部分可诉性,违反给付义务具有最低限度可诉性。

关键词：数字享益权尊重义务保护义务给付义务可诉性

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人工智能在肝纤维化影像学中的研究进展

磁共振成像 2024年第2期15卷 219-223页

作者：李富恺刘建莉兰州大学第二医院放射科兰州730030 兰州大学第二临床医学院兰州730030 甘肃省医学影像重点实验室兰州730030 医学影像人工智能甘肃省国际科技合作基地兰州730030

肝纤维化是各种慢性肝病(chronic liver disease,CLD)进展为肝硬化甚至肝癌的必经之路。有效的临床干预可以实现肝纤维化的逆转,故及时准确地评估肝纤维化严重程度对肝纤维化患者的治疗及预后意义重大。肝组织病理学检查是明确诊断、衡... 详细信息

肝纤维化是各种慢性肝病(chronic liver disease,CLD)进展为肝硬化甚至肝癌的必经之路。有效的临床干预可以实现肝纤维化的逆转,故及时准确地评估肝纤维化严重程度对肝纤维化患者的治疗及预后意义重大。肝组织病理学检查是明确诊断、衡量肝纤维化程度的重要依据,但其有创且结果受穿刺部位影响而不够精准和全面。探寻无创、全面、准确的评估模式至关重要。人工智能(artificial intelligence,AI)通过分析海量的影像数据和不断地自我学习,构建疾病评估和预测模型,对疾病的发生发展的影像学变化规律进行分析研究。随着影像学技术和计算机科学的快速发展,基于影像图像的AI技术在肝纤维化的无创诊断及分期中显示出其突出的临床价值及应用潜力。本文就近年来国内外AI技术在肝纤维化影像学[超声(ultrasound,US)、电子计算机断层扫描(computed tomography,CT)、MRI]等方面进行综述,旨在介绍该领域AI发展现状并试图分析当前面临的问题,以期实现肝纤维化无创、精准评估,为临床个体化精准医疗提供影像支持。

关键词：肝纤维化慢性肝病人工智能影像学磁共振成像定量评估

Efficient C-S Cross-Coupling of Thiols with Aryl Iodides Catalyzed by Cu(OAc)_(2)·H_(2)O and 2,2'-Biimidazole

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Chinese Journal of Chemistry 2014年第3期32卷 212-218页

作者： Chenglong Zong jianli liu Shengyan Chen Runsheng Zeng Jianping Zou Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China

The classical Ullmann C-S cross coupling reaction of aryl iodides with aromatic/alkyl thiols under catalysis of 15 mol%Cu(OAc)_(2)·H_(2)O and 15 mol%2,2'-biimidazole works at 80℃in DMSO for 3 h to provide a variety ... 详细信息

关键词： C-S cross coupling reaction Cu(OAc)_(2)·H_(2)O,2,2'-biimidazole aryl sulfides

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汲取与求新:抗战时期根据地“新年画”研究

云南艺术学院学报 2024年第1期 83-91页

作者：刘建理蒙古研究大学文化学院《云南艺术学院学报》编辑部

产生于抗战时期根据地的“新年画”,其耳目一新的艺术形式和紧扣现实语境的表现主题和内容,广受抗战时期根据地群众的喜爱与欢迎。抗战时期根据地的“新年画”在中国抗战时期根据地的美术宣传运动中发挥了重要作用。文章通过分析抗战时... 详细信息

产生于抗战时期根据地的“新年画”,其耳目一新的艺术形式和紧扣现实语境的表现主题和内容,广受抗战时期根据地群众的喜爱与欢迎。抗战时期根据地的“新年画”在中国抗战时期根据地的美术宣传运动中发挥了重要作用。文章通过分析抗战时期根据地“新年画”产生的时代背景及缘起、创作的转向与革新以及历史贡献等三个大的方面。进而指出,产生于抗战时期根据地的“新年画”,不仅在抗战时期根据地的美术宣传运动中国发挥了重要的作用,也积极有效的配合了我党在抗战时期根据地的政治宣传任务。抗战时期根据地年轻的美术家们在“新年画”创作中的探索、开拓与创新性的实践,既促进了日后延安新年画运动的开展,又为新中国年画的创作走向成熟提供了宝贵的经验。

关键词：抗战时期根据地新年画艺术形式创作研究

Single-molecule force spectroscopy study of the effect of cigarette carcinogens on thrombomodulin–thrombin interaction

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Science Bulletin 2016年第15期61卷 1187-1194页

作者： jianli liu Xuejie Zhang Xiaofeng Wang Li Xu Jingyuan Li Xiaohong Fang Key Laboratory of Molecular Nanostructure and Nanotechnology Institute of Chemistry Chinese Academy ofSciences Beijing 100190 China Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academyof Sciences Beijing 100049 China

Exposure to cigarette smoke is a major risk factor for cancer and cardiovascular disease. Thrombosis is regarded as the main reason for smoking-related cardiovascular disease. However, the detail mechanism of how smoking promotes thrombosis is not fully understood. In this work, we investigated the impacts of one major cigarette carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone(NNK) as well as its metabolite4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol(NNAL)on a key process in thrombosis regulation: thrombin–thrombomodulin(TM) binding. Atomic force microscopy based single-molecule force spectroscopy was applied to measure both in vitro and in vivo binding force of thrombin to TM in the absence and presence of NNK and NNAL respectively. The results revealed that NNK and NNAL can reduce the binding probability of TM and thrombin. The inhibition effect and underlying mechanism was further studied by molecular simulation. As indicated by our results, the cigarette carcinogens could cause a higher risk of thrombosis through the disruption of TM–thrombin interaction.

关键词：血栓调节蛋白单分子力谱香烟烟雾致癌物质相互作用凝血酶原子力显微镜技术心血管疾病