检索结果-南通市图书馆

Electrochemical protein biosensors for disease marker detection:progress and opportunities

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2024年第3期10卷 1-20页

作者： Lanpeng Guo Yunong Zhao Qing Huang Jing Huang Yanbing Tao jianjun chen Hua-Yao Li Huan Liu School of Integrated Circuits Wuhan National Laboratory for OptoelectronicsOptics Valley LaboratoryHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Integrated CircuitsAnhui UniversityHefei 230601China School of Optoelectronic Materials and Technology Jianghan UniversityWuhan 430056China Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology1277 Jiefang AvenueWuhan 430022China Wenzhou Institute of Advanced Manufacturing Technology Huazhong University of Science and TechnologyWenzhou 325000China

The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor *** are extensively used as biological macromolecular markers in disease diagnosis and the analysis of therapeutic *** protein biosensors have achieved desirable specificity by using the specific antibody–antigen binding principle in ***,the active centers of protein biomarkers are surrounded by a peptide matrix,which hinders charge transfer and results in insufficient sensor ***,electrode-modified materials and transducer devices have been designed to increase the sensitivity and improve the practical application prospects of electrochemical protein *** this review,we summarize recent reports of electrochemical biosensors for protein biomarker *** highlight the latest research on electrochemical protein biosensors for the detection of cancer,viral infectious diseases,inflammation,and other *** corresponding sensitive materials,transducer structures,and detection principles associated with such biosensors are also addressed ***,we present an outlook on the use of electrochemical protein biosensors for disease marker detection for the next few years.

关键词： diagnosis specificity Electrochemical

Boosting the catalytic performance of Cu-SAPO-34in NO_(x) removal via hydrothermal treatment

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第1期135卷 640-655页

作者： Xiaoyan Tian Huimin Wang Siyuan Xu Lianyun Gao Jinyan Cao jianjun chen Qiulin Zhang Ping Ning Jiming Hao Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China National-Regional Engineering Center for Recovery of Waste Gases from Metallurgical and Chemical Industries Kunming University of Science and TechnologyKunming 650500China School of Environment State Key Joint Laboratory of Environment Simulation and Pollution ControlTsinghua UniversityBeijing 100084China

Phosphate ions promoted Cu-SAPO-34(P-Cu-SAPO-34)were prepared using bulk CuO particles as Cu^(2+)precursor by a solid-state ion exchange technique for the selective catalytic reduction of NO_(x) with NH_3(NH_3-SCR).The effects of high temperature(H-T)hydrothermal aging on the NO_(x) removal(de-NO_(x))performance of Cu-SAPO-34 with and without phosphate ions were systematically investigated at atomic *** results displayed that both Cu-SAPO-34 and P-Cu-SAPO-34 presented relatively poor NO_(x) removal activity with a low conversion(<30%)at 250-500℃.However,after H-T hydrothermal treatment(800℃ for 10 hr at 10%H_2O),these two samples showed significantly satisfied NO_(x) elimination performance with a quite high conversion(70%-90%)at 250-500℃.Additionally,phosphate ions decoration can further enhance the catalytic performance of Cu-SAPO-34 after hydrothermal treatment(Cu-SAPO-34H).The textural properties,morphologies,structural feature,acidity,redox characteristic,and surface-active species of the fresh and hydrothermally aged samples were analyzed using various characterization *** systematical characterization results revealed that increases of 28%of the isolated Cu^(2+)active species(Cu^(2+)-2Z,Cu(OH)^(+)-Z)mainly from bulk CuO and 50%of the Bronsted acid sites,the high dispersion of isolated Cu^(2+)active component as well as the Bronsted acid sites were mainly responsible for the accepted catalytic activity of these two hydrothermally aged samples,especially for P-Cu-SAPO-34H.

关键词： NH_(3)-SCR Cu-SAPO-34 Hydrothermal induced Phosphate ions

Hexafluoropropylene oxide trimer acid,a perfluorooctanoic acid alternative,induces cardiovascular toxicity in zebrafish embryos

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第5期139卷 460-472页

作者： Sujie Sun Li Zhang Xue Li Lu Zang Ling Huang Junquan Zeng Zigang Cao Xinjun Liao Zilin Zhong Huiqiang Lu jianjun chen Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases Jiangxi Key Laboratory of Developmental Biology of OrgansCenter for Clinical Research Center of the Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Key Laboratory of Anesthesiology and Brain Functional ModulationDepartment of PediatricsShanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants School of Environmental Sciences and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Interventional and Vascular Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Department of Internal Medicine and Hematology Affiliated Hospital of Jinggangshan UniversityJi’an 343009China

As an increasingly used alternative to perfluorooctanoic acid(PFOA),hexafluoropropylene oxide trimer acid(HFPO-TA)has been widely detected in global water ***,little is known regarding its toxic effects on cardiovascular ***,zebrafish embryos were treated with egg water containing 0,60,120,or 240 mg/L *** showed that HFPO-TA treatment led to a significant reduction in both larval survival percentage and heart ***,HFPO-TA exposure caused severe pericardial edema and elongation of the sinus venous to bulbus arteriosus distance(SV-BA)in Tg(myl7:GFP)transgenic larvae,disrupting the expression of genes involved in heart development and thus causing abnormal heart *** sprouting angiogenesis was observed in the 120 and 240 mg/L exposed Tg(fli:GFP)transgenic ***-TA treatment also impacted the mRNA levels of genes involved in the vascular endothelial growth factor(VEGF)pathway and embryonic vascular ***-TA exposure significantly decreased erythrocyte number in Tg(gata1:DsRed)transgenic embryos and influenced gene expression associated with the heme metabolism ***-TA also induced oxidative stress and altered the transcriptional levels of genes related to cell cycle and apoptosis,inhibiting cell proliferation while promoting ***,HFPO-TA exposure may induce abnormal development of the cardiovascular and hematopoietic systems in zebrafish embryos,suggesting it may not be a suitable or safe alternative for PFOA.

关键词： Hexafluoropropylene oxide trimer acid Heart development Vascular development Hemopoiesis Zebrafish embryos

Zonal activation of molecular carbon dioxide and hydrogen over dual sites Ni-Co-MgO catalyst for CO_(2) methanation:Synergistic catalysis of Ni and Co species

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第4期91卷 213-225页

作者： Zonglin Li jianjun chen Yu Xie Junjie Wen Huiling Weng Mingxue Wang Jingyi Zhang Jinyan Cao Guocai Tian Qiulin Zhang Ping Ning Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500YunnanChina National-Regional Engineering Center for Recovery of Waste Gases from Metallurgical and Chemical Industries Kunming University of Science and TechnologyKunming 650500YunnanChina Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina

An in-depth mechanism in zonal activation of CO_(2)and H2molecular over dual-active sites has not been revealed ***,Ni-Co-MgO was rationally constructed to elucidate the CO_(2)methanation *** abundant surface nickel and cobalt components as active sites led to strong Ni-Co interaction with charge transfer from nickel to ***,electron-enriched Coδ-species participated in efficient chemisorption and activation of CO_(2)to generate monodentate ***,plentiful available Ni0sites facilitated H2dissociation,thus CO_(2)and H2were smoothly activated at zones of Coδ-species and Ni0,*** in situ DRIFTS,quasi situ XPS,TPSR,and DFT calculations substantiated a new formate evolution mechanism via monodentate carbonate instead of traditional bidentate carbonate based on synergistic catalysis of Coδ-species and *** zonal activation of CO_(2)and H2by tuning electron behaviors of double-center catalysts can boost heterogeneous catalytic hydrogenation performance.

关键词： Zonal activation CO_(2) methanation Dual active sites Synergistic effect

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng Peng Zhihao Hu Limei Zeng Meizhu Zhang Congcong Xu Benyan Lu chengpeng Tao Weiming chen Wen Hou Kui cheng Huichang Bi Wanyi Pan jianjun chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic Degrader PROTAC Molecularglue Hydrophobic tagging

RNA m^(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第1期11卷 382-396页

作者： Zheng Zhang Keren Zhou Li Han Andrew Small Jianhuang Xue Huilin Huang Hengyou Weng Rui Su Brandon Tan Chao Shen Wei Li Zhicong Zhao Ying Qing Xi Qin Kitty Wang Keith Leung Mark Boldin Chun-Wei chen David Ann Zhijian Qian Xiaolan Deng jianjun chen Zhenhua chen Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and Manella Graduate School of Biological Sciences Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr Family Center for Leukemia Research City of HopeDuarteCA 91010USA Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou Laboratory GuangzhouGuangdong 510005China Bioland Laboratory GuangzhouGuangdong 51005China Department of Liver Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes Complications and Metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Biochemistry and Molecular Biology University of FloridaGainesvilleFL 32603USA Tongji Hospital Affiliated to Tongji University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China School of Pharmacy China Medical UniversityShenyangLiaoning 110001China

As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including *** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTL3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its processing into precursor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to ***,we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia(AML)patients,especially in relapsed patients,and plays an onco-genic role in ***,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AML,through facilitating the processing of pre-miR-126 into mature ***,YTHDF2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA processing,to promote the maturation of ***2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AML patients,and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AML cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YTHDF2 in ***,our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AML and highlight the ther-apeutic potential of targeting this axis for AML treatment,but also suggest that m^(6)A plays a role in pre-miRNA processing that contributes to tumorigenesis.

关键词： AML miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2

Design of a 3D-printed liquid lithium divertor target plate and its interaction with high-density plasma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plasma Science and Technology 2024年第8期26卷 112-120页

作者：苑聪聪叶宗标刘建星郭恒鑫彭怡超廖加术陈波陈建军王宏彬韦建军张秀杰芶富均 Institute of Nuclear Science and Technology Sichuan UniversityChengdu 610064People’s Republic of China Institute of Atomic and Molecular Physics Sichuan UniversityChengdu 610064People’s Republic of China Southwestern Institute of Physics Chengdu 610064People’s Republic of China

A liquid Li divertor is a promising alternative for future fusion *** this work a new divertor model is proposed,which is processed by 3D-printing technology to accurately control the size of the internal capillary *** a steady-state heat load of 10 MW m^(-2),the thermal stress of the tungsten target is within the bearing range of tungsten by finite-element *** order to evaluate the wicking ability of the capillary structure,the wicking process at 600℃ was simulated by *** result was identical to that of the corresponding *** 1 s,liquid lithium was wicked to the target surface by the capillary structure of the target and quickly spread on the target *** the wicking process,the average wicking mass rate of lithium should reach 0.062 g s^(-1),which could even supplement the evaporation requirement of liquid lithium under an environment>950℃.Irradiation experiments under different plasma discharge currents were carried out in a linear plasma device(SCU-PSI),and the evolution of the vapor cloud during plasma irradiation was *** was found that the target temperature tends to plateau despite the gradually increased input current,indicating that the vapor shielding effect is gradually *** irradiation experiment also confirmed that the 3D-printed tungsten structure has better heat consumption performance than a tungsten mesh structure or multichannel *** results reveal the application potential and feasibility of a 3D-printed porous capillary structure in plasma-facing components and provide a reference for further liquid-solid combined target designs.

关键词： fusion divertor 3D-printing tungsten lithium liquid metal

在线全文

学校读者我要写书评

暂无评论

液态金属催化裂解甲烷制氢动力学研究

高等学校化学学报 2024年第2期45卷 97-103页

作者：廖加术刘建星王思蜀陈波陈建军韦建军叶宗标芶富均四川大学原子核科学技术研究所成都610064 四川大学原子与分子物理研究所成都610064

液态金属催化甲烷热解是一种高效生产氢气且无二氧化碳排放的新兴技术.本文开发了一个液态金属裂解反应器催化甲烷热解的数值模型,在实验室自主搭建的液态金属制氢平台上得到的实验数据与模型预测结果吻合良好.该模型是基于甲烷在气液... 详细信息

液态金属催化甲烷热解是一种高效生产氢气且无二氧化碳排放的新兴技术.本文开发了一个液态金属裂解反应器催化甲烷热解的数值模型,在实验室自主搭建的液态金属制氢平台上得到的实验数据与模型预测结果吻合良好.该模型是基于甲烷在气液界面发生的催化热解、气泡内部发生的非催化热解过程和气泡上升过程中的流动行为,耦合了催化和非催化反应动力学和流体力学所建立的.使用气体体积流速、压力、气体成分、温度和液态金属性质(密度、黏度和表面张力)预测气泡尺寸和熔体中的气含率.该模型较好地预测了液态铜铋合金(Cu_(0.45)Bi_(0.55))催化甲烷热解实验中不同温度、不同甲烷进气流量和液态金属高度下的甲烷转化率,得到了催化甲烷热解过程中的气含率、表观气体速率和压力沿液态金属高度的分布.实验数据与模型预测结果的高度吻合证明了模型的可靠性,该模型未来将有助于反应器优化和氢产率提高.

关键词：液态金属反应动力学流体力学催化甲烷热解

在线全文

学校读者我要写书评

暂无评论

新发现鲁迅致胡今虚书简考略

鲁迅研究月刊 2024年第8期 55-60页

作者：陈建军李明慧武汉大学文学院 430072

新见鲁迅致胡今虚信,作于1933年11月10日,原载1943年10月27日碧湖《浙江日报》副刊《江风》第527期,题为《鲁迅书简》。这封佚信的行文甚合鲁迅作风,内容上与此前鲁迅写给胡今虚的数封信多有关联,主要涉及《毁灭》的翻译及改编问题。人... 详细信息

新见鲁迅致胡今虚信,作于1933年11月10日,原载1943年10月27日碧湖《浙江日报》副刊《江风》第527期,题为《鲁迅书简》。这封佚信的行文甚合鲁迅作风,内容上与此前鲁迅写给胡今虚的数封信多有关联,主要涉及《毁灭》的翻译及改编问题。人民文学出版社已启动《鲁迅全集》修订工作,这封信理当补入。

关键词：鲁迅胡今虚佚信