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Transactions of Nonferrous Metals Society of China 2009年第S2期19卷 418-422页

作者： jiang shao-song ZHANG Kai-feng National Key Laboratory for Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China

Firstly,the relation between the coefficient of thermal expansion(CTE)and the volume fraction of TiO_(2) was investigated, and also the influence of relative density of ceramic on the CTE was *** results show that the volume fraction of TiO_(2) and the relative density both make influence on the CTE of ZrO_(2)-TiO_(2) *** to the results,the ZrO_(2)-TiO_(2)(volume fraction of TiO_(2) is 27%)ceramic die with the similar CTE(8.92×10^(-6) ℃^(-1))to Ti6Al4V was ***,to evaluate the dimensional accuracy of the workpiece superplastically formed,the Ti6Al4V impression experiment was *** result shows that the dimensional inaccuracy of workpiece is ***,in order to evaluate the practicability,the experiment of superplastic forming Ti6Al4V using ZrO_(2)-TiO_(2) cylinder ceramic die was carried *** Ti6Al4V cylinder shows good shape retention and surface quality,and high dimensional *** ceramic dies seem to be adequate for superplastic forming the high accuracy Ti6Al4V, and the trials have confirmed the potential of the ZrO_(2)-TiO_(2) ceramic die.

关键词： Ti6Al4V superplastic forming ceramic die linear coefficient of thermal expansion

Daphnane-type diterpenes from genus Daphne and their anti-tumor activity

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Chinese Herbal Medicines 2021年第2期13卷 145-156页

作者： Zi-lin Hou Guo-dong Yao shao-jiang song Liaoning Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development School of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China

Daphnane-type diterpenenoids are the major biologically active constituents in the genus *** find that there are about 101 Daphnane-type diterpenes in this genus,most of those compounds show different degrees of inhibitory effect on various cancer *** of them have been studied in depth and the potent molecular mechanisms might be associated with modulation of different cell-signaling *** addition,some compounds of this type also can inhibit the synthesis of protein and ***,the anti-tumor activity of Daphnane-type diterpenes is worthy of ***,most of the current research on the activity of these compounds is focused on simple drug efficacy,and its in-depth mechanism research is far from *** the other point of view,there still exists wide growing space on the depth of these compounds.

关键词： anti-tumor effect bcompound structure Daphne genus Daphnane-type diterpenes molecular mechanism

A new isoquinoline derivative from the leaves of Magnolia sieboldii ***

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Chinese Chemical Letters 2010年第12期21卷 1446-1448页

作者： Di Wu Ru Ping Wang shao jiang song Li Jun Wu Hui Yuan Gao The Liaoning Provincial Public Security Office Shenyang 110032 China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 China

Magnoline（1）,a new isoquinoline derivative,was isolated from the leaves of Magnolia sieboldii ***（Magnoliaceae）.Its structure was elucidated on the basis of spectral analysis including 1D,2D NMR and HR-TOF-MS.

关键词： Magnolia sieboldii K. Koch Isoquinoline Structural identification

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： song He Li Li Sai Wang shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Two new saponins from Anemarrhena asphodeloides Bge.

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Chinese Chemical Letters 2007年第2期18卷 171-174页

作者： Ying Peng Yu Jing Zhang Zhi Qiang Ma Wei San Pan Yu Qing Sun shao jiang song School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China No.2 Herbal Factory Haerbin Phamarceuticals GroupHaerbin 150078China

Two new saponins 3-O-β-d-glucopyranosyl (1 → 2)-β-d-mannopyranosyl sarsasapogenin, named timosaponin A IV(1) and (5β, 25S)-26-O-β-d-glucopyranosyl-furost-20(22)-en-3,26-diol-3-O-β-d-glucopyranosyl (1 → 4) glucopyranosyl (1 → 2)-β-d-galacopyranoside, named timosaponin B IV(2), were isolated by silica gel column chromatography and preparative HPLC from Anemarrhena asphodeloides Bge. Their structures were elucidated by chemical characters and spectroscopic analysis.

关键词： Anemarrhena asphodeloides Bge. Saponin Timosaponin A IV Timosaponin B IV Structural identification

Isolation of chemical compositions as dietary antioxidant supplements and neuroprotectants from Chaga mushroom (Inonotus obliquus)

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Food Bioscience 2022年第3期47卷 211-220页

作者： Ye Chang Ming Bai Xiao-Bian Xue Chun-Xin Zou Xiao-Xiao Huang shao-jiang song Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development Liaoning ProvinceChina Engineering Research Center of Natural Medicine Active Molecule Research & Development Liaoning ProvinceChina Key Laboratory of Natural Bioactive Compounds Discovery & Modification ShenyangChina School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyangLiaoning110016China

Excessive free radicals can cause oxidative stress (OS),which lead to neurodegenerative diseases (ND) are harmful to the human ***,it is necessary to explore dietary antioxidants and neuroprotectants from nutrient *** mushroom (Inonotus obliquus ) has been used as an important functional food in many countries for *** present study was carried out to discover active compounds from *** and investigate the in vitro antioxidant activity and neuroprotective *** natural products including two new isocoumarins (1 –2 ),a new 8-O -4′-neolignan (3 ),a new cyclic diarylheptanoid (4 ),and twelve known compounds (5 –16 ) were separated from *** .Their structures were elucidated by extensive spectroscopic analyses of high resolution electrospray mass spectrometry (HRESIMS),ultra violet (UV),and nuclear magnetic resonance (NMR).Among them,compounds 1 and 2 revealed remarkable antioxidant activities through the comprehensive analysis of DPPH,ABTS,and ferric reducing antioxidant power (FRAP) ***,compound 1 demonstrated significant neuroprotective activity by increasing SH-SY5Y cells viability and preventing mitochondrial *** from that,electronic analyses were performed using the highest occupied molecular orbital (HOMO),and the lowest unoccupied molecular orbital (LUMO) to analyze compound 1 .These results indicated that compound 1 had a significant implication for the search of natural raw material to prevent OS and nerve damage in the field of functional foods,and the isocoumarin fragment as well as an oxygenated cis double-bond might be the active sites to play prominent parts in antioxidant and neuroprotective activities of compound 1 .

关键词： Inonotus obliquus Chaga mushroom Functional food Neuroprotective activity Antioxidant activity

Quassinoids from the Root Barks of Ailanthus altissima:Isolation,Configurational Assignment,and Cytotoxic Activities

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Chinese Journal of Chemistry 2021年第4期39卷 879-886页

作者： Ye-Qing Du Ming Bai Xiao-Qi Yu Tian-Ming Lv Bin Lin Xiao-Xiao Huang shao-jiang song Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning ProvinceSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyangLiaoning 110016China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China

Main observation and conclusion Quassinoids,a class of highly oxygenated triterpenes,have been isolated as bitter principles from the plants of Simaroubaceae *** new quassinoids,chouchunlactone A-E(1-5),and two known ones were identified from the root barks of Ailanthus altissima Swingle(Simaroubaceae).The chemical structures of the new compounds were deduced by spectroscopic data analyses,NMR calculations and DP4+probability *** absolute configurations were defined by comparison of their experimental and calculated electronic circular dichroism(ECD)spectra data,and compounds 1-2 were further confirmed by single-crystal X-ray ***,compound 5 showed potencies equivalent to sorafenib(IC50 value,9.70μmol·L–1)against HepG2 *** Hoechst 33342 staining,JC-1 fluorescent dye and Annexin V/PI analysis studies demonstrated that 5 can induce apoptosis and attenuate mitochondrial membrane potential(MMP)in HepG2 cells.

关键词： Ailanthus altissima Simaroubaceae Quassinoids Cytotoxicity Apoptosis

Brusatol:A potential anti-tumor quassinoid from Brucea javanica

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Chinese Herbal Medicines 2020年第4期12卷 359-366页

作者： Xiao-qi Yu Xin-yue Shang Xiao-xiao Huang Guo-dong Yao shao-jiang song Liaoning Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development School of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China jiangsu Kanion Pharmaceutical Co. Ltd.Lianyungang 222001China

Brusatol,a triterpene lactone compound mainly from Brucea javanica,sensitizes a broad spectrum of cancer *** is known as a specific inhibitor of nuclear factor-erythroid 2-related factor 2(Nrf2)*** this review,we provide a comprehensive overview on the antitumor effect and molecular mechanisms of brusatol in vitro and in *** review also covers pharmacokinetics studies,modification of dosages forms of *** evidences have validated the value of brusatol as a chemotherapeutic agent in cancers,which may contribute to drug development and clinical application.

关键词： antitumor Brucea javanica(L.)Merr. brusatol triterpene lactone

Rapid discovery of two unprecedented meroterpenoids from Daphne altaica *** molecular networking integrated with MolNetEnhancer and Network Annotation Propagation

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Chinese Chemical Letters 2024年第8期35卷 294-298页

作者： Wei-Yu Zhou Zi-Han Xi Ning-Ning Du Li Ye Ming-Hao jiang Jin-Le Hao Bin Lin Guo-Dong Yao Xiao-Xiao Huang shao-jiang song Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning ProvinceEngineering Research Center of Natural Medicine Active Molecule Research&DevelopmentLiaoning ProvinceKey Laboratory of Natural Bioactive Compounds Discovery&ModificationShenyangSchool of Traditional Chinese Materia Medic1Shenyang Pharmaceutical UniversityShenyang 110016China Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China

Under the guidance of the approach which integrates molecular networking,MolNetEnhancer and Net-work Annotation Propagation(NAP),daphnaltaicanoids A and B(1 and 2)with unprecedented 9-oxa-tetracyclo[6.***.1.0^(2,6).0^(8,13)]pentadecane and tetracyclo[5.***.0.1^(2,5).2^(4,11)]tridecane central frameworks were iso-lated from Daphne altaica Pall.,representing two types of unparalleled meroterpenoid *** struc-tures were elucidated by extensive spectroscopic analysis,nuclear magnetic resonance(NMR)calcula-tions,DP4+analysis and electronic circular dichroism(ECD)*** plausible biosynthetic path-ways for 1 and 2 were ***,2 exerted potent neuroprotective activities which were su-perior to trolox at 12.5 and 25μmol/***,1 and 2 exhibited more noticeable acetylcholinesterase inhibitory activities than *** docking simulations were performed to explore the inter-molecular interaction of compounds 1 and 2 with *** bioactivity evaluation results highlight the prospects of 1 and 2 as a novel category of neurological agents.

关键词： Daphne altaica Pall. Molecular networking MolNetEnhancer NAP Unprecedented meroterpenoid frameworks Neuroprotective activities Acetylcholinesterase inhibitors

A natural product GENK suppresses invasion and metastasis by targeting Hippo-YAP signaling in hepatocellular carcinoma

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A natural product GENK suppresses invasion and metastasis by...