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Non-concomitant cortical structural and functional alterations in sensorimotor areas following incomplete spinal cord injury

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Neural Regeneration Research 2017年第12期12卷 2059-2066页

作者： Yu Pan Wei-bei Dou Yue-heng Wang Hui-wen Luo Yun-xiang Ge shu-yu Yan quan Xu Yuan-yuan Tu Yan-qing Xiao Qiong Wu Zhuo-zhao zheng Hong-liang Zhao Department of Rehabilitation Beijing Tsinghua Changgung Hospital Beijing China School of Clinical Medicine Tsinghua University Beijing China Department of Electronic Engineering Tsinghua University Beijing China Department of Radiology Beijing Tsinghua Changgung Hospital Beijing China

Brain plasticity, including anatomical changes and functional reorganization, is the physiological basis of functional recovery after spinal cord injury（SCI）. The correlation between brain anatomical changes and functional reorganization after SCI is unclear. This study aimed to explore whether alterations of cortical structure and network function are concomitant in sensorimotor areas after incomplete SCI. Eighteen patients with incomplete SCI（mean age 40.94 ± 14.10 years old; male：female, 7：11） and 18 healthy subjects（37.33 ± 11.79 years old; male：female, 7：11） were studied by resting state functional magnetic resonance imaging. Gray matter volume（GMV） and functional connectivity were used to evaluate cortical structure and network function, respectively. There was no significant alteration of GMV in sensorimotor areas in patients with incomplete SCI compared with healthy subjects. Intra-hemispheric functional connectivity between left primary somatosensory cortex（BA1） and left primary motor cortex（BA4）, and left BA1 and left somatosensory association cortex（BA5） was decreased, as well as inter-hemispheric functional connectivity between left BA1 and right BA4, left BA1 and right BA5, and left BA4 and right BA5 in patients with SCI. Functional connectivity between both BA4 areas was also decreased. The decreased functional connectivity between the left BA1 and the right BA4 positively correlated with American Spinal Injury Association sensory score in SCI patients. The results indicate that alterations of cortical anatomical structure and network functional connectivity in sensorimotor areas were non-concomitant in patients with incomplete SCI, indicating the network functional changes in sensorimotor areas may not be dependent on anatomic structure. The strength of functional connectivity within sensorimotor areas could serve as a potential imaging biomarker for assessment and prediction of sensory function in patients with incomplete SCI. This trial was register

关键词： nerve regeneration incomplete spinal cord injury gray matter volume functional connectivity sensorimotor areas functionalmagnetic resonance imaging brain plasticity non-concomitant anatomical structure network imaging biomarker neural regeneration

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Anisotropy of Nonlinear-Optical Property of RCOB (R = Gd, Y) Crystal

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Chinese Physics Letters 2001年第3期18卷 385-387页

作者： WANG zheng-Ping LIU Jun-Hai SONG Ren-Bo jiang Huai-Dong ZHANG shu-Jun FU Kun WANG Chang-qing WANG Ji-yang LIU Yao-Gang WEI Jing-Qian CHEN Huan-Chu SHAO Zong-shu National Key Laboratory of Crystal Materials Shandong UniversityJi’nan 250100

The nonlinear-optical coefficients of RCOB(R=Gd,Y)crystals are *** spatial distribution of deff effective nonlinear-optical coefficient is determined *** experiments show that the maximum deff occurs at the second *** second-harmonic-generation efficiency reaches 48%for a 6 mm-long,(113.2°,47.4°)-cut GdCOB,and 41.5%for a 5mm-long,(113°,36.5°)-cut YCOB,*** intracavity frequency doubling of GdCOB is reported for the first time.

关键词： optical Crystal doubling

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Proliferative and apoptotic effects of andrographolide on the BGC-823 human gastric cancer cell line

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Chinese Medical Journal 2013年第19期126卷 3739-3744页

作者： LI shu-guang WANG Yuan-yu YE Zai-yuan SHAO qing-shu TAO Hou-quan shu Li-sha ZHAO Yi-feng yang Yong-jiang yang Jing PENG Tao HAN Bo HUANG Di Department of Gastrointestinal Surgery the First Affiliated Hospital Hebei North University Zhangjiakou Hebei 075000 China Department of Gastrointestinal Surgery Zhejiang Provincial People's Hospital Hangzhou Zhejiang 310014 China

Background Andrographolide has been shown to have anticancer activity on diverse cancer cell lines representing different types of human *** aim of this research was to investigate the anticancer and apoptotic effects of andrographolide on the BGC-823 human gastric cancer cell *** Cell proliferation and IC50 were evaluated using MTT assay,cell-cycle analysis with flow cytometry apoptotic effects with Annexin-V/propidium iodide double-staining assay,and morphologic structure with transmission electron *** and reverse-transcription PCR was used to analyze Bcl-2,Bax,and caspase-3 *** Andrographolide showed a time-and concentration-dependent inhibitory effects on BGC-823 cell *** to controls,the number of cells in the G0-G1-phase increased significantly,S and G2-M-phase cells decreased after 48 hours of treatment with andrographolide,and both early and late apoptotic rates increased significantly compared to the controls,all in a concentration-dependent *** and caspase-3 expressions were markedly increased,and Bcl-2 expression was *** Andrographolide inhibits BGC-823 cell growth and induces BGC-823 cell apoptosis by up-regulating Bax and caspase-3 expressions and down-regulating Bcl-2 *** may be useful as a potent and selective agent in the treatment of human gastric cancers.

关键词： andrographolide tumor cells proliferative inhibition cell cycle apoptosis

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Expression of huCdc7 in colorectal cancer

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World Journal of Gastroenterology 2013年第20期19卷 3130-3133页

作者： Hai-Jun Chen Zhen Zhu Xue-Lin Wang quan-Lin Feng qing Wu zheng-Ping Xu jiang Wu Xiao-Feng Yu Hong-Liang Qian Qi Lu Department of Oncology Kunshan Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine

AIM:To detect the expression of huCdc7 in colorectal ***:The mRNA and protein expression of huCdc7 in 39 colorectal cancer tissue specimens and matched tumor-adjacent normal colorectal tissue specimens was detected by reverse transcription-polymerase chain reaction and immunohistochemistry,***:The relative expression level of huCdc7 mRNA in colorectal cancer was significantly higher than that in tumor-adjacent normal colorectal tissues(0.03675 ± 1.00 vs 0.01199 ± 0.44,P < 0.05).huCdc7-positive cells displayed brown granules in the *** tissues contained many huCdc7-positive cells,whereas normal colorectal tissues contained very few positive ***:huCdc7 may play an important role in the development and progression of colorectal cancer.

关键词： huCdc7 Semiquantitative reverse transcription-polymerase chain reaction Colorectal cancer

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Specific HLA-DQB1 alleles associated with risk for development of hepatocellular carcinoma:A meta-analysis

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World Journal of Gastroenterology 2011年第17期17卷 2248-2254页

作者： Yong-Ning Xin Zhong-Hua Lin Xiang-Jun jiang shu-Hui Zhan quan-jiang Dong qing Wang Shi-Ying Xuan Department of Gastroenterology Qingdao Municipal Hospital Qingdao 266071 Shandong Province China School of Medicine Qingdao University Qingdao 266021 Shandong Province China College of Medicine and Pharmaceutics Ocean University of China Qingdao 266003 Shandong Province China

AIM:To evaluate the association of human leukocyte antigen(HLA)-DQB1 alleles with hepatocellular carcinoma(HCC) through meta-analysis of published ***:Case-control studies on HLA-DQB1 allele association with HCC published up to January 2010 were included in the *** odds ratios(ORs) of HLADQB1 allele distributions in HCC patients were analyzed and compared with healthy *** meta-analysis software REVMAN 5.0 was applied for investigating heterogeneity among individual studies and for summarizing all the studies.A meta-analysis was performed using fixed-effect or random-effect methods,depending on the absence or presence of significant *** case-control studies containing 398 cases and 594 controls were included in the final ***:Among the five family alleles,two(DQB1*02 and DQB1*03) were found to be significantly associated with the risk of *** combined OR for the association of DQB1*02 and DQB1*03 allele with the risk for HCC was 1.78(95% CI:1.05-3.03,P = 0.03) and 0.65(95% CI:0.48-0.89,P = 0.007),*** the 13 specific alleles,two(DQB1*0502 and DQB1*0602) were significantly associated with risk of *** combined OR for the association of DQB1*0502 and DQB1*0602 allele with the risk for HCC was 1.82(95% CI:1.14-2.92,P = 0.01) and 0.58(95% CI:0.36-0.95,P = 0.03),*** significant association was established for other HLA-DQB1 family alleles and specific ***:Our results support the hypothesis that specific HLA-DQB1 allele families and alleles might influence the susceptibility or resistance to HCC,although it needs further investigations.

关键词： Hepatocellular carcinoma Human leukocyte antigen-DQB1 alleles Meta-analysis

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Senegenin inhibits neuronal apoptosis after spinal cord contusion injury

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Neural Regeneration Research 2016年第4期11卷 657-663页

作者： shu-quan Zhang Min-fei Wu Rui Gu Jia-bei Liu Ye Li qing-san Zhu Jin-lan jiang Department of Orthopedics Nankai Hospital Department of Orthopedics the Second Hospital of Jilin University Department of Orthopedics China-Japan Union HospitalJilin University Scientific Research Center China-Japan Union HospitalJilin University

Senegenin has been shown to inhibit neuronal apoptosis,thereby exerting a neuroprotective *** the present study,we established a rat model of spinal cord contusion injury using the modified Allen＇s *** hours after injury,senegenin（30 mg/g） was injected into the tail vein for 3 consecutive *** reduced the size of syringomyelic cavities,and it substantially reduced the number of apoptotic cells in the spinal *** the site of injury,Bax and Caspase-3 m RNA and protein levels were decreased by senegenin,while Bcl-2 m RNA and protein levels were *** fiber density was increased in the spinal cord proximal to the brain,and hindlimb motor function and electrophysiological properties of rat hindlimb were *** together,our results suggest that senegenin exerts a neuroprotective effect by suppressing neuronal apoptosis at the site of spinal cord injury.

关键词： nerve regeneration spinal cord contusion senegenin thinleaf milkwort root motor function apoptosis electrophysiology neural regeneration

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Scenario analysis of low carbon development in Tianjin, China

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Ecological Economy 2010年第1期6卷 2-20页

作者： ZHANG Fa-shu SUN Zhen-qing jiang Dong-mei yang zheng-jing TIAN Dong-lang SHI Hai-yan Institute of Energy Environment and Economy Tsinghua Universty Beijing 100084P.R.China Institute of Low Carbon Economy Tsinghua University Beijing 100084 P. R. China School of Economy and Management Tianjin University of Science and Technology Tianjin 300222P.R.China Tianjin Municipal Committee of Development and Reform Tianjin 300040P.R.China

Low-carbon economic development has become *** approach to coordinating economic development and carbon emissions mitigation. As rapid developing economic, aviation and navigation, and financial center of North China. Tianjin＇s energy demand and CO2 emissions are mushrooming, with per capita CO2 emission from fossil fuel combustion exceeding 20 t in 2020, which much exceeds current level of USA. In the background of global responding to climate change, China will likely be requested to commit peaking its GHG emissions during 2020-2030, which will inevitable reduce the room of development in Tianjin enormously. Tianjin should make deployment ahead, realizing win-win of addressing climate change and sustainable development, with low-carbon economic development as important strategic mission. First of all, Tianjin should devote more efforts to reducing energy intensity and realizing relative emission reduction. Scenario analysis shows that Tianjin＇s future CO2 emissions will continue to increase rapidly, but they can be significantly reduced by taking measures. Second, Tianjin should get ready for achieving absolute reduction of CO2 emissions as soon as possible, preparing system, technology and talent in advance, making great efforts to establish institutional meehanisms conducive to low-carbon development from now on. starting from energy conservation and emission reduction, actively carrying out low-carbon technology research and development, vigorously developing the tertiary industry with low emissions, developing new and renewable energy resources, actively promote low-carbon consumption.

关键词： Scenario analysis Low-carbon development Carbon productivity,Tianjin

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Effects of Hydrogen Treatment in Barrier on the Electroluminescence of Green InGaN/GaN Single-quantum-Well Light-Emitting Diodes with V-Shaped Pits Grown on Si Substrates

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Chinese Physics Letters 2018年第9期35卷 90-94页

作者： qing-feng Wu Sheng Cao Chun-lan Mo aian-li Zhang Xiao-lan Wang Zhi-jue quan Chang-da zheng Xiao-ming Wu shuan Pan Guang-xu Wang Jie Ding Long-quan Xu aun-lin Liu Feng-yi jiang National Institute of LED on Si Substrate Nanchang University

Effect of hydrogen （142） treatment during the GaN barrier growth on the electroluminescence performance of green InGaN/GaN single-quantum-well light-emitting diodes （LEDs） grown on Si substrates is experimentally investigated. We prepare two LED samples with different carrier gas compositions during the growth of GaN barrier. In the H2 free LED, the GaN barrier is grown in full nitrogen （N2） atmosphere. For the other H2 treated LED, a mixture of N2 and H2 was used as the carrier gas. It is observed that V-shaped pits decrease in size after H2 treatment by means of the scanning electron microscope. Due to the fact that the p n junction interface would be closer to the p-GaN as a result of smaller V-shaped pits, the tunneling barrier for holes to inject into the InGaN quantum well would become thicker after tt2 treatment. Hence, the external quantum efficiency of the H2 treated LED is lower compared to the H2 free LED. However, LEDs would exhibit a better leakage behavior after H2 treatment during the GaN barrier growth because of more effective blocking of the threading dislocations as a result of the H2 etching at V-shaped pits.

关键词： GaN Si

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一个新形式Kerr黑洞的纯热辐射谱与隧穿辐射谱的比较研究

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四川大学学报（自然科学版） 2007年第2期44卷 365-370页

作者：雷洁红蒋青权杨树政西华师范大学理论物理研究所南充637002

根据Hawking热辐射理论和Parikh的半经典量子隧穿模型,作者选择了一种零标架对该Kerr黑洞Dirac粒子热辐射的研究表明,其热辐射谱是纯热谱.对该Kerr黑洞量子隧穿辐射的研究结果却表明,在能量守恒和角动量守恒的条件下,此黑洞事件视界处... 详细信息

根据Hawking热辐射理论和Parikh的半经典量子隧穿模型,作者选择了一种零标架对该Kerr黑洞Dirac粒子热辐射的研究表明,其热辐射谱是纯热谱.对该Kerr黑洞量子隧穿辐射的研究结果却表明,在能量守恒和角动量守恒的条件下,此黑洞事件视界处粒子的隧穿率与Bekenstein-Hawking熵变有关,真实的辐射谱不再是严格的纯热谱,但满足量子力学中的么正性原理,这是对Hawking纯热谱的一种修正.

关键词： Kerr黑洞 Dirac方程纯热谱隧穿几率 Bekenstein-Hawking熵

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Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup

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Chinese Journal of Integrative Medicine 2023年第5期29卷 441-447页

作者： LIU Xiao-qing ZHANG Run-shun ZHOU Xue-zhong ZHOU Hong HE Yu-yao HAN shu ZHANG Jing shu Zi-xin ZHANG Xue-bin JI Jing-hui ZHONG quan ZHANG Li-li MOU Zi-jun HE Li-yun ZHANG Lun-zhong yang Jie HU Yan-jie CHEN zheng-guang LI Xiao-zhen TAN Yan YAN Zhan-feng CAO Ke-gang MENG Wei ZHAO He ZHANG Wei ZHONG Li-qun Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100700)China Department of Gastroenterology Guanganmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China School of Computer and Information Technology and Beijing Key Lab of Traffic Data Analysis and Mining Beijing Jiaotong UniversityBeijing(100044)China Department of Neurology Weifang Hospital of Traditional Chinese MedicineWeifangShandong Province(261041)China Beijing Zhong Teng Bai Mai Medical Technology Co.Ltd. Beijing(100027)China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing(100700)China Department of Radiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100700)China School of Life Sciences Beijing University of Chinese MedicineBeijing(100029)China Department of Otolaryngology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100029)China Department of Psychiatry Massachusetts General HospitalHarvard Medical SchoolBoston(MA 02115)United States

Objective: To derive the Chinese medicine(CM) syndrome classification and subgroup syndrome characteristics of ischemic stroke patients. Methods: By extracting the CM clinical electronic medical records(EMRs) of 7,170 hospitalized patients with ischemic stroke from 2016 to 2018 at Weifang Hospital of Traditional Chinese Medicine, Shandong Province, China, a patient similarity network(PSN) was constructed based on the symptomatic phenotype of the patients. Thereafter the efficient community detection method BGLL was used to identify subgroups of patients. Finally, subgroups with a large number of cases were selected to analyze the specific manifestations of clinical symptoms and CM syndromes in each subgroup. Results: Seven main subgroups of patients with specific symptom characteristics were identified, including M3, M2, M1, M5, M0, M29and M4. M3 and M0 subgroups had prominent posterior circulatory symptoms, while M3 was associated with autonomic disorders, and M4 manifested as anxiety;M2 and M4 had motor and motor coordination disorders;M1 had sensory disorders;M5 had more obvious lung infections;M29 had a disorder of consciousness. The specificity of CM syndromes of each subgroup was as follows. M3, M2, M1, M0, M29 and M4 all had the same syndrome as wind phlegm pattern;M3 and M0 both showed hyperactivity of Gan(Liver) yang pattern;M2 and M29 had similar syndromes, which corresponded to intertwined phlegm and blood stasis pattern and phlegm-stasis obstructing meridians pattern, respectively. The manifestations of CM syndromes often appeared in a combination of 2 or more syndrome elements. The most common combination of these 7 subgroups was wind-phlegm. The 7 subgroups of CM syndrome elements were specifically manifested as pathogenic wind, pathogenic phlegm,and deficiency pathogens. Conclusions: There were 7 main symptom similarity-based subgroups in ischemic stroke patients, and their specific characteristics were obvious. The main syndromes were wind phlegm pat

关键词： ischemic stroke patient similarity network subgroup syndrome Chinese medicine

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