Senegenin inhibits neuronal apoptosis after spinal cord contusion injury

作     者：Shu-quan Zhang Min-fei Wu Rui Gu Jia-bei Liu Ye Li Qing-san Zhu Jin-lan Jiang 

作者机构：Department of OrthopedicsNankai Hospital Department of Orthopedicsthe Second Hospital of Jilin University Department of OrthopedicsChina-Japan Union HospitalJilin University Scientific Research CenterChina-Japan Union HospitalJilin University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第4期

页      面：657-663页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by a grant from the Science and Technology Development Plan of Jilin Province of China No.2011084 

主　　题：nerve regeneration spinal cord contusion senegenin thinleaf milkwort root motor function apoptosis electrophysiology neural regeneration 

摘      要：Senegenin has been shown to inhibit neuronal apoptosis,thereby exerting a neuroprotective *** the present study,we established a rat model of spinal cord contusion injury using the modified Allen＇s *** hours after injury,senegenin（30 mg/g） was injected into the tail vein for 3 consecutive *** reduced the size of syringomyelic cavities,and it substantially reduced the number of apoptotic cells in the spinal *** the site of injury,Bax and Caspase-3 m RNA and protein levels were decreased by senegenin,while Bcl-2 m RNA and protein levels were *** fiber density was increased in the spinal cord proximal to the brain,and hindlimb motor function and electrophysiological properties of rat hindlimb were *** together,our results suggest that senegenin exerts a neuroprotective effect by suppressing neuronal apoptosis at the site of spinal cord injury.