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Development of methods for detecting the fate of mesenchymal stem cells regulated by bone bioactive materials

Bioactive Materials 2021年第3期6卷 613-626页

作者： jiang Le Liu Zhongqun Wang Zhaoyan Su Yijun Wang Yingjin Wei Yaojie jiang yanan Jia Zhanrong Ma Chunyang Gang Fangli Xu Nan Zhao Lingyun Wang Xiumei Wu Qiong Lu Xiong Sun Xiaodan State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084People's Republic of China Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and EngineeringTsinghua UniversityBeijing100084People's Republic of China Key Lab of Advanced Technologies of Materials of Ministry of Education School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu610031People's Republic of China MOE Key Laboratory of Bioinformatics Tsinghua UniversityBeijing100084People's Republic of China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing100084People's Republic of China School of Life Sciences Tsinghua UniversityBeijing100084People's Republic of China

The fate of mesenchymal stem cells(MSCs)is regulated by biological,physical and chemical *** in biotechnology and materials science promoted the occurrence of bioactive materials which can provide physical and chemical signals for MSCs to regulate their *** order to design and synthesize materials that can precisely regulate the fate of MSCs,the relationship between the properties of materials and the fate of mesenchymal stem cells need to be clarified,in which the detection of the fate of mesenchymal stem cells plays an important *** the past 30 years,a series of detection technologies have been developed to detect the fate of MSCs regulated by bioactive materials,among which high-throughput technology has shown great advantages due to its ability to detect large amounts of data at one *** this review,the latest research progresses of detecting the fate of MSCs regulated by bone bioactive materials(BBMs)are systematically reviewed from traditional technology to high-throughput technology which is emphasized ***,current problems and the future development direction of detection technologies of the MSCs fate regulated by BBMs are *** aim of this review is to provide a detection technical framework for researchers to establish the relationship between the properties of BMMs and the fate of MSCs,so as to help researchers to design and synthesize BBMs better which can precisely regulate the fate of MSCs.

关键词： Bone bioactive materials High-throughput technology Transcriptomics Single cell RNA-seq Proteomics

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Metal-organic framework-based biomaterials for biomedical applications

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Biosurface and Biotribology 2021年第3期7卷 99-112页

作者： Gang Luo yanan jiang Chaoming Xie Xiong Lu Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringYibin Institute of Southwest Jiaotong UniversitySouthwest Jiaotong UniversityChengduChina

Metal-organic frameworks(MOFs)refer to porous coordination materials that are formed from the assembly of metal ions and organic *** have unique features,such as a large specific surface area,multiple active sites,easy functionalisation,and adjustable *** have recently been widely used in the field of biomedical engineering owing to their unique structures and *** has enabled them to replace traditional materials and effectively address several *** continuous development,MOF-based biomaterials have been remarkably improved by clarifying the relationship between MOF structures and *** a result,they are being extensively studied in the fields of chemical and material ***-based biomaterials can meet the growing demands for efficient materials in biomedical *** review first discusses the basic structure of MOFs,followed by their preparation and functionalisation *** biomedical applications of MOF‐based biomaterials in the fields of antibacterial activity,tumour therapy,skin repair,and bone repair are then ***,challenges and future perspectives in the biomedical applications of MOF-based biomaterials are outlined.

关键词： properties biomaterials replace

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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

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Frontiers of Medicine 2023年第2期17卷 290-303页

作者： Yubing Zhou Xinyu He yanan jiang Zitong Wang Yin Yu Wenjie Wu Chenyang Zhang Jincheng Li Yaping Guo Xinhuan Chen Zhicai Liu Jimin Zhao Kangdong Liu Zigang Dong The Pathophysiology Department School of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhou 450000China The China-US(Henan)Hormel Cancer Institute Zhengzhou 450000China State Key Laboratory of Esophageal Cancer Prevention and Treatment Zhengzhou 450000China Provincial Cooperative Innovation Center for Cancer Chemoprevention Zhengzhou UniversityZhengzhou 450000China Cancer Chemoprevention International Collaboration Laboratory Zhengzhou 450000China Oncology Department The Tumor Hospital of Linzhou CityLinzhou 456500China

Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide. It is urgent to develop new drugs to improve the prognosis of ESCC patients. Here, we found benzydamine, a locally acting non-steroidal anti-inflammatory drug, had potent cytotoxic effect on ESCC cells. Benzydamine could suppress ESCC proliferation in vivo and in vitro. In terms of mechanism, CDK2 was identified as a target of benzydamine by molecular docking, pull-down assay and in vitro kinase assay. Specifically, benzydamine inhibited the growth of ESCC cells by inhibiting CDK2 activity and affecting downstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell cycle arrest. Our study illustrates that benzydamine inhibits the growth of ESCC cells by downregulating the CDK2 pathway.

关键词： benzydamine cyclin-dependent kinase 2 patient-derived xenograft esophageal squamous cell carcinoma

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Boosting cycling stability by regulating surface oxygen vacancies of LNMO by rapid calcination

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Nano Research 2024年第4期17卷 2671-2677页

作者： Haoran jiang Cuihua Zeng Wei Zhu Jiawei Luo Zhedong Liu Jingchao Zhang Rui Liu Yunhua Xu yanan Chen Wenbin Hu School of Materials Science and Engineering Tianjin UniversityTianjin 300072China School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China

Spinel LiNi_(0.5-x)Mn_(1.5+x)O_(4)(LNMO)has attracted intensive interest for lithium-ion battery due to its high voltage and high energy ***,severe capacity fade attributed to unstable surface structure has hampered its *** vacancies(OVs)tend to occur in the surface of the material and lead to surface structure reconstruction,which deteriorates the battery performance during electrochemical ***,we utilize high-temperature-shock(HTS)method to synthesize LNMO materials with fewer surface *** calcination drives lower surface OVs concentration,reducing the content of Mn^(3+)and surface reconstruction layers,which is beneficial to obtain a stable crystal *** LNMO material synthesized by HTS method delivers an initial capacity of 127 mAh·g^(-1) at 0.1 C and capacity retention of 81.6%after 300 cycles at 1 C,and exhibits excellent performance at low temperature.

关键词： ultrafast synthesis oxygen vacancy LiNi_(0.5-x)Mn_(1.5+x)O_(4)(LNMO)cathode high-temperature-shock lithium-ion batteries

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CRISPR/Cas9 system and its applications in nervous system diseases

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Genes & Diseases 2024年第2期11卷 675-686页

作者： Haibin jiang Mengyan Tang Zidi Xu yanan Wang Mopu Li Shuyin Zheng jianghu Zhu Zhenlang Lin Min Zhang The Second School of Medicine Wenzhou Medical UniversityWenzhouZhejiang 325035China The First School of Medicine Wenzhou Medical UniversityWenzhouZhejiang 325035China Department of Pediatrics The Second School of MedicineThe Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China Key Laboratory of Perinatal Medicine of Wenzhou WenzhouZhejiang 325027China Key Laboratory of Structural Malformations in Children of Zhejiang Province WenzhouZhejiang 325000China Zhejiang Provincial Clinical Research Center for Pediatric Disease WenzhouZhejiang 325027China

The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system is an acquired immune system of many bacteria and archaea,comprising CRISPR loci,Cas genes,and its associated *** system can recognize exogenous DNA and utilize the Cas9 protein's nuclease activity to break DNA double-strand and to achieve base insertion or deletion by subsequent DNA *** recent years,multiple laboratory and clinical studies have revealed the therapeutic role of the CRISPR/Cas9 system in neurological *** article reviews the CRISPR/Cas9-mediated gene editing technology and its potential for clinical application against neurological diseases.

关键词： CRISPR/Cas9 Gene editing Mutation Neurological diseases Therapeutics

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平行四面体纳米孔道中DNA超结构的组装和离子输运特性

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高等学校化学学报 2015年第7期36卷 1243-1245页

作者：蒋亚楠康倩郭维江雷北京航空航天大学化学与环境学院北京100191 首都师范大学化学系北京100048 中国科学院理化技术研究所仿生智能界面科学实验室北京100190

受生物膜离子通道结构和功能的启发,人工制备固体纳米孔道门控开关器件一直备受关注.基于仿生纳米孔道的非对称离子传输性质制备的离子二极管和场效应管装置对于构建离子电路和能量转换的纳米器件至关重要.然而,仿生制备的固体纳米孔道... 详细信息

受生物膜离子通道结构和功能的启发,人工制备固体纳米孔道门控开关器件一直备受关注.基于仿生纳米孔道的非对称离子传输性质制备的离子二极管和场效应管装置对于构建离子电路和能量转换的纳米器件至关重要.然而,仿生制备的固体纳米孔道在离子传输过程中有漏电流的存在,严重影响了固体纳米孔道应用的灵敏度和信噪比.针对这一问题,研究者利用DNA分子的特殊识别和自组装的功能特性,相继构筑了基于DNA和纳米孔道的智能响应体系.

关键词：仿生纳米孔道 DNA组装体离子输运

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Trunk‑Inspired SWCNT‑Based Wrinkled Films for Highly‑Stretchable Electromagnetic Interference Shielding and Wearable Thermotherapy

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Nano-Micro Letters 2024年第11期16卷 429-444页

作者： Xiaofeng Gong Tianjiao Hu You Zhang yanan Zeng Ye Zhang Zhenhua jiang Yinlong Tan Yanhong Zou Jing Wang Jiayu Dai Zengyong Chu College of Science National University of Defense TechnologyChangsha 410073People’s Republic of China Beijing Interdisciplinary Research Center National University of Defense TechnologyChangsha 410073People’s Republic of China School of Physics and Electronics Hunan UniversityChangsha 410082People’s Republic of China

Nowadays,the increasing electromagnetic waves generated by wearable devices are becoming an emerging issue for human health,so stretchable electromagnetic interference(EMI)shielding materials are highly *** trunks are capable of grabbing fragile vegetation and tearing trees thanks not only to their muscles but also to their folded *** by the wrinkled skin of the elephant trunks,herein,we propose a winkled conductive film based on single-walled carbon nanotubes(SWCNTs)for multifunctional EMI *** conductive film has a sandwich structure,which was prepared by coating SWCNTs on both sides of the stretched elastic latex cylindrical *** shrinking-induced winkled conductive network could withstand up to 200%tensile ***,when the stretching direction is parallel to the polarization direction of the electric field,the total EMI shielding effectiveness could surprisingly increase from 38.4 to 52.7 dB at 200%tensile *** is mainly contributed by the increased connection of the *** addition,the film also has good Joule heating performance at several voltages,capable of releasing pains in injured *** unique property makes it possible for strain-adjustable multifunctional EMI shielding and wearable thermotherapy applications.

关键词： Electromagnetic interference shielding Single-walled carbon nanotubes Wrinkles Stretchable Thermotherapy

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M₃ Muscarinic Acetylcholine Receptor Antagonist Darifenacin Protects against Pulmonary Fibrosis through ERK/NF-κB/miR-21 Pathway

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American Journal of Molecular Biology 2022年第2期12卷 11-22页

作者： Ying Liu yanan jiang Chao Wang Haiying Zhang Yan Liu Key Laboratory of Tropical Translational Medicine of Ministry of Education College of Pharmaceutical Hainan Medical University Haikou China Department of Pharmacology Harbin Medical University Harbin China Sanya Central Hospital Sanya China

Idiopathic pulmonary fibrosis is an untreatable lethal lung disease, which is related to the aberrant proliferation of fibroblasts. M3 muscarinic acetylcholine receptor (M3-mAChR) activation exerts proliferative effect on various kinds of cells. However, whether M3-mAChR inhibition has a protective effect on pulmonary fibrosis remains unexplored. A rat model of pulmonary fibrosis was established by intratracheal instillation of bleomycin. Darifenacin was used to block M3-mAChR. Histological changes were observed using Masson’s Trichrome and hematoxylin and eosin (HE) staining. Hydroxyproline was measured by Hydroxyproline detection kit. Transforming growth factor β1 (TGF-β1) and tumor necrosis factor-α (TNF-α) were measured by enzyme-linked immunosorbent assay (ELISA). In vitro, pulmonary fibroblasts were isolated from lungs of neonatal rat. After treatment, the cell viability, Hydroxyproline level was measured by MTT and Hydroxyproline detection kit respectively. The expression level of extracellular signal-regulated kinase (ERK), nuclear factor kappa-B (N-NF-κB), and microRNA-21 (miR-21) was detected by western blot or quantitative real-time PCR (qRT-PCR). Darifenacin relieved the fibrotic effects provoked by bleomycin. The expression level of hydroxyproline, TGF-β1 and TNF-α level was all downregulated after darifenacin treatment. In lung fibroblasts, darifenacin decreased cell viability and hydroxyproline level induced by bleomycin. Besides, phosphorylation-ERK and nuclear N-NF-κB protein level was downregulated, as well as miR-21 level. M3-mAChR antagonist darifenacin attenuates bleomycin-induced pulmonary fibrosis in rats, which may relate to the ERK/NF-κB/miRNA-21 signaling pathway.

关键词： Pulmonary Fibrosis M3 Muscarinic Acetylcholine Receptor Darifenacin

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Lead-free perovskite solar cells with inorganic cesium tin halides

Lead-free perovskite solar cells with inorganic cesium tin h...

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第四届新型太阳能电池学术研讨会

作者： yanan jiang Xiaofeng Qiu Bingqiang Cao Materials Research Centre for Energy and Photoelectrochemical Conversion School of Material Science and Engineering University of Jinan

All-inorganic and lead-free cesium tin halides(CsSnX, X=Cl, Br, I) are highly desirable for substituting the organolead halide perovskite solar ***, we develop a two-step sequential deposition method to grow high-quality B-γ-CsSnI thin ***, such B-γ-CsSnI film was unstable in *** find the spontaneous oxidative conversion from unstable B-γ-CsSnI to air-stable CsSnI in *** direct bandgap semiconductor perovskite CsSnI with a bandgap of 1.48 eV and high absorption coefficient(over 10 cm from 1.7 eV) was more thermal-stable than *** importantly, the CsSnI film is adopted as a light absorber layer for planar and mesoporous lead-free perovskite solar cells and preliminary power conversion efficiency(PCE) about 1% was *** solar cell stability measurements revealed pronounced stability of the unsealed solar cells for at least one week in air.

关键词： Inorganic perovskite solar cell CsSnI3 Cs2SnI6 stability

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Three rare anti-inflammatory sesquiterpene lactones from Magnolia grandiflora

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Chinese Journal of Natural Medicines 2024年第3期22卷 265-272页

作者： XU Shuangyu ZHANG Feng TAO Linlan jiang Yangming HUANG Tao LI yanan HU Zhanxing YANG Jue HAO Xiaojiang YUAN Chunmao State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang 550025China Natural Products Research Center of Guizhou Province Guiyang 550014China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

Four new sesquiterpene lactones(SLs)(1–4),along with a biosynthetically related SL(5),have been isolated from the leaves of Magnolia *** A(1)is notable as the first C18 homogemarane type SL,featuring a unique 1,7-dioxaspiro[4.4]nonan-6-one *** 2 and 3,representing the first instances of chlorine-substituted gemarane-type SL analogs in natural products,were also *** structures of these isolates were elucidated through a combination of spectroscopic data analysis,electronic circular dichroism calculations,and X-ray single-crystal diffraction *** isolates demonstrated anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 ***,3–5 showed a significant inhibitory effect on nitric oxide production,with IC50 values ranging from 0.79 to 4.73μmol·L^(−1).Additionally,4 and 5 exhibited moderate cytotoxic activities against three cancer cell lines,with IC50 values between 3.09 and 11.23μmol·L^(−1).

关键词： Magnolia grandiflora Sesquiterpene lactones Isolation and identification Anti-inflammatory activity

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