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各向异性量子点中的二维磁极化子效应

宁波大学学报（理工版） 2018年第4期31卷 92-98页

作者：蒋倩云王彦杰潘孝胤宁波大学理学院浙江宁波315211

本文研究了在垂直均匀磁场下各向异性量子点中具有中等电子-声子耦合强度的二维磁极化子效应.构造一个变分波函数,它由两部分的乘积组成,第一部分是相干声子态,由对声子真空态的Lee-Low-Pines变换得来;第二部分是电子波函数,由二维各向... 详细信息

本文研究了在垂直均匀磁场下各向异性量子点中具有中等电子-声子耦合强度的二维磁极化子效应.构造一个变分波函数,它由两部分的乘积组成,第一部分是相干声子态,由对声子真空态的Lee-Low-Pines变换得来;第二部分是电子波函数,由二维各向异性谐振子波函数通过特殊幺正变换得来.然后通过变分法获得极化子能谱的积分表达式.利用数值计算的结果,阐明了磁场和各向异性对小尺寸量子点的基态和第一、第二激发态能量的影响.

关键词：磁极化子电子-声子相互作用量子点

Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

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Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-Long Zhou Wei-Jin jiang Ji Yu Mao-Jun Yao yun-Tong Li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(P<0.05),with BE yielding the highest at 43.13±0.26%,higher than that of RE(34.29±0.81%).Ultrasound-assisted extraction significantly increased the DMY content of the extracts(P<0.05),whereas DMY content in the RE extracts was 59.94±1.70%,that of URE reached 66.14±2.78%.Analysis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

Cardiovascular response to nanosecond pulses is milder in percutaneous ablation of hepatocellular carcinoma compared with microsecond pulses

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 114-116页

作者： Hai-Ying Kong qian-Hui Jin Xin-Hua Chen Dan-Xia Xu Qi-Yu Zhao Xiong-Xin Zhang R James Swanson Tian-An jiang Department of Anesthesiology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary Pancreatic Surgery Department of SurgeryThe First Hospital of JiaxingJiaxing University College of MedicineJiaxing 314000China Key Laboratory of Pulsed Power Translational Medicine of Zhejiang Province Hangzhou 310003China Department of Ultrasound Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Anatomy Department Liberty University College of Osteopathic MedicineLynchburgVAUSA

To the Editor:Irreversible electroporation(IRE)is a promising ablative technique for hepatobiliary *** has unique advantages,including no detrimental heat sink effect[1]and no injury of the surrounding tissues[2].For lesions in complex areas,bile duct[3],and large blood vessels[4],IRE has been developed as an alternative to thermal ablation such as radiofrequency and *** IRE tumor ablative technique combines cell biology and pulsed high-voltage *** high-voltage,high-frequency and transient pulses can create irreversible electroporation in the phospholipid bilayer of the cell membrane and nuclear envelope,resulting in cell *** with radiofrequency ablation and microwave ablation[5],IRE does not cause damage to important vessels and *** has some unique shortcomings in delivering high currents,which has limited its clinical applications in the *** animal and clinical studies,side effects including muscle contraction,procedural hypertension,and arrhythmia are frequently reported[6].However,during the ablation process,if the pulse is synchronized with the heart rhythm,the risk of arrhythmia is *** muscle relaxant eliminates muscle ***,arrhythmia[7],hypertension[8],and myocardial infarction[9]are potential risks requiring proper *** adverse events are mostly moderate and self-limiting,but they may have serious consequences for patients with coronary artery *** to the potential risks,patients with a history of cardiovascular disease are not recommended for IRE treatment.

关键词： microwave consequences ablation

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu qian-qian jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng yun-Dong Wu Xiao-jiang Hao Key Laboratory of Phytochemistry and Natural Medicines(Chinese Academy of Sciences) Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201China yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesBeijing 100730China

In the intricate process of natural product biosynthesis,a metabolon can enhance metabolic flux by associating sequential enzymes.A fungal metabolon,comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G,is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide *** notoamide E as a substance,Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation,followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium ***,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol *** provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

High-resolution Simulation Dataset of Hourly PM_(2.5)Chemical Composition in China(CAQRA-aerosol)from 2013 to 2020

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Advances in Atmospheric Sciences 2025年第4期42卷 697-712页

作者： Lei KONG Xiao TANG jiang ZHU Zifa WANG Bing LIU Yuanyuan ZHU Lili ZHU Duohong CHEN Ke HU Huangjian WU qian WU Jin SHEN Yele SUN Zirui LIU Jinyuan XIN Dongsheng JI Mei ZHENG Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China China National Environmental Monitoring Centre Beijing 100012China Guangdong Ecological Environment Monitoring Centre Guangzhou 510308China Wuhan Environmental Monitoring Centre Hubei 430015China Hubei Province Academy of Eco-environmental Sciences Hubei 430072China Peking University Beijing 100871China

Scientific knowledge on the chemical compositions of fine particulate matter(PM_(2.5)) is essential for properly assessing its health and climate effects,and for decisionmakers to develop efficient mitigation strategies.A high-resolution PM_(2.5) chemical composition dataset(CAQRA-aerosol)is developed in this study,which provides hourly maps of organic carbon,black carbon,ammonium,nitrate,and sulfate in China from 2013 to 2020 with a horizontal resolution of 15 *** paper describes the method,access,and validation results of this *** shows that CAQRA-aerosol has good consistency with observations and achieves higher or comparable accuracy with previous PM_(2.5) composition *** on CAQRA-aerosol,spatiotemporal changes of different PM_(2.5) compositions were investigated from a national viewpoint,which emphasizes different changes of nitrate from other *** estimated annual rate of population-weighted concentrations of nitrate is 0.23μg m^(−3)yr^(−1) from 2015 to 2020,compared with−0.19 to−1.1μg m^(−3)yr^(−1) for other *** whole dataset is freely available from the China Air Pollution Data Center(https://***/10.12423/capdb_***).

关键词： PM_(2.5)composition dataset black carbon organic carbon ammonium nitrate sulfate

No association between SARS-CoV-2 infection and embryo chromosomal abnormalities: a prospective cohort study

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Science China Life Sciences 2025年

作者： Tianxiang Ni Yang Liu Weiran Cui Siying Chen Hongchang Li Yueting Zhu Wenjie jiang qian Zhang Wei Zhou Zijiang Chen Yan Li Guangyong Zhang Junhao Yan Shandong Technology Innovation Center for Reproductive Health Shandong Provincial Clinical Research Center for Reproductive Health Shandong Key Laboratory of Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical University Research Unit of Gametogenesis and Health of ART-Offspring Chinese Academy of Medical Sciences (No.2021RU001) Department of General Surgery The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial qianfoshan Hospital State Key Laboratory of Reproductive Medicine and Offspring Health Center for Reproductive Medicine Institute of Women Children and Reproductive Health Shandong University National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University Key Laboratory of Reproductive Endocrinology (Shandong University) Ministry of Education

Dear Editor,Assisted Reproductive Technology (ART)refers to the use of medical aids to achieve pregnancy in infertile couples, including Artificial Insemination (AI) and In vitro Fertilization-Embryo Transfer (IVF), of which IVF has been a common option for infertility treatment. In early December 2022, the Chinese government issued a Circular on Further Optimizing the Prevention and Control of Epidemics. This shift marked a relaxation of the dynamic clearance policy.

关键词：

Poorly controlled type Ⅱ diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage Ⅲ colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu Zi-yun Yuan Zhi-Yuan Liu Zi-Zhu Liu Zhi-Cong Xiao Jing-Hui Li Cheng-Zhi Huang Jun-jiang Wang Xue-Qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type Ⅱ diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage Ⅲ CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage Ⅲ *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage Ⅲ CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage Ⅲ CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis TypeⅡdiabetes mellitus

类别条件噪声下的半监督AUC优化理论与算法

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计算机学报 2025年第1期48卷 136-155页

作者：姜阳邦彦许倩倩杨智勇郝前秀操晓春黄庆明中国科学院大学计算机科学与技术学院北京101408 中国科学院计算技术研究所智能信息处理重点实验室北京100190 中山大学网络空间安全学院广东深圳518107

现有半监督AUC优化方法通常假设数据标注是准确的。然而在许多实际应用中,研究者往往会同时面临标注量不足和不准确的问题。为此,该文首次尝试在不完整和不准确的数据标注情况下优化AUC指标。具体而言,通过分析,对称替代损失在某些情况... 详细信息

现有半监督AUC优化方法通常假设数据标注是准确的。然而在许多实际应用中,研究者往往会同时面临标注量不足和不准确的问题。为此,该文首次尝试在不完整和不准确的数据标注情况下优化AUC指标。具体而言,通过分析,对称替代损失在某些情况下可以在半监督问题中具有噪声鲁棒性。在此基础上,该文构建了一个鲁棒半监督AUC优化框架,其导出的经验风险无需估计噪声率。此外,通过紧致泛化上界的分析表明,当模型基于足够大的训练数据集进行学习时,其在未见数据上能够很好地泛化。随后,使用Barrier hinge损失对该框架进行实例化。为加快训练过程,进一步开发了一种加速算法,将损失和梯度估计的复杂度从O(n^(2))降低至O(nlogn),在实验中可获得高达200倍的加速。最后,通过在15个基准数据集上进行实验验证,证明了所提方法的有效性。

关键词：半监督学习 AUC优化标签噪声二分类问题不平衡数据学习