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Ptip safeguards the epigenetic control of skeletal stem cell quiescence and potency in skeletogenesis

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Science Bulletin 2024年第13期69卷 2099-2113页

作者： jianfei Liang Jing wang Bingdong Sui Yibo Tong Jihua Chai Qin Zhou Chenxi Zheng Hao wang Liang Kong Haojian Zhang Yi Bai State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyTaikang Center for Life and Medical SciencesWuhan UniversityWuhan 430079China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710004China Department of Implant Dentistry College of StomatologyXi’an Jiaotong UniversityXi’an 710004China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyShaanxi International Joint Research Center for Oral DiseasesCenter for Tissue EngineeringSchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyDepartment of Oral and Maxillofacial SurgerySchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China Department of Hematology Zhongnan HospitalWuhan UniversityWuhan 430079China Frontier Science Center for Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhan 430079China Taikang Center for Life and Medical Sciences Wuhan UniversityWuhan 430079China

Stem cells remain in a quiescent state for long-term maintenance and preservation of potency;this process requires fine-tuning regulatory *** this study,we identified the epigenetic landscape along the developmental trajectory of skeletal stem cells(SSCs)in skeletogenesis governed by a key regulator,Ptip(also known as Paxip1,Pax interaction with transcription-activation domain protein-1).Our results showed that Ptip is required for maintaining the quiescence and potency of SSCs,and loss of Ptip in type II collagen(Col2)^(+)progenitors causes abnormal activation and differentiation of SSCs,impaired growth plate morphogenesis,and long bone *** also found that Ptip suppressed the glycolysis of SSCs through downregulation of phosphoglycerate kinase 1(Pgk1)by repressing histone H3 lysine 27 acetylation(H3K27ac)at the promoter ***,inhibition of glycolysis improved the function of SSCs despite Ptip *** the best of our knowledge,this is the first study to establish an epigenetic framework based on Ptip,which safeguards skeletal stem cell quiescence and potency through metabolic *** framework is expected to improve SSC-based treatments of bone developmental disorders.

关键词： Skeletal stem cells Bone development Epigenetics Ptip Glycolysis

TWO GENERALIZATIONS OF BOHR RADIUS

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Acta Mathematica Scientia 2023年第2期43卷 583-596页

作者：李程鹏陈铭新王建飞 School of Mathematical Sciences Huaqiao UniversityQuanzhou 362021China

The purpose of this paper is ***,by using the hyperbolic metric,we establish the Bohr radius for analytic functions from shifted disks containing the unit disk D into convex proper domains of the complex *** a consequence,we generalize the Bohr radius of Evdoridis,Ponnusamy and Rasila based on geometric *** introducing an alternative multidimensional Bohr radius,the second purpose is to obtain the Bohr radius of higher dimensions for Carathéodory families in the unit ball B of a complex Banach space *** that when B is the unit ball of the complex Hilbert space X,we show that the constant 1/3 is the Bohr radius for normalized convex mappings of B,which generalizes the result of convex functions on D.

关键词： Bohr radius hyperbolic metric holomorphic mapping convex mapping

叶面喷施亚硒酸钠对基质栽培辣椒产量和品质的影响

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安徽科技学院学报 2024年第1期38卷 58-64页

作者：赵丹丹周沪生陈鹏裴文霞袁先福汪建飞邢素芝安徽科技学院资源与环境学院安徽凤阳233100 农业农村部生物有机肥创制重点实验室安徽蚌埠233400

目的:研究叶面喷施亚硒酸钠对辣椒的产量、品质、硒及相关微量元素含量的影响,解析辣椒对亚硒酸钠的积累及耐受特性,并筛选出有利于辣椒生长的最佳叶面喷施的亚硒酸钠浓度。方法:采用基质栽培法,以“汴椒1号”辣椒品种为研究对象,设置5... 详细信息

目的:研究叶面喷施亚硒酸钠对辣椒的产量、品质、硒及相关微量元素含量的影响,解析辣椒对亚硒酸钠的积累及耐受特性,并筛选出有利于辣椒生长的最佳叶面喷施的亚硒酸钠浓度。方法:采用基质栽培法,以“汴椒1号”辣椒品种为研究对象,设置5个亚硒酸钠质量浓度(0、50、100、150、200 mg/L),各处理辣椒喷施亚硒酸钠量均为50 mL,每个处理设置3个重复。培育60 d后,对辣椒的产量、品质、硒及相关微量元素含量进行测定分析。结果:亚硒酸钠的施用对辣椒产量表现出“低浓度促进、高浓度抑制”的剂量效应。亚硒酸钠质量浓度为100 mg/L时,较对照处理(CK)产量增幅最大,达29%;当亚硒酸钠质量浓度为150 mg/L时,辣椒出现减产现象,较CK减产幅度达22.05%。当施用亚硒酸钠质量浓度为0~200 mg/L时,辣椒硒含量呈逐渐上升趋势,差异显著;辣椒果实中有机硒占总硒的百分比随着喷施亚硒酸钠浓度的增加呈现出先升后降的趋势。对于各试验处理,当亚硒酸钠浓度逐渐增加时,辣椒果实中钙、铁、铜含量均上升,但镁、锌含量无显著差异,粗蛋白、维生素C、总糖等品质指标含量均呈上升趋势。结论:叶面喷施适宜浓度的亚硒酸钠能显著提高辣椒产量和果实中的硒、钙和铁的含量,有效改善辣椒品质。叶面喷施亚硒酸钠质量浓度以50~100 mg/L为宜。因此,在农业生产中,亚硒酸钠的合理使用是富硒农业发展的重要方向之一,也是促进作物高产高效生产的重要环节。

关键词：辣椒亚硒酸钠叶面喷施硒含量产量品质

A Modified Iterative Learning Control Approach for the Active Suppression of Rotor Vibration Induced by Coupled Unbalance and Misalignment

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 242-253页

作者： Yifan Bao jianfei Yao Fabrizio Scarpa Yan Li College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of High-end Compressor and System Technology Beijing 100029China Beijing Key Laboratory of High-end Mechanical Equipment Health Monitoring and Self-Recovery Beijing University of Chemical TechnologyBeijing 100029China Key Lab of Engine Health Monitoring-Control and Networking of Ministry of Education Beijing University of Chemical TechnologyBeijing 100029China Bristol Composites Institute(ACCIS) University of BristolBristol BS81TRUK Dynamics and Control Research Group(DCRG) University of BristolBristol BS81TRUK

This paper proposes a modified iterative learning control(MILC)periodical feedback-feedforward algorithm to reduce the vibration of a rotor caused by coupled unbalance and parallel *** control of the vibration of the rotor is provided by an active magnetic actuator(AMA).The iterative gain of the MILC algorithm here presented has a self-adjustment based on the magnitude of the *** filters are adopted to extract the synchronous(1×Ω)and twice rotational frequency(2×Ω)components of the rotor *** the notch frequency of the filter and the size of feedforward storage used during the experiment have a real-time adaptation to the rotational *** method proposed in this work can provide effective suppression of the vibration of the rotor in case of sudden changes or fluctuations of the rotor *** and experiments using the MILC algorithm proposed here are carried out and give evidence to the feasibility and robustness of the technique proposed.

关键词： Rotor vibration suppression Modified iterative learning control Unbalance Parallel misalignment Active magnetic actuator

Advanced modeling of the absorption enhancement of black carbon particles in chamber experiments by considering the morphology and coating thickness

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Frontiers of Environmental Science & Engineering 2024年第9期18卷 129-142页

作者： Xiaodong Wei Jianlin Hu Chao Liu Xiaodong Xie Junjie Yin Song Guo Min Hu jianfei Peng Huijun wang Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science&TechnologyNanjing 210044China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Key Laboratory of Meteorological Disaster(Ministry of Education)Nanjing University of Information Science and TechnologyNanjing 210044China Nansen−Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China East China Air Traffic Management Bureau CAAC Shanghai 200335China State Key Joint Laboratory of Environmental Simulation and Pollution Control International Joint Laboratory for Regional Pollution Control(IJRC)(Ministry of Education)College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Tianjin Key Laboratory of Urban Transport Emission Research&State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control College of Environmental Science and EngineeringNankai UniversityTianjin 300071China

Measurements studies have shown that the absorption of radiation by black carbon(BC)increases as the particles ***,there are significant discrepancies between the measured and modeled absorption enhancement(E_(abs)),largely due to the simplifications used in modeling the mixing states and shape *** took advantage of chamber experiments on BC aging and developed an efficient method to resolve the particle shape based on the relationship between the coating fraction(ΔD_(ve)/D_(ve),0)and fractal dimension(D_(f)),which can also reflect the variations of D_(f)during the whole BC aging *** with externally and partly mixed states(0≤ΔD_(ve)/D_(ve),0≤0.5)can be considered to be uniformly distributed with the D_(f)values of 1.8–2.1,whereas the Df values are constrained in the range 2.2–2.8 for fully mixed states(ΔD_(ve)/D_(ve),0>0.5).The morphological parameters(i.e.,the effective density and the dynamic shape factor)were compared with the measured values to verify the simulated *** simulated mean deviations of morphological parameters were smaller than 8%for the method resolving the particle *** applying a realistic shape and refractive index,the mass absorption cross for fully mixed states can be improved by 11%compared with a simplified core–shell *** on our understanding of the influence of D_(f)andΔD_(ve)/D_(ve),0 on E_(abs),we propose a two-stage calibration equation to correct the E_(abs)values estimated by the core–shell model,which reduces the simulation error in the Mie calculation by 6%–14%.

关键词： Black carbon Mixing states Fractal dimension Dynamic shape factor Absorption enhancement

Numerical analysis of geosynthetic-reinforced embankment performance under moving loads

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 682-696页

作者： Xuanming Ding Jinqiao Zhao Qiang Ou jianfei Liu College of Civil Engineering Chongqing UniversityChongqing400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityChongqing400045China China United Engineering Corporation Limited Hangzhou310052China

The performance of geosynthetic-reinforced embankments under traffic moving loads is always a hotspot in the geotechnical engineering field.A three-dimensional(3D)model of a geosynthetic-reinforced embankment without drainage consolidation was established using the finite element software *** this model,the traffic loads were simulated by two moving loads of rectangular pattern,and their amplitude,range,and moving speed were realized by a Fortran *** embankment fill was simulated by an equivalent linear viscoelastic model,which can reflect its *** geogrid was simulated by the truss element,and the geocell was simulated by the membrane *** elements were utilized to weaken the boundary effect caused by the model geometry at the *** of the established numerical model was conducted by comparing the predicted deformations in the cross-section of the geosynthetic-reinforced embankment with those from the existing *** this basis,the dynamic stress and strain distribution in the pavement structure layer of the geosynthetic-reinforced embankment under a moving load was also ***,a parametric study was conducted to examine the influences of the different types of reinforcement,overload,and the moving load velocity on the geosynthetic-reinforced embankment.

关键词： Geosynthetic-reinforced layer Numerical model Moving load Embankment Deformation Stress

Utilizing Artificial intelligence to identify an Optimal Machine learning model for predicting fuel consumption in Diesel engines

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Energy and AI 2024年第2期16卷 289-305页

作者： Amirali Shateri Zhiyin Yang jianfei Xie School of Engineering University of DerbyDE223AWUK

This paper describes the utilization of artificial intelligence (AI) techniques to identify an optimal machine learning (ML) model for predicting dodecane fuel consumption in diesel combustion. The study incorporates sensitivity analysis to assess the impact levels of various parameters on fuel consumption, thereby highlighting the most influential factors. In addition, this study addresses the impact of noise and implements data cleaning techniques to ensure the reliability of the obtained results. To validate the accuracy of the predictions, the study performs several metrics and validation process, including comparisons with computational fluid dynamics (CFD) results and experimental data. Comprehensive comparisons are made among neural networks (NN), random forest regression (RFR), and Gaussian process regression (GPR) models, taking into account the complexity associated with fuel consumption predictions. The findings demonstrate that the GPR model outperforms the others in terms of accuracy, as evidenced by metrics such as mean absolute error (MAE), mean squared error (MSE), Pearson coefficient (PC), and R-squared (R2). The GPR model exhibits superior predictive ability, accurately detecting and predicting even individual data points that deviate from the overall trend. The significantly lower absolute error values also consistently indicate its higher accuracy compared with the NN and RFR models. Furthermore, the GPR model shows a remarkable speedup, approximately 1.7 times faster than traditional CFD solvers, and physically captures the momentum and thermal characteristics in a surface field prediction. Finally, the target optimization is assessed using the Euclidean distance as a fitness function, ensuring the reliability of predicted data.

关键词： AI evaluation Machine learning Diesel engine Fuel consumption Decarbonization

Ligand-dependent aggregation-enhanced photoacoustic of atomically precise metal nanocluster

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Aggregate

Aggregate 2024年第1期5卷 196-203页

作者： Changlin Zhou Meng wang Qiaofeng Yao Yu Zhou Chuantao Hou jianfei Xia Zonghua wang Jishi Chen Jianping Xie College of Chemistry and Chemical Engineering Shandong Sino-Japanese Center for Collaborative Research of Carbon NanomaterialsInstrumental Analysis Center of Qingdao UniversityQingdao UniversityQingdaoP.R.China Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin UniversityTianjinP.R.China Qingdao Boting Hydrogen Age Ocean Technol R&D Ctr. Qingdao Boting Technol Co.Ltd.Shandong Hydrogen Times Marine Technology Co.Ltd.QingdaoP.R.China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhouP.R.China

Atomically precise metal nanoclusters(MNCs),as a potential type of photoacoustic(PA)contrast agent,are limited in application due to their low PA conversion efficiency(PACE).Here,with hydrophilic Au25SR18(SR=thiolate)as model NCs,we present a result that weakly polar solvent induces aggregation,which effectively enhances PA intensity and *** PA intensity and PACE are highly dependent on the degree of aggregation,while the aggregation-enhanced PA intensity(AEPA)positively correlates to the protected *** an AEPA phenomenon indicates that aggregation actually accelerates the intramolecular motion of Au NCs,and enlarges the proportion of excited state energy dissipated through vibrational *** result conflicts with the restriction of intramolecular motion mechanism of aggregation-induced *** experiments show that the increased energy of AEPA originates from the aggregation inhibiting the intermolecular energy transfer from excited Au NCs to their surrounding medium molecules,including solvent molecule and dissolved oxygen,rather than restricting radiative *** study develops a new strategy for enhancing the PA intensity of Au NCs,and contributes to a deeper understanding of the origin of the PA signal and the excited state energy dissipation processes for MNCs.

关键词： aggregation-enhanced photoacoustic gold nanocluster intermolecular excited state energy transfer intramolecular motion ligand effect

Biochemical　genetic　structure　and　identification　of　hairtail　fish（Trichiurus）　populations　in　Chinese　coastal　waters

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Acta Oceanologica Sinica 1994年第4期13卷 565-577页

作者： wang Keling Zhang Peijun Liu Lanying You Feng Liu Jing Xu Cheng and wang jianfei (Institute of Oceanology, Academia Sinica, Qingdao 266071, China)

A total of 472 isozyme samples and about 1 000 myogen, esterase and morphyological samples of nine spawning stocks were collected from coastal waters of Hainan, Guangdong, Fujian, Zhejiang, Jiangsu and Sbandong Provinces of China during 1976￣1992. Eleven isozymes were analysed by starch-gel and polyacrylamide-gel electrophoresis. Biochemical genetic structures of 11 isozymes were analysed and 24 loci were recorded. According to the allele frequencies of individual isozymes of each sampling stock, the mean proportion of polymorphic (P) and average heterozygosity (H) were calculated; then the genetic similarity (I) and genetic distance (D) were obtained. The results of cluster for O and D of all the samplied stocks show that the hairtail fish from Chemise coastal waters should be classified into three different sped6s (D: 0. 223￣0. 382) and eight populations (D: 0. 007￣0. 048).

关键词： Isozyme electrophoresis genetic variation population identification Trichiurus