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Long-term outcome and prognostic factors of intrahepatic cholangiocarcinoma

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Chinese Medical Journal 2009年第19期122卷 2286-2291页

作者： LI Shao-qiang LIANG Li-jian HUA yun-peng peng Bao-gang HE Qiang LU Ming-de CHEN Dong Department of Hepatobiliary Surgery the First Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510080 China

Background The management of intrahepatic cholangiocarcinoma （ICC） remains a challenge due to poor prognosis. The aim of this study was to summarize the surgical management experience in recent 10 years and to identify the influencing factors related to outcome of patients with ICC in a single hepatobiliary center. Methods From January 1995 to June 2005, 136 patients with ICC undergoing surgery were reviewed retrospectively. Survival rates of patients were calculated using the Kaplan-Meier method and compared by using the log-rank test. The prognostic factors were identified by the Cox regression model. Results Seventy-nine of 136 patients underwent resection, and 65 of 79 patients were curative （R0）. The surgical mortality was 2.2%. The 1-, 3- and 5-year survival rates of patients undergoing R0 resection were 72.1%, 35.6% and 20.1% respectively, which were significantly longer than those who underwent palliative resection and exploration, respectively （P 〈0.01）. At stage IV of the disease, 10 patients who underwent aggressive curative resection achieved a better median survival than those （n=12） without resection （14 months vs 3 months, P 〈0.001）. The independent prognostic factors of the whole group were TNM stage （OR, 2.013, P=0.008） and curative resection （OR, 2.957, P=0.003）. Higher TNM stage （OR, 1.894, P=0.004） and lymph node metastasis （OR, 4.248, P=0.005） linked to poor prognosis after R0 resection. For patients without lymph node metastasis, the median survival of those who underwent regional lymphadenectomy was comparable with those who did not （18 months vs 22 months, P=0.817）. Conclusions R0 resection is mandatory for ICC patient to achieve long-term survival. Aggressive resection benefits for selected patients with local advanced disease. Higher TNM stage and lymph node metastasis were poor prognostic factors for ICC patients after R0 resection.

关键词： cholangiocarcinoma intrahepatic prognosis

Liver stiffness in hepatocellular carcinoma and chronic hepatitis patients:Hepatitis B virus infection and transaminases should be considered

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World Journal of Hepatology 2024年第7期16卷 1018-1028页

作者： Jia-Yao Huang jian-yun peng Hai-Yi Long Xian Zhong Yu-Hua Xie Lu Yao Xiao-Yan Xie Man-Xia Lin Department of Medical Ultrasonics The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Liver condition is a crucial prognostic factor for patients with hepatocellular carcinoma(HCC),but a convenient and comprehensive method to assess liver condition is *** stiffness(LS)measured by two-dimensional shear wave elastography may help in assessing liver fibrosis and liver *** hepatitis B(CHB)is an important risk factor for HCC progression,but LS was found to be less reliable in assessing liver fibrosis following hepatitis viral *** hypothesize that the status of hepatitis virus infection would affect the accuracy of LS in assessing the liver *** To test the feasibility and impact factors of using LS to assess liver condition in patients with HCC and *** A total of 284 patients were retrospectively recruited and classified into two groups on the basis of serum CHB virus hepatitis B virus(HBV)-DNA levels[HBV-DNA≥100.00 IU/mL as Pos group(n=200)and40 U/L),the correlations between LS and liver condition indices were not significant(P>0.05).CONCLUSION LS was significantly correlated with most liver condition indices in patients with CHB and ***,these correlations varied according to differences in HBV-DNA and transaminase concentrations.

关键词： Liver function Liver stiffness Elastography Chronic hepatitis B Hepatocellular carcinoma

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-yun Ma peng-peng Li Hai-Wei Pu Xin-Yian Guo jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

基于GMM与图像多元特征的自动决策树分类方法研究

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内蒙古师范大学学报（自然科学汉文版） 2016年第5期45卷 709-715,722页

作者：赵健赟彭军还中国地质大学(北京)土地科学技术学院北京100083 青海大学地质工程系青海西宁810016

通过对Landsat 8OLI影像空间和光谱特征的分析,使用GMM描述各地物的分布特征,并利用EM算法估计其参数.在获得影像GMM贝叶斯分类信息的基础上,融合主成分、相异性纹理、FNDWI、NDBI和NDVI等其他多元特征,自动构建CART决策树对图像进行分... 详细信息

通过对Landsat 8OLI影像空间和光谱特征的分析,使用GMM描述各地物的分布特征,并利用EM算法估计其参数.在获得影像GMM贝叶斯分类信息的基础上,融合主成分、相异性纹理、FNDWI、NDBI和NDVI等其他多元特征,自动构建CART决策树对图像进行分类.结果表明,该方法的总体分类精度比其他方法最大提高3.82%,比利用影像其他特征的分类精度最大提高9.78%,而高斯混合模型信息的融合可显著提高林地、耕地等地物分类的生产精度和用户精度.

关键词：自动决策树 GMM FNDWI EM算法多元特征

混合气体气水分离过程中节流装置的建模方法及仿真分析（英文）

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机床与液压 2019年第12期47卷 107-114页

作者：易俊张宝于银华张亚杰彭建云陈庆魏军会李见中国石油塔里木油田公司新疆库尔勒841000 能新科(西安)油气技术有限公司西安710000

从天然气中分离水分是一个复杂过程,气体混合只有通过节流效应才能使其温度达到露点以分离水分和碳氢化合物,而节流装置参数识别和分析的准确性将直接影响分离效果,因此通过研究气流通过节流阀时保持气流畅通的流动条件,在临界状态下通... 详细信息

从天然气中分离水分是一个复杂过程,气体混合只有通过节流效应才能使其温度达到露点以分离水分和碳氢化合物,而节流装置参数识别和分析的准确性将直接影响分离效果,因此通过研究气流通过节流阀时保持气流畅通的流动条件,在临界状态下通过Saint-Venant-Wantzel方程在高压条件下建立了通过节流阀气体的流动模型。同时,基于通道中"节流阀横截面面积/流体温度的值"和"节流阀横截面面积/流速的值"的互连控制,研究了节流阀横截面积值对湿度LTS下节流量的速率和温度之间的非线性特性,明确该条件下气水分离的条件限制,最终建立了亚临界状态下节流装置静态模型。在ANSYS环境下对节流效应下的流体进行仿真实验,仿真结果表明:在节流阀的不同初始参数设定下,提出的模型均能对节流阀参数进行准确识别,并能在亚临界模式下对限制性条件做出正确的分析。

关键词：亚临界状态气体流动模型节流装置流体参数露点温度

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结合区块链的可认证医疗图像共享方案

小型微型计算机系统 2022年第11期43卷 2354-2360页

作者：温文媖简云鹏方玉明张玉书杨勇江西财经大学信息管理学院南昌330000 南京航空航天大学计算机学院南京210000

在医疗图像的内容保护和安全分享领域,引入区块链技术存在密钥丢失问题,密钥一旦丢失便无法达到数据共享的目的.为此,提出一种结合区块链的可认证医疗图像共享方案.借助改进的基于多项式的秘密图像共享技术对医疗图像进行共享,利用区块... 详细信息

在医疗图像的内容保护和安全分享领域,引入区块链技术存在密钥丢失问题,密钥一旦丢失便无法达到数据共享的目的.为此,提出一种结合区块链的可认证医疗图像共享方案.借助改进的基于多项式的秘密图像共享技术对医疗图像进行共享,利用区块链中的智能合约和可视化秘密共享技术对影子图像进行认证,结合智能合约进行秘密图像的恢复以降低共享机构本地客户端的负载.实验结果表明,提出的医疗图像共享方案在无损恢复秘密图像的同时具有较高的安全性;并且使用简单的异或和堆叠操作便可以进行认证,具有较低的计算复杂度,可以应用于医疗图像的内容保护与安全分享.

关键词：医疗图像共享与认证区块链智能合约多项式秘密共享可视化秘密共享

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Synthesis and Crystal Structure of a Novel Ternary Ni(II) Complex with 2-Hydroxyl-1,10- phenanthroline and 2-Hydroxynicotinic Acid as Ligands

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Chinese Journal of Structural Chemistry 2006年第6期25卷 747-751页

作者： WANG jian-Ge DU Qiao-yun LI peng-yun Department of Chemistry Luoyang Normal University Luoyang 471022 China

A novel ternary complex of [NiL1L2·2H2O]·NO3·H2O （L1 = 2-hydroxyl-1,10-phenanthroline （HOphen）, L2 = 2-hydroxynicotinic acid （H2nicO）） was synthesized, and its crystal structure was determined by X-ray diffraction and further characterized by infrared and elementary analysis. The title complex （C18H18NiN4O10, Mr = 509.07） belongs to the triclinic system, space group P1^- with a = 712490（7）, b = 11.0164（10）, c = 13.3864（13）A, α = 91.6040（10）,β= 98.8620（10）, γ= 107.1140（10）°, V= 1006.43（17）A^3, Z = 2, Dc = 1.680 g/cm^3,μ= 1.032 mm^-1, F（000） = 524, the final R = 0.0461 and wR= 0.1238. In the complex, the Ni（H） ion is six-coordinated to assume a distorted octahedral geometry, and a 3D supramolecular network comes into being via weak intermolecular interactions of X-O--.H （X = N, O）.

关键词： 2-hydroxyl-1,10-phenanthroline 2-hydroxynicotinic acid nickel complex crystal structure

Endurable SSD-Based Read Cache for Improving the Performance of Selective Restore from Deduplication Systems

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Journal of Computer Science & Technology 2018年第1期33卷 58-78页

作者： jian Liu yun-peng Chai Xiao Qin Yao-Hong Liu Division of Computer Science and Engineering Louisiana State University Baton Rouge LA 70803 U.S.A. Key Laboratory of Data Engineering and Knowledge Engineering Ministry of Education of China Beijing 100872 China School of Information Renmin University of China Beijing 100872 China Shelby Center for Engineering Technology Department of Computer Science and Software Engineering Samuel Ginn College of Engineering Auburn University Auburn AL 368~9-53~7 U.S.A.

Deduplication has been commonly used in both enterprise storage systems and cloud storage. To overcome the performance challenge for the selective restore operations of deduplication systems, solid-state-drive-based （i.e., SSD-based） re^d cache cm, be deployed for speeding up by caching popular restore contents dynamically. Unfortunately, frequent data updates induced by classical cache schemes （e.g., LRU and LFU） significantly shorten SSDs＇ lifetime while slowing down I/O processes in SSDs. To address this problem, we propose a new solution -- LOP-Cache to greatly improve tile write durability of SSDs as well as I/O performance by enlarging the proportion of long-term popular （LOP） data among data written into SSD-based cache. LOP-Cache keeps LOP data in the SSD cache for a long time period to decrease the number of cache replacements. Furthermore, it prevents unpopular or unnecessary data in deduplication containers from being written into the SSD cache. We implemented LOP-Cache in a prototype deduplication system to evaluate its pertbrmance. Our experimental results indicate that LOP-Cache shortens the latency of selective restore by an average of 37.3% at the cost of a small SSD-based cache with only 5.56% capacity of the deduplicated data. Importantly, LOP-Cache improves SSDs＇ lifetime by a factor of 9.77. The evidence shows that LOP-Cache offers a cost-efficient SSD-based read cache solution to boost performance of selective restore for deduplication systems.

关键词： data deduplication solid state drive (SSD) flash cache endurance

Analysis of mechanical strengths of extreme line casing joint considering geometric, material, and contact nonlinearities

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Petroleum Science 2024年第3期21卷 1992-2004页

作者： Ji-yun Zhang Chi peng jian-Hong Fu Quan Cao Yu Su jian-yun Pang Zi-Qiang Yu Petroleum Engineering School Southwest Petroleum UniversityChengdu610500SichuanChina Engineering Technology Research Institute of CNPC Southwest Oil and Gas Field Company Chengdu610017SichuanChina

To address the challenges associated with difficult casing running,limited annular space,and poor cementing quality in the completion of ultra-deep wells,the extreme line casing offers an effective solution over conventional ***,due to its smaller size,the joint strength of extreme line casing is reduced,which may cause failure when running in the *** address this issue,this study focuses on the CST-ZTΦ139.7 mm×7.72 mm extreme line casing and employs the elastic-plastic mechanics to establish a comprehensive analysis of the casing joint,taking into account the influence of geometric and material nonlinearities.A finite element model is developed to analyze the forces and deformations of the extreme line casing joint under axial tension and external collapse *** model investigates the stress distribution of each thread tooth subjected to various tensile forces and external ***,the tensile strength and crushing strength of the extreme line casing joint are determined through both analytical and experimental *** findings reveal that,under axial tensile load,the bearing surface of each thread tooth experiences uneven stress,with relatively high equivalent stress at the root of each thread *** end thread teeth are valuable spots for *** is observed that the critical fracture axial load of thread decreases linearly with the increase of thread tooth *** external pressure,the circumferential stress is highest at the small end of the external thread,leading to yield *** tensile strength of the joint obtained from the finite element model exhibits a relative error of less than 7%compared to the analytical and experimental values,proving the reliability of the finite element *** tensile strength of the joint is 3091.9 k ***,in terms of anti-collapse capability,the joints demonstrate higher resistance to collapse compared to the casing body,which is consistent with the test resul

关键词： Extreme line casing Elastic-plastic mechanics Finite element analysis Tensile strength Collapse strength