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SP-141 targets Trs85 to inhibit rice blast fungus infection and functions as a potential broadspectrum antifungal agent

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Plant Communications 2024年第2期5卷 169-184页

作者： Xi-Yu Wu Bo Dong Xue-Ming Zhu Ying-Ying Cai Lin Li jian-ping lu Bin Yu Jing-Li Cheng Fei Xu jian-Dong Bao Ying Wang Xiao-Hong Liu Fu-Cheng Lin State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of BiotechnologyZhejiang UniversityHangzhou 310058Zhejiang ProvinceChina State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of Plant Protection and MicrobiologyZhejiang Academy of Agricultural SciencesHangzhou 310058Zhejiang ProvinceChina Department of Pharmacology and Nutritional Science College of MedicineThe University of KentuckyLexingtonKY 40506USA Markey Cancer Center College of MedicineThe University of KentuckyLexingtonKY 40506USA College of Life Sciences Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina Institute of Pesticide and Environmental Toxicology Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and InsectsZhejiang UniversityHangzhou 310058Zhejiang ProvinceChina Institute of Edible Fungi Shanghai Academy of Agricultural SciencesShanghai 201106ShanghaiChina

Rice blast is a devastating disease worldwide,threatening rice production and food *** blast fun-gus Magnaporthe oryzae invades the host via the appressorium,a specialized pressure-generating struc-ture that generates enormous turgor pressure to penetrate the host ***,owing to ongoing evolution of fungicide resistance,it is vitally important to identify new targets and ***,we show that Trs85,a subunit of the transport protein particle III complex,is essential for appressorium-mediated infection in *** explain how Trs85 regulates autophagy through Ypt1(a small guano-sine triphosphatase protein)in *** then identify a key conserved amphipathic a helix within Trs85 that is associated with pathogenicity of *** computer-aided screening,we identify a lead compound,SP-141,that affects autophagy and the Trs85–Ypt1 ***-141 demonstrates a substantial capacity to effectively inhibit infection caused by the rice blast fungus while also exhibiting wide-ranging potential as an antifungal agent with broad-spectrum *** together,our data show that Trs85 is a potential new target and that SP-141 has potential for the control of rice *** thus provide a novel strategy that may help in thefight against rice blast.

关键词： Magnaporthe oryzae rice blast TRAPPIII complex trs85 fungicide

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How far does China still need to go to internationalize her academic journals?

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第8期13卷 641-646页

作者： jian-ping lu School of International Studies Zhejiang UniversityHangzhou 310058China Publication Quality Supervsion and Inspection of General Admini-stration of Press and Publication(GAPP) Beijing 100073China

1 Purpose of the report When it comes to the volume of Englishlanguage articles published in international joumals, Chinese scientists are second only to those in the United States （Editorial, 2010）, but this is not... 详细信息

关键词： CLC number G237.5

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Is editing the roadblock to the internationalization of Chinese academic journals?

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第6期12卷 503-506页

作者： jian-ping lu School of International Studies Zhejiang University Hangzhou 310058 China

"China's internationalization" is in part realized through the dissemination of Chinese publications,such as academic ***,editorial proficiency in the English language is of vital importance to the quality of the *** article analyzes the results of the two projects sponsored by the General Administration of Press and Publication of the People's Republic of China in 2007 and 2010 respectively,namely the "Analytical Evaluation of Language and Editing Quality of Chinese Academic Journals in English Language Issued in 2006",and the "Evaluation of Publication Quality of the China-Grown English Periodicals Issued in 2009,Sanctioned from 2005 to 2009",and proposes solutions to the problems presented therein.

关键词： China internationalization Quality of academic journals Editorial proficiency

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Folded Solitary Wave Excitations for(2+1)-Dimensional Nizhnik-Novikov-Veselov System

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Communications in Theoretical Physics 2009年第3期51卷 479-484页

作者： MA Song-Hua FANG jian-ping lu Zhi-Jie College of Mathematics and Physics Lishui University Lishui 323000 China

With the help of an improved mapping approach and a linear-variable-separation approach, a new family of exact solutions with arbitrary functions of the （2＋1）-dimensional Nizhnik-Novikov-Veselov system （NNV） is derived. Based on the derived solutions and using some multi-valued functions, we find a few new folded solitary wave excitations for the （2＋1）-dimensional NNV system.

关键词： (2+1)-dimensional NNV system improved mapping approach~ multi-valued functions folded solitary wave excitations

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Study on chronic pancreatitis and pancreatic cancer using MRS and pancreatic juice samples

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World Journal of Gastroenterology 2011年第16期17卷 2126-2130页

作者： jian Wang Chao Ma Zhuan Liao Bing Tian jian-ping lu Department of Radiology Changhai Hospital The Second Military Medical University Shanghai 200433 China Department of Gastroenterology Changhai HospitalThe Second Military Medical University Shanghai 200433 China

AIM:To investigate the markers of pancreatic diseases and provide basic data and experimental methods for the diagnosis of pancreatic ***:There were 15 patients in the present study,among whom 10 had pancreatic cancer and 5,chronic *** all patients,pancreatic cancer or chronic pancreatitis was located on the head of the ***-thology da-ta-of a-ll p-a-tients wa-s confirmed by biopsy and *** the 10 patients with pancreatic cancer,3 people had a medical history of longterm alcohol *** 5 patients with chronic pancreatitis,4 men suffered from alcoholic chronic *** juice samples were obtained from patients by endoscopic retrograde *** resonance spectroscopyn was performed on an 11.7-T scanner (Bruker DRX-500) using Call-Purcell-Meiboom-Gill pulse *** parameters were as follows:spectral width,15 KHz;time domain,64 K;number of scans,512;and acquisition time,2.128 ***:The main component of pancreatic juice included leucine,iso-leucine,valine,lactate,alanine,acetate,aspartate,lysine,glycine,threonine,tyrosine,histidine,tryptophan,and *** performing 1D 1H and 2D total correlation spectroscopy,we found a triplet peak at the chemical shift of 1.19 ppm,which only appeared in the spectra of pancreatic juice obtained from patients with alcoholic chronic *** triplet peak was considered the resonance of the methyl of ethoxy group,which may be associated with the metabolism of alcohol in the ***:The triplet peak,at the chemical shift of 1.19 ppm is likely to be the characteristic metabolite of alcoholic chronic pancreatitis.

关键词： Pancreatic juice Pancreatic cancer Chronic pancreatitis Magnetic resonance spectroscopy Magnetic resonance imaging

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Magnaporthe oryzae MTP1 gene encodes a type Ⅲ transmembrane protein involved in conidiation and conidial germination

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第7期9卷 511-519页

作者： Qin lu jian-ping lu Xiao-dong LI Xiao-hong LIU Hang MIN Fu-cheng LIN College of Life Sciences Zhejiang University Hangzhou 310058 China Institute of Biotechnology Zhejiang University Hangzhou 310029 China

In this study the MTP1 gene, encoding a type III integral transmembrane protein, was isolated from the rice blast fungus Magnaporthe oryzae. The Mtp 1 protein is 520 amino acids long and is comparable to the Ytp 1 protein of Saccharomyces cerevisiae with 46% sequence similarity. Prediction programs and MTP1-GFP （green fluorescent protein） fusion expression results indicate that Mtp 1 is a protein located at several membranes in the cytoplasm. The functions of the MTP1 gene in the growth and development of the fungus were studied using an MTP1 gene knockout mutant. The MTP1 gene was primarily expressed at the hyphal and conidial stages and is necessary for conidiation and conidial germination, but is not required for pathogenicity. The Amtpl mutant grew more efficiently than the wild type strain on non-fermentable carbon sources, implying that the MTP1 gene has a unique role in respiratory growth and carbon source use.

关键词： Magnaporthe oryzae Magnaporthe grisea MTP1 cDNA Gene knockout Conidial germination

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China's new strategy for fighting misconduct in academic journals

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Chinese Medical Journal 2019年第15期132卷 1865-1866页

作者： jian-ping lu Research Centre for Quality of Foreign Language Media College of Media and International Culture Zhejiang University Hangzhou Zhejiang 310007 China

The Central Committee of the Communist Party of China issued its first policy related to academic ethics on May 30th,2018,together with the State Council.[1] It introduced in detail a raft of reforms aiming at the improvement of academic integrity across the research spectrum covering funding,job applications,peer-review,and *** new policy clarified that a high-level management system for scientific research integrity with clear responsibilities and efficient coordination should be established,requiring that the Ministry of Science and Technology (MOST) and the Chinese Academy of Social Sciences (CASS) be responsible for the overall coordination and guidance of scientific research integrity in the fields of natural sciences,philosophy,and social sciences.

关键词： strategy misconduct in academic journals

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A simple and effective method for total RNA isolation of appressoria in Magnaporthe oryzae

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第10期9卷 811-817页

作者： Tong-bao LIU jian-ping lu Xiao-hong LIU Hang MIN Fu-cheng LIN State Key Laboratory for Riee Biology Biotechnology Institute Zhejiang University Hangzhou 310029 China College of Life Sciences Zhejiang University Hangzhou 310058 China

Appressorium formation is an important event in establishing a successful interaction between the rice blast fungus, Magnaporthe oryzae, and its host plant, rice. An understanding of molecular events occurring in appressorium differentiation will give new strategies to control rice blast. A quick and reliable method to extract total RNA from appressorium is essential for studying gene expression during appressorium formation and its mechanism. We found that duplicate film is an efficient substratum for appressorium formation, even when inoculated with high density conidia. When inoculated with conidia at 1 × 106 ml^-1, the percentages of conidium germination and appressorium formation were （97.98±0.67）% and （97.88±0.45）%, respectively. We applied Trizol before appressorium collection for total RNA isolation, and as much as 113.6 lag total RNA was isolated from the mature appressoria at 24 h after inoculation. Functional analysis of two genes, MNH6 and MgATG1, isolated from the cDNA subtractive library, revealed that the quantity of RNA was good enough to construct a cDNA （complementary DNA） library or a cDNA subtractive library. This method may be also applicable for the appressorium RNA isolation of other pathogenic fungi in which conidia differentiate into appressoria in the early stages of host infection.

关键词： Appressorium Magnaporthe oryzae RNA isolation

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The Determination of Iodide Based on a Flow-injection Coupling Irreversible Biamperometry

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Chinese Chemical Letters 2005年第12期16卷 1629-1632页

作者： Li Jun LI Hao CHENG Wen Yi HUANG Hong Xing KONG jian Ling WU jian ping lu Wei GAO Jun Feng SONG Department of Biological and Chemical Engineering Guangxi University of Technology Liuzhou 545006 College of Chemistry and Chemical Engineering Guangxi University Nanning 530004 Institute of Analytical Science. Northwest University Xi＇an 710069

A novel flow-injection irreversible biamperometric method is described for the direct determination of iodide. The method is based on electrochemical oxidation of iodide at the gold electrode and the reduction of permanganate at the platinum electrode to form an irreversible biamperometric detection system. Under the applied potential difference of 0 V, in the 0.05 mol/L sulfuric acid, iodidecan be determined over the range 4.00×10^-7-1.00×10^-5 mol/L with a sampling frequency of 120 samples per hour. The detection limit for I- is 3.0×10^-7 mol/L and the RSD for 40 replicate determinations of 4.0×10^-5 mol/L potassium iodide is 1.68%. The new method was applied to the analysis of iodide in table salt with satisfactory results.

关键词： Iodide flow injection irreversible biamperometry gold electrode platinum electrode

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Overview of computation strategies on the dispersion analysis for explicit finite difference solution of acoustic wave equation

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Petroleum Science 2024年第4期21卷 2311-2328页

作者： jian-ping Huang Wei-Ting Peng Ji-Dong Yang lu-Feng Lou School of Geosciences China University of Petroleum (East China) Pilot National Laboratory for Marine Science and Technology (Qingdao)

Finite-difference(FD) method is the most extensively employed numerical modeling technique. Nevertheless, when using the FD method to simulate the seismic wave propagation, the large spatial or temporal sampling interval can lead to dispersion errors and numerical instability. In the FD scheme, the key factor in determining both dispersion errors and stability is the selection of the FD weights. Thus,How to obtain appropriate FD weights to guarantee a stable numerical modeling process with minimum dispersion error is critical. The FD weights computation strategies can be classified into three types based on different computational ideologies, window function strategy, optimization strategy, and Taylor expansion strategy. In this paper, we provide a comprehensive overview of these three strategies by presenting their fundamental theories. We conduct a set of comparative analyses of their strengths and weaknesses through various analysis tests and numerical modelings. According to these comparisons, we provide two potential research directions of this field: Firstly, the development of a computational strategy for FD weights that enhances stability; Secondly, obtaining FD weights that exhibit a wide bandwidth while minimizing dispersion errors.

关键词： Finite-difference scheme FD coefficients Dispersion error Forward modeling Numerical simulation

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