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Slag for Decopperization and Sulphur Control in Molten Steel

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Journal of Iron and Steel Research International 2009年第2期16卷 17-21页

作者： WANG jian-jun guo Shang-xing ZHOU Li LI Qiang Metallurgy and Resources Institute Anhui University of Technology Ma'anshan 243002 Anhui China

Decopperization in molten steel with FeS-Na2 S slag was investigated in the laboratory. It was found that with an increase in FeS content of the FeS-Na2 S slag, the decopperization ratio increased. The decopperization ratio could reach the maximum of 71.6% in hot metal. The decopperization ratio was closely related to the carbon content, and the higher the carbon content, the higher was the decopperization ratio. Sulphur addition was found in the process of decopperization, and the increase in sulphur content of molten steel was about 0. 2%-0. 42%. However, by adding 30%-50% of BaO to the FeS-Na2 S slag, the addition of sulfur content in molten steel could be reduced by about 50%. The finer slag system composition was FeS ： NazS ： BaO=40 ： 20 ： 40.

关键词： molten steel decopperization FeS

Response of Rice Varieties to Bound Residues of Metsulfuron-Methyl in a Paddy Soil

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Pedosphere 2007年第4期17卷 487-492页

作者： LI Zhao-jun WANG Hai-Zhen XU jian-Ming WU jian-jun MA guo-Rui Institute of Soil and Water Resources and Environmental Science Zhejiang University Hangzhou 310029 （China）. Institute of Agricultural Resources and Regional Planning Ministry of Agriculture Key Laboratory of Plant Nutrition and Nutrient Cycling Chinese Academy of Agricultural Sciences Beijing 100081 （China）

Metsulfuron-methyl is one of the widely used sulfonylurea herbicides. However, approximately half of the applied metsulfuron-methyl may remain as bound residues in soil. To characterize the response of rice plants to residual metsulfuron-methyl in soil, the activities of acetolactate synthase （ALS）, superoxide dismutase （SOD）, peroxidase （POD）, and catalase （CAT） were investigated in two rice varieties that differed in susceptibility to the herbicide. Changes in the activity of these enzymes in leaves and roots of Xiushui 63, a sensitive rice variety, were greater than those in a resistant variety Zhenong 952. Irrespective of variety, changes in the enzyme activity were greater in the roots than in the leaves. The activities of ALS and CAT decreased, while the SOD activity increased with the increase in the amounts of bound residues of metsulfuron-methyl （BRM） in soil. The POD activity increased at the BRM level of 0.025 mg kg^-1, but decreased at the BRM level of 0.05 mg kg^-1. The results showed that the bound residues of sulfonylurea herbicides may affect metabolism of rice plants.

关键词： ALS activity bound residues CAT activity metsulfuron-methyl SOD activity

Advances in traditional Chinese medicine for cardiovascular disease therapy in 2020

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Traditional Medicine Research 2021年第3期6卷 86-102页

作者： Kun Xiang Jin-Fu Yang Xun Wu jun Peng jian-jun guo Cheng-Ming Fan Department of Cardiovascular Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011China Hunan Provincial Key Laboratory of Cardiovascular Research Changsha 410078China Hunan Fangsheng Pharmaceutical Co. Ltd.Changsha 410205China

Cardiovascular diseases are a major cause of morbidity and mortality worldwide and there is an urgent need to develop new pharmacotherapies for managing cardiovascular *** China,traditional Chinese medicine has been used in clinical settings for thousands of *** traditional Chinese medicine is very popular,Western medicine experts have not yet accepted it because some ingredients and mechanisms of action for its therapeutic effect are not fully *** evidence has established that traditional Chinese medicine inhibits oxidative stress and inflammatory response,suppresses apoptosis,promotes angiogenesis,regulates autophagy and gut microbiota,and modulates metabolomics,among ***,it has a beneficial role against cardiovascular disease occurrence and progression,such as atherosclerosis,hypertension,myocardial ischemia/reperfusion injury,myocardial infarction,cardiomyopathy,arrhythmia,cardiac remodeling,pulmonary arterial hypertension,and heart *** this review,we have summarized the research progress on the relevant mechanisms by which traditional Chinese medicine regulates cardiovascular diseases in 2020 to reveal its application to cardiovascular disease prevention and/or therapy.

关键词： Traditional Chinese medicine Cardiovascular diseases Atherosclerosis Myocardial ischemia-reperfusion injury Mechanisms 2020

PRESSURE DISTRIBUTION ON THE WALL OF THE INNER CYLINDER RECIPROCATING AXIALLY TO THE UNSTEADY FLOW OF VISCOELASTIC FLUID IN ECCENTRIC ANNULUS

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Journal of Hydrodynamics 2006年第5期18卷 606-612页

作者： WANG Yan CUI Hai-qing YANG Yuan-jian guo jun-hui LI Nan Department of Petroleum Engineering China University of Petroleum Beijing 102249 China Department of Petroleum Engineering Daqing Petroleum Institute Daqing 163318 China

In this article, the governing equations for the unsteady flow of viscoelastic fluid in the eccentric annulus with the inner cylinder reciprocating axially and the expression of the pressure distribution on the wall of the inner cylinder of the annulus are established and derived, respectively, under the bipolar coordinate system. The equations and the expression are solved and calculated numerically using the finite difference method, respectively. The curves of the pressure distribution on the wall of the inner cylinder of the aqueous solution of Hydrolyzed Polyacrylamide （HPAM） are plotted and the influences of annular eccentricity, stroke, and stroke frequency on the pressure distribution are analyzed.

关键词： viscoelastic unsteady flow eccentric annulus fluid reciprocating axially pressure distribution

C-reactive protein decreases interleukin-8 production in human endothelial progenitor cells by inhibition of p38 MAPK pathway

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Chinese Medical Journal 2009年第16期122卷 1922-1928页

作者： NAN Jing-long LI jian-jun HE jian-guo Department of Cardiology Fu Wai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China

Background C-reactive protein （CRP） has been reported to damage the vascular wall by inducing endothelial dysfunction and inflammation, and it is also speculated to have a role in attenuating angiogenic functions of human endothelial progenitor cells （EPCs）. Interleukin-8 （IL-8） is an important mediator of the paracrine mitogenic effect of EPCs which has direct angiogenic effects on mature endothelial cells. We, herein, investigated the direct effect of CRP on IL-8 production and gene expression in cultured human EPCs. Methods EPCs were isolated from the peripheral venous blood of healthy male volunteers. Cells were cultured in EndoCultTM liquid medium in the absence and presence of CRP at clinically relevant concentrations （5 to 25 μg/ml） for different durations （3 to 48 hours）. IL-8 protein and mRNA of cultured EPCs were evaluated using ELISA and real-time PCR. Results The results showed that CRP at a concentration of 10 μg/ml significantly reduced IL-8 secretion of cultured EPCs with a peak at 25 μg/ml, and also decreased mRNA expression in EPCs with a peak at 12 hours. In addition, preincubation of EPCs with SB203580, an inhibitor of p38 mitogen-activated protein kinase （MAPK） decreased CRP inhibition of IL-8 mRNA expression at 12 hours in EPCs. Conclusions Our study, for the first time, demonstrates that CRP directly inhibits EPCs IL-8 secretion, a key cytokine player of angiogenesis induced by EPCs. Inhibition occurred in part via an effect of CRP to active the p38 MAPK signal transduction pathway in EPC. The ability of CRP to inhibit EPCs IL-8 secretion may represent an important mechanism that further links inflammation to cardiovascular disease.

关键词： C-reactive protein endothelial progenitor cells interleukin-8

Differential seeding and propagating efficiency ofα-synuclein strains generated in different conditions

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Translational Neurodegeneration 2021年第2期10卷 257-271页

作者： Di Liu jian-jun guo Ji-Hui Su Alexander Svanbergsson Lin Yuan Caroline Haikal Wen Li Gunnar Gouras Jia-Yi Li Institute of Neuroscience College of Life and Health SciencesNortheastern UniversityShenyang 110169China Neural Plasticity and Repair Unit Wallenberg Neuroscience CenterLund UniversityBMC A1022184 LundSweden Experimental Dementia Research Lund UniversityBMC B1122184 LundSweden Institute of Health Sciences China Medical UniversityShenyang 110122China

Background:Accumulation of alpha-synuclein(α-syn)is a main pathological hallmark of Parkinson’s and related diseases,which are collectively known as *** evidence has supported that the same protein can induce remarkably distinct pathological progresses and disease phenotypes,suggesting the existence of strain difference amongα-syn *** studies have shown thatα-syn pathology can propagate from the peripheral nervous system(PNS)to the central nervous system(CNS)in a“prion-like”***,the difference of the propagation potency from the periphery to CNS among differentα-syn strains remains unknown and the effect of different generation processes of these strains on the potency of seeding and propagation remains to be revealed in more ***:Three strains of preformedα-syn fibrils(PFFs)were generated in different buffer conditions which varied in pH and ionic ***α-syn PFFs were intramuscularly(IM)injected into a novel bacterial artificial chromosome(BAC)transgenic mouse line that expresses wild-type humanα-syn,and the efficiency of seeding and propagation of these PFFs from the PNS to the CNS was ***:The three strains ofα-syn PFFs triggered distinct propagation *** fibrils generated in mildly acidic buffer led to the most severeα-syn pathology,degeneration of motor neurons and microgliosis in the spinal ***:The differentα-syn conformers generated in different conditions exhibited strain-specific pathology and propagation patterns from the periphery to the CNS,which further supports the view thatα-syn strains may be responsible for the heterogeneity of pathological features and disease progresses among synucleinopathies.

关键词： α-Synuclein Strains Prion-like propagation Parkinson’s disease

An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes

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Journal of Pharmaceutical Analysis 2014年第4期4卷 270-278页

作者： Jing-Jing Wang jian-jun guo Jenny Zhan Hai-Zhi Bu Jiunn H.Lin First Affiliated Hospital of Kunming Medical University 3D Biooptima Co. Ltd

An efficient screening assay was developed and validated for simultaneous assessment of compound-mediated inhibition of six major human cytochrome P450 （CYP） enzymes. This method employed a cocktail of six probe substrates （i.e., phenacetin, amodiaquine, diclofenac, S-mephenytoin, dextromethorphan and midazolam for CYPIA2, 2C8, 2C9, 2C19, 2D6 and 3A4, respectively） as well as individual prototypical inhibitors of the six CYP enzymes in human liver microsomes under optimized incubation conditions. The corresponding marker metabolites （i.e., acetaminophen, N-desethylamodiaquine, 4-OH-diclofenac, 4-OH-S- mephenytoin, dextrorphan and 1-OH-midazolam） in the incubates were quantified using LC-MS/MS methods either by an internal standard （IS） calibration curve or a simpfified analyte-to-IS peak area ratio approach. The results showed that the IC5o values determined by the cocktail approach were in good agreement with those obtained by the individual substrate approach as well as those reported in the literature. Besides, no remarkable difference was observed between the two quantification approaches. In conclusion, this new cocktail assay can be used for reliable screening of compound-mediated CYP inhibition.

关键词： LC-MS/MS Cytochrome P450 Cocktail-probe Inhibition assessment Drug screenning

A gain-flatness optimization solution for feedback technology of wideband low noise amplifiers

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第7期12卷 608-613页

作者： Zhen-hua LI,Bang-hong guo,Zheng-jun WEI ,Song-hao LIU,Nan CHENG,Jin-dong WANG,jian-jun guo,Long YAN (Key Laboratory of Photonic Information Technology of Guangdong Higher Education Institutes,SIPSE & LQIT,South China Normal University,Guangzhou 510006,China) Key Laboratory of Photonic Information Technology of Guangdong Higher Education Institutes SIPSE & LQIT South China Normal University

The S parameter expression of high-frequency models of the high electron mobility transistors (HEMTs) with basic feedback structure,especially the transmission gain S 21,is presented and *** addition,an improved feedback structure and its theory are proposed and demonstrated,in order to obtain a better gain-flatness through the mutual interaction between the series inductor and the parallel capacitor in the feedback *** optimization solution for the feedback amplifier can eliminate the negative impacts on transmission gain S 21 caused by things such as resonance ***,our theory covers the shortage of conventional feedback amplifiers,to some extent.A wideband low-noise amplifier (LNA) with the improved feedback tech-nology is designed based on *** transmission gain is about 20 dB with the gain variation of 1.2 dB from 100 MHz to 6 *** noise figure is lower than 2.8 dB in the whole band and the amplifier is unconditionally stable.

关键词： Low-noise amplifier (LNA) Ultra-wideband HEMT Feedback Gain flatness

Bcl-2 enhances the formation of newborn striatal long-projection neurons in adult rat brain after a transient ischemic stroke

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Neuroscience Bulletin 2012年第6期28卷 669-679页

作者： jian-jun guo Fang Liu Xiao Sun jun-Jie Huang Ming Xu Feng-Yan Sun Department of Neurobiology and Institute of Stem Cell Research Institutes for Biomedical ScienceShanghai Medical CollegeFudan University State Key Laboratory of Medical Neurobiology of Fudan University

Objective It has been reported that B-cell lymphoma 2 （Bcl-2） enhances neurogenesis as well as supporting axonal growth after injury. In the present study, we investigated whether Bcl-2 overexpression plays a role in the formation of newborn striatonigral projection neurons in the adult rat brain after transient middle cerebral artery occlusion （MCAO）. Methods We infused human Bcl-2-expressing plasmid （pBcl-2） into the lateral ventricle immediately after 30 min of MCAO, injected 5＇-bromodeoxyuridine （BrdU） intraperitoneally to label proliferative cells, and microinjected fluorogold （FG） into the substantia nigra at 11 weeks of reperfusion followed by multiple immunostaining of striatonigral projection neurons at 12 weeks. Results We found that pBcl-2 treatment significantly increased the number of newborn neurons （BrdU＋-NeuN＋） in the striatum ipsilateral to the MCAO. We further detected newborn striatonigral projection neurons （BrdU＋-FG＋-NeuN＋） in the ipsilateral striatum at 12 weeks. More interestingly, the number of newborn striatonigral projection neurons （BrdU＋-FG＋） was significantly increased by pBcl-2 treatment compared to that by pEGFP, a control plasmid. Conclusion Taken together, we found that Bcl-2 overexpression in the brain enhanced the generation of newborn striatonigral projection neurons. This provides a potential strategy for promoting the reestablishment of neural networks and brain repair after ischemic injury.

关键词： cerebral ischemia Bcl-2 striatonigral projection neuron neurogenesis brain repair