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Effect of Strengthening Phase on Deformation Behaviour during Uniaxial Tension of Hot-rolled Dual Phase Steel

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Journal of Iron and Steel Research International 2014年第12期21卷 1111-1115页

作者： Le-yu ZHOU Bo jianG Tian-hao CUI Dan ZHANG jian-zhong he Ya-zheng LIU School of Materials Science and Engineering University of Science and Technology Beijing Technology Center Baotou Iron & Steel Group Co.Ltd.

Two kinds of C-Si-Mn-Cr series tested steels were designed to obtain dual phase microstructures of ferrite （F）＋martcnsite （M） or ferrite （F）-bainite （B） with different mechanical properties. Effects of strengthening phase on yielding and fracture behaviours during uniaxial tension of dual phase steel were discussed. Compared with hot-rolled martensite dual phase steel, ferrite-bainite dual phase steel has high ratio of yield strength to tensile strength （YS/TS） and low elongation. During necking process of uniaxial tension, microvoids of ferrite-martensite steel are generated by fracture of ferrite/martensite boundary or martensite islands with irregular shape. But ferrite matrix elongated remarkably along deformation direction, and strengthening phase also coordinated with ferrite matrix. Compatible de formation between ferrite and bainite is distinct. Ferrite-bainite dual phase steel has fine and less microvoid, and phase boundary of ferrite and bainite is beneficial for restraining generation and extending of microvoid.

关键词： hot-rolled dual phase steel strengthening phase yielding necking microvoid

Nitrogen interception in floodwater of rice field in Taihu region of China

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Journal of Environmental Sciences 2007年第12期19卷 1474-1481页

作者： LIANG Xin-qiang CheN Ying-xu LI Hua TIAN Guang-ming ZHANG Zhi-jian NI Wu-zhong he Miao-miao Department of Environmental Engineering College of Natural Resources and Environmental Science Zhejiang University Hangzhou 310029 China.

A field experiment located in Taihu Lake Basin of China was conducted, by application of urea or a mixture of urea with manure, to elucidate the interception of nitrogen （N） export in a typical rice field through ＂zero-drainage water management＂ combined with sound irrigation, rainfall forecasting and field drying. N concentrations in floodwater rapidly declined before the first event of field drying after three split fertilizations, and subsequently tended to rearm to the background level. Before the first field drying, total particulate nitrogen （TPN） was the predominant N form in floodwater of plots with no N input, dissolved inorganic nitrogen （DIN） on plots that received urea only, and dissolved organic nitrogen （DON） on plots treated with the mixture of urea and manure. Thereafter TPN became the major form. No N export was found from the rice field, but total nitrogen （TN） of 15.8 kg/hm^2 was remained, mainly due to soil N sorption. The results recommended the zero-drainage water management for full-scale areas for minimizing N export.

关键词： nitrogen paddy field surface floodwater interception Taihu region

Fascin lysine 471 acetylation cooperates with serine 39 phosphorylation to inhibit actin-bundling activity and tumor metastasis in esophageal squamous cell carcinoma

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Cancer Communications 2022年第7期42卷 668-672页

作者： Fa-Min Zeng Yin-Wei Cheng jian-zhong he Xiu-E Xu Lian-Di Liao Li-Yan Xu En-Min Li Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area Department of Biochemistry and Molecular BiologyShantou University Medical CollegeShantouGuangdong 515041P.R.China Department of Pathology the Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhaiGuangdong 519000P.R.China Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology Institute of Basic Medical ScienceCancer Research CenterShantou University Medical CollegeShantouGuangdong 515041P.R.China

Dear Editor,Fascin actin-bundling protein 1(Fascin,gene name:FSCN1)is the primary actin-bundling protein that clusters filaments into stable and bundled filopodia[1].In previous studies,elevated levels of Fascin promoted filopodia formation and enhanced the invasive ability of tumor cells,suggesting that Fascin is a target for therapeutic intervention[2,3].Therefore,it is necessary to elucidate the detailed molecular mechanism by which Fascin bundles F-actin filaments.

关键词： Fascin esophageal metastasis

睑板腺热脉动系统与热敷疗法治疗睑板腺功能障碍的疗效比较

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国际眼科杂志 2018年第7期18卷 1324-1328页

作者：何建中钟敏中国江西省萍乡市人民医院眼科 337055

目的:对比分析Lipi Flow睑板腺热脉动系统与传统的热敷疗法(warm compress)对睑板腺功能障碍(meibomian gland dysfunction,MGD)患者治疗的有效性及安全性。方法:选取MGD患者50例,随机分为试验组及对照组。试验组进行单独一次Lipi Flow... 详细信息

目的:对比分析Lipi Flow睑板腺热脉动系统与传统的热敷疗法(warm compress)对睑板腺功能障碍(meibomian gland dysfunction,MGD)患者治疗的有效性及安全性。方法:选取MGD患者50例,随机分为试验组及对照组。试验组进行单独一次Lipi Flow睑板腺热脉动系统治疗;对照组受试者每日在医生指导下使用热敷眼罩热敷治疗15min,每天1次,共2wk。对两组受试者在治疗前、治疗后4、8、12wk进行包括主观症状、泪膜破裂时间(TBUT)、脂质层厚度(LLT)、睑板腺缺失情况等8项指标的评估。采用重复测量数据的方差分析对两组的组间差异性及时间差异性进行分析。若两组存在组间差异性,进一步采用独立样本t检验;若组内存在时间差异性,则采用LSD-t检验分析。结果:两组受试者眼表疾病主观症状评分、睑板腺分泌物性状、Schirmer试验的改变差异均有统计学意义(P<0.05)。治疗后第12wk,试验组与对照组在OSDI、MGYSS、LLT、眼表染色评分、TBUT这些方面,改善程度的差值也具有统计学意义(P<0.05)。安全性方面,两组均未出现严重并发症或者不良医疗事件。结论:单独一次睑板腺热脉动系统疗法和热敷疗法均能够有效且安全地治疗MGD。前者的疗效优于后者。

关键词：睑板腺功能障碍睑板腺热脉动系统热敷对照研究

Development of County Economy in Hubei Province Based on Factor Analysis

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Asian Agricultural Research 2010年第12期2卷 48-51页

作者： FENG jian-zhong, he Xian-ping School of Information and Mathematics, Yangtze University, Jingzhou 434023, China

According to the 2008 Statistics Bulletin of the National Economic and Social Development of Hubei Province, factor analysis method is used to study on the development of county economy in Hubei Province. Result shows that there are great differences in the economic development and the development is imbalanced. The 76 counties (cities, districts) in Hubei Province are divided into three types of F>1, 0he development of county economy are put forward, such as adhering to the reform of market economy, developing private economy, speeding up the process of industrialization, making efforts to support leading enterprises, promoting the industrialized operation of agriculture, further attracting foreign investment, carrying out industrialization during the development of projects and enterprises, changing soft environment by measures, and promoting the development of county economy by innovation.

关键词： County economy Factor analysis Factor score Hubei

P300/CBP-associated factor(PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer

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Cancer Communications 2021年第12期41卷 1398-1416页

作者： Yin-Wei Cheng Fa-Min Zeng Da-Jia Li Shao-Hong Wang jian-zhong he Zhen-Chang Guo Ping-Juan Nie Zhi-Yong Wu Wen-Qi Shi Bing Wen Xiu-E Xu Lian-Di Liao Zhi-Mao Li jian-Yi Wu Jun Zhan Hong-Quan Zhang Zhi-Jie Chang Kai Zhang Li-Yan Xu En-Min Li The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area Department of Biochemistry and Molecular BiologyShantou University Medical CollegeShantouGuangdong 515041P.R.China Institute of Basic Medical Science Cancer Research CenterShantou University Medical CollegeShantouGuangdong 515041P.R.China Shantou Central Hospital Affiliated Shantou Hospital of Sun Yat-sen UniversityShantouGuangdong 515041P.R.China Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology Institute of Oncologic PathologyShantou University Medical CollegeShantouGuangdong 515041P.R.China Tianjin Key Laboratory of Medical Epigenetics Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesTianjin Medical UniversityTianjin 300070P.R.China State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science CenterBeijing 100191P.R.China School of Medicine Tsinghua UniversityBeijing 100084P.R.China

Background:Fascin is crucial for cancer cell filopodium formation and tumor metastasis,and is functionally regulated by post-translational ***,whether and how Fascin is regulated by acetylation remains *** study explored the regulation of Fascin acetylation and its corresponding roles in filopodium formation and tumor ***:Immunoprecipitation and glutathione-S-transferase pull-down assays were performed to examine the interaction between Fascin and acetyltransferase P300/CBP-associated factor(PCAF),and immunofluorescence was used to investigate their *** in vitro acetylation assay was performed to identify Fascin acetylation sites by using mass spectrometry.A specific antibody against acetylated Fascin was generated and used to detect the PCAF-mediated Fascin acetylation in esophageal squamous cell carcinoma(ESCC)cells using Western blotting by overexpressing and knocking down PCAF *** in vitro cell migration assay was performed,and a xenograft model was established to study in vivo tumor ***-cell imaging and fluorescence recovery after photobleaching were used to evaluate the function and dynamics of acetylated Fascin in filopodium *** clinical significance of acetylated Fascin and PCAF in ESCC was evaluated using ***:Fascin directly interacted and colocalized with PCAF in the cytoplasm and was acetylated at lysine 471(K471)by *** the specific antiAcK471-Fascin antibody,Fascin was found to be acetylated in ESCC cells,and the acetylation level was consequently increased after PCAF overexpression and decreased after PCAF ***,Fascin-K471 acetylation markedly suppressed in vitro ESCC cell migration and in vivo tumor metastasis,whereas Fascin-K471 deacetylation exhibited a potent oncogenic ***,Fascin-K471 acetylation reduced filopodial length and density,and lifespan of ESCC cells,while its deacetylation produced the opp

关键词： acetylation actin-bundling esophageal cancer fascin filopodium formation P300/CBPassociated factor(PCAF) tumor metastasis

Recent progress in metal-organic frameworks(Part II—material application)

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Science China Chemistry 2025年

作者： jiandong Pang Wentao jiang Xue-Wen Zhang Hao-Long Zhou Yuxiu Sun Wei Gong Bin Wang Fuyin Ma Linwei he Long Chen Qiang Chen he-Qi Zheng Yuanjing Cui Wen-Jie Shi Chao Zhang Mei Wang Yue-Biao Zhang Jie-Peng Zhang Chongli zhong Yong Cui Shuao Wang jian-Rong Li Guodong Qian Tong-Bu Lu Huan Pang Xian-he Bu Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of Chemistry and Chemical Engineering Yangzhou University School of Materials Science and Engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University Department of Chemistry Shantou University School of Chemical Engineering and Technology Tiangong University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of Materials Science & Engineering Beijing University of Technology State Key Laboratory of Silicon and Advanced Semiconductor Materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

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Hyperandrogenism induces epigenetic alterations in the granulosa cells:A mechanism underlying ovarian dysfunction of polycystic ovary syndrome

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Hyperandrogenism induces epigenetic alterations in the granu...

2011中国妇产科学术会议暨浙江省计划生育与生殖医学学术年会暨生殖健康讲习班

作者： WANG Fang-fang QV Fan DING Guo-lian SheNG jian-zhong and HUANG he-feng Department of Reproductive Endocrinology Women’s Hospital School of Medicine Zhejiang University China Key Laboratory of Reproductive Genetics Ministry of Education of China Department of Pathophysiology School of Medicine Zhejiang University China

Background Female mammals under exposure to androgen excess during early life program a permanent polycystic ovary syndrome(PCOS)-like phenotype in reproductive endocrinology. To explore whether hy

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抑癌基因RB-蛋白与肿瘤相关的研究进展

中国医院药学杂志 2016年第21期36卷 1931-1935页

作者：汤小玲马建秀钟建斌何人可刘文波冉晨曦西北民族大学医学院甘肃兰州730030

RB基因是人类最早发现和确定的抑癌基因,表达产物pRb是重要的细胞周期调节因子,参与细胞的生长分化。pRb功能的缺陷或丧失是很多肿瘤发生的基础,正常RB基因导入恶性肿瘤细胞能全部或部分抑制其恶性表现,也能增加常规化疗和放疗的效果,... 详细信息

RB基因是人类最早发现和确定的抑癌基因,表达产物pRb是重要的细胞周期调节因子,参与细胞的生长分化。pRb功能的缺陷或丧失是很多肿瘤发生的基础,正常RB基因导入恶性肿瘤细胞能全部或部分抑制其恶性表现,也能增加常规化疗和放疗的效果,经截短修饰的RB94在体内和体外都有更好的抑癌作用。但pRb同时也被证实具有保护细胞免于凋亡的作用,此点与其抑癌作用相悖,其各方面功能也可受MicroRNA分子的调控。正是由于RB功能的多面性,近年来对RB与肿瘤的发生、发展和抑制作用的研究从未间断,不断有新的疑问和功能路径被发现。

关键词： RB基因 pRb 肿瘤凋亡 MicroRNA 基因治疗