Fascin lysine 471 acetylation cooperates with serine 39 phosphorylation to inhibit actin-bundling activity and tumor metastasis in esophageal squamous cell carcinoma

作     者：Fa-Min Zeng Yin-Wei Cheng Jian-Zhong He Xiu-E Xu Lian-Di Liao Li-Yan Xu En-Min Li 

作者机构：Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan AreaDepartment of Biochemistry and Molecular BiologyShantou University Medical CollegeShantouGuangdong 515041P.R.China Department of Pathologythe Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhaiGuangdong 519000P.R.China Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyInstitute of Basic Medical ScienceCancer Research CenterShantou University Medical CollegeShantouGuangdong 515041P.R.China 

出 版 物：《Cancer Communications》 (癌症通讯（英文）)

年 卷 期：2022年第42卷第7期

页      面：668-672页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the grants from the National Natural Science Foundation of China(81872372) the Guangdong Basic and Applied Basic Research Foundation(2020A1515011532) the Natural Science Foundation of China-Guangdong Joint Fund(U0932001) the National Cohort of Esophageal Cancer of China(2016YFC0901400) the China Postdoctoral Science Foundation(2018M643134) 2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant(2020LKSFG07B) 

主　　题：Fascin esophageal metastasis 

摘      要：Dear Editor,Fascin actin-bundling protein 1(Fascin,gene name:FSCN1)is the primary actin-bundling protein that clusters filaments into stable and bundled filopodia[1].In previous studies,elevated levels of Fascin promoted filopodia formation and enhanced the invasive ability of tumor cells,suggesting that Fascin is a target for therapeutic intervention[2,3].Therefore,it is necessary to elucidate the detailed molecular mechanism by which Fascin bundles F-actin filaments.