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Mitigating growth-stress tradeoffs via elevated TOR signaling in rice

Molecular Plant 2024年第2期17卷 240-257页

作者： Wei Li Jiaqi Liu Zeqi Li Ruiqiang ye Wenzhen Chen Yuqing Huang Yue Yuan Yi Zhang Huayi Hu Peng Zheng Zhongming Fang Zeng Tao Shiyong Song Ronghui Pan jian Zhang Jumim Tu Jen Sheen Hao Du State Key Laboratory of Rice Biology College of Agriculture and BiotechnologyZhejiang UniversityYu-Hang-Tang Road No.866Hangzhou 310058China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China Hainan Institute of Zhejiang University Sanya 572025China National Key Laboratory of Plant Molecular Genetics CASCenter for Excellence in Molecular Plant SciencesShanghai lnstitute of Plant Physiology and EcologyChineseAcademy of SciencesShanghai 200032China Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education) College of Agricultural SciencesGuizhouUniversityGuiyang 550025China State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 311400China Department of Molecular Biology and Center for Computational and Integrative Biology Massachusetts General Hospitaland Department of GeneticsHarvard Medical SchoolBostonMA02114USA

Rice production accounts for approximately half of the freshwater resources utilized in agriculture,result-ing in greenhouse gas emissions such as methane(CH4)from flooded paddy *** address this chal-lenge,environmentally friendly and cost-effective water-saving techniques have become widely adopted in rice ***,the implementation of water-saving treatments(WsTs)in paddy-field rice has been associated with a substantial yield loss of up to 50%as well as a reduction in nitrogen use efficiency(NUE).In this study,we discovered that the target of rapamycin(TOR)signaling pathway is compromised in rice under *** profiling-coupled transcriptome sequencing(polysome-seq)analysis unveiled a substantial reduction in global translation in response to WST associated with the downregulation of TOR ***,biochemical,and genetic analyses revealed new insights into the impact of the positive TOR-S6K-RPS6 and negative TOR-MAF1 modules on translation repression under ***,ammonium exhibited a greater ability to alleviate growth constraints under WsT by enhancing TOR signaling,which simultaneously promoted uptake and utilization of ammonium and nitrogen *** further demonstrated that TOR modulates the ammonium transporter AMT1;1 as well as the amino acid permease APP1 and dipeptide transporter NPF7.3 at the translational level through the 5'untranslated ***,these findings reveal that enhancing TOR signaling could mitigate rice yield penalty due to WST by regulating the processes involved in protein synthesis and *** study will contribute to the breeding of new rice varieties with increased water and fertilizer utilization efficiency.

关键词： target of rapamycin TOR water-saving rice low-carbon agriculture drought nitrogen use efficiency NUE

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激素敏感性前列腺癌患者中PSMA PET/CT衍生参数与循环肿瘤DNA特征之间的相关性分析

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中国癌症杂志 2024年第7期34卷 680-685页

作者：潘剑叶定伟朱耀王备合复旦大学附属肿瘤医院泌尿外科复旦大学上海医学院肿瘤学系上海200032

背景与目的:前列腺特异性膜抗原(prostate-specific membrane antigen,PSMA)正电子发射计算机体层显像(positron emission tomography/computed tomography,PET/CT)和循环肿瘤DNA(circulating tumor DNA,ctDNA)的检测结果都是激素敏感性前列腺癌(hormone-sensitive prostate cancer,HSPC)治疗决策的参考依据。本研究旨在分析HSPC患者中PSMA PET/CT衍生参数与ctDNA特征之间的相关性。方法:回顾性纳入于复旦大学附属肿瘤医院就诊且接受PSMA PET/CT和ctDNA测序的间隔≤2周、有完整病历记录的HSPC患者。排除存在除前列腺癌外的活动性恶性肿瘤,以及组织学特征支持纯神经内分泌癌或小细胞癌诊断的患者。本研究经复旦大学附属肿瘤医院伦理委员会批注(伦理编号:1909207-12)。采用Spearman相关系数评价PSMA PET/CT衍生参数最大标准摄取值(maximum standardized uptake value,SUVmax)、总肿瘤体积(total tumor volume,TTV)、病灶摄取总量(total lesion uptake,TLU)与ctDNA分数(ctDNA%)之间的相关性。结果:共纳入60例HSPC患者,TP53(3.3%)、BRCA2(3.3%)和ATM(3.3%)是最常见的突变基因。在相关性分析中,ctDNA%与SUVmax有显著相关性(Spearman’s rho=0.272,P=0.036);ctDNA%与TLU(Spearman’s rho=0.160,P=0.222)和TTV(Spearman’s rho=0.162,P=0.215)无显著相关性。结论:SUVmax与ctDNA%之间有显著相关性,提示与无PSMA阳性病灶和低PSMA摄取病灶的患者相比,存在高PSMA摄取病灶的患者接受联合靶向治疗的概率增加,本研究结果有望作为制订个体化治疗方案的参考。

关键词：激素敏感性前列腺癌前列腺特异性膜抗原正电子发射计算机体层显像循环肿瘤DNA 相关性分析

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Experimental observation of the significant difference between surface and bulk Kondo processes in Kondo lattice YbCu_(2)Si_(2)

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 154-160页

作者： Yin-Zou Zhao Jiao-Jiao Song Qi-Yi Wu Hao Liu Chen Zhang Bo Chen Hong-Yi Zhang Zhen-Hua Chen Yao-Bo Huang Xue-Qing ye Ya-Hua Yuan Yu-Xia Duan Jun He jian-Qiao Meng School of Physics Central South UniversityChangsha 410083China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China

Synchrotron-based angle-resolved photoemission spectroscopy was employed to investigate the temperature evolution of the Yb 4 f spectral for surface and bulk in the Kondo lattice YbCu_(2)Si_(2).Our study quantitatively distinguishes between the surface and bulk hybridization processes,revealing that the onset temperatures for both surface and bulk hybridization processes are significantly higher than the Kondo ***,we found that the effective surface Kondo temperature is much lower than that of the *** findings offer valuable insights into the understanding of heavy fermion physics.

关键词： Kondo lattice angle-resolved photoemission spectroscopy electronic structure hybridization surface state

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R-bFGF凝胶联合银离子敷料在手部外伤植皮患者供皮区的应用效果

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中国基层医药 2024年第4期31卷 565-569页

作者：叶颖王程刘欢李健丽水市中心医院修复重建、手外、整形外科丽水323000

目的探讨重组牛碱性成纤维细胞生长因子(R-bFGF)凝胶与银离子敷料对手部外伤植皮患者供皮区联合修复效果。方法选取丽水市中心医院2020年10月至2021年10月收治的行植皮治疗的手部外伤患者80例为研究对象,采用简单随机分组方法,按照1∶1... 详细信息

目的探讨重组牛碱性成纤维细胞生长因子(R-bFGF)凝胶与银离子敷料对手部外伤植皮患者供皮区联合修复效果。方法选取丽水市中心医院2020年10月至2021年10月收治的行植皮治疗的手部外伤患者80例为研究对象,采用简单随机分组方法,按照1∶1的比例将研究对象分为对照组与观察组,每组40例。对照组采用常规凡士林纱布进行修复治疗,观察组采用R-bFGF凝胶联合银离子敷料进行治疗。治疗2周后评估两组患者修复效果,比较治疗前后两组患者心理弹性量表(CD-RISC)评分和视觉疼痛模拟评分(VAS)变化,对比两组患者创面愈合时间、肉芽组织生长时间、创面上皮形成时间以及换药次数等各项指标差异,观察两组手指总主动活动度(TAM)。结果观察组修复效果明显优于对照组(Z=4.92,P<0.05)。观察组手部功能恢复情况显著优于对照组(Z=4.31,P<0.05)。观察组CD-RISC评分[(77.54±11.35)分]显著高于对照组[(70.61±9.72)分](t=2.93,P<0.05),观察组VAS评分[(4.95±1.13)分]、创面愈合时间[(10.43±1.65)d]、肉芽组织生长时间[(7.42±2.35)d]、创面上皮形成时间[(10.25±2.47)d]和换药次数[(2.12±0.63)次]均显著低于、少于对照组[(5.52±1.24)分、(15.54±1.71)d、(11.56±2.71)d、(12.82±2.64)d、(3.35±0.86)次](t=-2.15、-13.60、-7.30、-4.50、-7.30,均P<0.05)。结论R-bFGF凝胶联合银离子敷料可有效提高手部外伤植皮患者供皮区的修复效果,改善其心理状态及疼痛感受,促进患者预后及功能恢复,对于手外伤患者的临床治疗具有较高的参考价值。

关键词：成纤维细胞生长因子生物敷料银创伤和损伤手皮肤移植疼痛韧性,心理功能恢复

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Changes in visual performance after implantation of different intraocular lenses

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1273-1282页

作者： Bo-Wen Li Hao Huang Man-Sha Huang Shuang-Lin Guo Lu Gao Yu-Ying Zeng Lu Cheng Si-Yang Yao jian-Qiang Lin Lin Liu ye Yang Xiao-Ming Lu Hao Cheng Department of Ophthalmology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Eye Center of Xiangya Hospital Hunan Key Laboratory of OphthalmologyCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Ophthalmology Zhuzhou Hospital Affiliated to Xiangya School of MedicineCentral South UniversityZhuzhou 412000Hunan ProvinceChina State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina Department of Ophthalmology Guangzhou Red Cross HospitalJinan UniversityGuangzhou 510000Guangdong ProvinceChina AIER Eye Hospital Jinan UniversityGuangzhou 510180Guangdong ProvinceChina

AIM:To evaluate the trending visual performance of different intraocular lenses(IOLs)over time after ***:Ninety-one patients received cataract surgery with implantations of monofocal(Mon)IOLs,segmental refractive(SegRef)IOLs,diffractive(Dif)IOLs,and extendeddepth-of-focus(EDoF)IOLs were *** aberrations and optical quality collected with iTrace and OQAS within postoperative 6mo were followed and ***:Most of the visual parameters improved over the postoperative *** postoperative visual acuity(POVA)of the Mon IOL,SegRef IOL,and EDoF IOL groups achieved relative stability in earlier states compared with the Dif IOL ***,the overall visual performance of the 3 IOLs continued to upturn in small extents within the postoperative *** optical quality initially improved in the EDoF IOL group,then in the Mon IOL,SegRef IOL,and Dif IOL *** and objective visual performance of the Mon IOL and EDoF IOL groups,as well as POVA and visual quality of the Dif IOL group,improved in the postoperative 1mo and *** the postoperative 6mo,gradual improvements were observed in the visual acuity and objective visual performance of the SegRef IOL group,as well as in the postoperative optical quality of the Dif IOL ***:The visual performance is different among eyes implanted with different *** findings of the current study provide a potential reference for ophthalmologists to choose suitable IOLs for cataract patients in a personalized solution.

关键词： intraocular lenses visual performance changing characteristics high-order wavefront aberration

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Reduced clinical severity during 2022 Shanghai Spring epidemic of SARS-CoV-2 omicron BA.2 variant infection——an integrated account of virus pathogenicity and vaccination effectiveness

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National Science Review 2024年第4期11卷 24-27页

作者： Xingyue Wu Yao Chen Kangli Cao Yao Shen Xueling Wu Yilin Yang Zhongshu Kuang Qingrun Li Zhenzhen Lu Yichen Jia Mian Shao Guorong Gu Xiangwei wang ye Yao Ying wang Shaodie Chen Zhigao Yu Wei Wei Longfei Ding Lulu Lan Tianwen Gu Xiangyu Long jian Sun Lingyu Xing Jiayuan Shen Yi Han Yue Luo Sucheng Mu Mengna Lin Xiaoyan Zhang Rong Zeng jianqing Xu Guoping Zhao Lihong Huang Zhenju Song Department of Emergency Medicine Clinical Center for Bio-Therapy Department of Biostatistics and Department of UrologyShanghai Key Laboratory of Lung Inflammation and Injury Zhongshan Hospital Fudan University Department of Respiratory and Critical Care Medicine Shanghai Pudong Hospital Fudan University Department of Pulmonology Renji Hospital Shanghai Jiao Tong University School of Medicine Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai Public Health Clinical Center Fudan University Department of Biostatistics School of Public Health Key Laboratory of Public Health Safety of Ministry of Education and Shanghai Institute of Infectious Disease and Biosecurity School of Public Health Fudan University Shanghai Institute of Immunology Department of Immunology and Microbiology Shanghai Institute of Virology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationSchool of Medicine Shanghai Jiao Tong University State Key Laboratory of Genetic Engineering Fudan Microbiome CenterSchool of Life Sciences Fudan University Bio-Med Big Data Center Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

The emergence of SARS-Co V-2 variant of concern omicron BA.2 led to high infection incidence rates as well as reduced severity of COVID-19 during the Shanghai Spring epidemic of 2022 [1]. We assessed the role of viral pathogenicity and the effectiveness of inactivated vaccines in a retrospective observational study including 10 258 confirmed COVID-19cases identified between April and June of 2022, from four COVID-19 designated hospitals located in two areas of Shanghai, namely the West Bund and the East Bund, where the populations’ demographic characteristics varied significantly (Table S1, Fig. S1).

关键词： REPLICATION

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Mechanism of photon-induced performance changes in silicon heterojunction solar cells

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Science China Materials 2024年第9期67卷 2873-2879页

作者： Qi Deng Haoran ye Shenglei Huang Zehua Sun Yanyun Yang Lei Li Zhu Ma Rong Su Wei Long Fangdan jiang Heng Guo Guoqiang Xing Wenzhu Liu jian Yu School of New Energy and Materials Southwest Petroleum UniversityChengdu610500China Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences(CAS)Shanghai201800China Tongwei Solar(Chengdu)Ltd. Chengdu600200China School of Physics and Electronical Science Chuxiong Normal UniversityChuxiong675000China School of Physical Science and Technology ShanghaiTech UniversityShanghai201210China Tianfu Yongxing Laboratory Chengdu610213China

Short-wavelength ultraviolet(UV)photons adversely affect hydrogenated amorphous silicon thin films,as well as on silicon heterojunction(SHJ)solar cells and *** research examines the impact and mechanisms of photon-induced performance *** A exposure disrupts Si-H bonds,significantly reducing hydrogen content in both intrinsic and doped hydrogenated amorphous silicon(a-Si:H)*** disruption impairs the interface passivation effect,leading to the degradation of SHJ solar cells and modules,primarily indicated by a decrease in open-circuit voltage(V_(oc))and fill factor(FF).UV irradiation from the front side of SHJ solar cells reduces V_(oc)and FF by 1.38%and 2.28%,respectively,resulting in a 2.28%efficiency *** irradiated from the backside show decreases in V_(oc)and FF of approximately 1.96%and 2.73%,respectively,leading to an overall efficiency reduction of approximately 3.58%.However,subsequent light-soaking increases V_(oc)and FF by approximately 0.96%and 1.37%,respectively,for frontside-irradiated cells,achieving an overall efficiency improvement of approximately 2.51%.Thus,light-soaking effectively recovers performance losses caused by UV irradiation in SHJ solar *** research clarifies the mechanisms influencing the performance of a-Si:H thin films,SHJ solar cells,and modules under UV irradiation and light-soaking,offering significant contributions towards the development of highly efficient and reliable SHJ devices.

关键词： silicon solar cells heterojunction UV irradiation light soaking hydrogen content

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彩色多普勒超声对高强度聚焦超声治疗腹、盆腔肿瘤疗效的评价意义

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复旦学报（医学版） 2003年第2期30卷 139-142页

作者：顾勇主王国民黄备建徐叶青王文平复旦大学附属中山医院超声科上海200032 复旦大学附属中山医院泌尿外科上海200032

目的　了解高强度聚焦超声 (highintensityfocusedultrasound ,HIFU)治疗腹、腔腔肿瘤近期的疗效及评价彩色多普勒超声 (colorDopplerflowimaging ,CDFI)在治疗前后的应用。方法　 135例腹、盆腔肿瘤行HIFU治疗 ,应用CDFI观察治疗前后... 详细信息

目的　了解高强度聚焦超声 (highintensityfocusedultrasound ,HIFU)治疗腹、腔腔肿瘤近期的疗效及评价彩色多普勒超声 (colorDopplerflowimaging ,CDFI)在治疗前后的应用。方法　 135例腹、盆腔肿瘤行HIFU治疗 ,应用CDFI观察治疗前后瘤体大小、回声、血流动力学变化等。结果　共 135例 ,其中Ⅰ期 3例 ,Ⅱ期 4 1例 ,Ⅲ期 80例 ,Ⅳ期 8例 ;3例良性肿瘤。 12 7例完成治疗。 10 5例随访 3～ 2 0月。死亡 15例 ,均为Ⅲ、Ⅳ期患者 ,治疗后平均生存期 8.9月。 3例Ⅰ期肿瘤消失 ,其他期肿瘤瘤体平均缩小 75 % (实质脏器 6 4 % ,空腔脏器 86 % )。CDFI检查 115例治疗前瘤体内均存在血流 ,治疗后 114例瘤内血流在 1～ 6月后消失。结论　HIFU治疗肿瘤的近期效果确切。

关键词：腹腔肿瘤盆腔肿瘤肿瘤治疗高强度聚焦超声彩色多普勒超声

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熔石英元件磁性复合流体抛光去除特性研究

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红外与激光工程 2024年第7期53卷 214-225页

作者：叶卉李壮王健姜晨孙来喜上海理工大学机械工程学院上海200093 中国工程物理研究院激光聚变研究中心四川绵阳621900

基于磁性复合流体(Magnetic Compound Fluid,MCF)抛光技术开展了熔石英元件抛光工艺研究,对比了传统MCF和超声辅助MCF(以下简称UMCF)抛光对熔石英材料去除特性的影响,探究了不同抛光时间下MCF和UMCF抛光对熔石英材料去除量/去除率和表... 详细信息

基于磁性复合流体(Magnetic Compound Fluid,MCF)抛光技术开展了熔石英元件抛光工艺研究,对比了传统MCF和超声辅助MCF(以下简称UMCF)抛光对熔石英材料去除特性的影响,探究了不同抛光时间下MCF和UMCF抛光对熔石英材料去除量/去除率和表面粗糙度的影响,并构建了与抛光应力和抛光时间有关的材料去除率模型。研究结果表明,相较于传统MCF,UMCF在提高材料去除率和降低表面粗糙度方面均有优势。两种抛光方式下材料去除机制均为弹塑性去除,UMCF抛光获得的表面粗糙度相比于MCF抛光优化了68.88%。由于流体动压力和超声振动压力的联合作用,UMCF抛光材料去除率最高可达5.74×10^(-3)mm^(3)/min,相比于MCF抛光提升了4.04倍。MCF和UMCF抛光材料去除率与抛光应力和抛光时间均呈现幂函数相关性,且在UMCF抛光中抛光应力对去除率的影响权重大于MCF抛光。

关键词：磁性复合流体抛光超声振动辅助材料去除率粗糙度抛光应力

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一体化管理干预在慢性难愈合创面患者中的应用

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中国基层医药 2024年第1期31卷 101-104页

作者：叶颖李键丽水市中心医院修复重建、手外、整形外科丽水323000

目的探讨一体化管理干预在慢性难愈合创面患者中的应用效果。方法采用前瞻性研究方法,在丽水市中心医院2022年1-12月收治的慢性难愈合创面患者中选择134例进行研究,根据随机数字表法分成对照组和观察组(各67例),分别接受常规干预和一体... 详细信息

目的探讨一体化管理干预在慢性难愈合创面患者中的应用效果。方法采用前瞻性研究方法,在丽水市中心医院2022年1-12月收治的慢性难愈合创面患者中选择134例进行研究,根据随机数字表法分成对照组和观察组(各67例),分别接受常规干预和一体化管理干预。结果观察组干预后疼痛评分[(3.71±0.89)分]、创面愈合时间[(19.15±2.68)d]均显著低于对照组[(4.87±0.75)分、(22.68±3.26)d],瘢痕评分[(5.12±1.09)分]显著高于对照组[(3.93±0.77)分](t=7.72、6.48、-6.91,均P<0.05);观察组干预后C反应蛋白[(30.24±3.16)mg/L]、白细胞计数[(7.11±1.62)×10^(9)/L]及创面细菌阳性率(1.49%)均显著低于对照组[(36.18±3.23)mg/L、(10.63±1.35)×10^(9)/L、(14.93%)](t=11.29、-6.73,χ^(2)=8.02,均P<0.05);观察组治疗总有效率91.04%(6/67)和干预满意度94.03%(63/67)均显著高于对照组[74.63%(50/67)和77.61%(52/67)],复发率(0)显著低于对照组8.96%(6/67),差异均有统计学意义(χ^(2)=6.35、7.42、6.28,均P<0.05)。结论一体化管理干预有利于提高慢性难愈合创面患者创面愈合速度、愈合质量和干预满意度,缓解疼痛程度和炎症反应,降低复发率,值得临床推广。

关键词：伤口愈合引流术疼痛 C反应蛋白质白细胞计数炎症复发病人满意度

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