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Spastin interacts with collapsin response mediator protein 3 to regulate neurite growth and branching

Neural Regeneration Research 2021年第12期16卷 2549-2556页

作者： Zhi-Sheng Ji jian-Ping Li Chao-Hua Fu jian-xian luo Hua Yang Guo-Wei Zhang Wutian Wu Hong-Sheng Lin Department of Orthopedics The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics Jiangmen Hospital of Sun Yat-sen UniversityJiangmenGuangdong ProvinceChina Re-Stem Biotechnology Co. Ltd.SuzhouJiangsu ProvinceChina Spine Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Cytoskeletal microtubule rearrangement and movement are crucial in the repair of spinal cord *** plays an important role in the regulation of microtubule *** spastin and collapsin response mediator proteins can regulate neurite growth and branching;however,whether spastin interacts with collapsin response mediator protein 3(CRMP3)during this process remains unclear,as is the mechanism by which CRMP3 participates in the repair of spinal cord *** this study,we used a proteomics approach to identify key proteins associated with spinal cord injury *** then employed liquid chromatography-mass spectrometry to identify proteins that were able to interact with glutathione ***,co-immunoprecipitation and staining approaches were used to evaluate potential interactions between spastin and ***,we co-transfected primary hippocampal neurons with CRMP3 and spastin to evaluate their role in neurite *** spectrometry identified the role of CRMP3 in the spinal cord injury repair *** chromatography-mass spectrometry pulldown assays identified three CRMP3 peptides that were able to interact with ***3 and spastin were co-expressed in the spinal cord and were able to interact with one another in vitro and in ***,CRMP3 overexpression was able to enhance the ability of spastin to promote neurite growth and ***,our results confirm that spastin and CRMP3 play roles in spinal cord injury repair by regulating neurite growth and *** proteins may therefore be novel targets for spinal cord injury *** Institutional Animal Care and Use Committee of Jinan University,China approved this study(approval ***-20181008-03)on October 8,2018.

关键词： collapsin response mediator protein 3 liquid chromatography-mass spectrometry microtubule neurite growth protein interactions proteomics spastin spinal cord injury

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Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan Sun Lulin Li jian luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of Care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation

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26-Membered Hexaazamacrocycle-bonded Silica Stationary Phase for the Separation of Ephedrines Using Liquid Chromatography

26-Membered Hexaazamacrocycle-bonded Silica Stationary Phase...

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全国第十四届大环化学暨第六届超分子化学学术讨论会

作者： SUN Yin-juan HE Li-jun~* WANG Chun-jian luo xian-li School of Chemistry and Chemical Engineering,Henan University of Technology,Zhengzhou(450001)

＜正＞As for ephedrines,they are basic compounds with polar functional groups,and such compounds exhibit severe band tailing and low plate numbers in HPLC *** the paper, 26-Membered Hexaazarnacrocycle bonded stationar... 详细信息

关键词： 26-Membered Hexaazamacrocyc stationary phase ephedrines

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu xiandeng Li Mi Li xian Wu Xiaohui Huang Ajing Xu Yan Liu jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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聚间苯二甲酰间苯二胺树脂的合成研究

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精细化工中间体 2017年第4期47卷 46-50页

作者：刘国文徐健罗先福臧阳陵湖南化工研究院有限公司湖南长沙410014 农用化学品湖南省重点实验室湖南长沙410014 湖南海利常德农药化工有限公司湖南常德415000

以间苯二胺为原料,在溶剂N,N-二甲基乙酰胺中与间苯二甲酰氯反应,聚合成间苯二甲酰间苯二胺树脂。通过在微通道反应器中进行聚合反应时,反应物配比有效控制在1.005~1.000,反应温度0~10℃,溶剂水份300×10^(-6)g/g以下,两种单体进料速率5... 详细信息

以间苯二胺为原料,在溶剂N,N-二甲基乙酰胺中与间苯二甲酰氯反应,聚合成间苯二甲酰间苯二胺树脂。通过在微通道反应器中进行聚合反应时,反应物配比有效控制在1.005~1.000,反应温度0~10℃,溶剂水份300×10^(-6)g/g以下,两种单体进料速率5∶4~5∶3,此条件下,聚合物粘度1.9~2.1,分子量分布稳定。

关键词：间苯二甲酰氯间苯二胺缚酸剂中和剂微通道反应器

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Study of Oxidation of Glutathione Treated with Hypochlorous Acid by Capillary Electrophoresis

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Chinese Chemical Letters 2001年第7期12卷 623-624页

作者： xian luo jian De LU Xiao Yun FU Analytical and Testing Center Zhejiang UniversityHangzhou 310027

Capillary electrophoresis (CE) method was developed for the separation and quantification of reduced glutathione (GSH), oxidized glutathione (GSSG) and glutathione sulphonic acid (GSO(3)H). Baseline separation was obtained within five minutes. The effects of reaction time and molar ratio of hypochlorous acid (HOCl) to GSH on the oxidation of GSH were investigated.

关键词： Glutathione oxidation capillary electrophoresis

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Study of Oxidation of Glutathione by Capillary Electrophoresis

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Chinese Chemical Letters 2001年第4期12卷 363-364页

作者： xian luo jian De LU Xiao Yun FU Department of Chemistry Zhejiang UniversityHangzhou 310027

A capillary electrophoresis method for the separation and quantification of reduced glutathione (GSH) and oxidized glutathione (GSSG) was developed. A baseline separation was achieved within five minutes. The effects ... 详细信息

关键词： Glutathione oxidation capillary electrophoresis

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Seismic response of the Lengzhuguan slope during Kangding Ms5.8 earthquake

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Journal of Mountain Science 2017年第11期14卷 2337-2347页

作者： WANG Yun-sheng HE jian-xian luo Yong-hong State Key Laboratory of Geohazard Prevention and Geoenvironmental Protection Chengdu University of Technology Key Laboratory of Shale Gas and Geoengineering Institute of Geology and Geophysics Chinese Academy of Sciences University of Chinese Academy of Sciences

In order to investigate the role of the amplification of peak ground acceleration(PGA) in seismic landslide formation mechanisms and study how earthquake waves interact with rock structures, a few strong-motion seismometers are installed at various locations on both sides of the Lengzhuguan gully. Five strong-motion seismometers were triggered at different depths in a tunnel at the same altitude during the Kangding Ms 5.8 earthquake on November 25 th, 2014. The data reveal that the horizontal peak acceleration(PGA_H) at each site decreased with increasing site depths. The PGAH at the deepest monitoring site(99 m from the tunnel entrance) was approximately half that of the outermost site. The amplitude of the acceleration response spectrum was also attenuated from the entrance inwards, the dynamic magnification factor(β) of the standard acceleration spectrum was less than 3.5, and rate of change was the same as that for the amplitude acceleration response. The Fourier spectra of each monitoring site also decreased from the outside inwards, and the components of the Fourier spectra were more complex at the surface.

关键词： Earthquake Tunnel Ground motionattenuation Topographic effects Lengzhuguan Horizontal peak acceleration

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A novel active-passive protection strategy endows carbonyl iron with excellent intelligent anti-corrosion and microwave absorption dual functional characteristics

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Nano Research 2025年第1期18卷 487-500页

作者： Wei Tian Quanyuan Feng Linbo Zhang Yinfan Liu xian jian Longjiang Deng Institute of Microelectronics School of Information Science and TechnologySouthwest Jiaotong UniversityChengdu 611756China National Engineering Researching Centre of Electromagnetic Radiation Control Materials Key Laboratory of Multi-Spectral Absorbing Materials and Structures of Ministry of EducationState Key Laboratory of Electronic Thin Films and Integrated DevicesSchool of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China The Yangtze Delta Region Institute(Huzhou)&School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaHuzhou 313001China

Carbonyl iron absorbers(CI)face significant challenges in practical applications,such as corrosion,interface bonding failure,detachment,and high maintenance ***,we have developed intelligent self-healing technology based on proactive/passive mechanisms via in situ synthesis of self-healing factors(polydopamine/benzotriazole(PDA/BTA))and physical barrier layers(SiO_(2)/1,1,1,3,3,3-hexamethyl disilazane,SiO_(2)/HMDS)to enhance corrosion resistance,while also being compatible with efficient microwave absorption *** unique multiscale structure gives full play to the utilization of the roles of each functional layer,including the intelligent self-healing features of PDA/BTA,physical shielding and spatial confinement characteristics of SiO_(2)/HMDS,and magnetic-dielectric synergistic mechanism resulted from the good impedance matching characteristics,the conduction loss,the interfacial polarization loss and natural *** asfabricated composites achieved an exceptional minimum reflection loss value of-55.4 dB at 10.7 GHz and the effective absorption band of 7.6 ***,it still exhibits obvious self-healing and corrosion resistance characteristics after 360 h corrosion treatment,ascribed to the self-healing mechanism of PDA/BTA and the blocking intervention effect of SiO_(2)/*** work is considered to pave the way for the synthesis of high-performance magnetic absorbers,especially in enhancing their intelligent self-healing ability in corrosive environments.

关键词： microwave absorption intelligent self-healing technology carbonyl iron multiscale structure magneticdielectric synergistic mechanism

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基于改进粒子群算法的光伏逆变器控制参数辨识

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河南理工大学学报（自然科学版） 2025年第1期44卷 124-133页

作者：罗建孙越江丽娟重庆大学输配电装备及系统安全与新技术国家重点实验室重庆400044 国网安徽省电力有限公司培训中心安徽合肥230022

精准的光伏并网逆变器模型是研究大规模光伏接入下电力系统故障特性的重要工具。目的为了解决现有光伏逆变器仿真模型与实际工作中的光伏逆变器特性相差较大的问题,方法提出采用参数辨识的方法构建逆变器的辨识模型。以重庆云阳某1 MW... 详细信息

精准的光伏并网逆变器模型是研究大规模光伏接入下电力系统故障特性的重要工具。目的为了解决现有光伏逆变器仿真模型与实际工作中的光伏逆变器特性相差较大的问题,方法提出采用参数辨识的方法构建逆变器的辨识模型。以重庆云阳某1 MW光伏电站为实际参照模型,首先根据实际工作情况将逆变器的工作区间划分为3个阶段,利用数学扰动法分别对3个阶段中的待辨识参数划分灵敏度高低等级,并由此提出不同阶段不同灵敏度参数分步辨识策略;其次,分阶段采集实际光伏电站工作数据,对该数据进行分析处理,获得各待辨识参数的初始取值范围,设计同步辨识参数实验作为参照;最后提出改进的混沌遗传粒子群优化算法(chaos genetic algorithm of particle swarm optimization,CGAPSO)作为辨识算法,分步分工作阶段辨识相关参数,通过对比参数的同步辨识结果,验证所提方法的优越性,并将辨识结果代入仿真模型。结果结果表明,低灵敏度参数的同步辨识结果误差远超过可接受范围,而CGAPSO分步辨识出的相关参数误差皆在1.1%以下,精度远高于同步辨识结果。结论基于改进粒子群算法构建的辨识模型输出数据与实际逆变器工作数据契合度高,可准确反映逆变器实际工作特性。

关键词：光伏并网逆变器逆变器控制策略参数辨识数学扰动法改进粒子群优化算法

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