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Future therapeutic implications of new molecular mechanism of colorectal cancer

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World Journal of Gastroenterology 2023年第16期29卷 2359-2368页

作者： Sen Lu Cheng-You Jia jian-she yang Department of Surgical Anesthesiology First Affiliated Hospital of Anhui University of Science and TechnologyHuainan 232001Anhui ProvinceChina Department of Nuclear Medicine and Oncology Research Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China

High incidence(10.2%)and mortality(9.2%)rates led to the ranking of colorectal cancer(CRC)as the second most malignant tumor spectrum worldwide in *** strategies are becoming highly dependent on the molecular characteristics of *** classical theories accept two models depicting the origin of CRC:The progression of adenoma to cancer and transformation from serrated polyps to ***,the molecular mechanism of CRC development is very *** instance,CRCs originating from laterally spreading tumors(LST)do not adhere to any of these models and exhibit extremely serious progression and poor *** this article,we present another possible pathway involved in CRC development,particularly from LST,with important molecular characteristics,which would facilitate the design of a novel strategy for targeted therapy.

关键词： Colorectal cancer Laterally spreading tumors Molecular mechanism Truncated adenomatous polyposis coli mutation Golgi fragmentation Cancerous mechanism

Comparison of clonogenic assay with premature chromosome condensation assay in prediction of human cell radiosensitivity

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World Journal of Gastroenterology 2006年第16期12卷 2601-2605页

作者： Zhuan-Zi Wang Wen-jian Li Hong Zhang jian-she yang Rong Qiu Xiao Wang Graduate School of Chinese Academy of Sciences Beijing 100039 China Institute of Modem PhysicsChinese Academy of Sciences Lanzhou 730000 Gansu ProvinceChina Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 Gansu Province China

AIM： To determine whether the number of non-rejoining G2-chromatid breaks can predict the radiosensitivity of human cell lines. METHODS： Cell lines of human ovary carcinoma cells （HO8910）, human hepatoma cells （HepG2） and liver cells （L02） were irradiated with a range of doses and assessed both of cell survival and non-rejoining G2-chromatid breaks at 24 h after irradiation. Cell survival was documented by a colony assay. Non-rejoining G2-chromatid breaks were measured by counting the number of non-rejoining G2 chromatid breaks at 24 h after irradiation, detected by the prematurely chromosome condensed （PCC） technique. RESULTS： A linear-quadratic survival curve was observed in three cell lines, and HepG2 was the most sensitive to γ-radiaUon. A dose-dependent linear increase was observed in radiation-induced non-rejoining G2- PCC breaks measured at 24 h after irradiation in all cell lines, and HepG2 was the most susceptible to induction of non-rejoining G2-PCC breaks. A close correlation was found between the clonogenic radiosensitivity and the radiation-induced non-rejoining G2-PCC breaks （r=0.923）. Furthermore, survival-aberration correlations for two or more than two doses lever were also significant. CONCLUSION： The number of non-rejoining G2 PCC breaks holds considerable promise for predicting the radiosensitMty of normal and tumor cells when two or more than two doses lever is tested.

关键词： Clonogenic radiosensitivity Non-rejoining G2-chromatid breaks Correlation

Premature chomosome condensation technique: A very promising approach to radiotherapy for digestive system cancers

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World Journal of Gastroenterology 2006年第44期12卷 7227-7227页

作者： jian-she yang Life Science School of Northwest Normal University Lanzhou 730070 Gansu Province China

Dear Editior-in-Chief, I am grateful to the renowned World Journal of Gastroenterology for publishing our manuscript about hepatoma radiosensitivity in volume 11 issue 26, page 4098-4101m, Since this paper appeared online first, it was widely considered. Up to date, it has been cited four times in various journals covered by Science Citation IndexE241, and the click count and download count added up to 459 and 163tsl, respectively.

关键词： CARBON-IONS

Treatment regimen design in clinical radiotherapy for hepatoma

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World Journal of Gastroenterology 2007年第4期13卷 651-651页

作者： jian-she yang Life Science School of Northwest Normal University Lanzhou 730070 Gansu Province China Shanghai Institute of Applied Physics ChineseAcademy of Sciences Shanghai 201800 China

Recently, the paper by Wang et at published in World Journal of Gastroenterology has given rise to great interest of many researchers. It is well known that hepatoma is one of the lethal diseases with a high incidence in the world, especially in Asia. Radiotherapy is the main treatment modality of hepatoma in clinical practice. Unfortunately, intrinsic radiosensitivity of cancer cells is not fully understood, though a large number of papers on it are now available. yang and colleagues 21 have developed the premature chromosome condensation technique for clinical radiotherapy of hepatoma. A precise and quick measurement of cell radiosensitivity can detect the highrisk results after exposure to a large dose.

关键词： Radiotherapy Treatment regimen design Treatment of hepatoma

How is artificial intelligence applied in solid tumor imaging?

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Artificial Intelligence in Cancer 2021年第4期2卷 49-50页

作者： jian-she yang Qiang Wang Shanghai Tenth People's Hospital Tongji UniversityShanghai 200072China Basic Medicine College Gansu Medical CollegePingliang 744000Gansu ProvinceChina

How is artificial intelligence(AI)applied in solid tumor imaging?What is the essential value of AI for tumor precision diagnosis and can it wholly replace the human beings?Some opinions in this letter should be consid... 详细信息

关键词： Artificial intelligence Tumor Imaging Diagnosis

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Review on nano-drugs

Natural Science 2010年第1期2卷 41-48页

作者： Yong Liu Tian-Shui Niu Long Zhang jian-she yang 不详

Nano materials is a new type of drug carriers with very promising application. In recent years, great progress was achieved in making drugs own the characteristics of targeted and con-trolled release via nanotechnologies. This paper addressed the capability of nano drugs on tar-geting to cells, penetrating through epicyte, controlled release and the security issues re-sulting from its using. We gave the prospect of nano drugs in biology and medicine applying.

关键词： Nano Drug Targeting Cell Penetration Controlled Release

Fabrication of a novel electrochemical sensor based on MnFe_(2)O_(4)/graphene modified glassy carbon electrode for the sensitive detection of bisphenol A

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Journal of Central South University 2024年第6期31卷 1856-1869页

作者： GAO Si-lei TANG jian-she XIANG Li LONG Jin-wei Department of Environmental and Energy Engineering Anhui Jianzhu UniversityHefei 230601China Anhui Provincial Key Laboratory of Environmental Pollution Control and Resource Reuse Hefei 230601China

Manganese ferrite(MnFe_(2)O_(4))has the advantages of simple preparation,high resistivity,and high crystal ***,we have developed an electrochemical sensor utilizing graphene and MnFe_(2)O_(4) nanocomposites modified glassy carbon electrode(GCE),which is very efficient and sensitive to detect bisphenol A(BPA).MnFe_(2)O_(4)/graphene(GR)was synthesized by immobilizing the MnFe_(2)O_(4) microspheres on the graphene nanosheets via a simple one-pot solvothermal *** morphology and structure of the MnFe_(2)O_(4)/GR nanocomposite have been characterized through scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FT-IR),X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS).In addition,electrochemical properties of the modified materials are comparably explored by means of cyclic voltammetry(CV),electrochemical impedance spectroscopy(EIS)and differential pulse voltammetry(DPV).Under the optimal conditions,the proposed electrochemical sensor for the detection of BPA has a linear range of 0.8-400μmol/L and a detection limit of 0.0235μmol/L(S/N=3)with high sensitivity,good selectivity and high *** addition,the proposed sensor was used to measure the content of BPA in real water samples with a recovery rate of 97.94%-104.56%.At present,the synthesis of MnFe_(2)O_(4)/GR provides more opportunities for the electrochemical detection of BPA in practical applications.

关键词： MnFe_(2)O_(4) graphene electrochemical sensor bisphenol A

Difference in microstructural characteristics of stamp-charged coke and gravity-charged coke with approximate macroscopic performance

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Journal of Iron and Steel Research International 2024年第5期31卷 1050-1062页

作者： Chong Zou Zheng-yan Huang jian-yun Li Bin Li Shi-wei Liu Yuan she School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710311ShaanxiChina Technical Center of Shandong Iron and Steel Co. Ltd.(Laiwu Branch)Jinan271104ShandongChina

The microstructural characteristics including optical texture,porosity and pore structure and chemical structure of stamp-charged coke(SCC)and gravity-charged coke(GCC)with similar conventional macro-indicators were investigated,and the properties including micro-strength,reactivity of coke matrix and that after alkali enrichment were comparatively studied by various characterization *** anisotropic structure of SCC is composed of high content of fine mosaic texture,while the content of medium mosaic texture,coarse texture and fibrous texture is *** statistical average shows that the fine mosaic average of SCC(24.89%)is 3.78 times the GCC average(6.58%),and the coarse mosaic average(1.24%)is only about 1/3 of the GCC average(3.43%).The porosity of SCC is lower than that of GCC,but tamping process does not lead to the fact that the number of closed pores of SCC is significantly lower than that of *** the structure of SCC is compact,its pore number is large and the pore wall is *** of coke with diameter less than 150 nm seem unaffected by tamping *** aromatic structure of SCC was less ordered than that of GCC,which was speculated to be related to the addition of more low metamorphic coal in *** microscopic strength and structural strength of SCC are lower than those of *** reactivity of coke matrix is affected by the specific surface area,but it is not the determining factor of its *** improvement in dissolution reactivity of coke after potassium enrichment is independent of coke type.

关键词： Stamp-charged coke Optical texture Porosity Microstructure Reactivity

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高师体育专业实施研究型教学的理论构建

武汉体育学院学报 2004年第1期38卷 100-102页

作者：周建社杨金云湖南师范大学体育学院湖南长沙410012

从教师教学的角度解读研究性学习,对高师体育专业实施研究型教学的类型、特点和条件,研究型教学的设计,研究型教学评价等理论问题进行了基本构建,旨在立足高师体育创新人才的培养,为高师体育专业如何实施研究型教学提供参考。

关键词：高师体育专业研究型教学理论构建