Future therapeutic implications of new molecular mechanism of colorectal cancer
作者机构：Department of Surgical AnesthesiologyFirst Affiliated Hospital of Anhui University of Science and TechnologyHuainan 232001Anhui ProvinceChina Department of Nuclear Medicine and Oncology ResearchShanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2023年第29卷第16期
页 面：2359-2368页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by the National Natural Science Foundation of China No.72171170 and 82071964.
主 题：Colorectal cancer Laterally spreading tumors Molecular mechanism Truncated adenomatous polyposis coli mutation Golgi fragmentation Cancerous mechanism
摘 要：High incidence(10.2%)and mortality(9.2%)rates led to the ranking of colorectal cancer(CRC)as the second most malignant tumor spectrum worldwide in 2020.Treatment strategies are becoming highly dependent on the molecular characteristics of CRC.The classical theories accept two models depicting the origin of CRC:The progression of adenoma to cancer and transformation from serrated polyps to cancer.However,the molecular mechanism of CRC development is very complex.For instance,CRCs originating from laterally spreading tumors(LST)do not adhere to any of these models and exhibit extremely serious progression and poor outcomes.In this article,we present another possible pathway involved in CRC development,particularly from LST,with important molecular characteristics,which would facilitate the design of a novel strategy for targeted therapy.
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