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Stability of rat models of fluid percussion-induced traumatic brain injury: comparison of three different impact forces

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Neural Regeneration Research 2015年第7期10卷 1088-1094页

作者： Yun-peng Lin Rong-cai jiang jian-ning zhang Department of Neurosurgery Tianjin Medical University General Hospital Tianjin Neurological Institute Key Laboratory of Post-trauma Neurorepair and Regeneration in Central Nervous System Ministry of Education Tianjin Key Laboratory of Injuries Variations and Regeneration of Nervous System Tianjin Medical University General Hospital

Fluid percussion-induced traumatic brain injury models have been widely used in experimental research for years. In an experiment, the stability of impaction is inevitably affected by factors such as the appearance of liquid spikes. Management of impact pressure is a crucial factor that determines the stability of these models, and direction of impact control is another basic element. To improve experimental stability, we calculated a pressure curve by generating repeated impacts using a fluid percussion device at different pendulum angles. A stereotactic frame was used to control the direction of impact. We produced stable and reproducible models, including mild, moderate, and severe traumatic brain injury, using the MODEL01-B device at pendulum angles of 6°, 11° and 13°, with corresponding impact force values of 1.0 ± 0.11 atm（101.32 ± 11.16 k Pa）, 2.6 ± 0.16 atm（263.44 ± 16.21 k Pa）, and 3.6 ± 0.16 atm（364.77 ± 16.21 k Pa）, respectively. Behavioral tests, hematoxylin-eosin staining, and magnetic resonance imaging revealed that models for different degrees of injury were consistent with the clinical properties of mild, moderate, and severe craniocerebral injuries. Using this method, we established fluid percussion models for different degrees of injury and stabilized pathological features based on precise power and direction control.

关键词： nerve regeneration traumatic brain injury fluid percussion impact force pressure curve head fixed impact peak animal models neural regeneration

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Perturbation to Lie Symmetry and Hojman Exact and Adiabatic Invariants of Generalized Raitzin Canonical Equation of Motion

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Communications in Theoretical Physics 2007年第4X期48卷 615-618页

作者： WANG Peng FANG jian-Hui DING ning zhang Xiao-Ni College of Physics and Technology China University of Petroleum Dongying 257061 China

In this paper, firstly, we get the Hojman exact invariants by Lie symmetry for an undisturbed generalized Raitzin equation of motion. Secondly, we study the perturbation to Lie symmetry of generalized Raitzin canonical equation of motion and get Hojman adiabatic invariants. Lastly, an example is given to illustrate the application of the results.

关键词： generalized mechanics symmetry Raitzin canonical equation perturbation adiabatic invariant

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Dynamic changes in growth factor levels over a 7-day period predict the functional outcomes of traumatic brain injury

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Neural Regeneration Research 2018年第12期13卷 2134-2140页

作者： Shuai Zhou Dong-Pei Yin Yi Wang Ye Tian Zeng-Guang Wang jian-ning zhang Department of Intensive Care Unit Tianjin Medical University General Hospital Tianjin China Tianjin Neurological Institute Tianjin China Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System Ministry of Education Tianjin China Tianjin Key Laboratory of Injuries Variations and Regeneration of Nervous System Tianjin China Department of Neurosurgery Tianjin Medical University General Hospital Tianjin China

Traumatic brain injury（TBI） can result in poor functional outcomes and death, and overall outcomes are varied. Growth factors, such as angiopoietin-1（Ang-1）, vascular endothelial growth factor（VEGF）, and granulocyte-colony stimulating factor（G-CSF）, play important roles in the neurological functions. This study investigated the relationship between serum growth factor levels and long-term outcomes after TBI. Blood samples from 55 patients were collected at 1, 3 and 7 days after TBI. Blood samples from 39 healthy controls were collected as a control group. Serum Ang-1, G-CSF, and VEGF levels were measured using ELISA. Patients were monitored for 3 months using the Glasgow Outcome Scale-Extended（GOSE）. Patients having a GOSE score of 〉 5 at 3 months were categorized as a good outcome, and patients with a GOSE score of 1-5 were categorized as a bad outcome. Our data demonstrated that TBI patients showed significantly increased growth factor levels within 7 days compared with healthy controls. Serum levels of Ang-1 at 1 and 7 days and G-CSF levels at 7 days were significantly higher in patients with good outcomes than in patients with poor outcomes. VEGF levels at 7 days were remarkably higher in patients with poor outcomes than in patients with good outcomes. Receiver operating characteristic analysis showed that the best cut-off points of serum growth factor levels at 7 days to predict functional outcome were 1,333 pg/mL for VEGF, 447.2 pg/mL for G-CSF, and 90.6 ng/mL for Ang-1. These data suggest that patients with elevated levels of serum Ang-1, G-CSF, and decreased VEGF levels had a better prognosis in the acute phase of TBI（within 7 days）. This study was registered with the Chinese Clinical Trial Registry（registration number： ChiCTR1800018251） on September 7, 2018.

关键词： nerve regeneration traumatic brain injury vascular endothelial growth factor angiopoietin-1 granulocyte-colony stimulating factor outcomes secondary brain injuries blood-brain barrier brain edema acute phase clinical trial neural regeneration

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Dexmedetomidine attenuates traumatic brain injury: action pathway and mechanisms

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Neural Regeneration Research 2018年第5期13卷 819-826页

作者： Dong Wang Xin Xu Yin-Gang Wu Li Lyu Zi-Wei Zhou jian-ning zhang Department of Neurosurgery Tianjin Medical University General Hospital Tianjin Neurological Institute Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System Ministry of Education and Tianjin City Department of Cardiovascular Tianjin Children's Hospital

Traumatic brain injury induces potent inflammatory responses that can exacerbate secondary blood-brain barrier（BBB） disruption, neuronal injury, and neurological dysfunction. Dexmedetomidine is a novel α2-adrenergic receptor agonist that exert protective effects in various central nervous system diseases. The present study was designed to investigate the neuroprotective action of dexmedetomidine in a mouse traumatic brain injury model, and to explore the possible mechanisms. Adult male C57 BL/6 J mice were subjected to controlled cortical impact. After injury, animals received 3 days of consecutive dexmedetomidine therapy（25 μg/kg per day）. The modified neurological severity score was used to assess neurological deficits. The rotarod test was used to evaluate accurate motor coordination and balance. Immunofluorescence was used to determine expression of ionized calcium binding adapter molecule-1, myeloperoxidase, and zonula occluden-1 at the injury site. An enzyme linked immunosorbent assay was used to measure the concentration of interleukin-1β（IL-1β）, tumor necrosis factor α, and IL-6. The dry-wet weight method was used to measure brain water content. The Evans blue dye extravasation assay was used to measure BBB disruption. Western blot assay was used to measure protein expression of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3（NLRP3）, caspase-1 p20, IL-1β, nuclear factor kappa B（NF-κB） p65, occluding, and zonula occluden-1. Flow cytometry was used to measure cellular apoptosis. Results showed that dexmedetomidine treatment attenuated early neurological dysfunction and brain edema. Further, dexmedetomidine attenuated post-traumatic inflammation, up-regulated tight junction protein expression, and reduced secondary BBB damage and apoptosis. These protective effects were accompanied by down-regulation of the NF-κB and NLRP3 inflammasome pathways. These findings suggest that dexmedetomidine exhibits neuroprotective effects

关键词： nerve regeneration traumatic brain injury neuroinflammation nuclear factor kappa B NLRP3 inflammasome brain edema blood-brain barrier tight junction proteins apoptosis neuroprotection dexmedetomidine neural regeneration

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Hotspots and frontiers of the relationship between gastric cancer and depression:A bibliometric study

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World Journal of Gastroenterology 2023年第46期29卷 6076-6088页

作者： Jia-Yu Liu Ji-Qi Zheng Cheng-Liang Yin Wen-Pei Tang jian-ning zhang Department of Neurosurgery The First Medical CentreChinese PLA General HospitalBeijing 100853China School of Health Humanities Peking UniversityBeijing 100191China Medical Big Data Research Center Medical Innovation Research Division of Chinese PLA General HospitalBeijing 100853China National Engineering Research Center for Medical Big Data Application Technology Chinese PLA General HospitalBeijing 100853China

BACKGROUND A significant relationship between gastric cancer(GC)and depression has been found in the last 20 ***,there is no comprehensive information that helps researchers find popular and potential research directions on GC and *** To determine the research status and hotspots by bibliometric analysis of relevant publications on the relationship between GC and *** We used the Web of Science Core Collection to search and collate the literature on GC and depression from 2000 to 2022 on 31 May,***,visualization analysis was performed using VOSviewer software(version 1.6.19)and the Bibliometrix package in R *** We retrieved 153 pertinent publications from 2000 to *** annual publication count showed an overall upward *** had the most prominent publications and significant contributions to this field(n=64,41.83%).Before 2020,most studies focused on“the effect of GC on the development and progression of depression in patients.”The latest research trends indicate that“the effect of depression on the occurrence and development of GC and its mechanism”will receive more attention in the *** The study of“the effect of depression on the occurrence and development of GC and its mechanism”has emerged as a novel research theme over the past two years,which may become a research hotspot in this *** study provides new insights into the hotpots and frontiers of the relationship between GC and depression,potentially guiding researchers toward hot research topics in the future.

关键词： Gastric cancer Depression Bibliometric analysis Visualization Web of Science

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Atorvastatin combined with low-dose dexamethasone for vascular endothelial cell dysfunction induced by chronic subdural hematoma

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Neural Regeneration Research 2021年第3期16卷 523-530页

作者： Yue-Shan Fan Bo Wang Dong Wang Xin Xu Chuang Gao Ying Li Shu zhang Gui-Li Yang Xiao Liu Rong-Cai jiang jian-ning zhang Department of Neurosurgery General Hospital of Tianjin Medical UniversityTianjinChina Tianjin Neurological Institute Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Graduate School Tianjin Medical UniversityTianjinChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Atorvastatin has been shown to be a safe and effective non-surgical treatment option for patients with chronic subdural ***,treatment with atorvastatin is not effective in some patients,who must undergo further surgical *** has anti-inflammatory and immunomodulatory effects,and low dosages are safe and effective for the treatment of many diseases,such as ankylosing spondylitis and community-acquired ***,the effects of atorvastatin and low-dose dexamethasone for the treatment of chronic subdural hematoma remain poorly *** samples of patients with chronic subdural hematoma admitted to the General Hospital of Tianjin Medical University of China were collected and diluted in endothelial cell medium at 1:1 as the hematoma ***,dexamethasone,or their combination was added to the culture *** main results were as follows:hopping probe ion conductance microscopy and permeability detection revealed that the best dosages to improve endothelial cell permeability were 0.1μM atorvastatin and 0.1μM ***,dexamethasone,or their combination could markedly improve the recovery of injured endothelial *** subcutaneously injected with diluted hematoma solution and then treated with atorvastatin,dexamethasone,or their combination exhibited varying levels of rescue of endothelial cell *** probe ion conductance microscopy,western blot assay,and polymerase chain reaction to evaluate the status of human cerebral endothelial cell status and expression level of tight junction protein indicated that atorvastatin,dexamethasone,or their combination could reduce subcutaneous vascular leakage caused by hematoma ***,the curative effect of the combined treatment was significantly better than that of either single *** of Krüppel-like factor 2 protein in human cerebral endothelial cells was significantly increased,as was expression of the tight junctio

关键词： brain brain trauma cells central nervous system inflammation plasticity protein repair

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Risk factors for corticosteroid insufficiency during the sub-acute phase of acute traumatic brain injury

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Neural Regeneration Research 2020年第7期15卷 1259-1265页

作者： Xin Chen Yan Chai Shao-Bo Wang Jia-Chong Wang Shu-Yuan Yue Rong-Cai jiang jian-ning zhang Department of Neurosurgery General Hospital of Tianjin Medical UniversityTianjinChina Tianjin Neurological Institute Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous SystemTianjinChina Department of Neurosurgery Ordos Central HospitalOrdosInnerMongolia Autonomous RegionChina Department of Neurosurgery Affiliated Haikou Hospital of Xiangya Medical CollegeCentral South UniversityChangshaHunan ProvinceChina

Hypothalamic-pituitary-adrenal axis dysfunction may lead to the occurrence of critical illness-related corticosteroid *** illness-related corticosteroid insufficiency can easily occur after traumatic brain injury,but few studies have examined this occurrence.A multicenter,prospective,cohort study was performed to evaluate the function of the hypothalamic-pituitary-adrenal axis and the incidence of critical illness-related corticosteroid insufficiency during the sub-acute phase of traumatic brain *** hundred and forty patients with acute traumatic brain injury were enrolled from the neurosurgical departments of three tertiary-level hospitals in China,and the critical illness-related corticosteroid insufficiency incidence,critical-illness-related corticosteroid insufficiency-related risk factors,complications,and 28-day mortality among these patients was *** illness-related corticosteroid insufficiency was diagnosed in patients with plasma total cortisol levels less than 10μg/dL(275.9 nM)on post-injury day 4 or when serum cortisol was insufficiently suppressed(less than 50%)during a dexamethasone suppression test on post-injury day *** results demonstrated that critical illness-related corticosteroid insufficiency occurred during the sub-acute phase of traumatic brain injury in 5.6%of patients with mild injury,22.5%of patients with moderate injury,and 52.2%of patients with severe *** brain injury-induced critical illness-related corticosteroid insufficiency was strongly correlated to injury severity during the sub-acute stage of traumatic brain *** brain injury patients with critical illness-related corticosteroid insufficiency frequently presented with hemorrhagic cerebral contusions,diffuse axonal injury,brain herniation,and *** in the incidence of hospital-acquired pneumonia,gastrointestinal bleeding,and 28-day mortality were observed between patients with and without critical i

关键词： brain herniation corticosteroid critical illness-related corticosteroid dexamethasone suppression test diffuse axonal injury gastrointestinal bleeding hemorrhagic cerebral contusions hospital-acquired pneumonia insufficiency prognosis traumatic brain injury

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Neuroprotective effects of cold-inducible RNA-binding protein during mild hypothermia on traumatic brain injury

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Neural Regeneration Research 2016年第5期11卷 771-778页

作者： Guan Wang jian-ning zhang Jia-kui Guo Ying Cai Hong-sheng Sun Kun Dong Cheng-gang Wu Postgraduate Institution Tianjin Medical University Department of Neurosurgery Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Department of Neurosurgery General Hospital of Tianjin Medical University Department of Neurosurgery Tianjin Huanhu Hospital

Cold-inducible RNA-binding protein（CIRP）, a key regulatory protein, could be facilitated by mild hypothermia in the brain, heart and liver. This study observed the effects of mild hypothermia at 31 ± 0.5℃ on traumatic brain injury in rats. Results demonstrated that mild hypothermia suppressed apoptosis in the cortex, hippocampus and hypothalamus, facilitated CIRP m RNA and protein expression in these regions, especially in the hypothalamus. The anti-apoptotic effect of mild hypothermia disappeared after CIRP silencing. There was no correlation between mitogen-activated extracellular signal-regulated kinase activation and CIRP silencing. CIRP silencing inhibited extracellular signal-regulated kinase-1/2 activation. These indicate that CIRP inhibits apoptosis by affecting extracellular signal-regulated kinase-1/2 activation, and exerts a neuroprotective effect during mild hypothermia for traumatic brain injury.

关键词： nerve regeneration traumatic brain injury mild hypothermia cold-inducible RNA-binding protein mitogen-activated extracellular signal-regulated kinase anti-apoptosis neural regeneration

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Cold water swimming pretreatment reduces cognitive deficits in a rat model of traumatic brain injury

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Neural Regeneration Research 2017年第8期12卷 1322-1328页

作者： Zi-wei Zhou Ya-dan Li Wei-wei Gao Jie-li Chen Shu-yuan Yue jian-ning zhang Department of Neurosurgery Tianjin Medical University General Hospital Tianjin China Tianjin Neurological Institute Tianjin China Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System Ministry of Education Tianjin China Tianjin Key Laboratory of Injuries Variations and Regeneration of Nervous System Tianjin China Intensive Care Units Tianjin Huanhu Hospital Tianjin China Department of Neurology Henry Ford Hospital Detroit MI USA

A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this study, we used a classic rat model of traumatic brain injury to test the hypothesis that cold water swimming preconditioning improved the recovery of cognitive functions and explored the mechanisms. Results showed that after traumatic brain injury, pre-conditioned rats（cold water swimming for 3 minutes at 4℃） spent a significantly higher percent of times in the goal quadrant of cold water swim, and escape latencies were shorter than for non-pretreated rats. The number of circulating endothelial progenitor cells was significantly higher in pre-conditioned rats than those without pretreatment at 0, 3, 6 and 24 hours after traumatic brain injury. Immunohistochemical staining and Von Willebrand factor staining demonstrated that the number of CD34~＋ stem cells and new blood vessels in the injured hippocampus tissue increased significantly in pre-conditioned rats. These data suggest that pretreatment with cold water swimming could promote the proliferation of endothelial progenitor cells and angiogenesis in the peripheral blood and hippocampus. It also ameliorated cognitive deficits caused by experimental traumatic brain injury.

关键词： nerve regeneration cold water swimming cognitive deficits endothelial progenitor cells angiogenesis neural repair stress Morriswater maze fluid percussion injury model CD34 Von Willebrand factor neural regeneration

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Cognitive impairment after traumatic brain injury is associated with reduced long-term depression of excitatory postsynaptic potential in the rat hippocampal dentate gyrus

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Neural Regeneration Research 2018年第10期13卷 1753-1758页

作者： Bao-Liang zhang Yue-Shan Fan Ji-Wei Wang Zi-Wei Zhou Yin-Gang Wu Meng-Chen Yang Dong-Dong Sun jian-ning zhang Department of Neurosurgery Tianjin Medical University General HospitalTianjin Neurological InstituteKey Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous SystemTianjin China

Traumatic brain injury can cause loss of neuronal tissue, remote symptomatic epilepsy, and cognitive deficits. However, the mechanisms underlying the effects of traumatic brain injury are not yet clear. Hippocampal excitability is strongly correlated with cognitive dysfunction and remote symptomatic epilepsy. In this study, we examined the relationship between traumatic brain injury-induced neuronal loss and subsequent hippocampal regional excitability. We used hydraulic percussion to generate a rat model of traumatic brain injury. At 7 days after injury, the mean modified neurological severity score was 9.5, suggesting that the neurological function of the rats was remarkably impaired. Electrophysiology and immunocytochemical staining revealed increases in the slope of excitatory postsynaptic potentials and long-term depression（indicating weakened long-term inhibition）, and the numbers of cholecystokinin and parvalbumin immunoreactive cells were clearly reduced in the rat hippocampal dentate gyrus. These results indicate that interneuronal loss and changes in excitability occurred in the hippocampal dentate gyrus. Thus, traumatic brain injury-induced loss of interneurons appears to be associated with reduced long-term depression in the hippocampal dentate gyrus.

关键词： nerve regeneration long-term depression traumatic brain injury hippocampus interneurons excitability dentate gyrus parvalbumin cholecystokinin electrophysiology quantification neural regeneration

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