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International Journal of Ophthalmology(English edition) 2020年第2期13卷 317-324页

作者： Chun-Yan Guo Xiao-Hui qi jian-ming qi People’s Hospital of Dingxi Dingxi 743000Gansu ProvinceChina

●AIM:To systematically review and Meta-analyze studies of managing open angle glaucoma(OAG)with gonioscopyassisted transluminal trabeculotomy(GATT)and to evaluate its effectiveness and safety.●METHODS:Eligible studies were retrieved and screened from five main electronic *** difference(MD)was hired to show the pooled effectiveness of intraocular pressure(IOP)and medication decrease achieved by *** addition,combined surgical success and reoperation rates were calculated,and complications were also summarized.●RESULTS:Ten studies were included for systematic review,but one study was not pooled for Meta-analysis due to the repeated *** combined IOP decrease after GATT was 9.81 mm Hg(95%CI:7.98-11.63 mm Hg)which showed significant reduction from the baselines(Z=10.52,P<0.0001).Similarly,the number of medications after GATT also decreased distinctly compared with that of medication before the surgery(Z=9.09,P<0.0001),and the pooled medication decrease was 1.68(95%CI:1.31-2.04).In addition,the combined surgical success rate was 85%,while the pooled reoperation rate was 20%.Sightthreatening complications occurred scarcely,whereas the pooled occurrence rate of hyphemia was as high as 36.0%.●CONCLUSION:GATT could effectively lower IOP and decrease medications for patients with ***,the procedure appears to be a safe and promising treatment for OAG due to its minimally-invasive and conjunctiva-sparing nature.

关键词： gonioscopy-assisted transluminal trabeculotomy open angle glaucoma intraocular pressure complication Meta-analysis

Development of a large-scale isolation chamber system for the safe and humane care of medium-sized laboratory animals harboring infectious diseases

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第10期11卷 771-778页

作者： Xin PAN jian-cheng qi ming LONG Hao LIANG Xiao CHEN Han LI Guang-bo LI Hao ZHENG Department of Microbiology the Second Military Medical University Shanghai 200433 China

The close phylogenetic relationship between humans and non-human primates makes non-human primates an irreplaceable model for the study of human infectious *** this study,we describe the development of a large-scale automatic multi-functional isolation chamber for use with medium-sized laboratory animals carrying infectious *** isolation chamber,including the transfer chain,disinfection chain,negative air pressure isolation system,animal welfare system,and the automated system,is designed to meet all biological safety *** create an internal chamber environment that is completely isolated from the exterior,variable frequency drive blowers are used in the air-intake and air-exhaust system,precisely controlling the filtered air flow and providing an air-barrier protection.A double door transfer port is used to transfer material between the interior of the isolation chamber and the outside.A peracetic acid sterilizer and its associated pipeline allow for complete disinfection of the isolation *** of the isolation chamber parameters can be automatically controlled by a programmable computerized menu,allowing for work with different animals in different-sized cages depending on the research *** large-scale multi-functional isolation chamber provides a useful and safe system for working with infectious medium-sized laboratory animals in high-level bio-safety laboratories.

关键词： Multi-function Medium-sized animal Isolation chamber Biological safety

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甲烷气相均相选择氧化合成甲醇

石油化工 2003年第3期32卷 195-199页

作者：张昕贺德华张启俭朱起明清华大学化学系一碳化学与化工国家重点实验室北京100084

在特殊设计的不同尺寸的微型反应器和模试反应器中考察了反应温度、气体流速、压力、CH4/O2体积比、反应器恒温段长度以及运行时间等因素对CH4气相均相选择氧化合成CH3OH的影响。结果表明:430～470℃、较高的反应压力、较高的V(CH4)/V(O... 详细信息

在特殊设计的不同尺寸的微型反应器和模试反应器中考察了反应温度、气体流速、压力、CH4/O2体积比、反应器恒温段长度以及运行时间等因素对CH4气相均相选择氧化合成CH3OH的影响。结果表明:430～470℃、较高的反应压力、较高的V(CH4)/V(O2),较大的反应气体流量的条件下,甲烷转化率为10%～13%,甲醇选择性为55%～65%,收率为7%～8%。反应尾气中还含有相当量的CO和H2,CO2选择性可以被控制在较低水平(≤5%)。提出了以管道天然气为原料一次通过直接氧化法合成CH3OH的新构想。

关键词：甲烷合成甲醇选择氧化气相均相反应一次通过法

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu qi Li Ruihua Li qingwen Li Kai-Yu Tong Xiaosong Gu Dong ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

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伐尼克兰戒烟研究进展

中国新药与临床杂志 2017年第6期36卷 324-329页

作者：简启明马金龙汤彦广州医科大学/广州医科大学附属第一医院/广州呼吸疾病研究所/呼吸疾病国家重点实验室广东广州510120

伐尼克兰作为一种专门针对成人戒烟的处方药在中国上市已经8年有余。临床实践中伐尼克兰戒烟的有效性已经得到广泛肯定,对其安全性的研究,近年也取得了更深入的发展,在新研究成果的支撑之下,欧美已先后取消伐尼克兰安全警告标签。本文... 详细信息

伐尼克兰作为一种专门针对成人戒烟的处方药在中国上市已经8年有余。临床实践中伐尼克兰戒烟的有效性已经得到广泛肯定,对其安全性的研究,近年也取得了更深入的发展,在新研究成果的支撑之下,欧美已先后取消伐尼克兰安全警告标签。本文综述了伐尼克兰戒烟有效性及安全性的相关文献,以期澄清用药疑虑,促进合理用药,提高戒烟成功率。

关键词：戒烟伐尼克兰治疗结果安全临床研究

Effects of glutamic acid on spontaneous discharges of arcuate nucleus in hypothalamic slice from normal and inflamed rats

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Effects of glutamic acid on spontaneous discharges of arcuat...

Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： jian-ming PENG,qi ZHU,Xing-Hong jianG Department of Neurobiology,Laboratory of Aging and Nervous Diseases,School of Medicine,Soochow University, Suzhou 215123,China

＜正＞To study the influence of glutamic acid（Glu） on the electric activities of arcuate nucleus（ARC） neurons in the normal rats and inflamed rats which were induced by complete Freund’s adjuvant（CFA）.The experiment was performed on isolated mediobasal hypothalamus slice to observe the effect of Glu on unit discharges of ARC *** NMDA receptor agonist NMDA,NMDA receptor antagonist MK-801 and non-NMDA receptor antagonist CNQX were used to analyze the receptor mechanism of *** unit discharges were recorded *** immunohistochemistry was imployed to observe the expression of NMDAR 1 in the ARC neurons of normal rats and the CFA *** experimental results indicated that:（1） Three types of spontaneous discharge（regular firing,irregular firing,firing in bursts） were observed in ARC neurons.（2） Glu（200μmol/L） can enhance the electric activities of ARC *** effects can be mimicried by NMDA（25 umol/L） and blocked by MK-801（100 umol/L）.（3） The spontaneous discharge frequency of ARC neurons in CFA rats was higher than those in normal rats.（4） The excitatory effects of Glu and NMDA in the ARC neurons of CFA rats were more *** spontaneous discharge frequency of ARC neurons incresed significantly,the latency of drug action was shortened and the duration was *** excitatory response of ARC neurons to Glu and NMDA couldn’t be blocked by CNQX but could be partly blocked by MK-801.（5） The results of immunohistochemistry indicated an up-regulation of the expression of NMDAR 1 in the ARC neurons of the CFA *** results suggested that glutamate mechanism（mediated by NMDA receptor） is involved in the modulation of the electric activities of ARC *** response of ARC neurons to glutamic acid is sensitized in CFA-inflamed rats.

关键词： glutamic acid(Glu) NMDA receptor MK-801 arcuate nucleus(ARC) brain slice inflammation central sensitization

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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan Chenzhe Ma Bin qi qingqiang Min ming Li Huabing Chen Hengte Ke Xingyue Ji jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-jian Tang Yuan-ming Pan Wei Li Rui-qiong Ma jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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文冠果种皮黑色素稳定性与抗氧化活性研究

西北林学院学报 2018年第2期33卷 104-109页

作者：石长春肖建明戚建华高荣李剑陕西省治沙研究所陕西榆林719000 陕西榆林毛乌素沙地荒漠生态系统国家定位观测研究站陕西榆林719000 榆林市林业科学研究所陕西榆林719000 西南林业大学林学院云南昆明650224

天然黑色素兼具着色剂和抗氧化剂的双重作用。研究对文冠果种皮黑色素作为着色剂的稳定性和抗氧化活性进行评价。结果表明,该黑色素在pH<4时发生部分沉淀,其溶液的颜色随着pH值的增大而逐渐加深。加热和光照对该黑色素具有增色效应。氧... 详细信息

天然黑色素兼具着色剂和抗氧化剂的双重作用。研究对文冠果种皮黑色素作为着色剂的稳定性和抗氧化活性进行评价。结果表明,该黑色素在pH<4时发生部分沉淀,其溶液的颜色随着pH值的增大而逐渐加深。加热和光照对该黑色素具有增色效应。氧化剂可使其褪色,而还原剂和蔗糖对其无明显影响。该色素对Al^(3+)、Ca^(2+)、Fe^(2+)、Fe^(3+)、Cu^(2+)和Zn^(2+)不稳定而对Na^+和Mg^(2+)稳定。文冠果种皮黑色素具有较强的抗氧化能力,其对·OH的清除率与2,6-二叔丁基对甲酚(BHT)相当,高浓度下清除二苯代苦味酰基自由基能力强于BHT,还原能力高于BHT,但总抗氧化能力不及BHT。文冠果种皮黑色素是一种具有抗氧化功能的着色剂资源,可进一步开发利用。

关键词：文冠果种皮黑色素稳定性抗氧化

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo jian-Gang Shen Su-Hua qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin