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World Journal of Gastroenterology 2014年第15期20卷 4428-4432页

作者： Cheng-Yu Lv Tao Zhou Wei Chen Xin-Dao Yin jian-hong yao Yi-Fan Zhang Department of General Surgery Nanjing Hospital Affiliated to Nanjing Medical University

AIM: To study the relationship between the CX3CL1 chemokine, its receptor CX3CR1, and gastric carcinoma/gastric carcinoma perineural invasion (PNI).

关键词： Gastric carcinoma Perineural invasion CX3CL1 CX3CR1

A morphing machining strategy for artificial bonet

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第3期15卷 157-171页

作者： Wen-feng GAN jian-zhong FU hong-yao SHEN Zhi-wei LIN State Key Laboratory of Fluid Power Transmission and Control Department of Mechanical Engineering Zhejiang University Hangzhou 310027 China

In this work, a novel morphing machining strategy （MMS） is proposed. In the method, the workpiece is progressively carved out from the stock. Pitfalls in conventional iso-height strategy, such as sharp edges and unevenly distributed left-over materials, are overcome. Moreover, to calculate different levels in the MMS, an energy-based morphing algorithm is proposed. Finally, the proposed strategy is employed in the machining of artificial bone represented by a T-spline surface. The excellent properties of T-spline, such as expressing complex shapes with a single surface, have been well adopted to artificial bone fabri- cation. Computer simulation and the actual machining of the middle finger bone show the feasibility of the proposed strategy.

关键词： Morphing machining strategy (MMS) Energy-based morphing Tool path generation T-spline surface Artificialbone

Strengthening the Disciplinary Construction of History of Medicine: A Call for Action by Chinese Academy of Medical Sciences & Peking Union Medical College

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Chinese Medical Sciences Journal 2023年第2期38卷 94-96页

作者： jian-hong yao Da-Qing Zhang Xin-Zhong Yu Shu-jian Zhang Yong-An Zhang Xiang-Yin Yang Zhong He Huan Liu Yong Wang Yue-Ying Jin School of Medical Humanities and Social Sciences Peking Union Medical College&Chinese Academy of Medical SciencesBejing 100730China School of Medical Humanities Peking UniversityBejing 100191China Faculty of History Nankai UniversityTianjin 300072China institute of Chinese Medical Literature and Culture Shandong University of Traditional Chinese MedicineJinan250355China College of Liberal Arts Shanghai UniversityShanghai 200444China School of History Renmin University of ChinaBeijing 100086China

Recent years have witnessed a dynamic develop of Peking Union Medical College(PUMC),which was founded in 1921,and Chinese Academy of Medical Sciences(CAMS),which was founded in *** the new era of building a"Healthy China",General Secretary Xi Jinping has emphasized the importance of a profound understanding of the Chinese civilization to let the world better know and understand China,and urged efforts to combine theories and practices to expound how to better uphold the Chinese path,promote the Chinese spirit,and pool together the Chinese strength[1].As an active response,PUMC organized the first Conference of History of Medicine on May 20-21,2023[2],Based on the rich history of PUMC and with an attempt to explore history,inherit the traditional Chinese culture,and promote the spirit of modern medicine,we issued the following call at the conference。

关键词： History combine Peking

Potential energy sequences of characteristic atoms on basis of heats of formation of disordered Au（1-x）Cux alloys（Part 2）

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材料科学与工程（中英文版） 2009年第3期3卷 44-57页

作者： XIE You-qing LI Xiao-bo LIU Xin-bi PENG hong-jian NIE yao-zhuang State Key Laboratory for Powder Metallurgy College of Materials Science and Engineering Institute of Powder Metallurgy Central South University Changsha 410083 China

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu hong-Wei Li jian-hong Shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

Cloning and molecular characterization of a novel lectin gene from Pinellia ternata

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Cell Research 2003年第4期13卷 301-308页

作者： jian hong yao, XIU YUN ZHAO, ZHI HUA LIAO, JUAN LIN, Zhong HAI CHEN, FEI CHEN, JUN SONG, XIAO FEN SUN, KE XUAN TANG State Key Laboratory of Genetic Engineering, School of Life Sciences, Morgan- Tan International Center for Life Sciences, Fudan-SJTU-Nottingham Plant Biotechnology R and D Center, Fudan University, Shanghai 200433, ChinaFudan-SJTU-Nottingham Plant Biotechnology R and D Center, Plant Biotechnology Research Center, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200030, China State Key Laboratory of Genetic Engineering School of Life Sciences Morgan-Tan International Center for Life Sciences Fudan-SJTU-Nottingham Plant Biotechnology R and D Center Fudan University Shanghai 200433 China

The full-length cDNA of Pinellia ternata agglutinin (PTA) was cloned from inflorescences using RACE PCR. Through comparative analysis of PTA gene (pta) and its deduced amino acid sequence with those of other Araceae species, pta was found to encode a precursor lectin with signal peptide and to have extensive homology with those of other Araceae species. PTA was a heterotetrameric mannose-binding lectin with three mannose-binding boxes like lectins from other Araceae and Amaryllidaceae species. Southern blot analysis of the genomic DNA revealed that pta belonged to a low-copy gene family. Northern blot analysis demonstrated that pta constitutively expressed in various plant tissues including root, leaf, stem and inflorescence. The pta cDNA sequence encoding for mature PTA protein was cloned into pET-32a plasmid and the resulting plasmid, pET-32a-PTA containing Trx-PTA fusion protein, was investigated for the expression in E. coli BL21. SDS-PAGE gel analysis showed that the Trx-PTA fusion protein was succ

关键词： araceae cDNA cloning lectin Pinellia ternata RACE-PCR.

mmunotherapy of mugwort pollen extract decreases nasal mucosa inflammation and hyperresponsiveness in a recombinant Art v1-induced guinea pig model of allergic rhinitis

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mmunotherapy of mugwort pollen extract decreases nasal mucos...

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

第十届全国抗炎免疫药理学学术会议

作者： Zhu jian-ping,yao hong-yi,Zhao Meng-hui,Wang Zhe-pei,Zheng Ying-ming,Xu Tian,Xie Qiang-min (Medical College of Zhejiang University,Hangzhou 310058,China)

Aim:Sublingual or oral immunotherapy(OIT)is a clinically effective treatment in allergic diseases Art v 1,the major allergen of mugwort pollen,is a modular glycoprotein with a defensin-like and a hydroxyproline-rich *** aim of the study was to establish a guinea pig model of allergic rhinitis induced by a recombinant Art v1 and to study the effect and mechanisms of mugwort pollen extract(MPE) treatment through ***:Guinea pigs were sensitized by subcutaneous plus intra-peritoneal injections of alum-adsorbed Art v1(0.01 mg protein/guinea pig) every 10 days for three *** number of sneezes was counted immediately after intranasal *** measure nasal mucosa inflammation and airway hyperresponsiveness,guinea pig were repeatedly challenged by once daily intranasal instillation of allergen from day 36-42 and treated with MPE(0.1mg,1mg and 10mg

关键词：

来源： cnki会议评论

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin yao Mei Tian jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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核岛设备焊接见证件弯曲不合格分析和处理

电站辅机 2018年第1期39卷 6-8,12页

作者：王建林洪尧上海电气电站设备有限公司电站辅机厂上海200090

对核岛设备焊接见证件试样进行侧弯试验时,发现试样有裂纹,判定试样为不合格。随后,对焊材入厂验收单、工艺评定和施焊过程等记录进行了复查,均符合相关的技术要求。经过宏观检验,表明该裂纹不是由焊接缺陷所致。因此,对试样进行了固溶... 详细信息

对核岛设备焊接见证件试样进行侧弯试验时,发现试样有裂纹,判定试样为不合格。随后,对焊材入厂验收单、工艺评定和施焊过程等记录进行了复查,均符合相关的技术要求。经过宏观检验,表明该裂纹不是由焊接缺陷所致。因此,对试样进行了固溶处理。对固溶态和焊态试样重新进行弯曲试验,均无开裂现象。试验结果表明,产生裂纹的原因,是试样在局部区域内超出了金属变形能力所致。

关键词：核岛设备焊接见证件侧弯试验开裂宏观检验固溶处理变形能力

Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： yao Yuan Lingqi Yu Xudong Zhuang Dongjing Wen Jin He Jingmei hong Jiayu Xie Shengan Ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump