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Chinese Chemical Letters 2006年第6期17卷 757-760页

作者： jian wen jiang ming zhong cai Department of Chemistry Jiangxi Normal University Nanchang 330027

（E）-α-Iodovinyl sulfides 1 underwent the Sonogashira coupling reactions with terminal alkynes 2 in piperidine at room temperature in the presence of 5 mol % of Pd（PPh3）4 and 10 mol % of CuI to afford the correspo... 详细信息

关键词： (E)-α-Iodovinyl sulfide 1 3-enynylsulfide Sonogashira coupling terminal alkyne.

A facile stereospecific synthesis of (Z)-2-sulfonyl-substituted 1,3-enynes via Sonogashira coupling of (E)-α-iodovinyl sulfones with 1-alkynes

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Chinese Chemical Letters 2007年第7期18卷 773-776页

作者： wen Yan Hao jian wen jiang ming zhong cai Department of Chemistry Jiangxi Normal University Nanchang 330022 China

（E）-α-Iodovinyl sulfones 1 underwent the Sonogashira coupling reactions with terminal alkynes 2 in piperidine at room temperature in the presence of 5 mol% of Pd（PPh3）4 and 10 mol% of CuI to stereospecifically af... 详细信息

关键词： (E)-α-Iodovinyl sulfone 1,3-Enynylsulfone Sonogashira coupling Terminal alkyne

Ganoderma lucidum spore oil enhances the effect of paclitaxel,improves the tolerance to paclitaxel and prolongs the survival in Lewis tumor-bearing mice

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Cancer Advances 2024年第12期7卷 1-6页

作者： Hong-Fei cai Zhao-jian jiang Cheng Yuan Lin Cao Qin Wang Ya-ming Han Qin Zhang Jing Li wen-Dong Xu Ju-Yan Liu Guangzhou HanFang Pharmaceutical Company Limited National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug InnovationGuangdong Provincial Key Laboratory of Medicinal LipidsGuangzhou 510240China Nanchang Research Institute Sun Yat-Sen UniversityNanchang 330096China Guangzhou Pharmaceutical Holdings Limited Guangzhou 510130China

Purpose:This study aims to investigate whether Ganoderma lucidum spore oil(GLSO)could enhance the effect of paclitaxel(PTX),improve the tolerance to PTX and prolong the overall survival of Lewis tumor-bearing mice,which has never been reported ***:The tumor,spleen,and thymus were weighed at the end of the *** blood was collected for hematological index analysis,and the intact femur was removed to determine the bone marrow nucleated cell count(BMN).The percentage of lymphocytes in the spleen of mice was detected by flow cytometry,the activity of NK cells was detected by LDH assay,and the proliferation index of lymphocytes was determined by CCK-8 *** overall and mean survival time and life extension rate were calculated using SPSS ***:Our data showed that GLSO could enhance the anti-tumor effect of PTX and prolong the survival of *** underlying mechanisms of the above effects might be related to the toxic reduction effect of GLSO by relieving hematotoxicity,myelosuppression and ***,GLSO could increase the number of blood cells and bone marrow cells,alleviate the thymic index,and elevate the number and activity of NK cells in mice treated with ***:GLSO may enhance the efficacy of PTX by boosting the activity of immune NK cells and prolong survival by counteracting PTX-induced bone marrow alterations and improving *** findings suggested the promising role of GLSO in combination with PTX to extend the survival and increase the tolerance of patients in clinical chemotherapy of lung cancer.

关键词： Ganoderma lucidum spore oil Traditional Chinese Medicine lung cancer paclitaxel tolerance survival

Endoscopic resection for calcifying fibrous tumors of the gastrointestinal tract

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World Journal of Clinical Oncology 2024年第2期15卷 282-289页

作者： Zi-Han Geng Yan Zhu Pei-Yao Fu Yi-Fan Qu Shi-Yao Chen Yun-Shi zhong Yi-Qun Zhang Wei-Feng Chen wen-Zheng Qin jian-Wei Hu ming-Yan cai Li-Qing Yao Quan-Lin Li Ping-Hong Zhou Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai 200032China Shanghai Collaborative Innovation Center of Endoscopy Shanghai 200032China

BACKGROUND Calcifying fibrous tumors(CFTs)are rare mesenchymal lesions that can occur in various sites throughout the body,including the tubular gastrointestinal(GI)*** To analyze the clinical findings of 36 patients with GI tract CFTs to provide guidance for diagnosis and *** This retrospective study included 36 patients diagnosed with CFTs of the GI *** collected demographic and clinical information and conducted regular follow-ups to assess for local *** The stomach was the most commonly involved site,accounting for 72.2%of the 36 *** mucosal resection(n=1,2.8%),endoscopic submucosal dissection(n=14,38.9%),endoscopic full-thickness resection(n=16,44.4%),and submucosal tunneling endoscopic resection(n=5,13.9%)were used to resect calcifying fibrous ***,34(94.4%)CFTs underwent complete endoscopic resections with a mean procedure time of 39.8±29.8 *** average maximum diameter of the tumors was 10.6±4.3 *** complications,such as bleeding or perforation,occurred during an average hospital stay of 2.9±1.2 *** addition,two patients developed new growth of CFTs near the primary tumor sites,and none of the patients developed distant metastases during the follow-up *** GI tract CFTs are rare and typically benign tumors that can be effectively managed with endoscopic procedures.

关键词： Endoscopic resection Calcifying fibrous tumor Gastrointestinal tract

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基于单目SLAM稀疏特征的避障方法

计算机工程与设计 2024年第6期45卷 1735-1742页

作者：江明曾碧刘建圻彭泽鑫林中文广东工业大学计算机学院广东广州510006

为在使用单目相机的低成本移动机器人上实现避障,提出一种基于现有单目SLAM系统生成的稀疏特征的可通行区域检测方法。通过使用单目SLAM生成的稀疏地标点标识障碍物,根据环境信息恢复构建三维体素地图,生成二维栅格代价地图。为解决单目... 详细信息

为在使用单目相机的低成本移动机器人上实现避障,提出一种基于现有单目SLAM系统生成的稀疏特征的可通行区域检测方法。通过使用单目SLAM生成的稀疏地标点标识障碍物,根据环境信息恢复构建三维体素地图,生成二维栅格代价地图。为解决单目SLAM中尺度不明确的问题,提出一种基于视觉-轮式编码器的尺度求解器。通过直接使用机器人已有的SLAM框架生成的地标点,在降低系统整合成本同时降低计算量。实验结果表明,在KITTI和DRE数据集上构图的耗时在10 ms~20 ms,可以很好满足在性能受限的设备上的实时避障需求。

关键词：单目视觉同步定位与地图构建代价地图可通行区域避障稀疏特征尺度恢复

社区2型糖尿病患者健康管理依从性与血糖控制达标关系研究

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现代预防医学 2024年第2期51卷 273-278页

作者：李殿江潘恩春孙中明文进博武鸣樊宏苏健周金意沈冲南京医科大学公共卫生学院淮安市疾病预防控制中心江苏省疾病预防控制中心

目的探究社区2型糖尿病患者健康管理依从性与血糖控制达标的关系。方法以淮安区2 171例纳入社区健康管理的2型糖尿病患者为研究对象。采用《糖尿病治疗依从性问卷》综合评估药物治疗、饮食、运动、自我监测及定期复查等维度依从性，... 详细信息

目的探究社区2型糖尿病患者健康管理依从性与血糖控制达标的关系。方法以淮安区2 171例纳入社区健康管理的2型糖尿病患者为研究对象。采用《糖尿病治疗依从性问卷》综合评估药物治疗、饮食、运动、自我监测及定期复查等维度依从性，并以得分的中位数作为依从性好\差的分界点；将HbAlc<7.0%定义为血糖控制达标；采用logistic回归评估依从性与血糖控制达标关系。结果调整混杂因素后，相对于依从性差组，具有良好药物治疗、饮食、运动、自我监测、复查及总体依从性组的血糖控制达标OR分别为1.402(95%CI:1.173～1.677)、1.231(95%CI:1.030～1.471)、0.985(95%CI:0.821～1.183)、0.968(95%CI:0.806～1.162)、1.107(95%CI:0.924～1.326)和1.050(95%CI:0.880～1.252)。进一步剔除合并高血压、冠心病、脑卒中及肿瘤的患者后显示，相对于依从性差组，具有良好药物治疗、饮食、运动、自我监测、复查及总体依从性组的血糖控制达标OR分别为1.987(95%CI:1.321～2.990)、1.606(95%CI:1.077～2.397)、1.282(95%CI:0.867～1.895)、1.378(95%CI:0.910～2.085)、1.663(95%CI:1.126～2.456)和1.593(95%CI:1.077～2.354)。结论提高社区2型糖尿病健康管理依从性有助于改善患者血糖控制达标率，其中坚持药物治疗及饮食控制的血糖控制效果明显。

关键词： 2型糖尿病健康管理依从性血糖控制社区

Organic matter accumulation in lacustrine shale of the Permian Jimsar Sag,Junggar Basin,NW China

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Petroleum Science 2023年第3期20卷 1327-1346页

作者： Xiu-jian Ding wen-Jun He Hai-Lei Liu Xu-Guang Guo ming Zha zhong-Fa jiang School of Geosciences in China University of Petroleum QingdaoShandong266580China Research Institute of Petroleum Exploration and Development PetroChina Xinjiang Oilfield CompanyKaramayXinjiang841000China

The lacustrine organic-rich shale in the Permian Lucaogou(LCG)Formation of the Jimsar Sag,Junggar Basin,is one of the main shale oil plays in *** this paper,geological and geochemical research techniques were employed to evaluate the geochemical variability of the lacustrine shale and the pro-duction of organic matter and its preservation *** LcG Formation is characterized by its complex mineral compositions and a wide range of organic matter richness and *** presence of high proportions ofβ-carotane and C2g steranes,indicates that the organic matter mainly originated from phytoplankton and aquatic algal-bacterial organisms,especially *** study found that the productivity of the Lower LCG Member(P2li)was highest,and the Middle LCG Member(P_(2)l_(2))was the *** the deposition of the Lower LCG Member,the lake's bottom water was predominantly a reducing environment,and the degradation of organic matter was largely a result of bacterial sulfate *** the deposition of the Middle and Upper LCG members,the lake's bottom water was mainly oxidizing,and the degradation of organic matter was likely to be caused by aerobic *** on a comprehensive analysis of the origin and production of organic matter,as well as its depo-sitional environment and preservation conditions,two organic matter accumulation models were pro-posed to explain the distribution of the organic-rich *** model A,the high influx of volcanic ash released nutrients and brought abundant sulfate into the water,the accumulation of organic matter was mainly controlled by the preservation of organic matter,which was mainly controlled by *** the model B,the influx of volcanic ash was small,organic matter was mainly degraded by oxygen and the accumulation of organic matter is mainly determined by the production of organic matter.

关键词： Lucaogou formation Jimsar sag Organic-matter-rich shale Organic matter accumulation Organic matter productivity Bacterial sulfate reduction

Clinical significance of combined determination of serum PGⅠ , PGⅡ and GAS for diagnosis of gastric cancer

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Nuclear Science and Techniques 2005年第4期16卷 217-220页

作者： jiang Meng-Jun LI wen-Xin XIAO Zhi-jian ZHANG Rong-Jun cai Gang-ming State Key Laboratory of Nuclear Medicine Jiangsu Institute of Nuclear Medicine. Wuxi 214063

To evaluate the clinical value of combined determination of serum PGⅠ, PGⅡ and GAS for early diag-nosis of gastric cancer, the serum levels of PGⅠ, PGⅡ and GAS in 190 healthy controls and 129 patients with gas-tric disorders were measured by RIA. The 129 patients include 68 cases of gastric cancer. The results showed that the serum levels of PGⅠ and PGⅠ/PGⅡ ratio in gastric cancer patients were obviously lower than those in healthy controls, while comparing with controls, the serum GAS levels were significantly higher. The diagnostic accuracy of the determinations for gastric cancer was evaluated by receiver operating characteristic (ROC) curve analysis. The area under the curve (AUC) levels of serum PGⅠ, PGⅠ/PGⅡ ratio and GAS were 0.833, 0.842 and 0.851, respec-tively. As serum PGⅠ or PGⅠ/PGⅡ ratio or GAS were combined, the sensitivity and specificity of determination for gastric cancer diagnosis were 94.2% and 73.4%, respectively. All these results indicated that the combined deter-mination of serum PGⅠ, PGⅡ and GAS levels may be used as a tool for primary screening of gastric cancer.

关键词：免疫血清诊断方法胃癌放射性疗法实验室诊断放射性同位素

Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-Zheng Wang Li-Tao Yang Qian Yue Ke-Jun Kang Yuan-Jing Li Hai-Peng An C.Greeshma jian-Ping Chang Yun-Huan Chen jian-Ping Cheng wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-Yuan Guo Li He Sheng-ming He Jin-Wei Hu Han-Xiong Huang Tu-Chen Huang Hai-Tao Jia Xi jiang S.Karmakar Hao-Bin Li jian-Min Li Jin Li Qian-Yun Li Ren-ming-Jie Li Xue-Qian Li Yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-Xuan Liu Shu-Kui Liu Yan-Dong Liu Yu Liu Yuan-Yuan Liu zhong-Zhi Liu Hao Ma Yu-cai Mao Qi-Yuan Nie Jin-Hua Ning Hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-jian Tang Wei-You Tang Yang Tian Guang-Fu Wang Li Wang Qing Wang Yu-Feng Wang Yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu Hao-Yang Xing Rui Xu Yin Xu Tao Xue Yu-Lu Yan Nan Yi Chun-Xu Yu Hai-Jun Yu jian-Feng Yue ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-Yu Zhang Kang-Kang Zhao ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

Design study on medium beta superconducting half-wave resonator at IMP

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Nuclear Science and Techniques 2016年第4期27卷 21-27页

作者： An-Dong Wu Sheng-Hu Zhang Wei-ming Yue Tian-cai jiang Yong-ming Li Feng-Feng Wang Sheng-Xue Zhang Liang-jian wen Ran Huang Yuan He Hong-Wei Zhao Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China University of Chinese Academy of Sciences Beijing 100049 China

A 325-MHz superconducting half-wave resonator has been designed with β = 0.51. Three shapes of the inner conductors(race track, ring shape and elliptical shape) were optimized to decrease the peak electromagnetic fields and minimize the dissipated RF power on the cavity walls. In order to suppress the operation frequency shift caused by fluctuations of the helium pressure and maximize the tuning ranges, the frequency shifts and mechanical properties were studied on the electric and magnetic areas. The helium vessel was designed to keep the mechanical structure as robust as possible.

关键词：超导谐振器设计 IMP 射频功率压力波动调谐范围机械性能频率变化