Clinical significance of combined determination of serum PGⅠ , PGⅡ and GAS for diagnosis of gastric cancer

作     者：JIANG Meng-Jun LI Wen-Xin XIAO Zhi-Jian ZHANG Rong-Jun CAI Gang-Ming 

作者机构：State Key Laboratory of Nuclear Medicine Jiangsu Institute of Nuclear Medicine. Wuxi 214063 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：2005年第16卷第4期

页      面：217-220页

核心收录：

学科分类：08[工学] 1010[医学-医学技术（可授医学、理学学位）] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0807[工学-动力工程及工程热物理] 0827[工学-核科学与技术] 0703[理学-化学] 100214[医学-肿瘤学] 100106[医学-放射医学] 0702[理学-物理学] 0801[工学-力学（可授工学、理学学位）] 10[医学] 100602[医学-中西医结合临床] 

基　　金：Supported by the Society Development Fund of Jiangsu Province (No.BS94012) 

主　　题：免疫血清 诊断方法 胃癌 放射性疗法 实验室诊断 放射性同位素 

摘      要：To evaluate the clinical value of combined determination of serum PGⅠ, PGⅡ and GAS for early diag-nosis of gastric cancer, the serum levels of PGⅠ, PGⅡ and GAS in 190 healthy controls and 129 patients with gas-tric disorders were measured by RIA. The 129 patients include 68 cases of gastric cancer. The results showed that the serum levels of PGⅠ and PGⅠ/PGⅡ ratio in gastric cancer patients were obviously lower than those in healthy controls, while comparing with controls, the serum GAS levels were significantly higher. The diagnostic accuracy of the determinations for gastric cancer was evaluated by receiver operating characteristic (ROC) curve analysis. The area under the curve (AUC) levels of serum PGⅠ, PGⅠ/PGⅡ ratio and GAS were 0.833, 0.842 and 0.851, respec-tively. As serum PGⅠ or PGⅠ/PGⅡ ratio or GAS were combined, the sensitivity and specificity of determination for gastric cancer diagnosis were 94.2% and 73.4%, respectively. All these results indicated that the combined deter-mination of serum PGⅠ, PGⅡ and GAS levels may be used as a tool for primary screening of gastric cancer.