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Study on the Total Amount Control of Atmospheric Pollutant Based on GIS

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Biomedical and Environmental Sciences 2005年第4期18卷 233-237页

作者： jian-ping wang XI-KUN GUO College of Science Shantou University Shantou 51500 Guangdong China

To provide effective environmental management for total amount control of atmospheric pollutants. Methods An atmospheric diffusion model of sulfur dioxide on the surface of the earth was established and tested in Shantou of Guangdong Province on the basis of an overall assessment of regional natural environment, social economic state of development, pollution sources and atmospheric environmental quality. Compared with actual monitoring results in a studied region, simulation values fell within the range of two times of error and were evenly distributed in the two sides of the monitored values. Predicted with the largest emission model method, the largest emission of sulfur dioxide would be 54 279.792 tons per year in 2010. Conclusion The mathematical model established and revised on the basis of GIS is more rational and suitable for the regional characteristics of total amount control of air pollutants.

关键词： Total amount control of atmospheric pollutants Atmospheric diffusion model Pollution source GIS

Anharmonic Vibrational Signatures of DNA Bases and Watson-Crick Base Pairs

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Chinese Journal of Chemical Physics 2009年第6期22卷 563-570,J0001页

作者： Gui-xiu wang Xiao-yan Ma jian-ping wang Beijing National Laboratory for Molecular Sciences State Key Laboratory of Molecular Reaction Dynamics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

Changes of molecular structure and associated charge distributions, and changes of anharmonic vibrational parameters from DNA base monomers to the Watson-Crick base pairs, have been investigated at the density functional theory level. Through examination of the NH2, N H, and C=O stretching vibrational modes that are involved in the multiple H-bonds in the base pairs, sensitivity of their diagonal and off-diagonal anharmonicities, as well as anharmonic vibrational couplings, to the structure change are predicted. Our results reveal the intrinsic connection between the anharmonic vibrational potentials, H-bonding, and electrostatic interactions in DNA bases.

关键词： Anharmonic vibration Anharmonicity Coupling Two-dimensional infrared spectroscopy DNA base

ShRNA-mediated gene silencing of β-catenin inhibits growth of human colon cancer cells

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World Journal of Gastroenterology 2007年第48期13卷 6581-6587页

作者： Wen-Sheng Huang jian-ping wang Ting wang Jie-Yu Fang ping Lan Jin-ping Ma Surgery Department The First Affiliated Hospital Sun Yat-sen University Guangzhou 510080 Guangdong Province China

AIM: To observe the gene silencing mediated by the specific shRNA targeted against β-catenin and its effect on cell proliferation and cycle distribution in the human colon cancer cell line Colo205. METHODS: Two shRNA plasmid vectors against β-catenin were constructed and transfected into Colo205 cells with LipofectamineTM2000. The down-regulations of β-catenin, c-myc and cyclinD1 expressions were detected by RT-PCR and western blot analysis. The cell proliferation inhibitions were determined by MTT assay and soft agar colony formation assay. The effect of these two β-catenin shRNAs on cell cycle distribution and apoptosis was examined by flow cytometry. RESULTS: These two shRNA vectors targeted against β-catenin efficiently suppressed the expression of β-catenin and its down stream genes, c-myc and cyclinD1. The expression inhibition rates were around 40%-50% either at the mRNA or at the protein level. The shRNA-mediated gene silencing of β-catenin resulted in significant inhibition of cell growth both on the culture plates and in the soft agar. Moreover, the cancer cells showed significant G0/G1 arrest and increased apoptosis at 72 h post transfection due to gene silencing. CONCLUSION: These specific shRNAs targeted against β-catenin could have a gene silencing effect and block the WNT signaling pathway. They could inhibit cell growth, increase apoptosis, and induce cell cycle arrest in Colo205 cells. ShRNA interference against β-catenin is of potential value in gene therapy of colon cancer.

关键词： β-catenin RNA interference Apoptosis Colon cancer WNT

Is there a Di-Ω State?

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Communications in Theoretical Physics 2002年第10期38卷 424-428页

作者： Hou-Rong PANG jian-Lun ping Fan wang Department of Physics Nanjing University Nanjing 210093 China Department of Physics Nanjing Normal University Nanjing 210097 China Center of Theoretical Physics Nanjing University Nanjing 210093 China Department of Physics Nanjing Normal University Nanjing 210097 China Center of Theoretical Physics Nanjing University Nanjing 210093 China

Resonating-group method has been applied to calculate the ΩΩ (SIJ = -6,0,0) dibaryon state in theframework of the extended quark-delocalization color-screening model. The mass of the di-Ω is predicted to be about45 MeV lower than the Ω-Ω threshold. The effect of channel coupling due to the tensor force and sensitivity to mesonexchange short-range cutoff radius, ro have also been studied.

关键词： dibaryon, meson exchange

Efficacy of β-adrenergic blocker plus 5-isosorbide mononitrate and endoscopic band ligation for prophylaxis of esophageal variceal rebleeding:A meta-analysis

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World Journal of Gastroenterology 2009年第17期15卷 2151-2155页

作者： Shi-Hua Ding Jun Liu jian-ping wang Department of Gastroenterology The Affiliated Shenzhen Hospital Nanfang Medical University Shenzhen 518035 Guangdong Province China

AIM: To systematically assess the efficacy and safety of β-adrenergic blocker plus 5-isosorbide mononitrate (BB + ISMN) and endoscopic band ligation (EBL) on prophylaxis of esophageal variceal rebleeding. METHODS: Randomized controlled trials (RCTs) comparing the efficacy and safety of BB + ISMN and EBL on prophylaxis of esophageal variceal rebleeding were gathered from Medline, Embase, Cochrane Controlled Trial Registry and China Biological Medicine database between January 1980 and August 2007. Data from five trials were extracted and pooled. The analyses of the available data using the Revman 4.2 software were based on the intention-to-treat principle. RESULTS: Four RCTs met the inclusion criteria. In comparison with BB + ISMN with EBL in prophylaxis of esophageal variceal rebleeding, there was no significant difference in the rate of rebleeding [relative risk (RR), 0.79; 95% CI: 0.62-1.00; P = 0.05], bleeding-related mortality (RR, 0.76; 95% CI: 0.31-1.42; P = 0.40), overall mortality (RR, 0.81; 95% CI: 0.61-1.08; P = 0.15) and complications (RR, 1.26; 95% CI: 0.93-1.70; P = 0.13). CONCLUSION:In the prevention of esophageal variceal rebleeding, BB + ISMN are as effective as EBL. There are few complications with the two treatment modalities. Both BB + ISMN and EBL would be considered as the first-line therapy in the prevention of esophageal variceal rebleeding.

关键词： Meta-analysis Esophageal variceal rebleeding Endoscopic band ligation β-adrenergicblocker 5-isosorbide mononitrate Prophylaxis

A Message-array-based Mechanism for Tracking Control Effects in Supervisory Control Software

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International Journal of Automation and computing 2011年第1期8卷 83-91页

作者： Qi-Liang Yang jian-Chun Xing ping wang Engineering Institute of Corps of Engineers PLA University of Science and Technology Nanjing 210007 PRC

Supervisory control is a very popular paradigm for computer-controlled systems. Knowledge and tracking the control effect of every control operation is crucial to the control tasks. In the paper, we present a message-array-based mechanism to track control effects in supervisory control software. A novel data type, message array, is designed to efficiently support this tracking mechanism. The operation algorithms, adding algorithm （AA）, removing algorithm （RA）, and scheduler algorithm （SA） are proposed to operate the tracking messages in message array, which forms the special first input X output （FIXO） strategy of message array. Automatically tracking, recording, and rolling back are the characteristics of our tracking mechanism. We implement this messagearray-based mechanism on the famous human machine interface （HMI） software platform-proficy iFix, and construct experiments to evaluate the performance of the mechanism in various cases. The results show our mechanism can be well satisfied with supervisory control software.

关键词： Supervisory control software message array tracking control effects computer-controlled system.

MiR-34a overexpression enhances the inhibitory effect of doxorubicin on HepG2 cells

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World Journal of Gastroenterology 2019年第22期25卷 2752-2762页

作者： Shun-Zhen Zheng ping Sun jian-ping wang Yong Liu Wei Gong Jun Liu Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021Shandong ProvinceChina Department of Clinical Laboratory Blood Station of JinanJinan 250021Shandong ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC) is the third leading cause of death from malignant tumors worldwide. More than 50% of HCC cases occur in China. The prognosis remains poor and overall efficacy is still unsatisfactory. Chemotherapy resistance is the most important reason for the poor outcome. Much progress has been made in the study of chemotherapy resistance of HCC;however, the specific mechanisms of progression of HCC have still only been partially ***, the mechanism of chemotherapy resistance in HCC requires more *** To investigate the effect of miR-34 a expression on the growth inhibition of HepG2 cells by *** A recombinant lentiviral vector containing miR-34 a was constructed and transfected into HepG2 cells. The expression of miR-34 a was detected by reverse transcription-polymerase chain reaction(commonly known as RT-PCR) before and after transfection. Cells were exposed to 2 μM doxorubicin or phosphatebuffered saline before and after transfection. Cell viability in each group was detected by MTT assay, and cell cycle and apoptosis were detected by flow cytometry. Changes in expression levels of phospho(p)-p53, sirtuin(SIRT) 1,cyclin D1, cyclin-dependent kinase(CDK) 4, CDK6, BCL-2, multidrug resistance protein(MDR) 1/P glycoprotein(P-gp), and AXL were detected by Western *** Recombinant lentiviral vector LV-hsa-mir-34 a was successfully constructed by restriction endonuclease digestion and sequencing. RT-PCR showed that expression of miR-34 a in HepG2 cells was significantly upregulated after transfection(P < 0.01). MTT assay showed that growth of HepG2 cells was inhibited after upregulation of miR-34 a, and viability was significantly decreased after combined treatment with doxorubicin(P < 0.01). Flow cytometry showed that the number of HepG2 cells in G1 phase increased, and G1 phase arrest was more obvious after intervention with doxorubicin(P < 0.01). The apoptosis rate of HepG2 cells was incre

关键词： miR-34a Doxorubicin Hepatocellular carcinoma HepG2 cells Growth inhibition

Male gender is associated with an increased risk of anastomotic leak in rectal cancer patients after total mesorectal excision

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Gastroenterology Report 2018年第2期6卷 137-143,I0003页

作者： jian-ping wang and ping Lan Chi Zhou Xian-rui Wu Xuan-hui Liu Yu-feng Chen Jia Ke Xiao-wen He Xiao-sheng He Tuo Hu Yi-feng Zou Xiao-bin Zheng Hua-shan Liu jian-cong Hu Xiao-jian Wu jian-ping wang ping Lan Department of Colorectal Surgery the Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesGuangzhouGuangdong 510065China

Background:The impact of a patient’s gender on the development of anastomotic leak(AL)in rectal cancer patients following total mesorectal excision(TME)remains *** aim of this study was to evaluate the association between patients’gender and the risk of ***:All rectal cancer patients following TME with a primary anastomosis during the study period from 2010 to 2014 were *** of the post-operative AL incidence rate between male and female patients were ***:Of all patients examined(n¼956),587(61.4%)were males and 369(38.6%)were *** patients were more likely to have a history of smoking and drinking alcohol,but less likely to have a history of abdominal surgery compared to female patients.A higher incidence rate of pre-operative bowel obstruction and larger tumor volume in male patients was observed in our *** all the patients,81(8.5%)developed post-operative *** male patients(n¼62,10.6%)suffered from AL than females(n¼19,5.1%)(P¼0.003).Multivariate logistic regression analyses confirmed the association between male gender and AL[odds ratio(OR):2.41,95%confidence interval(CI):1.37–4.23,P¼0.002].Similar results were also obtained in patients who underwent laparoscopic TME(OR:2.11,95%CI:1.15–3.89,P¼0.016).Conclusions:Male patents were found to have an increased risk for AL following TME with a primary anastomosis.A temporary protecting stoma may help to protect the anastomosis and lessen the risk for AL especially in male patients.

关键词： rectal cancer anastomotic leak gender risk factor total mesorectal excision primary anastomosis

Joint bandwidth allocation and power control with interference constraints in multi-hop cognitive radio networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第2期11卷 139-150页

作者： Guang-xi ZHU Xue-bing PEI Dai-ming QU jian LIU Qing-ping wang Gang SU Wuhan National Laboratory for Optoelectronics Department of Electronics & Information Engineering Huazhong University of Science and Technology Wuhan 430074 China

We investigate the bandwidth allocation and power control schemes in orthogonal frequency division multiplexing (OFDM) based multi-hop cognitive radio networks,and the color-sensitive graph coloring (CSGC) model is viewed as an efficient solution to the spectrum assignment problem. We extend the model by taking into account the power control strategy to avoid interference among secondary users and adapt dynamic topology. We formulate the optimization problem encompassing the channel allocation,power control with the interference constrained below a tolerable limit. The optimization objective with two different optimization strategies focuses on the routes rather than the links as in traditional approaches. A heuristic solution to this nondeterministic polynomial (NP)-hard problem is presented,which performs iterative channel allocation according to the lowest transmission power that guarantees the link connection and makes channel reuse as much as possible,and then the transmission power of each link is maximized to improve the channel capacity by gradually adding power level from the lowest transmission power until all co-channel links cannot satisfy the interference constraints. Numerical results show that our proposed strategies outperform the existing spectrum assignment algorithms in the performance of both the total network bandwidth and minimum route bandwidth of all routes,meanwhile,saving the transmission power.

关键词： Bandwidth allocation Power control Multi-hop cognitive radio networks Spectrum management Heterogeneous networks