Male gender is associated with an increased risk of anastomotic leak in rectal cancer patients after total mesorectal excision

作     者：Jian-ping Wang and Ping Lan Chi Zhou Xian-rui Wu Xuan-hui Liu Yu-feng Chen Jia Ke Xiao-wen He Xiao-sheng He Tuo Hu Yi-feng Zou Xiao-bin Zheng Hua-shan Liu Jian-cong Hu Xiao-jian Wu Jian-ping Wang Ping Lan 

作者机构：Department of Colorectal Surgerythe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesGuangzhouGuangdong 510065China 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2018年第6卷第2期

页      面：137-143,I0003页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(No.81400603) Guangdong Natural Science Foundation(No.2015A030310190) Science and Technology Planning Project of Guangdong Province(No.2015B020229001) 

主　　题：rectal cancer anastomotic leak gender risk factor total mesorectal excision primary anastomosis 

摘      要：Background:The impact of a patient’s gender on the development of anastomotic leak(AL)in rectal cancer patients following total mesorectal excision(TME)remains *** aim of this study was to evaluate the association between patients’gender and the risk of ***:All rectal cancer patients following TME with a primary anastomosis during the study period from 2010 to 2014 were *** of the post-operative AL incidence rate between male and female patients were ***:Of all patients examined(n¼956),587(61.4%)were males and 369(38.6%)were *** patients were more likely to have a history of smoking and drinking alcohol,but less likely to have a history of abdominal surgery compared to female patients.A higher incidence rate of pre-operative bowel obstruction and larger tumor volume in male patients was observed in our *** all the patients,81(8.5%)developed post-operative *** male patients(n¼62,10.6%)suffered from AL than females(n¼19,5.1%)(P¼0.003).Multivariate logistic regression analyses confirmed the association between male gender and AL[odds ratio(OR):2.41,95%confidence interval(CI):1.37–4.23,P¼0.002].Similar results were also obtained in patients who underwent laparoscopic TME(OR:2.11,95%CI:1.15–3.89,P¼0.016).Conclusions:Male patents were found to have an increased risk for AL following TME with a primary anastomosis.A temporary protecting stoma may help to protect the anastomosis and lessen the risk for AL especially in male patients.