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Journal of Environmental Sciences 2013年第7期25卷 1424-1430页

作者： Junfeng Niu Dusmant Maharana jiale xu Zhen Chai Yueping Bao State Key Laboratory of Water Environment Simulation School of Environment Beijing Normal University School of Chemical and Environmental Engineering China University of Mining & Technology

Electrochemicaldegradation of2,4-dichlorophenol （2,4-DCP） in aqueous solutionwas investigated over Ti/SnO2-Sb anode. The factors influencing thedegradation rate, such as applied currentdensity （2-40 mA/cm2 ）, pH （3-11） and initial concentration （5-200 mg/L）were evaluated. Thedegradation of2,4-DCP followed apparent pseudo first-order kinetics. Thedegradation ratio on Ti/SnO2 -Sb anode attained 〉 99.9% after 20 min of electrolysis at initial 5-200 mg/L concentrations at a constant currentdensity of 30 mA/cm2 with a 10 mmol/L sodium sulphate （Na2SO4 ） supporting electrolyte solution. The results showed that 2,4-DCP （100 mg/L）degradation and total organic carbon （TOC） removal ratio achieved 99.9% and 92.8%, respectively, at the optimal conditions after 30 min electrolysis. Under this condition, thedegradation rate constant （k） and thedegradation half-life （t1/2 ）were 0.21 min1 and （2.8 ± 0.2） min, respectively. Mainly carboxylic acids （propanoic acid, maleic acid, propanedioic acid, acetic acid and oxalic acid） weredetected as intermediates. The energy efficiencies for2,4-DCPdegradation （5-200 mg/L）with Ti/SnO2-Sb anode ranged from 0.672 to 1.602 g/kWh. The Ti/SnO2-Sb anodewith a high activity to rapid organic oxidation could be employed todegrade chlorophenols, particularly2,4-DCP inwastewater.

关键词： 2 4-dichlorphenol Ti/SnO2 -Sb electrode electrochemicaldegradation total organic carbon

微胶囊相变材料对聚氨酯注浆材料固化放热行为的影响

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高分子材料科学与工程 2024年第7期40卷 1-9页

作者：樊康鑫董晓宇王俊杰刘志徐佳乐王晨曦齐新慧张雪敏丁运生合肥工业大学化学与化工学院安徽合肥230009 先进功能材料与器件安徽省重点实验室安徽合肥230009

聚氨酯注浆材料在固化时由于芯部热量的聚集会发生热解甚至阴燃,造成材料性能劣化和使用安全性隐患。文中通过将相变蓄热微胶囊引入聚氨酯注浆材料中实现对材料固化放热行为的可控调节。通过界面聚合制备了一系列以聚氨酯为壳、石蜡为... 详细信息

聚氨酯注浆材料在固化时由于芯部热量的聚集会发生热解甚至阴燃,造成材料性能劣化和使用安全性隐患。文中通过将相变蓄热微胶囊引入聚氨酯注浆材料中实现对材料固化放热行为的可控调节。通过界面聚合制备了一系列以聚氨酯为壳、石蜡为芯的微胶囊相变材料(MEPCMs),并与多元醇、催化剂共混后与多异氰酸酯反应制备聚氨酯注浆材料。使用激光粒度仪、差示扫描量热仪、热重分析仪和红外热像仪对所合成的MEPCMs的粒径与热行为进行了表征,并使用旋转黏度计、万能试验机等测试了聚氨酯注浆材料A组分的浆液黏度、固结体的力学性能与固化行为。结果表明,与未改性的聚氨酯注浆材料相比,加入MEPCMs可使固化最高反应温度显著降低,固化时间明显延长,固化放热速率降低。随着MEPCMs含量的增加,A组分浆液黏度增加,固结体强度下降。当MEPCMs质量分数为15%时,A组分浆液黏度为551.9 m Pa·s,固化最高反应温度为98.7℃,固化时间为235 s,固结体压缩及拉伸强度分别为44.9 MPa和14.7 MPa。所制备的相变材料改性的聚氨酯注浆材料在保持良好的浆液可注性、固结体强度及热稳定性的同时,实现了对固化放热行为的调控。

关键词：微胶囊相变材料聚氨酯注浆材料固化放热

全氟辛酸对成骨细胞骨形成和破骨细胞骨吸收作用研究

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日用化学工业（中英文） 2024年第6期54卷 648-655页

作者：薛黎明林元杰金玉娥徐佳乐卢大胜汪国权上海市疾病预防控制中心国家环境保护新型污染物环境健康影响评价重点实验室上海200336

考察全氟辛酸(PFOA)对成骨细胞骨形成和破骨细胞骨吸收的作用和机制,为探索PFOA暴露引起骨丢失提供科学依据。采用原代新生大鼠颅盖骨分离成骨细胞,考察1,10和100μmol/L PFOA对成骨细胞增殖,碱性磷酸酶(ALP)活性和骨结节形成的影响;采... 详细信息

考察全氟辛酸(PFOA)对成骨细胞骨形成和破骨细胞骨吸收的作用和机制,为探索PFOA暴露引起骨丢失提供科学依据。采用原代新生大鼠颅盖骨分离成骨细胞,考察1,10和100μmol/L PFOA对成骨细胞增殖,碱性磷酸酶(ALP)活性和骨结节形成的影响;采用巨噬细胞集落刺激因子(M-CSF)及核因子κB受体激活因子配体(RANKL)诱导大鼠骨髓单核细胞分化破骨细胞模型,考察1,10和100μmol/L PFOA对破骨细胞活力,抗酒石酸酸性磷酸酶(TRAP)活性和骨吸收陷窝形成指标的影响;采用Western blot考察成骨细胞护骨素(OPG)和RANKL蛋白表达。PFOA在1和10μmol/L时促进成骨细胞活力,但对ALP活性和骨结节形成无影响。100μmol/L PFOA可显著抑制细胞增殖,ALP活性和骨结节形成,同时抑制OPG/RANKL蛋白表达的比例。PFOA对破骨细胞活力无影响,10和100μmol/L PFOA可显著抑制促进TRAP活性和骨吸收陷窝形成面积。PFOA抑制成骨细胞骨形成作用可能通过下调Wnt通路,通过抑制OPG/RANKL/RANK通路,促进破骨细胞骨吸收作用。

关键词：全氟辛酸骨丢失成骨细胞破骨细胞 OPG/RANKL/RANK通路

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吴A区侏罗系油藏黏弹自调剂调驱效果分析

石油化工应用 2024年第4期43卷 83-87页

作者：付红许开国王鹏王迪许嘉乐李博张雷中国石油长庆油田分公司第三采油厂宁夏银川750006

吴A区延9、延10底水油藏于2017年开始水驱动用程度大幅度下降,只有38.0%,受重力影响,吸水段逐渐下移,受地层平面非均质性和层间非均质性强、前期注入强度和采液强度大的影响,底水过早锥进导致油井见水,甚至见注入水发生水淹,常规堵水调... 详细信息

吴A区延9、延10底水油藏于2017年开始水驱动用程度大幅度下降,只有38.0%,受重力影响,吸水段逐渐下移,受地层平面非均质性和层间非均质性强、前期注入强度和采液强度大的影响,底水过早锥进导致油井见水,甚至见注入水发生水淹,常规堵水调剖措施无法完成地层深部地带封堵。为延缓注入水沿大孔道和微裂缝等地层深部高渗通道突进,提高注入水的波及体积,改善吸水剖面,吴A区延9、延10油藏于2022年8月开展黏弹自调剂调驱矿场试验。试验结果表明,2022年8月-2023年10月注入黏弹自调剂后,调驱效果较好,深入地层后能有效滞留于孔喉,平均单井日注水量下降,注入压力由7.20MPa上升到7.80MPa;整体吸水指数由38.1m^(3)/(d·MPa)下降到25.1m^(3)/(d·MPa);黏弹自调剂在地层中形成有效封堵,有效改善油水流度比以及提高洗油效率,注入黏弹自调剂后月度递减率由0.10%下降到-0.40%,月度含水率上升幅度由0.03%下降到0.02%。

关键词：底水油藏聚合物黏弹性深部调驱

Multi-Stream Temporally Enhanced Network for Video Salient Object Detection

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Computers, Materials & Continua 2024年第1期78卷 85-104页

作者： Dan xu jiale Ru Jinlong Shi School of Computer Science Jiangsu University of Science and TechnologyZhenjiang212100China

Video salient object detection(VSOD)aims at locating the most attractive objects in a video by exploring the spatial and temporal *** poses a challenging task in computer vision,as it involves processing complex spatial data that is also influenced by temporal *** the progress made in existing VSOD models,they still struggle in scenes of great background diversity within and between ***,they encounter difficulties related to accumulated noise and high time consumption during the extraction of temporal features over a long-term *** propose a multi-stream temporal enhanced network(MSTENet)to address these *** investigates saliency cues collaboration in the spatial domain with a multi-stream structure to deal with the great background diversity challenge.A straightforward,yet efficient approach for temporal feature extraction is developed to avoid the accumulative noises and reduce time *** distinction between MSTENet and other VSOD methods stems from its incorporation of both foreground supervision and background supervision,facilitating enhanced extraction of collaborative saliency *** notable differentiation is the innovative integration of spatial and temporal features,wherein the temporal module is integrated into the multi-stream structure,enabling comprehensive spatial-temporal interactions within an end-to-end *** experimental results demonstrate that the proposed method achieves state-of-the-art performance on five benchmark datasets while maintaining a real-time speed of 27 fps(Titan XP).Our code and models are available at https://***/Rujiale/MSTENet.

关键词： Video salient object detection deep learning temporally enhanced foreground-background collaboration

气候变化背景下内蒙古中西部植被覆盖度演变特征研究

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生态环境学报 2024年第7期33卷 1008-1018页

作者：徐佳乐杨兴川赵文吉杨志强钟一雪师乐颜马鹏飞首都师范大学资源环境与旅游学院北京100048 国家环境保护卫星遥感重点实验室北京100094

植被覆盖的动态演变能够有效地反映区域生态环境变化。为探究内蒙古中西部5个盟市植被覆盖度时空演变特征及对气候变化的响应,基于MODISNDVI数据和同期气候因子(平均气温、累计降水、平均日照时数、平均相对湿度)数据,利用Theil-Sen Med... 详细信息

植被覆盖的动态演变能够有效地反映区域生态环境变化。为探究内蒙古中西部5个盟市植被覆盖度时空演变特征及对气候变化的响应,基于MODISNDVI数据和同期气候因子(平均气温、累计降水、平均日照时数、平均相对湿度)数据,利用Theil-Sen Median趋势分析、MK检验、Hurst指数、偏相关分析等方法分析了内蒙古中西部5个盟市2000-2021年植被覆盖度和气候因子的时空变化特征及植被覆盖度对气候因子的响应。结果表明:2000-2021年,内蒙古中西部5个盟市的平均植被覆盖度为0.321,处于较低水平;22年间,植被覆盖度呈波动上升趋势,增长速度为0.4%。研究区植被覆盖度呈现东高西低的分布格局,低覆盖度面积为53.2%,中高覆盖度和高覆盖度约占总面积的10%。研究区植被覆盖度的平均Sen斜率为0.004,表明植被覆盖整体呈上升趋势;植被改善区域面积达89.1%,植被退化部分占比为10.6%。Hurst指数均值为0.423。结合Sen趋势,预测出未来覆盖度以稳步增长为主,其中48.4%的区域不会发生显著的植被改善或退化现象,30.6%的区域未来以植被改善为主。研究区平均气温、累计降水量呈上升趋势,而平均日照时数和平均相对湿度呈下降趋势。植被覆盖度与平均气温的关系以不显著相关为主,其中通过显著性检验(p<0.05)的正相关面积为14.7%;植被覆盖度与累计降水量的关系以正相关为主,正相关面积占比为98.1%;与平均日照时数和平均相对湿度的关系均以不显著相关为主。

关键词：植被覆盖度时空格局气候变化相关分析趋势预测归一化植被指数

Ga-In liquid metal nanoparticles prepared by physical vapor deposition

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Progress in Natural Science:Materials International 2018年第1期28卷 28-33页

作者： Fan Yu jiale xu Huiqin Li Zizhao Wang Limin Sun Tao Deng Peng Tao Qi Liang State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Instrumental Analysis Center Shanghai Jiao Tong University

Controlled synthesis and appropriate characterization of nanoscale particles of gallium-based liquid metals are critical to fulfilling their broad range of applications in the field of flexible, stretchable, and printable micro-/nanoelectronics. Herein, we report a new way to synthesize surfactant-free gallium-indium nanoparticles with controlled particle size on a variety of substrates through a facile physical vapor deposition method. It was found that with prolonged deposition time the liquid metal nanoparticles gradually grew from near-monodispersed small particles with a diameter of ～25 nm to bimodal distributed particles. A nucleation, growth, ripening and merging process was proposed to explain the observed evolution of particle size. Atomic force microscopy measurement indicates that the fabricated liquid metal nanoparticles demonstrate elastic deformation with a certain range of loads and the scanned particle size is dependent on the applied loads. We further investigated the gradual breaking process of the core-shell structured liquid metal nanoparticles, which was evidenced by multiple kinks on the force-separation curve. This work presents a new bottom-up approach to prepare nanoscale liquid metal particles and demonstrates that atomic force microscopy is a suitable technique to characterize the synthesized liquid metal nanoparticles.

关键词： Gallium-Indium alloy Atomic force microscopy Liquid metal Nanoparticle

Dispersion stability of thermal nanofluids

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Progress in Natural Science:Materials International 2017年第5期27卷 531-542页

作者： Fan Yu Yingying Chen Xingbo Liang jiale xu Chiahsun Lee Qi Liang Peng Tao Tao Deng School of Materials Science and Engineering and State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong University Science and Technology on Solid-State Laser Laboratory

Thermal nanofluids, the engineered fluids with dispersed functional nanoparticles, have exhibited extraordinary thermophysical properties and added functionalities, and thus have enabled a broad range of important applications. The poor dispersion stability of thermal nanofluids, however, has been considered as a longexisting issue that limits their further development and practical application. This review overviews the recent efforts and progresses in improving the dispersion stability of thermal nanofluids such as mechanistic understanding of dispersion behavior of nanofluids, examples of both water-based and oil-based nanofluids,strategies to stabilize nanofluids, and characterization techniques for dispersion behavior of nanofluids. Finally,on-going research needs, and possible solutions to research challenges and future research directions in exploring stably dispersed thermal nanofluids are discussed.

关键词： Thermal nanofluids Dispersion Aggregation Electrostatic stabilization Steric stabilization

Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis

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Acta Pharmaceutica Sinica B 2022年第1期12卷 291-307页

作者： Zhangxu He Haomiao Jiao Qi An Xin Zhang Dan Zengyangzong jiale xu Hongmin Liu Liying Ma Wen Zhao State Key Laboratory of Esophageal Cancer Prevention and Treatment Key Laboratory of Advanced Pharmaceutical TechnologyMinistry of Education of ChinaSchool of Pharmaceutical SciencesZhengzhou UniversityZhenzhou 450001China China Meheco Topfond Pharmaceutical Co. Zhumadian 463000China

Bromodomain containing protein 4(BRD4), as an epigenetic reader, can specifically bind to the acetyl lysine residues of histones and has emerged as an attractive therapeutic target for various diseases,including cancer, cardiac remodeling and heart failure. Herein, we described the discovery of hit 5 bearing4-phenylquinazoline skeleton through a high-throughput virtual screen using 2,003,400 compound library(enamine). Then, structure-activity relationship(SAR) study was performed and 47 new 4-phenylquinazoline derivatives toward BRD4 were further designed, synthesized and evaluated, using HTRF assay set up in our lab. Eventually, we identified compound C-34, which possessed better pharmacokinetic and physicochemical properties as well as lower cytotoxicity against NRCF and NRCM cells, compared to the positive control JQ1. Using computer-based molecular docking and cellular thermal shift assay, we further verified that C-34 could target BRD4 at molecular and cellular levels. Furthermore, treatment with C-34 effectively alleviated fibroblast activation in vitro and cardiac fibrosis in vivo, which was correlated with the decreased expression of BRD4 downstream target c-MYC as well as the depressed TGF-β1/Smad2/3 signaling *** together, our findings indicate that novel BRD4 inhibitor C-34 tethering a 4-phenylquinazoline scaffold can serve as a lead compound for further development to treat fibrotic cardiovascular disease.

关键词： BRD4 Inhibitor 4-Phenylquinazoline Cardiac fibrosis

Efficient concentration of trace analyte with ordered hotspot construction for a robust and sensitive SERS platform

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International Journal of Extreme Manufacturing 2024年第3期6卷 532-542页

作者： Youdi Hu Yanlei Hu Zhenyu Wang jiale Yong Wei Xiong Dong Wu Shixiang xu Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenGuangdong 518060People’s Republic of China CAS Key Laboratory of Mechanical Behavior and Design of Materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefeiAnhui 230027People’s Republic of China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubeiPeople’s Republic of China

Surface-enhanced Raman scattering(SERS)platform,which enables trace analyte detection,has important application *** structuring/modifying the surface of the SERSsubstrate,analyte in highly diluted solutions can be concentrated into localized active areas for highly sensitive ***,subject to the difficulty of the fabrication process,itremains challenging to balance hot-spot construction and the concentration capacity of analyte ***,preparing SERS substrates with densely ordered hot spots andefficient concentration capacity is of great significance for highly sensitive ***,we propose an Ag and fluoroalkyl-modified hierarchical armour substrate(Ag/F-HA),which has a double-layer stacking design to combine analyte concentration with hotspot *** microarmour structure is fabricated by femtosecond-laser processing to serve as asuperhydrophobic and low-adhesive surface to concentrate analyte,while the anodic aluminium oxide(AAO)template creates a nanopillar array serving as dense and ordered hot *** the synergistic action of hot spots and analyte concentration,Ag/F-HA achieves a detectionlimit down to 10^(-7)M doxorubicin(DOX)molecules with a RSD of 7.69%.Additionally,Ag/F-HA exhibits excellent robustness to resist external disturbances such as liquid splash or *** on our strategy,SERS substrates with directional analyte concentrations are further explored by patterning microcone arrays with *** work opens a way to the realistic implementation of SERS in diverse scenarios.

关键词： surface-enhanced Raman scattering anodic aluminium oxide femtosecond laser processing concentration of trace analytes mechanical robustness