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Tal6b/AvrXa27A,a hidden TALE targeting the susceptibility gene OsSWEET11a and the resistance gene Xa27 in rice

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Plant Communications 2024年第2期5卷 122-134页

作者： Zhengyin Xu Xiameng Xu Ying Li Linlin Liu Qi Wang Yijie Wang Yong Wang jiali Yan Guanyun cheng Lifang Zou Bo Zhu Gongyou chen Shanghai Collaborative Innovation Center of Agri-Seeds School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Microbial Metabolism Shanghai Jiao Tong UniversityShanghai 200240China

Xanthomonas oryzae ***(Xoo)secretes transcription activator-like effectors(TALEs)to activate rice susceptibility(S)genes,causing bacterial blight(BB),as well as resistance(R)genes,leading to de-fense against *** activation follows a gene-for-gene paradigm that results in an arms race between the TALE of the pathogen and effector-binding elements(EBEs)in the promoters of host *** this study,we characterized a novel TALE,designated Tal6b/AvrXa27A,that activates the rice S gene OsSWEET11a and the rice R gene ***6b/AvrXa27A is a member of the AvrXa27/TalAO class and contains 16 repeat variable diresidues(RVDs);one RVD is altered and one is deleted in Tal6b/AvrXa27A compared with AvrXa27,a known avirulence(avr)effector of ***6b/AvrXa27A can transcriptionally activate the expression of Xa27 and OsSWEET11a via EBEs in their corresponding promoters,leading to effector-triggered immunity and susceptibility,*** 16 RVDs in Tal6b/AvrXa27A have no obvious similarity to the 24 RVDs in the effector PthXo1,but EBETal6b and EBEPthXo1 are overlapped in the OsSWEET11a ***6b/AvrXa27A is prevalent among Asian Xoo isolates,but PthXo1 has only been reported in the Philippine strain *** editing of EBETal6b in the OsSWEET11a pro-moter further confirmed the requirement for OsSWEET11a expression in Tal6b/AvrXa27A-dependent susceptibility to ***,Tal6b/AvrXa27A resulted in higher transcription of Xa27 than of OsSWEET11a,which led to a strong,rapid resistance response that blocked disease *** suggest that Tal6b/AvrXa27A has a dual function:triggering resistance by activating Xa27 gene expression as an avirulence factor and inducing transcription of the S gene OsSWEET11a,resulting in ***,Tal6b/AvrXa27A,but not AvrXa27,can bind to the promoter of *** underlying recognition mechanism for this binding remains unclear but appears to deviate from the currently accepted TALE code.

关键词： Xanthomonas oryzae pv.oryzae TALE AvrXa27 tal6b Xa27 OsSWEET11a

New potential barite reference materials for LA-MC-ICP-MS sulfur isotope analysis with application to hydrothermal barite in the Huayangchuan deposit， western China

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Journal of Earth Science 2024年

作者： jiali Fu Xinqian He Zhaochu Hu Shuo Yin Jian Ma Kaiyun chen Wen Zhang National Key Laboratory of Prospecting， Mining and Remote Sense Detecting on Uranium Resources， East China University of Technology State Key Laboratory of Nuclear Resources and Environment， East China University of Technology School of Earth Sciences， East China University of Technology State Key Laboratory of Geological Processes and Mineral Resources， China University of Geosciences Wuhan State Key Laboratory of Continental Dynamics， Department of Geo logy， Northwest University

Sulfur isotopes of S-bearing materials are powerful tools to trace various geological processes and sulfur sources in earth sciences， especially in ore deposits where sulfide-sulfate pair coprecipitates widely. However， in-situ S isotope determination of barite is challenging without natural matrix-matched reference material. In this study， we present two natural barite reference materials （1-YS and 294-YS） for in-situ sulfur isotopic analysis. Independent LA-MC-ICP-MS laboratories were utilized to test the δ34S micron-scale homogeneity of 1-YS and 294-YS barites that have 2s repeatabilities of better than ±0.45 ‰ and ±0.41 ‰， respectively. Meanwhile， the in-situ analysis results are consistent with the results of the bulk analysis by GS-IRMS within uncertainty. The grand mean δ34S values of 1-YS （13.37‰ ± 0.42 ‰， 2s） and 294-YS （14.38‰ ± 0.44 ‰， 2s） are the final recommended values obtained from four independent laboratories. All the results confirm the suitability of 1-YS and 294-YS barite used as calibration materials with respect to in-situ S isotopic analysis. Moreover， the new developed barite reference materials were used as matrix-matched standard to calibrate the barite samples from the Huayangchuan carbonatite-hosted U-polymetallic deposit （Qinling orogenic belt， western China） to obtain δ34S values. Utilizing the temperature-dependent δ34S fractionation of barite-pyrite pair， we calculate the formation temperature of barite （i.e.， 506 to 537 ℃） and the δ34S value of mineralizing fluid （i.e.， -7.11‰ to -7.59 ‰） in the Huayangchuan deposit. The results indicate an involvement of sedimentary sulfur， presumably acting as a potential uranium source （e.g.， upper crustal materials） for the giant Huayangchuan deposit.

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物流企业人力资源建设初探

物流技术 2014年第12期33卷 22-24页

作者：陈佳丽贵州财经大学贵州贵阳550004

针对物流企业人力资源的特征,从人力资源规划、招聘与录用、培训开发、绩效考核和薪酬管理等角度探讨了物流企业人力资源建设问题。

关键词：物流企业人力资源管理职业化

Effect of CYP3A5 Polymorphism on Tacrolimus Concentration during Early Period after Kidney Transplantation in Recipients

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器官移植内科学杂志 2009年第2期4卷 73-76页

作者： Lichen Teng changxi Wang Lizhong chen jiali Li Jiguang Fei Suxiong Deng Jiang Qiu Jun Li Guodong chen Department of Organ Transplantation First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080 China

Objective To investigate the effect of cytochrome P-450 CYP3A5 polymorphism on the through level of tacrolimus in renal transplant recipients during the early stage after operation. Methods All of the 90 recipients were treated with tacrolimus in combination with mycophenolate mofetil and prednisone for preventing rejection episode after operation. Tacrolimus at a dose of 0.15 mg·kg^-1·d^-1 was initiated at the second or third day post-transplantation. The blood trough level of tacrolimus was detected by means of ELISA for one month after transplantation, and its dosage was frequently adjusted to keep its blood concentration at the range of 5-10 g/L. The ratio of concentration-to-dose (C/D) and the decline rate of serum creatinine level per day were recorded. PCR-RFPL method was used for analyzing the occurrence of CYP3A5 polymorphisms. Results The recipients with wild homozygote (CYP3A5 * 1/* 1), mutant homozygote (CYP3A5*3/*3), and mutant heterozygote (CYP3A5*1/*3) were 9, 41 and 40 cases respectively. The initial trough blood level of tacrolimus (9.8±3.1 g/L) in recipients with CYP3A5*3/*3 was markedly higher than that in recipients with CYP3A5* 1/*1, and CYP3A5*1/*3 (both P *1/*3 >*1/*1 for the first two weeks after operation and the ratio was markedly higher in recipients with CYP3A5*3/*3 than that in recipients with latter two genotypes (both P<0.05). The decline rate of serum creatinine level (127.4±59.6μmol·L^-1·d^-1) in CYP3A5*3/*3 recipients was higher than that in CYP3A5* 1/* 1 and CYP3A5* 1/*3 recipients in the first week post-transplantation (both P<0.05). Conclusion CYP3A5 genotypes can affect the trough level of tacrolimus during the first month post-transplantation in recipients.

关键词： CYP3A5 细胞色素多形性强的松药品

基于可转移土地发展权的农村土地整治项目融资机制分析——以浙江省嘉兴市秀洲区为例

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农业经济问题 2010年第10期31卷 53-59页

作者：陈佳骊徐保根浙江财经学院不动产研究所杭州310018 浙江大学管理学院

处于高速城市化进程中的浙江省创造性地设计出类似于美国可转移发展权制度的建设用地复垦指标政策,此项政策使地方政府可通过农村建设用地复垦换取建设用地指标,从而为农村土地整治项目提供重要的资金支持。基于对浙江省嘉兴市秀洲区的... 详细信息

处于高速城市化进程中的浙江省创造性地设计出类似于美国可转移发展权制度的建设用地复垦指标政策,此项政策使地方政府可通过农村建设用地复垦换取建设用地指标,从而为农村土地整治项目提供重要的资金支持。基于对浙江省嘉兴市秀洲区的实地调查,本文分析了这种创新融资机制生成的内在需求和制度背景、机制运行现状及效果,探讨了这一融资机制的局限性以及项目参与者土地利益关系问题。研究认为,单独依靠可转移建设用地复垦指标不能完全满足农村土地整治项目资金需求;政府主导参与对项目融资成功有正面影响;在建设用地复垦指标转移过程中需给予农民选择权、增加农民市场参与权。

关键词：可转移土地发展权农村土地整治建设用地复垦指标项目融资土地利益关系

The COVID‐19 vaccine: Attitudes and vaccination in patients with autoimmune inflammatory rheumatic diseases

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Rheumatology & Autoimmunity 2022年第2期2卷 82-91页

作者： jiali chen Wenxin Cai Tian Liu Yunshan Zhou Yuebo Jin Yue Yang Shi chen Kun Tang Chun Li Department of Rheumatology and Immunology Peking University People's HospitalBeijingChina Department of Rheumatology and Immunology The Second Xiangya HospitalCentral South UniversityChangshaChina Tsinghua Research Center for Public Health Tsinghua UniversityBeijingChina

Background:We examined attitudes toward the COVID‐19 vaccine,potential factors underlying these attitudes,and ways to increase vaccination willingness in autoimmune inflammatory rheumatic diseases(AIIRD)***:A multicenter,web‐based,observational survey using an online questionnaire was conducted among AIIRD patients aged≥18 years from May 24,2021,to June 3,*** were 3104 AIIRD patients(2921 unvaccinated and 183 vaccinated).Results:Of the unvaccinated patients,32.9%were willing to receive the COVID‐19 vaccine,45.0%were uncertain,and 14.8%were *** vaccination was recommended by physicians,patients'willingness increased to 93.8%.Participants'main concerns were that the vaccine may aggravate AIIRD disease(63.0%)and may cause vaccine‐related adverse events(19.9%).Female patients were less likely to be ***,patients who had children aged≤18 years were more willing to be *** addition,vaccination willingness was higher in patients with trust in the safety and efficacy of the COVID‐19 ***,183(5.9%)patients were vacci*** major vaccination side effects were injection reaction,myalgia,and *** a median follow‐up of 88(38,131)days,patients'disease activities were ***:The findings show that AIIRD patients were unwilling to receive the COVID‐19 vaccine because of fears of potential disease exacerbation and additional adverse *** characteristics and concerns about COVID‐19 disease and vaccines had a significant effect on vaccination willingness.

关键词： autoimmune rheumatic diseases COVID‐19 vaccine SARS‐CoV‐2 vaccine hesitancy

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ICU护士照护长期昏迷患者真实体验的研究

中华护理杂志 2020年第3期55卷 422-426页

作者：陈佳丽曾莉同济大学附属第十人民医院产房上海市200072 同济大学附属第十人民医院神经重症监护病房上海市200072

目的深入了解神经外科ICU护士照护长期昏迷患者的真实体验。方法采用现象学研究法,对11名神经外科ICU护士进行半结构式深入访谈,并用Colaizzi 7步法对访谈资料进行分析。结果神经外科ICU护士照护长期昏迷患者的真实体验共提炼出5个主题... 详细信息

目的深入了解神经外科ICU护士照护长期昏迷患者的真实体验。方法采用现象学研究法,对11名神经外科ICU护士进行半结构式深入访谈,并用Colaizzi 7步法对访谈资料进行分析。结果神经外科ICU护士照护长期昏迷患者的真实体验共提炼出5个主题:形成多种情感体验(爱伤与共情共存;失望与希望交织)、领会职业素养必要性(慎独躬行,提高护理质量;视患犹亲,体现护理人文性)、感知重症思维重要性(批判性思维是应用专业知识的关键;病情预判为成功抢救提供有效保障)、获得自我价值认同感、审视血脉伦理与临床决策(坚持源于亲情血脉相连;放弃源自不忍生命质量低下)。结论神经外科ICU护士对照护长期昏迷患者的体验呈多维度,提示护理管理者应培养神经外科ICU护士职业素养、强化护士专业思维、提升护士自身价值、权衡血脉与伦理进行临床决策,进而为长期昏迷的神经重症患者提供更好的照护。

关键词：神经外科重症监护病房质性研究心理护理

持挖掘银发经济带来的出版机遇——华龄出版社老年图书出版现状分析

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出版科学 2015年第4期23卷 43-46页

作者：邓香莲陈佳莉华东师范大学传播学院上海200241

老龄化社会的到来为老年读物的出版带来了难得的发展机遇。现实中老龄读物存在品种单调、质量参差不齐等诸多问题。本文以华龄出版社为例展开个案分析,以管窥我国当前老年图书出版的现状,为相关出版机构的发展提供借鉴和参考。

关键词：华龄出版社老年图书银发经济

结构化理论在国内信息系统(IS)领域的应用评述

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科技管理研究 2016年第19期36卷 202-209页

作者：戚桂杰陈佳丽山东大学山东济南250100

吉登斯的结构化理论是信息系统(IS)领域引用较多的社会学理论之一,并有信息系统学者提出针对IS领域的结构化理论。与国外相比,国内IS领域对结构化理论的研究尚浅,尚存在一定问题。广泛搜集国内运用结构化理论研究IS领域问题的中文文献,... 详细信息

吉登斯的结构化理论是信息系统(IS)领域引用较多的社会学理论之一,并有信息系统学者提出针对IS领域的结构化理论。与国外相比,国内IS领域对结构化理论的研究尚浅,尚存在一定问题。广泛搜集国内运用结构化理论研究IS领域问题的中文文献,对最终确定的20篇文献分别从研究类型、研究主题、研究方法、理论引用4个方面进行分析,在分析基础上指出尚存在的问题。最后,为国内IS领域更好地利用结构化理论进行研究提出发展方向。

关键词：信息系统吉登斯结构化理论技术结构化模型适应性结构化理论