The COVID‐19 vaccine: Attitudes and vaccination in patients with autoimmune inflammatory rheumatic diseases

作     者：Jiali Chen Wenxin Cai Tian Liu Yunshan Zhou Yuebo Jin Yue Yang Shi Chen Kun Tang Chun Li Jiali Chen;Wenxin Cai;Tian Liu;Yunshan Zhou;Yuebo Jin;Yue Yang;Shi Chen;Kun Tang;Chun Li

作者机构：Department of Rheumatology and ImmunologyPeking University People's HospitalBeijingChina Department of Rheumatology and ImmunologyThe Second Xiangya HospitalCentral South UniversityChangshaChina Tsinghua Research Center for Public HealthTsinghua UniversityBeijingChina 

出 版 物：《Rheumatology & Autoimmunity》 (风湿病与自身免疫（英文）)

年 卷 期：2022年第2卷第2期

页      面：82-91页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Beijing Natural Science Foundation,Grant/Award Number:7192211 The study was approved by the ethics committee of Peking University People's Hospital(2018PHB115) 

主　　题：autoimmune rheumatic diseases COVID‐19 vaccine SARS‐CoV‐2 vaccine hesitancy 

摘      要：Background:We examined attitudes toward the COVID‐19 vaccine,potential factors underlying these attitudes,and ways to increase vaccination willingness in autoimmune inflammatory rheumatic diseases(AIIRD)***:A multicenter,web‐based,observational survey using an online questionnaire was conducted among AIIRD patients aged≥18 years from May 24,2021,to June 3,*** were 3104 AIIRD patients(2921 unvaccinated and 183 vaccinated).Results:Of the unvaccinated patients,32.9%were willing to receive the COVID‐19 vaccine,45.0%were uncertain,and 14.8%were *** vaccination was recommended by physicians,patients willingness increased to 93.8%.Participants main concerns were that the vaccine may aggravate AIIRD disease(63.0%)and may cause vaccine‐related adverse events(19.9%).Female patients were less likely to be ***,patients who had children aged≤18 years were more willing to be *** addition,vaccination willingness was higher in patients with trust in the safety and efficacy of the COVID‐19 ***,183(5.9%)patients were vacci*** major vaccination side effects were injection reaction,myalgia,and *** a median follow‐up of 88(38,131)days,patients disease activities were ***:The findings show that AIIRD patients were unwilling to receive the COVID‐19 vaccine because of fears of potential disease exacerbation and additional adverse *** characteristics and concerns about COVID‐19 disease and vaccines had a significant effect on vaccination willingness.