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Tanshinone ⅡA prevents acute lung injury by regulating macrophage polarization

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Journal of Integrative Medicine 2022年第3期20卷 274-280页

作者： jia-yi zhao Jin Pu jian Fan Xin-yu Feng jian-wen Xu Rong Zhang Yan Shang Department of General Practice Changhai HospitalNaval Medical UniversityShanghai 200433China Department of General Practice Changhai Hongkou HospitalShanghai 200081China Department of Special Clinic Changhai HospitalNaval Medical UniversityShanghai 200433China Shanghai Institute of Biochemical and Cell biology Chinese Academy of SciencesShanghai 200031China Department of Nursing Shidong HospitalUniversity of Shanghai for Science and TechnologyShanghai 200438China Department of Respiratory and Critical Care Medicine Changhai HospitalNaval Medical UniversityShanghai 200433China

Objective: Acute lung injury(ALI) is a serious respiratory dysfunction caused by pathogen or physical invasion. The strong induced inflammation often causes death. Tanshinone ⅡA(Tan-ⅡA) is the major constituent of Salvia miltiorrhiza Bunge and has been shown to display anti-inflammatory effects. The aim of the current study was to investigate the effects of Tan-ⅡA on ***: A murine model of lipopolysaccharide(LPS)-induced ALI was used. The lungs and serum samples of mice were extracted at 3 days after treatment. ALI-induced inflammatory damages were confirmed from cytokine detections and histomorphology observations. Effects of Tan-ⅡA were investigated using in vivo and in vitro ALI models. Tan-ⅡA mechanisms were investigated by performing Western blot and flow cytometry experiments. A wound-healing assay was performed to confirm the Tan-ⅡA ***: The cytokine storm induced by LPS treatment was detected at 3 days after LPS treatment, and alveolar epithelial damage and lymphocyte aggregation were observed. Tan-ⅡA treatment attenuated the LPS-induced inflammation and reduced the levels of inflammatory cytokines released not only by inhibiting neutrophils, but also by macrophage. Moreover, we found that macrophage activation and polarization after LPS treatment were abrogated after applying the Tan-ⅡA treatment. An in vitro assay also confirmed that including the Tan-ⅡA supplement increased the relative amount of the M2 subtype and decreased that of M1. Rebalanced macrophages and Tan-ⅡA inhibited activations of the nuclear factor-κB and hypoxia-inducible factor pathways. Including Tan-ⅡA and macrophages also improved alveolar epithelial repair by regulating macrophage ***: This study found that while an LPS-induced cytokine storm exacerbated ALI, including Tan-ⅡA could prevent ALI-induced inflammation and improve the alveolar epithelial repair, and do so by regulating macrophage polarization.

关键词： Acute lung injury Inflammation Cytokine storm TanshinoneⅡA Macrophages

Clinical efflcacy of botulinum toxin type A on acute acquired comitant esotropia

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1845-1851页

作者： Xiao-Qi Huang Xue-Min Hu yi-jia zhao Mei-Hong Ye Bei-Xi yi Lian-Hong Zhou Department of Ophthalmology Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

AIM: To investigate the effects of micro-injection of botulinum toxin A(BTXA) on acute acquired comitant esotropia(AACE). METHODS: A total of 33 AACE patients who underwent BTXA micro-injection at Renmin Hospital of Wuhan University from September 1^(st), 2019 to July 1^(st), 2021 were retrospective analyzed. Esotropia, eye alignment, stereopsis, and complications were examined at baseline(except complications), 1wk, 1, 3, and 6mo after injection. RESULTS: The average angle of deviation before injection was(+20.24±6.80)^(Δ) at near and(+24.76±6.43)^(Δ) at distance, while(+5.15±5.85)^(Δ) at near and(+7.30±6.17)^(Δ) at distance 6mo after treatment(P800 seconds of arc) decreased from 11 to 3. The number of patients having peripheral stereopsis(300-800 seconds of arc), macular stereopsis(70-200 seconds of arc) and central concave stereopsis(≤60 seconds of arc) increased from 10 to 11, 10 to 12, and 2 to 7, respectively. At the follow-ups at 1wk, 1, 3, and 6mo after injection, success rates were 96.97%, 96.97%, 93.94% and 87.88%, respectively. One week after injection, two patients(6.07%) showed subconjunctival hemorrhage;three patients(9.09%) showed limited eye movement and one patient(3.03%) showed mild vertical strabismus. All the symptoms disappeared by the final ***: Micro-injection of BTXA can reduce diplopia and improve binocular vision function of AACE patients. Furthermore, the operation is relatively safe with few complications, making it an ideal treatment modality for AACE.

关键词： acute acquired comitant esotropia botulinum toxin A binocular visual function stereopsis diplopia

Effects of slanted bilateral lateral recession vs conventional bilateral lateral recession on convergence insufficiency intermittent exotropia:a prospective study

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 245-250页

作者： Yuan-Jin Li Xiao-Qi Huang Bei-Qian yi yi-jia zhao Die-Wen-Jie Hu Run-Ting Ma Wen-Ping Li Mei-Hong Ye Lian-Hong Zhou Department of Ophthalmology Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

AIM:To observe the surgical effects of slanted bilateral lateral recession(S-BLR)versus conventional bilateral lateral recession(C-BLR)in convergence insufficiency intermittent exotropia(CI-IXT).METHODS:Using a randomized,double-blind,prospective design,22 patients with CI-IXT who were admitted to Renmin Hospital of Wuhan University from July 2019 to December 2020 were *** were randomly divided into either S-BLR or C-BLR group for their subsequent strabismus *** patients were followed up for *** deviation,distant deviation,and neardistance difference(NDD)were measured in all ***:Twelve months after surgery,NDD improvement was 10(8,13)prismatic degrees(PD)in S-BLR group and 3(1,6)PD in C-BLR group(P=0.011).The near deviation of S-BLR group was 0(-2,2)PD,while that of C-BLR group was-4(-6,-3)PD(P=0.005).Before and after surgery,the difference in the distant deviation between the two groups was not statistically *** was no statistically significant difference in near stereopsis between the two groups(P=0.380)at *** success rate at 12mo after operation was 90.91%and 72.73%in the two groups(P=0.280).CONCLUSION:CI-IXT patients treated with S-BLR have better surgical outcomes than those treated with C-BLR,which indicates S-BLR is a safe and effective operation pattern.

关键词： ocular surgery exotropia convergence insufficiency prognosis pediatric disease

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： jia zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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关节镜下分期治疗渔民膝关节多发韧带损伤

中国内镜杂志 2015年第9期21卷 978-981页

作者：郑杰赵嘉懿浙江省舟山医院骨科浙江舟山316000

目的观察关节镜下分期治疗渔民膝关节多发韧带损伤的临床疗效。方法 15例膝关节多发韧带损伤的渔民患者一期修复外侧副韧带、内侧副韧带和半月板,术后1周开始功能锻炼;待患者屈膝超过110°和伸膝无障碍,二期关节镜下重建前交叉韧带和后... 详细信息

目的观察关节镜下分期治疗渔民膝关节多发韧带损伤的临床疗效。方法 15例膝关节多发韧带损伤的渔民患者一期修复外侧副韧带、内侧副韧带和半月板,术后1周开始功能锻炼;待患者屈膝超过110°和伸膝无障碍,二期关节镜下重建前交叉韧带和后交叉韧带。术后1年评估膝关节功能恢复情况。结果 15例患者均获随访,时间14～34个月,平均21个月。1例屈膝受限25°,3例屈膝受限10°～15°,无伸膝受限;内外翻应力试验均阴性,2例Lachman试验（＋）,1例后抽屉试验（＋＋）,3例后抽屉试验（＋）。Lysholm膝关节功能评分术前（42.6±8.2）分,术后1年（86.9±5.6）分（P〈0.05）。结论关节镜下分期治疗是治疗渔民膝关节多发韧带损伤的一种有效的方法。

关键词：膝关节多发韧带损伤关节镜分期治疗

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创新型国家社会基础培育的实现路径

西安建筑科技大学学报（社会科学版） 2013年第3期32卷 6-12页

作者：贾兆义北京科技大学北京100083

建设创新型国家需要诸多领域的协同推进,创新型国家的社会基础是创新型国家建成和运转的土壤,在创新型国家建设中具有基础性作用。突破现有束缚创新产生和发展的现有的体制制度、组织形式、落后观念等障碍,从推进政府职能转变,实现社会... 详细信息

建设创新型国家需要诸多领域的协同推进,创新型国家的社会基础是创新型国家建成和运转的土壤,在创新型国家建设中具有基础性作用。突破现有束缚创新产生和发展的现有的体制制度、组织形式、落后观念等障碍,从推进政府职能转变,实现社会阶层结构优化、协调社会利益关系、制定系统合理的社会政策,实现社会管理体制创新以及构建社会创新系统等方面培育创新型国家的社会基础,以实现全社会创新资源的高效配置、创新活力的迸发,从而助推创新型国家建设。

关键词：创新型国家社会基础社会建设

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来华国际学生跨文化适应支持系统构建研究

宁波大学学报（教育科学版） 2017年第1期39卷 99-103页

作者：贾兆义北京科技大学留学生中心北京100083

来华国际学生的跨文化适应已经成为教育工作者关心的重要课题,但是目前来华国际学生在跨文化适应支持系统存在着较大的缺失,国际学生跨文化适应的内涵主要包括日常生活的适应、学习与教育环境适应、社会环境及人际交往适应和制度文化适... 详细信息

来华国际学生的跨文化适应已经成为教育工作者关心的重要课题,但是目前来华国际学生在跨文化适应支持系统存在着较大的缺失,国际学生跨文化适应的内涵主要包括日常生活的适应、学习与教育环境适应、社会环境及人际交往适应和制度文化适应。创新国际学生管理体制机制,采取更加灵活的国际学生事务管理方式,在国家政策、学校内部体制、国际学生管理机构及国际学生管理干部能力等方面,为国际学生完成学业奠定较为坚实的基础,在潜移默化中传播中国文化、讲好中国故事、达到培养知华、友华的国际学生的目标。

关键词：来华留学国际学生跨文化适应国际学生管理

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经济全球化背景下的我国生态农业发展

信阳农业高等专科学校学报 2010年第4期20卷 63-64页

作者：贾兆义山东大学马克思主义学院山东济南250100

发展生态农业是经济全球化的必然趋势。我国发展生态农业要增强农民的生态意识,搞好农业规划(区划),完善有利于生态农业发展的运行机制,走可持续发展的生态农业发展之路。

关键词：经济全球化生态农业可持续发展

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来华留学教育服务“一带一路”的研究路径

新余学院学报 2018年第6期23卷 137-140页

作者：贾兆义北京科技大学北京100083

来华留学教育服务"一带一路"是系统性、科学性、时代性和宏观性的重大课题。研究来华留学教育如何服务"一带一路"倡议的实施,应当在学术界和实务界研究成果的基础上,把课题置身于全球化的时代语境之中,把握来华留学教育发展的规律,采用... 详细信息

来华留学教育服务"一带一路"是系统性、科学性、时代性和宏观性的重大课题。研究来华留学教育如何服务"一带一路"倡议的实施,应当在学术界和实务界研究成果的基础上,把课题置身于全球化的时代语境之中,把握来华留学教育发展的规律,采用多维度系统分析来华留学教育服务"一带一路"的方式和途径,注重学理性、开放性和可操作性,在服务国家战略中推动来华留学教育发展的质量和效益。

关键词：来华留学一带一路研究路径