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Feasible synthesis of porous h-BN by Mg^(2+)induced lattice dislocations for hydrogen and ammonia storage

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Nano Research 2025年第1期18卷 94-99页

作者： Xiaojia Huang Zihao Wang Yihan Kong li jiang Baolin Wang jiangtao jia Heping Ma Guangshan Zhu Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Northeast Normal UniversityChangchun 130024China School of Chemical Engineering and Technology Xi’an jiaotong University Xi’an 710049China

Hexagonal boron nitride(h-BN)is a two-dimensional(2D)layered material with a structure similar to graphite and it has potential as a hydrogen and ammonia storage ***,dense packing in the standard h-BN structure limits its surface area and prevents the B and N from being adsorption *** this study,the addition of Mg^(2+)during h-BN synthesis facilitated the growth of lattice dislocations and led to a crosslinked three-dimensional(3D)porous structure.A proposed formation mechanism for porous h-BN was confirmed by several characterization routes,most clearly by high-resolution transmission electron microscopy(HRTEM).Porous Mg/BNs exhibited high H_(2)and NH_(3)uptakes and showed potential for H_(2)and NH_(3)storage.

关键词： hexagonal boron nitride porous material dislocation gas storage

不同抗菌药物治疗方案在急性胰腺炎治疗中的用药成本分析

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中华医院感染学杂志 2017年第7期27卷 1583-1586页

作者：张艳苏静薛加林厉青晏成阳武警浙江总队嘉兴医院药械科浙江嘉兴314000

目的观察和分析不同抗菌药物治疗方案在急性胰腺炎(AP)治疗中的用药成本,为合理制订临床治疗方案提供客观依据。方法选取2015年8月-2016年6月80例接受保守治疗的AP患者为研究对象,根据抗菌药物治疗方案将患者分为A组(应用拉氧头孢方案,2... 详细信息

目的观察和分析不同抗菌药物治疗方案在急性胰腺炎(AP)治疗中的用药成本,为合理制订临床治疗方案提供客观依据。方法选取2015年8月-2016年6月80例接受保守治疗的AP患者为研究对象,根据抗菌药物治疗方案将患者分为A组(应用拉氧头孢方案,27例)、B组(应用头孢哌酮/他唑巴坦方案,13例)、C组(应用奥硝唑+头孢他啶方案,9例)、D组(应用奥硝唑+拉氧头孢方案,18例)、E组(应用奥硝唑+头孢哌酮/他唑巴坦方案,13例);对5组患者的疗效分布、治愈率、临床有效率进行评价和比较。结果 5组患者的疗效分布、治愈率、临床有效率比较差异均无统计学意义;C组患者的日均抗菌药物费用低于其他各组,差异有统计学意义(P<0.05),假设药价下降10.0%进行敏感度检测,C组患者的日均抗菌药物费用仍低于其他各组,差异均有统计学意义(P<0.05)。结论在AP治疗中,不同抗菌药物治疗方案可获得基本相当的治疗效果,应用奥硝唑+头孢他啶治疗方案能够在保证治疗效果的前提下付出最小的用药成本。

关键词：抗菌药物急性胰腺炎用药成本

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑life lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang li Wen‑Xia Su jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous li deposition and highly reversible li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous li+flux lithium metal battery

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糖尿病视网膜病变的激光光凝治疗效果观察

国际眼科杂志 2009年第2期9卷 380-381页

作者：张红卞烂焰刘林平李加青中国广东省东莞市莞城医院眼科 523000 中国广东省东莞市光明眼科医院 523000 中国浙江省丽水市人民医院眼科 323000 中山大学眼科中心中国广东省广州市510060

目的：探讨糖尿病视网膜病变的激光光凝治疗效果。方法：1998／2006对256例（392眼）糖尿病视网膜病变患者行视网膜激光光凝术，观察视力及眼底荧光血管造影等情况，并随访1～5a。结果：在接受激光光凝治疗的392眼中，108眼（27．6％）... 详细信息

目的：探讨糖尿病视网膜病变的激光光凝治疗效果。方法：1998／2006对256例（392眼）糖尿病视网膜病变患者行视网膜激光光凝术，观察视力及眼底荧光血管造影等情况，并随访1～5a。结果：在接受激光光凝治疗的392眼中，108眼（27．6％）视力提高，173眼（44．1％）视力无变化，111眼（28．3％）视力下降。结论：激光光凝术是治疗糖尿病视网膜病变的有效方法。

关键词：糖尿病视网膜病变激光光凝治疗方法疗效观察

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming Ji jia liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu jiao Wen-Hua Wan Hong-Wei Zhang Xiao Guo Hua Guo Shou-Feng jia Xiao-Xin li Shi-Xian Cao li-Bin Fu Meng-Meng liu Tian Zhou Lv-Feng Zhang qing-Quan jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

后G20杭州峰会时期西塘古镇夜间旅游发展研究

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特区经济 2017年第2期 101-103页

作者：陈思佳马丽卿浙江海洋大学经济与管理学院浙江舟山316022

西塘古镇是江南六大古镇之一,发展夜间旅游能够延长其旅游资源的利用时间,分散游客旅游时间,保护和发展本地特色文化和传统手艺,实现景区单纯门票经济收入的转型,增加旅游目的地的生命力。杭州夜间旅游的发展相对成熟,尤其是在G20杭州... 详细信息

西塘古镇是江南六大古镇之一,发展夜间旅游能够延长其旅游资源的利用时间,分散游客旅游时间,保护和发展本地特色文化和传统手艺,实现景区单纯门票经济收入的转型,增加旅游目的地的生命力。杭州夜间旅游的发展相对成熟,尤其是在G20杭州峰会之后其夜间旅游的吸引力剧增,本文试图在分析西塘古镇夜间旅游的不足之处后,借鉴杭州夜间旅游的丰富经验提出对西塘古镇夜间旅游的一些建议。

关键词：夜间旅游 G20杭州峰会古镇旅游

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-li li Xiao-Ting Sun li-Ting Wang Xia Wu ling-Jie Zhu Xiao-jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Surfing the nano-wave:Emerging trends in cancer diagnostics and therapy

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Nano Research 2025年第1期18卷 520-544页

作者： Genping Fu Yuting Weng Yunfan li Carl Ho Yiyu Fu Wenxuan Wang Songbin Fu Wenjing Sun Jie lin Xiaoyu Fan Binbin jia Mengdi Cai linlin li Laboratory of Medical Genetics Harbin Medical UniversityHarbin 150081China Key Laboratory of Preservation of Human Genetics Resources and Disease Control in China(Harbin Medical University) Ministry of EducationHarbin 150081China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Washington University School of Medicine in St.Louis St.LouisMO 63110USA Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Aix-Marseille College Wuhan University of TechnologyWuhan 430070China

Facing the growing global challenge posed by cancer,the quest for more accurate and potent cancer diagnostic and therapeutic strategies continues to require a multidisciplinary integration *** review firstly summarizes various types of nanoparticles in cancer ***,it offers a comprehensive overview of signalenhancing techniques for visualizing in situ tumors,along with multimodal diagnostic methods for detecting *** for tumor therapy,cutting-edge drug delivery methods that can cross biological barriers and the pinpoint targeting of tumor lesions for precise medical intervention are *** the domain of therapeutic diagnostics,we elucidate the theoretical underpinnings and structural paradigms that underlie a spectrum of advanced diagnostic and therapeutic ***,we present a compendium of publications delineating the clinical applications of each nano-based theragnostic integration ***,this comprehensive review discusses the safety concerns pertaining to the clinical application of nanoparticles and proposes some strategic recommendations to enhance the precision and safety of theragnostic-guided,nanotechnology-based clinical practices.A deeper understanding of nanomaterials,together with intimate interdisciplinary collaborations,nano-wave will most probably guide human beings to win the battle against cancers.

关键词： nanoparticles drug delivery gastric cancer glioma glioblastoma