检索结果-南通市图书馆

The influence of admission glucose on epicardial and microvascular flow after primary angioplasty

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2006年第2期119卷 95-102页

作者： SHEN Xu-hua jia San-qing li Hong-wei Department of Cardiology Beijing Friendship Hospital Beijing 100050 China

Background Patients with elevated admission glucose levels may be at increased risk of death after myocardial infarction, independent of other baseline risk factors and more severe coronary artery disease. However, data regarding admission glucose and epicardial and microvascular flow after primary angioplasty is limited. Methods Angioplasty was performed in 308 ST-segment elevated myocardial infarction patients. Patients were divided into 3 groups on the basis of admission glucose level： group 1, 〈7.8 mmol/L; group 2, （7.8 - 11.0） mmol/L; and group 3, ≥ 11.0 mmol/L. Results Compared with group 1, patients in group 2 and group 3 were more often female and older. Triglycerides （TG） in group 3 were significantly higher than group 1. At angiography, they more frequently had 2-vessel or 3-vessel disease. In the infarct-related artery, there was no relationship between hyperglycemia and thrombolysis in myocardial infarction （TIMI） 3 flow after percutaneous coronary intervention （PCI）（89.7%, 86.0% and 86.3%, P=NS）. However, corrected TIMI frame count （CTFC） in group 2 and group 3 were more than group 1. TIMI myocardial perfusion grade （TMPG） 0-1 grade among patients with hyperglycemia after PCI were more frequent （30.9% and 29.0% vs 17.3%, P〈0.05）. There was less frequent complete ST-segment resolution （STR） and early T wave inversion among patients with hyperglycemia after PCI. Conclusion Elevated admission glucose levels in ST-segment elevation myocardial infarction patients treated with primary PCI are independently associated with impaired microvascular flow. Abnormal microvascular flow may contribute at least in part to the poor outcomes observed in patients with elevated admission glucose.

关键词： myocardial infarction glucose percutaneous transluminal coronary angioplasty

Molecular mechanisms of Buqing granule for the treatment of diabetic retinopathy:Network pharmacology analysis and experimental validation

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第9期15卷 1942-1961页

作者： Yi-Fan Yang ling Yuan Xiang-Yang li Qian liu Wen-Jie jiang Tai-Qiang jiao jia-qing li Meng-Yi Ye Yang Niu Yi Nan Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetic retinopathy(DR)is a common microvascular complication of diabetes *** blindness rate is high;therefore,finding a reasonable and safe treatment plan to prevent and control DR is ***,there are abundant and diverse research results on the treatment of DR by Chinese medicine Traditional Chinese medicine compounds are potentially advantageous for DR prevention and treatment because of its safe and effective therapeutic *** To investigate the effects of Buqing granule(BQKL)on DR and its mechanism from a systemic perspective and at the molecular level by combining network pharmacology and in vivo *** This study collected information on the drug targets of BQKL and the therapeutic targets of DR for intersecting target gene analysis and protein-protein interactions(PPI),identified various biological pathways related to DR treatment by BQKL through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses,and preliminarily validated the screened core targets by molecular ***,we constructed a diabetic rat model with a high-fat and high-sugar diet and intraperitoneal streptozotocin injection,and administered the appropriate drugs for 12 weeks after the model was successfully *** mass and fasting blood glucose and lipid levels were measured,and pathological changes in retinal tissue were detected by hematoxylin and eosin *** was used to detect the oxidative stress index expression in serum and retinal tissue,and immunohistochemistry,real-time quantitative reverse transcription PCR,and western blotting were used to verify the changes in the expression of core *** Six potential therapeutic targets of BQKL for DR treatment,including Caspase-3,c-Jun,TP53,AKT1,MAPK1,and MAPK3,were screened using *** analysis indicated that the MAPK signaling pathway might be the core target pathway of BQKL in DR *** docking prediction indica

关键词： Diabetic retinopathy Network pharmacology Animal models Oxidative stress Inflammatory

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

水厂膜处理过程中阻垢剂的典型种类及应用

中国给水排水 2024年第12期40卷 57-62页

作者：贾丽晴刘成河海大学浅水湖泊综合治理与资源开发教育部重点实验室江苏南京210098 河海大学环境学院江苏南京210098

膜结垢会降低膜的渗透通量,影响膜的使用寿命,是水厂膜处理过程的重要限制因素之一。投加阻垢剂是阻止膜结垢的一种方便、有效的方法,分别从阻垢机理、阻垢剂的种类和阻垢剂的应用三方面介绍了水厂膜处理过程中含磷阻垢剂、聚合物阻垢... 详细信息

膜结垢会降低膜的渗透通量,影响膜的使用寿命,是水厂膜处理过程的重要限制因素之一。投加阻垢剂是阻止膜结垢的一种方便、有效的方法,分别从阻垢机理、阻垢剂的种类和阻垢剂的应用三方面介绍了水厂膜处理过程中含磷阻垢剂、聚合物阻垢剂和环保阻垢剂的特点及合成方法,阐述了阻垢剂在水厂膜处理过程中的应用形式和阻垢性能。在此基础上,总结了阻垢剂应用过程中仍存在的问题,并对阻垢剂的未来发展和应用进行了展望。

关键词：阻垢剂膜结垢反渗透纳滤饮用水

Direct measurement of the break-out ^(19)F(p,γ)^(20)Ne reaction in the China Jinping underground laboratory(CJPL)

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第8期35卷 142-152页

作者： Yin‑Ji Chen Hao Zhang li‑Yong Zhang jian‑Jun He Richard James deBoer Michael Wiescher Alexander Heger David Kahl Jun Su Daniel Odell Xin‑Yue li jian‑Guo Wang Long Zhang Fu‑Qiang Cao Zhi‑Cheng Zhang Xin‑Zhi jiang Luo‑Huan Wang Zi‑Ming li Lu‑Yang Song liang‑Ting Sun Qi Wu jia‑qing li Bao‑Qun Cui li‑Hua Chen Rui‑Gang Ma Er‑Tao li Gang lian Yao‑De Sheng Zhi‑Hong li Bing Guo Wei‑Ping liu Key Laboratory of Beam Technology of the Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Department of Physics and Astronomy The Joint Institute for Nuclear AstrophysicsUniversity of Notre DameNotre DameIN 46556USA School of Physics and Astronomy Monash UniversityClaytonVIC 3800Australia Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI 48824USA Institute of Nuclear and Particle Physics and Department of Physics and Astronomy Ohio UniversityAthensOH 45701USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China China Institute of Atomic Energy Beijing 102413China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China College of Science Southern University of Science and TechnologyShenzhen 518055China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Mathematics and Physics Handan UniversityHandan 056005China

Calcium production and the stellar evolution of first-generation stars remain fascinating mysteries in *** one possible nucleosynthesis scenario,break-out from the hot carbon–nitrogen–oxygen(HCNO)cycle was thought to be the source of the calcium observed in these oldest ***,according to the stellar modeling,a nearly tenfold increase in the thermonuclear rate ratio of the break-out ^(19)F(p,γ)^(20) Ne reaction with respect to the competing ^(19)F(p,α)^(16) O back-processing reaction is required to reproduce the observed calcium *** performed a direct measurement of this break-out reaction at the China Jinping underground *** measurement was performed down to the low-energy limit of E_(c.m.)=186 keV in the center-of-mass *** key resonance was observed at 225.2 keV for the first *** a temperature of approximately 0.1 GK,this new resonance enhanced the thermonuclear ^(19)F(p,γ)^(20) Ne rate by up to a factor of≈7.4,compared with the previously recommended NACRE *** is of particular interest to the study of the evolution of the first stars and implies a stronger breakdown in their“warm”CNO cycle through the ^(19)F(p,γ)^(20) Ne reaction than previously *** break-out resulted in the production of the calcium observed in the oldest stars,enhancing our understanding of the evolution of the first stars.

关键词： Nuclear astrophysics First stars Abundance of calcium Reaction cross section Reaction rate China Jinping underground laboratory(CJPL) JUNA

长链非编码RNA在结直肠癌中的作用及临床价值

在线全文

学校读者我要写书评

暂无评论

世界华人消化杂志 2017年第25期25卷 2261-2267页

作者：李佳茜孙青潍坊医学院临床医学院病理与病理生理学系山东省潍坊市261000 山东省千佛山医院病理科山东省济南市250014

结直肠癌是常见的消化系恶性肿瘤之一,其发生和发展是一个涉及多因素、多步骤的复杂过程.长链非编码RNA(long non-coding RNA,LncRNA)是一类长度大于200个核苷酸,缺乏开放阅读框,无蛋白质编码功能的RNA.通过诱饵分子、信号分子、支架分... 详细信息

结直肠癌是常见的消化系恶性肿瘤之一,其发生和发展是一个涉及多因素、多步骤的复杂过程.长链非编码RNA(long non-coding RNA,LncRNA)是一类长度大于200个核苷酸,缺乏开放阅读框,无蛋白质编码功能的RNA.通过诱饵分子、信号分子、支架分子、引导分子等4种形式在转录、转录后和表观遗传学多个水平调控基因的表达,参与了多种疾病的发生发展.同时,LncRNA在结直肠癌的临床应用中也有重大价值,参与结直肠癌的诊断、预防、治疗与预后.本文就近年来人们对于LncRNA与结直肠癌关系的研究进展作一综述,并探讨通过LncRNA治疗结直肠癌的现状和前景.

关键词：长链非编码RNA 结直肠癌转录

辣椒定位于叶绿体的13-脂氧合酶基因(CaLOX2)克隆及表达分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

农业生物技术学报 2012年第10期20卷 1126-1134页

作者：贾庆利巩振辉李大伟西北农林科技大学园艺学院西北农林科技大学旱区作物逆境生物学国家重点实验室

植物脂氧合酶参与环境胁迫应答,并在植物生长发育过程中起重要的作用。利用电子克隆及RT-PCR技术从辣椒(Capsicum annuum)中分离出一个脂氧合酶基因,该基因cDNA全长2843bp,含有一个2730bp的完整开放阅读框(ORF),编码910个氨基酸,该基因... 详细信息

植物脂氧合酶参与环境胁迫应答,并在植物生长发育过程中起重要的作用。利用电子克隆及RT-PCR技术从辣椒(Capsicum annuum)中分离出一个脂氧合酶基因,该基因cDNA全长2843bp,含有一个2730bp的完整开放阅读框(ORF),编码910个氨基酸,该基因命名为CaLOX2(GenBank登录号:JQ219046)。序列分析表明,CaLOX2基因编码的氨基酸序列含有脂氧合酶保守结构域,定位于叶绿体基质内。系统进化树分析表明,CaLOX2属于TypeⅡ型13-LOX基因,和番茄(Solanum lycopersicum)TomLOXD、马铃薯(Solanum tuberosum)StLOXH3、野生烟草(Nicotiana attenuate)NaLOX3基因同源性高。实时定量PCR分析显示,CaLOX2在辣椒各个器官都表达,但其表达水平具有组织特异性,在叶片中表达量最高,在花中表达量最低;CaLOX2基因在辣椒与疫霉菌(Phytophthora capsici)亲和与非亲和互作中均受诱导,但在非亲和组合中受诱导表达的强度更大,并且诱导表达的时间在非亲和组合中也相对较早,表明CaLOX2与辣椒疫霉菌专化型抗性有关。辣椒不同器官接种疫霉菌后该基因表达模式也有差异,叶部接种诱导后CaLOX2基因的表达相对于根部接种诱导的强度要更剧烈一些,且最高峰较根部接种的延迟。机械伤害和高盐胁迫诱导该基因上调表达,低温抑制其表达,植物激素茉莉酸甲酯、水杨酸和H2O2均诱导其上调表达。和已知生物学功能的其他植物脂氧合酶基因聚类及表达模式比较揭示,CaLOX2可能参与茉莉酸而不是C6醛类合成。这些结果表明,CaLOX2基因可能通过水杨酸和茉莉酸信号途径参与辣椒对疫霉菌及低温、高盐等逆境条件的防卫反应。该研究为阐明CaLOX2基因在辣椒抗疫病和抗逆反应中的功能提供了基础资料。

关键词：辣椒脂氧合酶茉莉酸基因表达

多孔金属纤维烧结板多尺度形貌的快速三维建模

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

软件学报 2016年第10期27卷 2622-2631页

作者：徐志佳王清辉李静蓉华南理工大学机械与汽车工程学院广东广州510640

针对多孔金属纤维烧结板这一新型功能材料的多尺度形貌建模问题,基于机械加工表面微观形貌中存在的自仿射分形特性,拓展前期发展的三周期极小化曲面与Weierstrass-Mandelbrot分形几何快速合成方法,重点根据多孔金属纤维烧结板的结构特点... 详细信息

针对多孔金属纤维烧结板这一新型功能材料的多尺度形貌建模问题,基于机械加工表面微观形貌中存在的自仿射分形特性,拓展前期发展的三周期极小化曲面与Weierstrass-Mandelbrot分形几何快速合成方法,重点根据多孔金属纤维烧结板的结构特点,对Marching Cubes算法进行优化,以更高效地建立烧结板三维多尺度形貌的几何模型.同时,引入参数表征方法驱动分形TPMS对烧结板的形貌进行调整与控制.实例分析结果表明,所提出的方法可更有效地建立/控制多孔金属纤维烧结板的多尺度形貌模型;模型的有效性通过数值仿真和与其他方法的比较得到了验证.该建模方法可直接用于其他具有多尺度形貌的功能材料的数字化设计中,并促进其数值模拟技术的发展.

关键词：多孔金属纤维烧结板多尺度形貌周期曲面分形几何三维建模功能材料

在线全文

学校读者我要写书评

暂无评论

辣椒LRR类抗病基因同源序列的克隆与分析

西北农林科技大学学报（自然科学版） 2008年第1期36卷 143-148页

作者：马维巩振辉李大伟贾庆利西北农林科技大学园艺学院陕西杨凌712100

【目的】克隆和分析抗、感疫病辣椒材料的抗病基因同源序列，为辣椒抗疫病相关基因的克隆奠定基础。【方法】根据番茄抗叶霉病基因Cf2和Cf9C端的LRR类保守结构域设计简并引物，对6个不同抗、感疫病的辣椒种质材料基因组DNA进行抗病基因... 详细信息

【目的】克隆和分析抗、感疫病辣椒材料的抗病基因同源序列，为辣椒抗疫病相关基因的克隆奠定基础。【方法】根据番茄抗叶霉病基因Cf2和Cf9C端的LRR类保守结构域设计简并引物，对6个不同抗、感疫病的辣椒种质材料基因组DNA进行抗病基因同源序列的PCR扩增。【结果】得到27个抗病基因同源序列（RGAs），其在GenBank中的登录号为EF064260～EF064286。其中，21个RGAs与番茄抗叶霉病基因Cf2和Cf9有较高的相似性。感病材料的辣椒基因组中也存在抗疫病相关RGAs。【结论】上述21个RGAs可能与辣椒抗疫病作用有关，可为辣椒抗疫病相关基因的克隆提供依据。

关键词：辣椒 LRR 抗病基因克隆同源序列分析

在线全文

学校读者我要写书评

暂无评论

黄瓜CsPGIP基因的克隆及表达分析

西北植物学报 2012年第1期32卷 11-16页

作者：贾庆利巩振辉李大伟黄炜西北农林科技大学园艺学院陕西杨陵712100

以加工型黄瓜材料NW99为对象,利用RT-PCR技术克隆黄瓜多聚半乳糖醛酸酶抑制蛋白基因(PGIP),并分析其基因编码序列、组织表达特异性和诱导表达模式。结果表明:(1)从黄瓜中克隆到一个PGIP基因,命名为CsPGIP;CsPGIP基因全长1 026bp,读码框9... 详细信息

以加工型黄瓜材料NW99为对象,利用RT-PCR技术克隆黄瓜多聚半乳糖醛酸酶抑制蛋白基因(PGIP),并分析其基因编码序列、组织表达特异性和诱导表达模式。结果表明:(1)从黄瓜中克隆到一个PGIP基因,命名为CsPGIP;CsPGIP基因全长1 026bp,读码框987bp,无内含子,编码328个氨基酸残基,具有xxLxLxxNxLt/sGxIPxxLxxLxxL结构域,属于Pgip基因家族。(2)CsPGIP基因与甜瓜PGIP基因同源性最高,与十字花科Pgip基因同源性较高。(3)CsPGIP在黄瓜各个器官都表达,但表达水平具有组织特异性,在嫩叶中表达量最高,在茎中表达量最低;该基因表达明显受到水杨酸诱导,可能在抵御外界病原菌入侵过程中起重要作用。

关键词：黄瓜多聚半乳糖醛酸酶抑制蛋白基因克隆实时定量PCR 水杨酸