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Static Recrystallization Kinetics Model After Hot Deformation of Low-Alloy Steel Q345B

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Journal of Iron and Steel Research International 2010年第8期17卷 61-66页

作者： MA Bo PENG Yan jia Bin liu yun-fei State Key Laboratory of Metastable Materials Science and Technology Engineering Research Center of Rolling Equipmentand Complete Technology of Ministry of EducationYanshan UniversityQinhuangdao 066004HebeiChina

The static recrystallization behavior of low-alloy steel Q345B during double-pass hot compression deformation tests was investigated in the temperature range of 900-1000 ℃,the true strain range of 0.15-0.25 and the interpass time range of 0.5-50 s on Gleeble-3500 thermo-simulation *** results show that static recrystallization during the interpass time is *** the deformation temperature and strain increase,softening caused by static recrystallization is *** to the analysis and calculation of thermo-simulation data,the static recrystallization activation energy was obtained and static recrystallization kinetics model was ***,the error analysis of static recrystallization kinetics model proved that the model had good ***,this model provides a theoretical basis for static recrystallization（SRX）and will contribute to the development of multipass hot rolling process,in order to control the rolling process more accurately.

关键词： Gleeble-3500 low-alloy steel static recrystallization activation energy kinetics model

Research on Evaluation of Degree of Complexity of Mining Fault Network Based on GIS

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Journal of China University of Mining and Technology 2007年第1期17卷 63-67页

作者： ZHANG Hua WANG yun-jia liu Chuan-zhi School of Environment Science and Spatial Infornlatics China Universit3.＇ of Mining ＆ Technology Xuzhou Jiangsu 221008 China

A large number of spatial and attribute data are involved in coal resource evaluation. Database is a relatively advanced data management technology, but its Major defects are the poor graphic and spatial data functions, from which it is difficult to realize scientific management of evaluation data with spatial characteristics and evaluation result maps. On account of these deficiencies, the evaluation of degree of complexity of mining fault network, based on GIS, is proposed, which integrates management of spatial and attribute data. Fractal is an index which can reflect the comprehensive information of faults' number, density, size, composition and dynamics mechanism. Fractal dimension is used as the quantitative evaluation index. Evaluation software has been developed based on a component GIS-MapX, with which the degree of complexity of fault network is evaluated quantitatively using the quantitative index of fractal dimensions in liuqiao No.2 coal mine as an example. Results show that it is effective in acquiring model parameters and enhancing the definition of data and evaluation results with the application of GIS technology. The fault network is a system with fractal structure and its complexity can be described reasonably and accurately by fractal dimension, which provides an effective method for coal resource evaluation.

关键词： spatial data fractal dimension fault network quantitative evaluation GIS

Reaction degree of composition B explosive with multi-layered compound structure protection subjected to detonation loading

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Defence Technology（防务技术） 2021年第2期17卷 315-326页

作者： jia-yun liu Yong-xiang Dong Xuan-yi An Ping Ye Qi-tian Sun Qian Gao State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China

The explosive reaction degree and protection from explosions are concerns in the military *** this work,the reaction degree of the composition B explosive was investigated ***-layered compound structures were used as barriers to weaken the blast loads.A comprehensive experiment using a high-speed camera and image processing techniques,side witness plates,and bottom witness plates was *** the experimental fragment velocities,fragment piercing patterns,and damage characteristics,the reaction degree of the explosive impeded by different multi-layered compound structures could be precisely *** parameters of the explosive obstructed by compound structures were obtained by theoretical analysis and numerical *** the common method in which the explosive reaction degree is only distinguished based on the initial pressure amplitude transmitted into the explosive,a following shock wave reflected from the side steel casing was also *** detonation growth paths in the explosive ***,all these shock wave propagation characteristics must be considered to analyze the explosive response impeded by compound structures.

关键词： Reaction degree Explosive protection Compound structure Comprehensive experiment

SDCC: software-defined collective communication for distributed training

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Science China(Information Sciences) 2024年第9期67卷 105-125页

作者： Xin JIN Zhen ZHANG yunshan jia yun MA Xuanzhe liu School of Computer Science Peking University Department of Computer Science and Technology Johns Hopkins University

Communication is crucial to the performance of distributed training. Today's solutions tightly couple the control and data planes and lack flexibility, generality, and performance. In this study, we present SDCC, a software-defined collective communication framework for distributed training. SDCC is based on the principle of modern systems design to effectively decouple the control plane from the data *** abstracts the operations for collective communication in distributed training with dataflow operations and unifies computing and communication with a single dataflow graph. The abstraction, together with the unification, is powerful: it enables users to easily express new and existing collective communication algorithms and optimizations, simplifies the integration with different computing engines(e.g., Py Torch and Tensor Flow) and network transports(e.g., Linux TCP and kernel bypass), and allows the system to improve performance by exploiting parallelism exposed by the dataflow graph. We further demonstrate the benefits of SDCC in four use cases.

关键词： machine learning systems distributed training deep learning collective communication software-defined networking

In vitro drug resistance of clinical isolated Brucella against antimicrobial agents

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Asian Pacific Journal of Tropical Medicine 2013年第11期6卷 921-924页

作者： Xiu-Li Xu Xiao Chen Pei-Hong Yang jia-yun liu Xiao-Ke Hao Laboratory Department Xijing HospitalFourth Military Medical University

Objective:To explore the antibiotic resistance of Brucella melitensis and instruct rational use of antimicrobial agents in clinical treatment of Brucella ***:Bacteria were cultured and identified by BACTEC9120 and VTTEK Ⅱ automicrobic system.E-test was used to detect the minimal inhibitory concentration(MIC) of antimicrobial agents in the drug susceptivity ***:A total of 19 brucella strains(all Brucella melitensis) were isolated from 19 patients,who had fever between January 2010 and June 2012,and 17 samples were blood,one was bone marrow,the other sample was cerebrospinal *** MIC range of ceftazidime was 2.0-8.0 mg/L,rifampicin was 0.06-2.0 mg/L,amikacin was 4.0-12.0 mg/L,levofloxacin was 2.0-8.0 mg/ L,doxycycline was 8.0-32.0 mg/L,sulfamethoxazole-trimethoprim was 4.0-16.0 mg/L,ampicillin was 1.5-2.0 mg/L and gentamicin was 0.50-0.75 mg/***:The drugs used in this experiment cover common drugs for treating ***,the results are consistent with clinical *** is suggested personalized regimen according to patients' status in treatment of Brucella.

关键词： Brucella Antimicrobial agents Minimal inhibitory concentration

Optimization of the co-closing law of guide vanes and blades for bulb turbines based on CFD

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Journal of Hydrodynamics 2024年第2期36卷 363-377页

作者： Hui liu yun-fa Lin Yong-guang Cheng Song Xue Mao-jia Tang jian Zhang jia-yi Fan State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan430072China Dongfang Electric Machinery Co. Ltd.Deyang618000China

The load rejection transient process of bulb turbine units is critical to safety of hydropower stations,and determining appropriate closing laws of guide vanes(GVs)and runner blades(RBs)for this process is of *** this study,we proposed a procedure to optimize the co-closing law of GVs and RBs by using computational fluid dynamics(CFD),combined with the design of experiment(DOE)method,approximation model,and genetic optimization *** sensitivity of closing law parameters on the histories of head,speed,and thrust was analyzed,and a two-stage GVs’closing law associating with a linear RBs’closing law was *** results show that GVs dominate the transient characteristics by controlling the change of *** GVs’first-stage closing speed while shortening first-stage closing time can not only significantly reduce the maximum rotational speed but also suppress the water hammer pressure;slowing GVs’second-stage closing speed is conducive to controlling the maximum reverse axial *** directly affect the runner *** RBs’closing speed can further reduce the rotational speed and the maximum reverse axial *** safety margin of each control parameter,flow patterns,and pressure pulsations of a practical hydropower station were all improved after optimization,demonstrating the effectiveness of this method.

关键词： Bulb turbine load rejection transient process double regulation closing law optimization computational fluid dynamics(CFD)

Single-site Baseline and Short-term Outcomes of Clinical Characteristics and Life Quality Evaluation of Chinese Wet Age-related Macular Degeneration Patients in Routine Clinical Practice

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Chinese Medical Journal 2015年第9期128卷 1154-1159页

作者： Li-Li Wang Wen-jia liu Hai-yun liu Xun Xu Department of Ophthalmology Shanghai First People@s Hospital Shanghai 200080 China

Background：Age-related macular degeneration （AMD） is the leading cause of irreversible vision loss among the older *** China,treatment of age-related ocular diseases is becoming a priority in eye care *** study was to investigate the clinical characteristics and quality of life of Chinese patients with wet AMD and current treatment types,to evaluate short-term gains in different treatments,and to investigate associations between visual function and vision-related quality of life （VRQoL）.Methods：A prospective,observational,noninterventional study was *** data were collected from patients with clinical diagnoses of wet AMD before clinical assessments at *** was measured with the Chinese version of the National Eye Institute Visual Function Questionnaire-25 （NEI VFQ-25）.Correlations of the NEI VFQ-25 subscale scores with best-corrected visual acuity （BCVA） and between-group differences were ***：A total of 80 wet AMD patients were enrolled,with the mean age of 68.40 *** one-quarter ofwetAMD patients received intravitreal （IVT） ranibizumab treatment,and 67％ of them were treated on apro re nata *** visual acuity of patients treated with IVT ranibizumab at month 3 after treatment was significantly increased,whereas patients treated with traditional Chinese medicine achieved no significant ***＇s α for the NEI VFQ-25 subscales ranged from 0.697 to *** subscale and overall composite scores were moderately correlated with the BCVA of the better-seeing *** differences in the overall NEI VFQ-25 scores and other subscales were observed between patients with BCVA in the better-seeing eye of less than 50 letters and the ***：Patients treated with IVT ranibizumab experienced better vision improvement at short-term *** Chinese version of the NEI VFQ-25 is a valid and reliable tool for assessing the VRQoL of Chinese wet AMD patients.

关键词： Chinese Version of National Eye Institute Visual Function Questionnaire-25 Ranibizumab Vision-related Quality of Life Wet Age-related Macular Degeneration

A Dynamic Covalent Bonding-based Nanoplatform for Intracellular Co-Delivery of Protein Drugs and Chemotherapeutics with Enhanced Anti-Cancer Effect

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Chinese Journal of Polymer Science 2024年第5期42卷 559-569,I0005页

作者： Sai-Nan liu jia-Hui Meng Li-yun Cui Hua Chen Lin-Qi Shi Ru-jiang Ma Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryTianjin Key Laboratory of Functional Polymer MaterialsState Key Laboratory of Medicinal Chemical BiologyFrontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

Efficient intracellular delivery of protein drugs is critical for protein *** combination of protein drugs with chemotherapeutics represents a promising strategy in enhancing anti-cancer ***,co-delivery systems for efficient delivery of these two kinds of drugs are still lacking because of their different ***,we show a well-designed delivery system based on dynamic covalent bond for efficient intracellular co-delivery of ribonuclease A(RNase A)and doxorubicin(DOX).Two polymers,PEG-b-P(Asp-co-AspDA)and PAE-b-P(Asp-co-AspPBA),and two 2-acetylphenylboronic acid(2-APBA)-functionalized drugs,2-APBA-RNase A and 2-APBA-DOX,self-assemble into mixed-shell nanoparticles(RNase A/DOX@MNPs)via dynamic phenylboronic acid(PBA)-catechol bond between PBA and dopamine(DA)*** PBA-catechol bond endows the nanoparticles with high stability and excellent stimulus-responsive drug release *** the slight acidic environment at tumor tissue,RNase A/DOX@MNPs are positively charged,promoting their *** cellular uptake into endosome,further protonation of PAE chains leads to the rupture of endosomes because of the proton sponge effect and the cleavage of PBA-catechol bond promotes the release of two *** cytoplasm,the high level of GSH removed the modification of 2-APBA on *** restored RNase A and DOX show a synergistic and enhanced antic-cancer *** system may be a promising platform for intracellular co-delivery of protein drugs and chemotherapeutics.

关键词： Drug co-delivery Combination therapy Dynamic covalent bond

Temporal and spatial regulation of biomimetic vascularization in 3D-printed skeletal muscles

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Bio-Design and Manufacturing 2024年第5期7卷 597-610页

作者： Minxuan jia Tingting Fan Tan jia Xin liu Heng liu Qi Gu Key Laboratory of Organ Regeneration and Reconstruction State Key Laboratory of Membrane BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Orthopaedics Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China

In the intricate skeletal muscle tissue,the symbiotic relationship between myotubes and their supporting vasculature is pivotal in delivering essential oxygen and *** study explored the complex interplay between skeletal muscle and endothelial cells in the vascularization ofmuscle *** harnessing the capabilities of three-dimensional(3D)bioprinting and modeling,we developed a novel approach involving the co-construction of endothelial and muscle cells,followed by their subsequent *** findings highlight the importance of the interaction dynamics between these two cell ***,introducing endothelial cells during the advanced phases of muscle differentiation enhanced myotube ***,it stimulated the development of the vascular network,paving the way for the early stages of vascularized skeletal muscle *** methodology proposed in this study indicates the potential for constructing large-scale,physiologically aligned skeletal ***,it highlights the need for exploring the delicate equilibrium and mutual interactions between muscle and endothelial *** on the multicell-type interaction model,we can predict promising pathways for constructing even more intricate tissues or organs.

关键词： Skeletal muscle Vascularization 3D bioprinting Cell interaction