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Conditional survival probability of distant-metastatic hepatocellular carcinoma: A population-based study

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1874-1890页

作者： Yong-Ping Yang Cheng-Jun Guo Zhao-xuan Gu Jun-Jie Hua jia-xuan zhang jian Shi Department of General Surgery The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

BACKGROUND The prognosis of many patients with distant metastatic hepatocellular carcinoma(HCC)improved after they survived for several *** with tradi-tional survival analysis,conditional survival(CS)which takes into account changes in survival risk could be used to describe dynamic survival *** To evaluate CS of distant metastatic HCC *** Patients diagnosed with distant metastatic HCC between 2010 and 2015 were extracted from the Surveillance,Epidemiology and End Results *** and multivariate Cox regression analysis were used to identify factors for overall survival(OS),while competing risk model was used to identify risk factors for cancer-specific survival(CSS).Six-month CS was used to calculate the probability of survival for an additional 6 mo at a specific time after initial diagnosis,and standardized difference(d)was used to evaluate the survival differences between *** were constructed to predict ***α-fetoprotein expression,higher T stage(T3 and T4),N1 stage,non-primary site surgery,non-chemotherapy,non-radiotherapy,and lung metastasis were independent risk factors for actual OS and CSS through univariate and multivariate *** survival rates decreased over time,while CS rates gradually *** for the 6-month CS,the survival difference caused by chemotherapy and radiotherapy gradually disappeared over time,and the survival difference caused by lung metastasis ***,the influence of age and gender on survival gradually *** were fitted for patients who have lived for 2,4 and 6 mo to predict 6-month conditional OS and CSS,*** area under the curve(AUC)of nomograms for conditional OS decreased as time passed,and the AUC for conditional CSS gradually *** CS for distant metastatic HCC patients substantially increased over *** dynamic risk factors,nomograms constructed at a specific time could predict more accur

关键词： Conditional survival Hepatocellular carcinoma Distant metastasis Prognosis Nomogram

A prognostic four-gene signature and a therapeutic strategy for hepatocellular carcinoma:Construction and analysis of a circRNA-mediated competing endogenous RNA network

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 272-287页

作者： Hai-Yan zhang jia-Jie Zhu Zong-Ming Liu Yu-xuan zhang jia-jia Chen Ke-Da Chen Zhejiang Chinese Medical University Hangzhou 310053China Shulan International Medical College Zhejiang Shuren UniversityHangzhou 310015China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Background:Hepatocellular carcinoma(HCC)has a poor long-term *** competition of circular RNAs(circRNAs)with endogenous RNA is a novel tool for predicting HCC *** on the alterations of circRNA regulatory networks,the analysis of gene modules related to HCC is ***:Multiple expression datasets and RNA element targeting prediction tools were used to construct a circRNA-microRNA-mRNA network in *** function,pathway,and protein interaction analyses were performed for the differentially expressed genes(DEGs)in this regulatory *** the proteinprotein interaction network,hub genes were identified and subjected to regression analysis,producing an optimized four-gene signature for prognostic risk stratification in HCC ***-HCC drugs were excavated by assessing the DEGs between the low-and high-risk groups.A circRNA-microRNA-hub gene subnetwork was constructed,in which three hallmark genes,KIF4A,CCNA2,and PBK,were subjected to functional enrichment ***:A four-gene signature(KIF4A,CCNA2,PBK,and ZWINT)that effectively estimated the overall survival and aided in prognostic risk assessment in the The Cancer Genome Atlas(TCGA)cohort and International Cancer Genome Consortium(ICGC)cohort was *** inhibitors,PI3K inhibitors,HDAC inhibitors,and EGFR inhibitors were predicted as four potential mechanisms of drug action(MOA)in high-risk HCC *** analysis has revealed that PBK,CCNA2,and KIF4A play a crucial role in regulating the tumor microenvironment by promoting immune cell invasion,regulating microsatellite instability(MSI),and exerting an impact on HCC ***:The present study highlights the role of the circRNA-related regulatory network,identifies a four-gene prognostic signature and biomarkers,and further identifies novel therapy for HCC.

关键词： Hepatocellular carcinoma circRNA-related ceRNA network Biomarker Least absolute shrinkage and selection operator Bioinformatics

A Comparative Study Between Tumor Blood Vessels and Dynamic Contrast-enhanced MRI for Identifying Isocitrate Dehydrogenase Gene 1(IDH1)Mutation Status in Glioma

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Current Medical Science 2022年第3期42卷 650-657页

作者： Shi-hui LI Nan-xi SHEN Di WU Ju zhang jia-xuan zhang Jing-jing jiaNG Wen-zhen ZHU Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective Isocitrate dehydrogenase gene(IDH)mutations are associated with tumor angiogenesis and therefore play an important role in glioma *** study compared the performance of tumor blood vessels counted from contrast-enhanced 3D brain volume(3D-BRAVO)sequence and dynamic contrast-enhanced(DCE)MRI in differentiating IDH1 status in *** Forty-four glioma patients[16 with IDH1 mutant-type(IDH1-MT),28 with IDH1 wild-type(IDH1-WT)]were retrospectively analyzed.A blood vessel entering a tumor was defined as an intratumoral vessel;a blood vessel adjacent to the edge of a tumor was defined as a peritumoral *** vessels were defined as the sum of the intratumoral and peritumoral ***-derived metrics of tumor were normalized to the contralateral normal-appearing white *** Intratumoral,peritumoral,and combined tumor blood vessels were all significantly different between IDH1-MT and IDH1-WT gliomas,and the range of area under curves(AUCs)was 0.816–*** DCE-derived parameters,cerebral blood volume,cerebral blood flow,mean transit time,and volume transfer constant were significantly different between IDH1-MT and IDH1-WT gliomas,and the range of AUCs was 0.703–*** vessels possessed the best performance for identifying IDH1 mutations in gliomas(AUC:0.855,sensitivity:0.857,specificity:0.812,P<0.001).Conclusion The number of tumor blood vessels has comparable diagnostic performance with DCE-derived parameters for differentiating IDH1 mutations and can serve as a potential imaging biomarker to reflect IDH1 mutations in gliomas.

关键词： dynamic contrast-enhanced perfusion glioma isocitrate dehydrogenase gene tumor blood vessel

Perturbation of autophagy pathways in murine alveolar macrophage by 2D TMDCs is chalcogen-dependent

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Journal of Environmental Sciences 2024年第1期135卷 97-107页

作者： Xiaofei Zhou Weitao Jin Rui zhang xuan Mao jianbo jia Hongyu Zhou College of Science&Technology Hebei Agricultural UniversityHuanghua 061100China Institute of Environmental Research at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006China

Increasing risks of incidental and occupational exposures to two-dimensional transition metal dichalcogenides(2D TMDCs)due to their broad application in various areas raised their public health *** the composition-dependent cytotoxicity of 2D TMDCs has been well-recognized,how the outer chalcogenide atoms and inner transition metal atoms differentially contribute to their perturbation on cell homeostasis at non-lethal doses remains to be *** the present work,we compared the autophagy induction and related mechanisms in response to WS_(2),NbS_(2),WSe_(2)and Nb Se_(2)nanosheets exposures in MH-S murine alveolar *** these 2D TMDCs had comparable physicochemical properties,overall cytotoxicity and capability in triggering autophagy in MH-S cells,but showed outer chalcogen-dependent subcellular localization and activation of autophagy ***,WS_(2)and NbS_(2)nanosheets adhered on the cell surface and internalized in the lysosomes,and triggered m TOR-dependent activation of ***,WSe_(2)and Nb Se_(2)nanosheets had extensive distribution in cytoplasm of MH-S cells and induced autophagy in an m TOR-independent ***,the 2D TMDCs-induced perturbation on autophagy aggravated the cytotoxicity of respirable benzo[a]*** findings provide a deeper insight into the potential health risk of environmental 2D TMDCs from the perspective of homeostasis perturbation.

关键词： Chalcogen group Autophagy pathway Cell function Endosomal escape Inhalation toxicity

Pressure transient characteristics of non-uniform conductivity fractured wells in viscoelasticity polymer flooding based on oil-water two-phase flow

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Petroleum Science 2024年第1期21卷 343-351页

作者： Yang Wang jia zhang Shi-Long Yang Ze-xuan Xu Shi-Qing Cheng National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China

Polymer flooding in fractured wells has been extensively applied in oilfields to enhance oil *** contrast to water,polymer solution exhibits non-Newtonian and nonlinear behavior such as effects of shear thinning and shear thickening,polymer convection,diffusion,adsorption retention,inaccessible pore volume and reduced effective ***,the flux density and fracture conductivity along the hydraulic fracture are generally non-uniform due to the effects of pressure distribution,formation damage,and proppant *** this paper,we present an oil-water two-phase flow model that captures these complex non-Newtonian and nonlinear behavior,and non-uniform fracture characteristics in fractured polymer *** hydraulic fracture is firstly divided into two parts:high-conductivity fracture near the wellbore and low-conductivity fracture in the far-wellbore section.A hybrid grid system,including perpendicular bisection(PEBI)and Cartesian grid,is applied to discrete the partial differential flow equations,and the local grid refinement method is applied in the near-wellbore region to accurately calculate the pressure distribution and shear rate of polymer *** combination of polymer behavior characterizations and numerical flow simulations are applied,resulting in the calculation for the distribution of water saturation,polymer concentration and reservoir *** with the polymer flooding well with uniform fracture conductivity,this non-uniform fracture conductivity model exhibits the larger pressure difference,and the shorter bilinear flow period due to the decrease of fracture flow ability in the far-wellbore *** field case of the fall-off test demonstrates that the proposed method characterizes fracture characteristics more accurately,and yields fracture half-lengths that better match engineering reality,enabling a quantitative segmented characterization of the near-wellbore section with high fracture conductivity and th

关键词： Polymer flooding Non-Newtonian fluid Non-uniform fracture conductivity Two-phase flow Pressure transient analysis

Tailored ionically conductive graphene oxide-encased metal ions for ultrasensitive cadaverine sensor

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Chinese Chemical Letters 2024年第8期35卷 508-513页

作者： Ying Chen Li Li Junyao zhang Tongrui Sun xuan zhang Shiqi zhang jia Huang Yidong Zou School of Materials Science and Engineering Tongji UniversityShanghai 201804China Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Translational Research Institute of Brain and Brain-Like IntelligenceShanghai Fourth People’s Hospital Affiliated to Tongji UniversityTongji UniversityShanghai 200434China School of Mechanical Engineering Nantong UniversityNantong 226019China

Intelligent chemical sensors have been extensively used in food safety and environmental assessment,while limited sensitivity and homogeneity bring about huge obstacles to their practical ***,novel ionically conductive sensitive materials were elaborately designed based on metal ion decorated graphene oxide(GO)via a facile and general in-situ spin-coating strategy,where the abundant functional groups(-OH and-COOH)of GO layer could provide natural binding sites for various bivalent metal cations(such as Cu^(2+),Ni^(2+),Zn^(2+),Co^(2+),and Mg^(2+))through coordination and electrostatic *** intercalated metal cations on the layered GO nanosheets can be regarded as charge carriers and complexation with targeted gas(cadaverine,Cad),which is a typical metabolites production and food *** contrast,the designed GO@Cu(Ⅱ)sensor exhibited the optimal sensing performance toward Cad molecules at room temperature,including ultra-low detection limit(ca.3 nL),excellent sensitivity,and rapid low concentration detection rate(only 16 s).Interestingly,the sensor exhibited an irreversible and specific response toward Cad,while it showed a transient and reversible response to other interfering gases,implying its outstanding *** addition,the GO@Cu(Ⅱ)sensor enabled real-time monitoring of the decay progression of cheese,and it exhibited great potential for large-scale production via its excellent *** provides an efficient approach to tailoring intelligent chemical sensors for real-time food safety monitoring and human health warning.

关键词： Graphene oxide Cadaverine monitoring Chemical sensor Ionically conductive Homogeneity

Self organizing optimization and phase transition in reinforcement learning minority game system

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Frontiers of physics 2024年第4期19卷 297-309页

作者： Si-Ping zhang jia-Qi Dong Hui-Yu zhang Yi-xuan Lü Jue Wang Zi-Gang Huang Key Laboratory of Biomedical Information Engineering of Ministry of Education Key Laboratory of Neuro-informatics&Rehabilitation Engineering of Ministry of Civil Affairsand Institute of Health and Rehabilitation ScienceSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Lanzhou Center for Theoretical Physics and Key Laboratory of Theoretical Physics of Gansu Province Lanzhou UniversityLanzhou 730000China

Whether the complex game system composed of a large number of artificial intelligence(AI)agents empowered with reinforcement learning can produce extremely favorable collective behaviors just through the way of agent self-exploration is a matter of practical *** this paper,we address this question by combining the typical theoretical model of resource allocation system,the minority game model,with reinforcement *** individual participating in the game is set to have a certain degree of intelligence based on reinforcement learning *** particular,we demonstrate that as AI agents gradually becomes familiar with the unknown environment and tries to provide optimal actions to maximize payoff,the whole system continues to approach the optimal state under certain parameter combinations,herding is effectively suppressed by an oscillating collective behavior which is a self-organizing pattern without any external *** interesting phenomenon is that a first-order phase transition is revealed based on some numerical results in our multi-agents system with reinforcement *** order to further understand the dynamic behavior of agent learning,we define and analyze the conversion path of belief mode,and find that the self-organizing condensation of belief modes appeared for the given trial and error rates in the AI ***,we provide a detection method for period-two oscillation collective pattern emergence based on the Kullback–Leibler divergence and give the parameter position where the period-two appears.

关键词： oscillatory evolution collective behaviors phase transition reinforcement learning minority game

Recent progress in carbene-catalyzed fluoroalkylation

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Science China Chemistry 2024年第8期67卷 2448-2460页

作者： Bei zhang xuan zhang jian Wang jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China

The fluoroalkyl fragment plays a vital role in various fields such as pharmaceuticals and materials science, and has a significant impact on human life not only on the present but also in the future. The insertion of fluoroalkyl groups into the chemical skeletons can cause considerable alternations in the chemical, physical and biological properties of molecules, which has attracted numerous scientists from different fields. This review focuses on N-heterocyclic carbene(NHC)-catalyzed fluoroalkylation reactions, providing a detailed analysis and summary of the achievements in the past two decades. Many successful examples clearly indicate that NHCs can catalyze the tranformation of fluoroalkylation reagents with various electronic characteristics, whether electrophilic, nucleophilic, or radical precursors. Herein, the fluoroalkylation reactions are classified based on different catalytic modes of NHCs: Lewis base catalysis, Umploung catalysis, radical catalysis and others. Meanwhile, by refining and systematically studying the contribution of NHC catalysis in fluoroalkylation reactions, this review is expected to provide valuable insights and enlightenment for related fields.

关键词： N-heterocyclic carbene fluoroalkylation radical catalysis

Unexpected BrdU inhibition on astrocyte-to-neuron conversion

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Neural Regeneration Research 2022年第7期17卷 1526-1534页

作者： Tao Wang jian-Cheng Liao Xu Wang Qing-Song Wang Kai-Ying Wan Yi-Yi Yang Qing He jia-xuan zhang Gong Chen Wen Li Guangdong-Hong Kong-Macao Institute of CNS Regeneration(GHMICR) Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Neurosurgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina

5-Bromo-2′-deoxyuridine(BrdU)is a halogenated pyrimidine that can be incorporated into newly synthesized DNA during the S phase of the cell *** is widely used in fate-mapping studies of embryonic and adult neurogenesis to identify newborn neurons,however side effects on neural stem cells and their progeny have been *** vivo astrocyte-to-neuron(AtN)conversion is a new approach for generating newborn neurons by directly converting endogenous astrocytes into *** BrdU-labeling strategy has been used to trace astrocyte-converted neurons,but whether BrdU has any effect on the AtN conversion is ***,while conducting a NeuroD1-mediated AtN conversion study using BrdU to label dividing reactive astrocytes following ischemic injury,we accidentally discovered that BrdU inhibited AtN *** initially found a gradual reduction in BrdU-labeled astrocytes during NeuroD1-mediated AtN conversion in the mouse *** most NeuroD1-infected astrocytes were converted into neurons,the number of BrdU-labeled neurons was surprisingly *** exclude the possibility that this BrdU inhibition was caused by the ischemic injury,we conducted an in vitro AtN conversion study by overexpressing NeuroD1 in cultured cortical astrocytes in the presence or absence of ***,we also found a significantly lower conversion rate and a smaller number of converted neurons in the BrdU-treated group compared with the untreated *** results revealed an unexpected inhibitory effect of BrdU on AtN conversion,suggesting more caution is needed when using BrdU in AtN conversion studies and in data interpretation.

关键词： 5-bromo-2′-deoxyuridine NeuroD1 astrocyte-to-neuron conversion reprogramming neural regeneration reactive astrocytes neurons lineage tracing fate mapping neural stem cell