Conditional survival probability of distant-metastatic hepatocellular carcinoma: A population-based study
作者机构：Department of General SurgeryThe Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2023年第15卷第11期
页 面：1874-1890页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Conditional survival Hepatocellular carcinoma Distant metastasis Prognosis Nomogram
摘 要：BACKGROUND The prognosis of many patients with distant metastatic hepatocellular carcinoma(HCC)improved after they survived for several *** with tradi-tional survival analysis,conditional survival(CS)which takes into account changes in survival risk could be used to describe dynamic survival *** To evaluate CS of distant metastatic HCC *** Patients diagnosed with distant metastatic HCC between 2010 and 2015 were extracted from the Surveillance,Epidemiology and End Results *** and multivariate Cox regression analysis were used to identify factors for overall survival(OS),while competing risk model was used to identify risk factors for cancer-specific survival(CSS).Six-month CS was used to calculate the probability of survival for an additional 6 mo at a specific time after initial diagnosis,and standardized difference(d)was used to evaluate the survival differences between *** were constructed to predict ***α-fetoprotein expression,higher T stage(T3 and T4),N1 stage,non-primary site surgery,non-chemotherapy,non-radiotherapy,and lung metastasis were independent risk factors for actual OS and CSS through univariate and multivariate *** survival rates decreased over time,while CS rates gradually *** for the 6-month CS,the survival difference caused by chemotherapy and radiotherapy gradually disappeared over time,and the survival difference caused by lung metastasis ***,the influence of age and gender on survival gradually *** were fitted for patients who have lived for 2,4 and 6 mo to predict 6-month conditional OS and CSS,*** area under the curve(AUC)of nomograms for conditional OS decreased as time passed,and the AUC for conditional CSS gradually *** CS for distant metastatic HCC patients substantially increased over *** dynamic risk factors,nomograms constructed at a specific time could predict more accur
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