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Hollow-structured all-silicon terahertz metasurface supporting quasi-bound states in the continuum for refractive index based Auramine O concentration sensing

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Photonics Research 2024年第7期12卷 1574-1582页

作者： xin TANG HAODUO jia LANBIN LI MING LI DAI WU KUI ZHOU PENG LI WEIJUN wang JITAO LI DINGYU YANG College of Optoelectronic Engineering Chengdu University of Information TechnologyChengdu 610225China Institute of Applied Electronics China Academy of Engineering PhysicsMianyang 621000China School of Precision Instruments and Opto-Electronics Engineering Tianjin UniversityTianjin 300072China Guizhou Zhenhua Fengguang Semiconductor Co. Ltd.Guiyang 550000China Chengdu Huanyuxin Technology Co. Ltd.Chengdu 610095China

Quasi-bound states in the continuum (QBIC),with exceptionally high-Q factors and the local field enhancement effect,have found potential applications in matter *** the QBIC mechanism into terahertz(THz) metasurfaces can significantly enhance the interaction between incident THz waves and matter,providing a feasible platform for the detection of biochemical ***,most experimental studies on terahertz QBIC metasurfaces utilize metallic *** contrast,research on terahertz all-dielectric QBIC metasurfaces generally remains at the simulation stage due to the high fabrication process requirements,and transitioning to the experimental stage still poses many *** this paper,a hollow-structured all-silicon metasurface supporting THz QBIC is *** resonance of THz QBIC is excited via a simple hollow structure and observed in *** and experimental results demonstrated that the designed THz QBIC metasurface can achieve sensing of Auramine ***,it is the first study,to our knowledge,to employ a metasurface to sense Auramine ***,the sensing performance maintains good stability under different humidity and temperature *** study provides new references and insights for the design and implementation of THz QBIC,and also opens a new pathway for the detection of Auramine O.

关键词： supporting continuum refractive

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Heavy-atom-free orthogonal configurative dye 1,7-di-anthra-aza-BODIPY for singlet oxygen generation

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Chinese Chemical Letters 2024年第10期35卷 291-294页

作者： Yan Zhu jia Liu Meiheng Lv Tingting wang Dongxiang Zhang Rong Shang xin-Dong jiang jianjun Du Guiling wang Liaoning&Shenyang Key Laboratory of Functional Dye and Pigment Shenyang University of Chemical TechnologyShenyang 110142China Department of Cell Biology China Medical UniversityShenyang 110122China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China Department of Chemistry Graduate School of Advanced Science and EngineeringHiroshima UniversityHigashi-Hiroshima 7398526Japan

Spin-orbit,charge-transfer intersystem crossing(SOCT-ISC)can directly overcome the disadvantages of the traditional heavy-atom effect and improve the generation efficiency of reactive oxygen species(ROS).Since orthogonal molecular orbitals of donor-acceptor(D-A)pairs favor the SOCT-ISC transition,herein aza-borondipyrromethenes(aza-BODIPYs)with 1,7-di-anthracyl groups(An-azaBDP)was successfully prepared,owing to steric hindrance to produce a big dihedral angle between the two molecular orbital(MO)***,according to density functional theory(DFT)and time-dependent density functional theory(TDDFT),the energy difference between the S1-T1orbitals of An-aza BDP is small and more inclined towards ***-aza BDP can effectively generate singlet oxygen under light ***-aza BDP with light irradiation can induce apoptosis in SW620 cells,and can serve as a potential candidate for the treatment of cancer cells and tumors.

关键词： Orthogonal configuration Anthracene Heavy-atom-free Aza-BODIPY Singlet oxygen

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Sensitivity Analysis of Guardrail Impact Parameters Based on Deflection Index

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现代交通（中英文版） 2014年第1期3卷 1-7页

作者： Shuming Yan Ning jia Yaping Liang, xin wang Beijing Zhongluan Traffic Technology Co. Ltd Beijing 100071 China

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Metal-based inorganic nanocrystals for biological sonodynamic therapy applications:recent progress and perspectives

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Rare Metals 2024年第2期43卷 413-430页

作者： Dong wang jia-Tao Zhang Institute of Medical-Industrial Integration Beijing Key Laboratory of Structurally Controllable Advanced Functional Materials and Green ApplicationsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing100081China Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologySchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing100081China

With the fast development of technology for the treatment of tumor and bacteria,photo-therapeutic strate-gies emerge as a kind of highly effective and common treatment,but the low tissue penetration depth of light limits their *** therapy(SDT),as an efficient and non-invasive treatment,attracts more people's attention due to the inherent property of high tissue *** soft tissue penetration depth of ultrasound(US)can even reach more than 10 cm,which has great advantage over that of ***,many sonosensitizers are studied and applied to SDT-based ***-based inorganic nanocrystals are able to generate more reactive oxygen species(ROS)due to the special composition and band *** representative achievements and the specific functions of the nanocrystals sonosensitizers are summarized in this work,and the relationship of structure/composition-SDT performance and the internally regulated composite is ***-gistic effects of SDT in combination with other therapeutic modalities are mainly *** the same time,the critical and potential issues and future perspectives are addressed.

关键词： Metal-based inorganic nanocrystals Sonodynamic therapy(SDT) Tumor treatment Antibacteria

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Perenniality:From model plants to applications in agriculture

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Molecular Plant 2024年第1期17卷 141-157页

作者： Bo Zhao jia-Wei wang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences(CEMPS)Institute of Plant Physiology and Ecology(SIPPE)Chinese Academy of Sciences(CAS)Shanghai 200032China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Plant Carbon Capture CASShanghai 200032China New Cornerstone Science Laboratory Shanghai 200032China

To compensate for their sessile nature,plants have evolved sophisticated mechanisms enabling them to adapt to ever-changing *** such prominent feature is the evolution of diverse life history strategies,particularly such that annuals reproduce once followed by seasonal death,while perennials live longer by cycling growth *** intrinsic phenology is primarily genetic and can be altered by environmental *** evolutionary transitions between annual and perennial life history strategies are common,perennials account for most species in nature because they survive well under year-round *** proportion,however,is reversed in ***,perennial crops promise to likewise protect and enhance the resilience of agricultural ecosystems in response to climate *** significant endeavors that have been made to generate perennial crops,progress is slow because of barriers in studying perennials,and many developed species await further *** findings in model species have illustrated that simply rewiring existing genetic networks can lead to lifestyle *** implies that engineering plant life history strategy can be achieved by manipulating only a few key *** this review,we summarize our current understanding of genetic basis of perenniality and discuss major questions and challenges that remain to be addressed.

关键词： perenniality developmental plasticity flowering time poplar Arabis alpina perennial crops life history strategy

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Delocalizedπ_(3)^(6) Bond in OX_(2) (X=Halogen) Molecules

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Chinese Journal of Chemical Physics 2022年第3期35卷 542-550,I0003页

作者： Yi-han Tang Pu Yang Meng-yuan Chen Yu-ru wang jia-xin wang jia-wei Xu School of Petrochemical Engineering Changzhou UniversityChangzhou 213164China jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China jiangsu Key Laboratory of Numerical Simulation of Large Scale Complex System Nanjing Normal UniversityNanjing 210023China

OX_(2)(X=halogen)molecules was studied *** results show that delocalizedπ_(3)^(6) bonds exist in their electronic structures and O atoms adopt the sp^(2) type of hybridization,which violates the prediction of the valence shell electron pair repulsion theory of sp^(3) *** stabilization energy is proposed to measure the contribution of delocalizedπ_(3)^(6) bond to energy decrease and proves to bring extra-stability to the *** phenomena can be summarized as a kind of coordinating effect.

关键词： Theoretical and computational chemistry Valence shell electron pair repulsion theory Delocalizedπbond Delocalization stabilization energy Dihalogen monoxide

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Efficacy and safety of perioperative therapy for locally resectable gastric cancer:A network meta-analysis of randomized clinical trials

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1046-1058页

作者： Zi-Yu Kuang Qian-Hui Sun Lu-Chang Cao xin-Yi Ma jia-Xi wang Ke-xin Liu Jie Li Graduate College Beijing University of Traditional Chinese MedicineBeijing 100029China Oncology Department Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

BACKGROUND Gastric cancer(GC)is the fifth most commonly diagnosed malignancy worldwide,with over 1 million new cases per year,and the third leading cause of cancer-related *** To determine the optimal perioperative treatment regimen for patients with locally resectable *** A comprehensive literature search was conducted,focusing on phase II/III randomized controlled trials(RCTs)assessing perioperative chemotherapy and chemoradiotherapy in treating locally resectable *** R0 resection rate,overall survival(OS),disease-free survival(DFS),and incidence of grade 3 or higher nonsurgical severe adverse events(SAEs)associated with various perioperative regimens were analyzed.A Bayesian network meta-analysis was performed to compare treatment regimens and rank their *** Thirty RCTs involving 8346 patients were included in this *** XELOX plus neoadjuvant radiotherapy and neoadjuvant CF were found to significantly improve the R0 resection rate compared with surgery alone,and the former had the highest probability of being the most effective option in this *** plus adjuvant FLOT was associated with the highest probability of being the best regimen for improving *** to limited data,no definitive ranking could be determined for *** nonsurgical SAEs,FLO has emerged as the safest treatment *** This study provides valuable insights for clinicians when selecting perioperative treatment regimens for patients with locally resectable *** studies are required to validate these findings.

关键词： Gastric cancer Perioperative treatment Network meta-analysis Efficacy and safety

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Interleukin-1 beta induction of neuron apoptosis depends on p38 mitogen-activated protein kinase activity after spinal cord injury~1

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Acta Pharmacologica Sinica 2005年第8期26卷 934-942页

作者： xin-jia wang~2, Kang-mei KONG, Wei-li QI, Wei-lian YE, Pei-song SONG Department of Spine Surgery, The Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China Department of Spine Surgery The Second Affiliated Hospital Shantou University Medical College Shantou China

Aim: Interleukin-1 beta (IL-1β) has been implicated as an extracellular signal in the initiation of apoptosis in neurons and oligodendrocytes after spinal cord injury (SCI). To further characterize the apoptotic cascade initiated by IL- 1β after SCI, we examined the expression of IL-1β, p38 mitogen-activated protein kinase (p38 MAPK) and caspase-3 after SCI, and further investigated whether p38 MAPK was involved in neuron apoptosis induced by IL- 1β. Methods: Adult rats were given contusion SCI at the T-10 vertebrae level with a weight-drop impactor (10 g weight dropped 25.0 mm). The expression levels of IL-1β, p38 MAPK and caspase-3 after SCI were assessed with Western blots, immunohistochemistry staining, and real time reverse transcription polymerase chain reactions (RT-PCR). Neuron apoptosis was assessed with the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL) method. Results: Increased levels of IL-1β and p38 MAPK were observed soon after injury, with a peak in expression levels within 6 h of injury. By 24 h after injury, caspase-3 expression was markedly increased in the injured spinal cord. TUNEL-positive cells were first observed in the lesioned area 6 h after SCI. The largest number of TUNEL-positive cells was observed at 24 h post-SCI. Intrathecal injection of the IL-1 receptor antagonist IL- 1Ra significantly reduced expression of p38 MAPK and caspase-3, and reduced the number of TUNEL-positive cells. Moreover, intrathecal injection of an inhibitor of p38 MAPK, SB203580, also significantly reduced the expression of caspase-3, and reduced the number of TUNEL-positive cells in the injured spinal cord. Conclusion: The p38MAPK signaling pathway plays an important role in IL-1β mediated induction of neuron apoptosis following SCI in rats.

关键词： apoptosis interleukin-1 interleukin-1-receptor antagonist protein p38 mitogen-activated protein kinase spinal cord injury TUNEL

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The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study

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Food Science and Human Wellness 2024年第2期13卷 778-790页

作者： Tao wang Shuang wang Shuchen Dong Ruiling wang Shuxuan wang Jie Yang xin wang xin Lü College of Food Science and Engineering Northwest Agriculture and Forestry UniversityYangling 712100China Faculty of Food Science and Engineering Kunming University of Science and TechnologyKunming 650500China School of Life Science and Technology Xinjiang UniversityUrumqi 830046China

Intestinal microbiota imbalance may worsen the progression of ulcerative colitis(UC).Lacticaseibacillus rhamnosus LS8(LR)has the potential ability to regulate microbiota through producing a novel antibacterial substance,cyclic opine:*** study aimed to investigate whether LR could ameliorate dextran sulfate sodium-induced UC in mice via modulating intestinal microbiota using fecal microbiota transplantation(FMT)*** results showed that both LR and FMT attenuated UC as evidenced by 1)alleviating disease activity index and colonic pathology;2)up-regulating MUCs and tight junction proteins;3)increasing oxidative mediators and decreasing antioxidant mediators;4)down-regulating proinflammatory cytokines and *** results were mainly attributable to the microbiota-regulating effect of LR,including increasing beneficial bacteria(like Akkermansia)and its related SCFAs,while decreasing harmful bacteria(like Proteobacteria)and its related LPS,thereby suppressing the hyperactivation of TLR4/NF-κB ***,LR can alleviate UC and is a potential dietary supplement to attenuate UC.

关键词： Gut barrier Gut microbiota Fecal microbiota transplantation Lacticaseibacillus rhamnosus Oxidative stress Ulcerative colitis

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Composition operators on weighted Bergman spaces induced by doubling weights

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Science China Mathematics 2024年第7期67卷 1571-1598页

作者： xin Guo Maofa wang School of Mathematics and Statistics Wuhan UniversityWuhan430072China

Given a doubling weightωon the unit disk D,let A_(ω)^(p) be the space of all the holomorphic functions f,where∥f∥A_(ω)^(p):=(∫_(D)|f(z)|_(p)ω(z)dA(z))^(1/p)<∞.We completely characterize the topological connectedness of the set of composition operators on A_(ω)^(p).As an application,we construct an interesting example which reveals that two composition operators on A_(α)^(p) in the same path component may fail to have a compact difference and give a negative answer to the Shapiro-Sundberg question in the(standard)weighted Bergman *** addition,we completely describe the central compactness of any finite linear combinations of composition operators on A_(ω)^(p) in three terms:a Julia-Carathéodory-type function-theoretic characterization,a power-type characterization,and a Carleson-type measure-theoretic characterization.

关键词： composition operator linear combination linearly connected weighted Bergman space doubling weight

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