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Cd Se/Zn S quantum dots induce photodynamic effects and cytotoxicity in pancreatic cancer cells

World Journal of Gastroenterology 2016年第21期22卷 5012-5022页

作者： Si-jia He jia Cao Yong-Sheng Li jia-chun yang Min Zhou chun-Ying Qu Yi Zhang Feng Shen Ying Chen Ming-Ming Li Lei-Ming Xu Department of Gastroenterology Xinhua Hospital School of Medicine Shanghai Jiaotong University the Comprehensive Cancer Center and Shanghai Key Laboratory for Pancreatic Diseases Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Department of General Surgery Xinhua Hospital School of Medicine Shanghai Jiaotong University

AIM: To investigate the photodynamic effect of Cd Se/Zn S quantum dots(QDs) on pancreatic cancer cells and elucidate the probable ***: The pancreatic cancer cell line SW1990 was treated with different concentrations of Cd Se/Zn S QDs(0, 0.5, 1.0, 1.5, 2.0, 2.5 μmol/L), with or without illumination. The viability of SW1990 cells was tested using the Cell Counting Kit-8(CCK-8) assay. The ultrastructural changes of SW1990 cells were observed by transmission electron microscopy. Apoptosis was detected by nuclear staining and flow cytometry(FCM). Reactive oxygen species(ROS) were measured by dichlorofluorescein diacetate via fluorescence microscopy. Expression of Bax, Bcl-2 and caspase-3 was measured by real-time polymerase chain reaction(PCR) and protein immunoblotting 24 h after SW1990 cells were treated with Cd Se/Zn S QDs and ***: The CCK-8 assay results showed that both Cd Se/Zn S QDs with and without illumination suppressed SW1990 cell proliferation. Cell viability was significantly lower when illuminated or with a longer incubation time and a higher light dose. Cd Se/Zn S QDs with illumination caused ultrastructural changes in SW1990 cells, such as organelle degeneration and chromatin condensation and aggregation at the periphery of the nucleus. Fluorescence microscopy and FCM showed that Cd Se/Zn S QDs(1.5 μmol/L) with illumination increased SW1990 cell apoptosis(53.2%) and ROS generation compared with no illumination. Real-time PCR showed that expression of Bax and caspase-3 was upregulated and Bcl-2 was downregulated. Immunoblotting results were consistent with real-time PCR results. Inhibition of ROS and apoptosis both attenuated QD-photodynamictherapy-induced cell ***: Cd Se/Zn S QDs can be used as a photosensitizer to inhibit SW1990 cell proliferation through ROS generation and apoptotic protein expression regulation.

关键词： Quantum dots Pancreatic cancer Apoptosis Photodynamic therapy Reactive oxygen species

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Novel lactylation-related signature to predict prognosis for pancreatic adenocarcinoma

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World Journal of Gastroenterology 2024年第19期30卷 2575-2602页

作者： Tian Peng Fang Sun jia-chun yang Mei-Hong Cai Man-Xiu Huai jia-Xing Pan Fei-Yu Zhang Lei-Ming Xu Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai 200092China

BACKGROUND Lactate,previously considered a metabolic byproduct,is pivotal in cancer progression and maintaining the immunosuppressive tumor *** investigations confirmed that lactate is a primary regulator,introducing recently described post-translational modifications of histone and non-histone proteins,termed lysine *** adenocarcinomas are characterized by increased glycolysis and lactate ***,our understanding of lactylation-related genes in pancreatic adenocarcinomas remains *** To construct a novel lactylation-related gene signature to predict the survival of patients with pancreatic *** RNA-seq and clinical data of pancreatic adenocarcinoma(PDAC)were obtained from the GTEx(Genotype-Tissue Expression)and TCGA(The Cancer Genome Atlas)databases via Xena Explorer,and GSE62452 datasets from *** on lactylation-related genes were obtained from publicly available *** expressed genes(DEGs)were acquired by using R package“DESeq2”in *** COX regression analysis,LASSO Cox and multivariate Cox regressions were produced to construct the lactylation-related prognostic *** analyses,including functional enrichment,ESTIMATE,and CIBERSORT,were performed to analyze immune status and treatment responses in patients with pancreatic *** and normal human cell lines were subjected to western blot analysis under lactic acid intervention;two PDAC cell lines with the most pronounced lactylation were ***,RT-PCR was employed to assess the expression of LRGs genes;SLC16A1,which showed the highest expression,was selected for further ***16A1-mediated lactylation was analyzed by immunofluorescence,lactate production analysis,colony formation,transwell,and wound healing assays to investigate its role in promoting the proliferation and migration of PDAC *** vivo validation was performed using an established tumor *** In this stud

关键词： Pancreatic adenocarcinoma Lactylation Prognosis Immunotherapy Tumor microenvironment

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Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai jian Hui jia Yu Wang chun Cheng yang Qing jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

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基于Schiff-Base反应的成环策略及应用

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有机化学 2010年第8期30卷 1142-1155页

作者：张家强贾春阳电子科技大学微电子与固体电子学院电子薄膜与集成器件国家重点实验室成都610054

基于Schiff-base反应的大环化合物是近些年来超分子领域研究的热点.这些大环化合物不但在传感器、功能材料等领域发挥着重要的作用,而且在自组装研究领域具有重要的意义.从模板法和非模板法两方面分析了一些具有代表性Schiff-base大环... 详细信息

基于Schiff-base反应的大环化合物是近些年来超分子领域研究的热点.这些大环化合物不但在传感器、功能材料等领域发挥着重要的作用,而且在自组装研究领域具有重要的意义.从模板法和非模板法两方面分析了一些具有代表性Schiff-base大环的合成,发现,不但具有合适半径和构型的离子可以作为成环反应的模板,而且强烈的分子内氢键也能有效地驱动成环反应.同时,对于该类大环分子合成所面临的问题及发展方向进行了评述和预测.

关键词：大环化合物 Schiff-base反应模板氢键

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Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 148-155页

作者： Yunhan yang Han jia Tuo Liu Yuzhen yang Jun yang Key Laboratory of Noise and Vibration Research Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

The phenomenon of induced transparency, characterized by a high quality(Q) factor, holds significant importance in the fields of high-precision sensing, energy storage and wave manipulation. Conventional transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters, thereby hindering advanced research on high-Q effects. Here we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection spectrum. By virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom, we achieve the manipulation of induced transparency in a decoupled, wide-ranging, and elaborate manner. Exploiting the diverse evolutions across the intrinsic parameter space, we show experimentally a counter-intuitive increase in the Q-factor of the transparency window, which is attributed to the enhanced dissipation of the bright ***, a constant group delay at the center frequency is observed accompanying this evolution. Our work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon, and paves the way towards applications in programmable acoustic sensors, filters and slow-wave devices.

关键词： induced transparency acoustic meta-atom high quality-factor scattering programmable intrinsic parameter

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论法治建设的市场逻辑

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河南师范大学学报（哲学社会科学版） 2013年第4期40卷 41-44页

作者：贾阳春华北电力大学人文与社会科学院北京102206

法治生成的最重要的条件,在于作为法治重要基石的自由、平等以及宪法主治、有限政府和基本人权等价值,在社会的不断进化过程中得以演进形成。而市场经济的发展、市场逻辑的拓展,对于法治基本价值的孕育、演进和发展,起到了不可或缺的作... 详细信息

法治生成的最重要的条件,在于作为法治重要基石的自由、平等以及宪法主治、有限政府和基本人权等价值,在社会的不断进化过程中得以演进形成。而市场经济的发展、市场逻辑的拓展,对于法治基本价值的孕育、演进和发展,起到了不可或缺的作用:从经济独立到身份平等,从市场规则到宪法主治,从市场平衡到有限政府,从市场自由到基本人权,均印证了市场经济与法治之间存在的逻辑联系。二者之间关系的普遍经验,对我国同样具有参考价值。社会主义市场经济的运行与发展,对社会主义法治国家和法治政府的构建来说,同样是基础性和前提性的条件。而法治建设的历史要求,反过来会进一步推进市场经济体制改革,促进经济更加开放、权利更有保障的制度环境的构建。

关键词：法治市场经济市民社会

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Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang yang jianfeng Zheng Guoyu Wang Yifei Gao Yatao yang jia Li Xiaojin Han Yan Cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Ethanol

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无线传感器网络三维节点的插值规划定位

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北京邮电大学学报 2016年第5期39卷 94-98页

作者：李彬吕晓军贾新春杨波山西大学数学科学学院太原030006 中国铁道科学研究院电子计算技术研究所北京100081

针对无线传感器网络中传感器节点的初始位置未知的问题,提出一种基于插值和规划算法的无线传感器网络三维节点定位算法.该算法利用锚节点坐标将节点所在空间曲面建立,并利用接收信号强度指示(RSSI)值和无线信号传播模型推导出所有可通... 详细信息

针对无线传感器网络中传感器节点的初始位置未知的问题,提出一种基于插值和规划算法的无线传感器网络三维节点定位算法.该算法利用锚节点坐标将节点所在空间曲面建立,并利用接收信号强度指示(RSSI)值和无线信号传播模型推导出所有可通信节点间相对距离.最后,利用0-1规划在空间曲面上选出满足距离约束且与未知节点数量相同的插值节点,从而估计出未知节点的空间位置.该算法设计简单,通信开销少.仿真结果表明,该算法具有较小的节点定位误差,并具有良好的稳定性和扩展性.

关键词：无线传感器网络定位接收信号强度指示插值 0-1规划

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding chun Chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai Huang jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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异形复层结构TiO_2纳米棒薄膜的水热合成及性能(英文)

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无机化学学报 2013年第5期29卷 1057-1064页

作者：庄稼秦海洋李林峰周莹贾春阳万中全曾宪光西南石油大学材料科学与工程学院成都610500 电子科技大学电子薄膜与集成器件国家重点实验室成都610054 材料腐蚀与防护四川省重点实验室自贡643000

本文采用水热反应法．通过改变合成条件，经XRD和FESEM表征，证实合成了四方金红石相异形复层f阵列一团簇）结构的TiO2薄膜。合成薄膜的下层是TiO2的阵列，上层是团簇状的TiO2。并且构成阵列和团簇的每个方柱又由多根纳米棒（25．65nm... 详细信息

本文采用水热反应法．通过改变合成条件，经XRD和FESEM表征，证实合成了四方金红石相异形复层f阵列一团簇）结构的TiO2薄膜。合成薄膜的下层是TiO2的阵列，上层是团簇状的TiO2。并且构成阵列和团簇的每个方柱又由多根纳米棒（25．65nm）组成。上层团簇的生成量和厚度可以通过改变反应物的初始浓度、反应时间和生长基片的角度进行调控。将这种异形复层结构薄膜试用于染料敏化太阳能电池（DSSC）光阳极．发现其光电转化效率比单层阵列TiO2薄膜提高了2．6倍。由此表明TiO2这种以纳米棒为单元结构的异形复层薄膜．上层团簇结构有利于产生采光作用以及吸附微粒的作用．下层阵列结构有利于载流子的定向快速传输．其复合结构的形成。致使光电转换效果明显提高。

关键词：水热法纳米棒薄膜 TiO2 阵列-团簇结构光电转换效率

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